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1. 发明授权

US08974769B2 Magnetic nanocomposite with multi-biofunctional groups and method for fabricating the same 有权
标题翻译：具有多功能组的磁性纳米复合物及其制造方法
公开(公告)号：US08974769B2
公开(公告)日：2015-03-10
申请号：US12799893
申请日：2010-05-04
申请人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Hao-Li Liu
发明人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Hao-Li Liu
IPC分类号： A61K49/18 , A61K47/34 , A61K9/50 , A61K31/785 , A61K47/48 , B82Y5/00
CPC分类号： A61K47/48661 , A61K47/6875 , A61K47/6923 , A61K49/1857 , B82Y5/00 , Y10S977/892
摘要： The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.
摘要翻译：本发明提出一种具有多生物功能组的磁性纳米复合材料，其包含芯和包裹芯的外壳，其中所述芯包含磁性纳米颗粒，并且其中壳由具有多生物功能基团的导电聚合物制成，其中药物，可以连接抗体或荧光标记。

2. 发明授权

US08889192B2 Magnetic nanomedicine for inhibiting/treating human prostate cancer 有权
标题翻译：用于抑制/治疗人类前列腺癌的磁性纳米医药
公开(公告)号：US08889192B2
公开(公告)日：2014-11-18
申请号：US13177034
申请日：2011-07-06
申请人： Mu-Yi Hua , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
发明人： Mu-Yi Hua , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
IPC分类号： A61K9/16 , A61K31/74 , A61K47/48 , A61K31/337 , A61K9/50 , B82Y5/00
CPC分类号： A61K47/48861 , A61K9/5094 , A61K31/337 , A61K47/6923 , B82Y5/00 , Y10S977/773 , Y10S977/788 , Y10S977/906
摘要： The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
摘要翻译：本发明公开了一种用于抑制/治疗人前列腺癌的磁性纳米医药，其包含含有直径小于10nm的磁性颗粒的核心; 由羧基化聚苯胺制成的壳，并封装核心; 和与壳共价连接并能够抑制/治疗前列腺癌的药物。本发明的磁性纳米医药不仅具有优异的热稳定性，而且还具有比常规抗前列腺癌药物更高的水溶性。此外，本发明的磁性纳米医药可以磁性地导入癌症区域，以增加药物的局部浓度，增强治疗效果。

3. 发明授权

US08462326B2 Schlieren type ultrasonic wave observer system 有权
标题翻译： Schlieren型超声波观测系统
公开(公告)号：US08462326B2
公开(公告)日：2013-06-11
申请号：US12929219
申请日：2011-01-10
申请人： Hao-Li Liu , Chung-Cheng Kung , Ting-Chia Chang
发明人： Hao-Li Liu , Chung-Cheng Kung , Ting-Chia Chang
IPC分类号： G01N21/41 , G01J3/45
CPC分类号： G01N29/2418 , G01N29/0654
摘要： The invention discloses the Schlieren type ultrasonic wave observer system. The invention states optics interference by the ultrasonic wave sound field after perturbation the medium, and combines to make the interference penetration optical projection the image, the goal lies in the observation ordinary naked eye blind ultrasonic wave sound field distribution. Characteristic of the invention using the spectroscope and the reflector combination, as well as microcontroller precise time delay control, might formerly be limited under the 4F optical field length limit to enhance largely the field of vision the several fold.
摘要翻译：本发明公开了Schlieren型超声波观测系统。本发明通过对介质进行扰动后的超声波声场表示光学干涉，并结合使干涉穿透光学投影成像，目标在于观察普通裸眼超声波声场分布。使用分光镜和反射器组合的本发明的特征以及微控制器精确的时间延迟控制可能以前在4F光场长度限制下受到限制，从而在很大程度上增强了视场的数倍。

4. 发明申请

US20120113430A1 Schlieren type ultrasonic wave observer system 有权
标题翻译： Schlieren型超声波观测系统
公开(公告)号：US20120113430A1
公开(公告)日：2012-05-10
申请号：US12929219
申请日：2011-01-10
申请人： Hao-Li Liu , Chung-Cheng Kung , Ting-Chia Chang
发明人： Hao-Li Liu , Chung-Cheng Kung , Ting-Chia Chang
IPC分类号： G01J3/45
CPC分类号： G01N29/2418 , G01N29/0654
摘要： The invention discloses the Schlieren type ultrasonic wave observer system. The invention states optics interference by the ultrasonic wave sound field after perturbation the medium, and combines to make the interference penetration optical projection the image, the goal lies in the observation ordinary naked eye blind ultrasonic wave sound field distribution. Characteristic of the invention using the spectroscope and the reflector combination, as well as microcontroller precise time delay control, might formerly be limited under the 4F optical field length limit to enhance largely the field of vision the several fold.
摘要翻译：本发明公开了Schlieren型超声波观测系统。本发明通过对介质进行扰动后的超声波声场表示光学干涉，并结合使干涉穿透光学投影成像，目标在于观察普通裸眼超声波声场分布。使用分光镜和反射器组合的本发明的特征以及微控制器精确的时间延迟控制可能以前在4F光场长度限制下受到限制，从而在很大程度上增强了视场的数倍。

5. 发明授权

US08046994B2 Precision method and apparatus for controlling the shape memory alloy 有权
标题翻译：用于控制形状记忆合金的精密方法和装置
公开(公告)号：US08046994B2
公开(公告)日：2011-11-01
申请号：US12289419
申请日：2008-10-28
申请人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
发明人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
IPC分类号： F01B29/10 , H02N10/00
CPC分类号： F03G7/065
摘要： The invention discloses a method and apparatus to control the shaping change of Shape-Memory-Alloy (SMA). The piece-wised current drain control device is designed to independently deliver current to stimulate sectional SMA but not the entire one. The invention is also successfully implemented on an automatic light sensitive aperture control device to simulate the light response of a pupil. The control technique can extend the application potential of SMA toward precise actuation, aeronautical applications, surgical tools, or biomedical applications such as artificial organ or muscles.
摘要翻译：本发明公开了一种控制形状记忆合金（SMA）成型变化的方法和装置。分流电流漏极控制装置被设计成独立地传递电流以刺激SMA部分而不是整个SMA。本发明也成功地实现在自动光敏光圈控制装置上以模拟光瞳的光响应。控制技术可以将SMA的应用潜力扩大到精确致动，航空应用，外科手术工具或生物医学应用，如人造器官或肌肉。

6. 发明申请

US20100005795A1 Precision method and apparatus for controlling the shape memory alloy 有权
标题翻译：用于控制形状记忆合金的精密方法和装置
公开(公告)号：US20100005795A1
公开(公告)日：2010-01-14
申请号：US12289419
申请日：2008-10-28
申请人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
发明人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
IPC分类号： F03G7/06
CPC分类号： F03G7/065
摘要： The invention discloses a method and apparatus to control the shaping change of Shape-Memory-Alloy (SMA). The piece-wised current drain control device is designed to independently deliver current to stimulate sectional SMA but not the entire one. The invention is also successfully implemented on an automatic light sensitive aperture control device to simulate the light response of a pupil. The control technique can extend the application potential of SMA toward precise actuation, aeronautical applications, surgical tools, or biomedical applications such as artificial organ or muscles.
摘要翻译：本发明公开了一种控制形状记忆合金（SMA）成型变化的方法和装置。分流电流漏极控制装置被设计成独立地传递电流以刺激SMA部分而不是整个SMA。本发明也成功地实现在自动光敏光圈控制装置上以模拟光瞳的光响应。控制技术可以将SMA的应用潜力扩大到精确致动，航空应用，外科手术工具或生物医学应用，如人造器官或肌肉。

7. 发明申请

US20090149781A1 Biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus 有权
标题翻译：生物医学用多通道半球聚焦超声相控阵仪
公开(公告)号：US20090149781A1
公开(公告)日：2009-06-11
申请号：US12000118
申请日：2007-12-10
申请人： Hao-Li Liu , Jhen-Hao Guo , Heng-Wun Chen
发明人： Hao-Li Liu , Jhen-Hao Guo , Heng-Wun Chen
IPC分类号： A61H1/00
CPC分类号： A61N7/02 , A61B2018/00642 , A61N2007/0078
摘要： The invention is to a biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus. The invention comprises of a graphic user interface, digital multiple channel phase control kernel, multiple channel driving system, and impedance matching module, power feedback device, as well as the hemispherical low-frequency ultrasound phased array. The invention also serves as a good platform reference to develop a focused ultrasound system in the assisted brain drug delivery application.
摘要翻译：本发明涉及一种生物医学多通道半球聚焦超声相控阵装置。本发明包括图形用户界面，数字多通道相位控制核，多通道驱动系统，阻抗匹配模块，功率反馈装置以及半球型低频超声相控阵。本发明也是辅助脑药物递送应用中开发聚焦超声系统的良好平台参考。

8. 发明授权

US08287471B2 Medical treatment using an ultrasound phased array 有权
标题翻译：使用超声相控阵的医疗
公开(公告)号：US08287471B2
公开(公告)日：2012-10-16
申请号：US12033370
申请日：2008-02-19
申请人： Hao-li Liu , Win-li Lin , Hsu Chang
发明人： Hao-li Liu , Win-li Lin , Hsu Chang
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B34/10 , A61B90/37 , A61B2090/392
摘要： A medical system and method for treating a disorder of a subject by thermal ablation, e.g., focused ultrasound thermal ablation, are provided. The method includes obtaining medical images that include at least one image of subject's chest and ribs to reconstruct a three-dimensional chest-rib distribution; and applying ultrasound waves on a target point beyond the subject's ribs by selectively activating one or more elements of an ultrasound phased array to avoid ultrasonic energy absorption or reflection by an intervening rib based on a calculation of a relationship between the three-dimensional chest-rib distribution and an acoustic emission direction.
摘要翻译：提供了一种通过热消融治疗受试者病症的医疗系统和方法，例如聚焦超声热消融。该方法包括获得包括受试者胸部和肋骨的至少一个图像的医学图像，以重建三维胸肋分布; 以及通过选择性地激活超声相控阵列的一个或多个元件，将目标点上的超声波施加到目标点之上，以避免超声能量吸收或由中间肋反射，基于三维胸肋之间的关系的计算分布和声发射方向。

9. 发明授权

US08226559B2 Method and apparatus for real-time temperature measuring for high-intensity focused ultrasound(HIFU) therapy system 有权
标题翻译：用于高强度聚焦超声（HIFU）治疗系统的实时温度测量方法和装置
公开(公告)号：US08226559B2
公开(公告)日：2012-07-24
申请号：US12155689
申请日：2008-06-09
申请人： Hao-Li Liu , I-Yeh Lu , Sheng-Min Huang
发明人： Hao-Li Liu , I-Yeh Lu , Sheng-Min Huang
IPC分类号： A61B8/00 , G01N29/00
CPC分类号： A61N7/02 , A61B5/01 , A61B34/25 , A61B2017/00084 , A61B2017/00106
摘要： The invention is disclosed to design a real-time pulse/echo system to perform 1-D real-time temperature measurement and integrate in the high-intensity focused ultrasound system. In the invention, a modified echo-time shifting algorithm is developed to calculate the corresponding phase shift from echo signal, which correlates with the instantaneous temperature change during heating process.
摘要翻译：公开了本发明，以设计实时脉冲/回波系统来执行1-D实时温度测量并集成在高强度聚焦超声系统中。在本发明中，开发了一种改进的回波 - 时移算法，用于计算回波信号的相应相移，这与加热过程中的瞬时温度变化相关。

10. 发明申请

US20120095325A1 TREATMENT OF BRAIN DISEASES VIA ULTRASOUND/MAGNETIC TARGETING DELIVERY AND TRACING OF THERAPEUTIC AGENTS 审中-公开
标题翻译：通过超声波/磁性定向递送和治疗药物的治疗来治疗脑疾病
公开(公告)号：US20120095325A1
公开(公告)日：2012-04-19
申请号：US13273368
申请日：2011-10-14
申请人： Kuo-Chen Wei , Hao-Li Liu , Mu-Yi Hua
发明人： Kuo-Chen Wei , Hao-Li Liu , Mu-Yi Hua
IPC分类号： A61B5/055 , A61N7/00 , B82Y5/00
CPC分类号： A61B5/0515 , A61B5/0042 , A61M37/0092 , A61M2210/0693 , B82Y5/00
摘要： Disclosed herein is a method for treating a brain disease in which focused ultrasound and magnetic targeting are applied to a subject in need of such treatment, so that therapeutic agent-magnetic nanoparticle composites are directed across the blood-brain barrier to a designated locus inside the brain of the subject. Each of the composites includes a magnetic nanoparticle that is formed of an iron-based core and a shell encapsulating the iron-based core, and a therapeutic agent that is bound to the shell of the magnetic nanoparticle. The magnetic nanoparticle has a size ranging from 5 to 200 nm. The iron-based core has a crystalline structure that imparts the composites with a sufficiently high magnetization, thereby enhancing magnetic targeting of the composites to the designated locus inside the brain of the subject. The magnetic targeting treatment is conducted via a magnet providing a magnetic flux density not less than 0.18 T.
摘要翻译：本文公开了一种治疗脑疾病的方法，其中将聚焦超声和磁性靶向应用于需要这种治疗的受试者，使得治疗剂 - 磁性纳米颗粒复合物穿过血脑屏障被引导到内部的指定位点主题的大脑。每种复合材料包括由铁基核心和包封铁基核心的壳形成的磁性纳米颗粒，以及结合到磁性纳米颗粒的壳的治疗剂。磁性纳米粒子的尺寸范围为5〜200nm。铁基芯具有赋予复合材料足够高的磁化强度的晶体结构，从而增强复合材料对受试者脑内指定位点的磁性靶向。磁性靶向处理通过提供磁通密度不小于0.18T的磁体进行。

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