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    • 4. 发明授权
    • Adaptive lazy merging
    • 自适应懒惰合并
    • US08676865B2
    • 2014-03-18
    • US12123598
    • 2008-05-20
    • Wei HanLin QiaoVijayshankar Raman
    • Wei HanLin QiaoVijayshankar Raman
    • G06F7/00G06F17/30
    • G06F17/30958
    • A query processing method intersects two or more unsorted lists based on a conjunction of predicates. Each list comprises a union of multiple sorted segments. The method performs lazy segment merging and an adaptive n-ary intersecting process. The lazy segment merging comprises starting with each list being a union of completely unmerged segments, such that lookups into a given list involve separate lookups into each segment of the given list. The method intersects the lists according to the predicates while performing the lazy segment merging, such that the lazy segment merging reads in only those portions of each segment that are needed for the intersecting. As the intersecting proceeds and the lookups are performed, the intersecting selectively merges the segments together, based on a cost-benefit analysis of the cost of merging compared to the benefit produced by reducing a number of lookups.
    • 查询处理方法基于谓词的连接与两个或多个未排序的列表相交。 每个列表包括多个排序段的并集。 该方法执行延迟段合并和自适应n元相交处理。 懒惰段合并包括从每个列表开始,这些列是完全未合并的段的并集,使得到给定列表中的查找涉及到给定列表的每个段的单独查找。 该方法在执行延迟段合并时根据谓词与列表相交,使得懒惰段合并仅读取相交所需的每个段的那些部分。 当相交进行和查找被执行时,相交的选择性地将段合在一起,基于与合并成本的成本效益分析相比,通过减少多个查找产生的收益。
    • 5. 发明申请
    • Hybrid push-down/pull-up of unions with expensive operations in a federated query processor
    • 在联合查询处理器中使用昂贵的操作的工会的混合下推/上拉
    • US20070067274A1
    • 2007-03-22
    • US11228888
    • 2005-09-16
    • Wei HanInderpal NarangVijayshankar Raman
    • Wei HanInderpal NarangVijayshankar Raman
    • G06F17/30
    • G06F16/2456
    • Disclosed are a method and a system for executing a query that requires an expensive process, such as a join, between two or more datasets. If each dataset has multiple partitions that are located at multiple sources, then each of the multiple partitions for each dataset must be unioned prior to completing execution of the query. The method and system develop both a query execution plan and at least one alternative query execution plan to indicate when the process should be pushed down below the unions and when the process should be pulled up above the unions based on collocation of partitions. The query execution plan and the alternative query execution plan(s) are embedded in a composite query execution plan which is evaluated and re-evaluated at run time to determine which of the query execution plan and the alternative query execution plan is currently the most efficient plan and the query is executed, accordingly.
    • 公开了一种执行查询的方法和系统,该查询需要在两个或更多个数据集之间的昂贵的处理,诸如连接。 如果每个数据集具有位于多个源的多个分区,则在完成执行查询之前,必须对每个数据集的每个分区进行联合。 该方法和系统开发查询执行计划和至少一个替代查询执行计划,以指示何时将流程推送到工会下方,以及何时应该根据分区的搭配将工作提升到工会以上。 查询执行计划和替代查询执行计划嵌入在复合查询执行计划中,该计划在运行时进行评估和重新评估,以确定查询执行计划和备用查询执行计划中的哪一个当前是最有效的 相应地执行计划并执行查询。
    • 6. 发明申请
    • ADAPTIVE LAZY MERGING
    • 自适应LAZY MERGING
    • US20090292714A1
    • 2009-11-26
    • US12123598
    • 2008-05-20
    • Wei HanLin QiaoVijayshankar Raman
    • Wei HanLin QiaoVijayshankar Raman
    • G06F17/30
    • G06F17/30958
    • A query processing method intersects two or more unsorted lists based on a conjunction of predicates. Each list comprises a union of multiple sorted segments. The method performs lazy segment merging and an adaptive n-ary intersecting process. The lazy segment merging comprises starting with each list being a union of completely unmerged segments, such that lookups into a given list involve separate lookups into each segment of the given list. The method intersects the lists according to the predicates while performing the lazy segment merging, such that the lazy segment merging reads in only those portions of each segment that are needed for the intersecting. As the intersecting proceeds and the lookups are performed, the intersecting selectively merges the segments together, based on a cost-benefit analysis of the cost of merging compared to the benefit produced by reducing a number of lookups.
    • 查询处理方法基于谓词的连接与两个或多个未排序的列表相交。 每个列表包括多个排序段的并集。 该方法执行延迟段合并和自适应n元相交处理。 懒惰段合并包括从每个列表开始,这些列是完全未合并的段的并集,使得到给定列表中的查找涉及到给定列表的每个段的单独查找。 该方法在执行延迟段合并时根据谓词与列表相交,使得懒惰段合并仅读取相交所需的每个段的那些部分。 当相交进行和查找被执行时,相交的选择性地将段合在一起,基于与合并成本的成本效益分析相比,通过减少多个查找产生的收益。
    • 8. 发明授权
    • Use of midkine protein and the protein-containing medical device
    • 使用中期蛋白和含蛋白质的医疗器械
    • US09283300B2
    • 2016-03-15
    • US13322443
    • 2010-05-25
    • Wei HanZhonghui Zhang
    • Wei HanZhonghui Zhang
    • A61K38/17A61P19/02A61L27/54A61L27/24A61L27/22A61K38/18A61F2/30
    • A61L27/227A61F2/30756A61F2002/30677A61K38/18A61L27/54A61L2300/252A61L2300/414A61L2430/06
    • The applications and medical devices of Midkine in the field of biotechnology are described in this invention. This invention describes the applications of the protein as follow in (a) or (b) in preparing drugs for promoting cartilage growth or treating cartilage diseases, the protein as a growth factor for promoting chondrocyte proliferation, or medical devices containing this protein: (a) the protein whose amino acid sequence is shown as SEQ ID NO.1; (b) the proteins whose amino acid sequence have at least 60% homology comparing with amino acid sequence described in (a). The present invention is different from the present knowledge of MK and its related proteins. The experimental results demonstrated that MK promotes proliferation of three types of chondrocytes and is used for preparing drugs for treating cartilage disease. It may provide new therapy for treating cartilage diseases clinically, and new technology for expansion of chondrocytes in vitro for cartilage tissue engineering.
    • 本发明描述了Midkine在生物技术领域的应用和医疗设备。 本发明描述了如下(a)或(b)中的蛋白质在制备用于促进软骨生长或治疗软骨疾病的药物中的应用,所述蛋白质作为促进软骨细胞增殖的生长因子,或含有该蛋白质的医学装置:(a )其氨基酸序列显示为SEQ ID NO.1的蛋白质; (b)与(a)中所述的氨基酸序列相比,其氨基酸序列具有至少60%同源性的蛋白质。 本发明与MK及其相关蛋白质的现有知识不同。 实验结果表明,MK促进三种软骨细胞增殖,用于制备治疗软骨疾病的药物。 可能提供临床治疗软骨疾病的新疗法,软骨组织工程体外软骨细胞扩增的新技术。
    • 10. 发明授权
    • Thiophene derivatives as factor XIa inhibitors
    • 噻吩衍生物作为因子XIa抑制剂
    • US08466295B2
    • 2013-06-18
    • US12097068
    • 2006-12-13
    • Wei Han
    • Wei Han
    • C07D231/56C07D333/22A61K31/415A61K31/38
    • C07D333/24C07D333/28C07D409/04
    • The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, L1, R3, and R11 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
    • 本发明提供式(I)的化合物或其立体异构体,互变异构体,药学上可接受的盐,溶剂合物或前药,其中变量A,L1,R3和R11如本文所定义。 式(I)的化合物可用作凝血级联和/或接触激活系统的丝氨酸蛋白酶的选择性抑制剂; 例如凝血酶,因子Xa,因子XIa,因子IXa,因子VIIa和/或血浆激肽释放酶。 特别地,它涉及作为选择性因子XIa抑制剂的化合物。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。