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1. 发明授权

US07785892B2 Method of determining iron concentration 失效
标题翻译：铁浓度测定方法
公开(公告)号：US07785892B2
公开(公告)日：2010-08-31
申请号：US11918151
申请日：2006-05-09
申请人： Wataru Akahane , Haruhisa Ijiri , Toshiro Hanada
发明人： Wataru Akahane , Haruhisa Ijiri , Toshiro Hanada
IPC分类号： G01N33/20 , G01N33/48
CPC分类号： G01N33/84 , G01N21/78 , G01N21/80 , G01N31/22 , G01N33/52
摘要： The present invention discloses a method of measuring iron concentration in a sample. The method includes bringing iron contained in the sample into contact with a metallochromic indicator for iron in the presence of lithium ion and determining the iron concentration based on the degree of resultant coloring. The present disclosure further includes a reagent and a kit using therefor.
摘要翻译：本发明公开了一种测量样品中铁浓度的方法。该方法包括在锂离子的存在下使包含在样品中的铁与铁的金属致变色指示剂接触，并且基于所得着色程度确定铁浓度。本公开还包括试剂和使用它的试剂盒。

2. 发明申请

US20090068750A1 Method of Determining Iron Concentration 失效
标题翻译：铁浓度测定方法
公开(公告)号：US20090068750A1
公开(公告)日：2009-03-12
申请号：US11918151
申请日：2006-05-09
申请人： Wataru Akahane , Haruhisa Ijiri , Toshiro Hanada
发明人： Wataru Akahane , Haruhisa Ijiri , Toshiro Hanada
IPC分类号： G01N33/20
CPC分类号： G01N33/84 , G01N21/78 , G01N21/80 , G01N31/22 , G01N33/52
摘要： The present invention discloses a method of measuring iron concentration in a sample, characterized by bringing the iron contained in the sample into contact with a metallochromic indicator for iron in the presence of lithium ion and determining the iron concentration based on the degree of resultant coloring, a reagent and a kit using therefor.By performing the method of measuring iron concentration of the present invention, the conventional problem that the measured value is lower as compared with that obtained by the International Standard Method is solved; a complicated procedures such as protein removal treatment or the like are not required; the measurement of iron concentration with an automated analyzer is enabled; and more accurate measurement becomes possible, since the measured value obtained by the present method is very close to that obtained by the standard addition method according to the International Standard Method,
摘要翻译：本发明公开了一种测定样品中铁浓度的方法，其特征在于，在锂离子的存在下使包含在样品中的铁与铁的金属致变色指示剂接触，并且基于所得着色程度确定铁浓度，试剂和使用它的试剂盒。通过进行本发明的铁浓度测定方法，解决了与国际标准方法相比测定值低的常规问题，不需要诸如蛋白质去除处理等复杂的程序; 使用自动分析仪测量铁浓度; 并且由于通过本方法得到的测定值与通过国际标准法的标准添加方法得到的测定值非常接近，所以能够进行更精确的测定，

3. 发明授权

US5925534A Method for measuring LDL-cholesterol 失效
标题翻译： LDL胆固醇测定方法
公开(公告)号：US5925534A
公开(公告)日：1999-07-20
申请号：US128930
申请日：1998-08-05
申请人： Yutaka Miki , Isao Koyama , Nobuko Imajo , Masayuki Futatsugi , Toshiro Hanada
发明人： Yutaka Miki , Isao Koyama , Nobuko Imajo , Masayuki Futatsugi , Toshiro Hanada
IPC分类号： G01N33/48 , C12Q1/32 , C12Q1/60 , C12Q1/00
CPC分类号： C12Q1/60 , C12Q1/32
摘要： The amount of cholesterol in low density lipoproteins in a sample can be measured by contacting the sample with one or more reagent solutions to carry out the reaction in the presence of a polyanion and an amphoteric surfactant, followed by optical measurement of the reaction product.
摘要翻译：样品中低密度脂蛋白中胆固醇的量可以通过使样品与一种或多种试剂溶液接触来测量，以在聚阴离子和两性表面活性剂存在下进行反应，随后光学测量反应产物。

4. 发明授权

US5885788A Method for measuring an amount of LDL-Cholesterol 失效
标题翻译：测定LDL-胆固醇含量的方法
公开(公告)号：US5885788A
公开(公告)日：1999-03-23
申请号：US897954
申请日：1997-07-24
申请人： Yutaka Miki , Nobuko Imajo , Toshiro Hanada
发明人： Yutaka Miki , Nobuko Imajo , Toshiro Hanada
IPC分类号： G01N33/92 , C12Q1/26 , C12Q1/00 , C12Q1/28 , C12Q1/44
CPC分类号： G01N33/92 , G01N2800/044 , Y10S435/975
摘要： The present invention is to provide a method for measuring an amount of cholesterol in low density lipoproteins (LDL-cholesterol) in a sample specifically at high accuracy and a reagent used in this method, and the present invention can attain such effect that direct measuring an amount of LDL-cholesterol by widely used automatic analyzers can be conducted by using the invention, which has not been possible after known methods.
摘要翻译：本发明提供一种以高精度测定样品中低密度脂蛋白（LDL-胆固醇）的胆固醇含量的方法和该方法中使用的试剂，本发明可以获得直接测定通过广泛使用的自动分析仪的LDL-胆固醇的量可以通过使用本发明进行，这在现有方法之后是不可能的。

5. 发明授权

US4940660A Color developing method in clinical examinations 失效
标题翻译：彩色显影方法在临床检查
公开(公告)号：US4940660A
公开(公告)日：1990-07-10
申请号：US914834
申请日：1986-10-02
申请人： Hidematsu Hirai , Toshiro Hanada , Kazuhiko Yamanishi , Hideko Nohara
发明人： Hidematsu Hirai , Toshiro Hanada , Kazuhiko Yamanishi , Hideko Nohara
IPC分类号： C12Q1/28 , G01N33/548
CPC分类号： G01N33/548 , C12Q1/28
摘要： A process for the determination of peroxidase activity or hydrogen peroxide in a clinical sample colorometrically by adding to the sample a reduced form coenzyme, a reagent selected from amines, phenols, and naphthols, a compound which is colored in the reduced form, and peroxidase or an aqueous solution of hydrogen peroxide. The process is essentially unaffected by the presence of ascorbic acid, bilirubin or other reducing substances of body fluids.
摘要翻译：通过向样品中加入还原型辅酶，选自胺，酚和萘酚的试剂，还原形式着色的化合物，以及过氧化物酶或过氧化物酶或过氧化物酶过氧化氢水溶液。该方法基本上不受抗坏血酸，胆红素或其它体液还原物质的存在的影响。

6. 发明授权

US07223546B2 Method for measuring the amount of constituent contained in a specific lipoprotein 有权
标题翻译：测定特定脂蛋白中含有的成分的量的方法
公开(公告)号：US07223546B2
公开(公告)日：2007-05-29
申请号：US10396477
申请日：2003-03-26
申请人： Yutaka Miki , Toshiro Hanada , Kiyoko Tanaka
发明人： Yutaka Miki , Toshiro Hanada , Kiyoko Tanaka
IPC分类号： G01N33/53
CPC分类号： G01N33/92 , G01N21/59 , G01N2800/044 , Y10S435/805 , Y10S435/962 , Y10S436/805 , Y10S436/81 , Y10S436/811 , Y10S436/824 , Y10S436/825
摘要： There is provided a method and kit for measuring the amount of an objective constituent contained in a specific lipoprotein in a biological sample such as serum and plasma, specifically for measuring the amount of cholesterol contained in high density lipoprotein, which can be applicable to clinical tests.
摘要翻译：提供了用于测量生物样品如血清和血浆中特定脂蛋白中包含的客观成分的量的方法和试剂盒，特别是用于测量高密度脂蛋白中含有的胆固醇的量，其可应用于临床试验。

7. 发明授权

US5716797A Stable two-part reagent for the measurement of creatine kinase activity 失效
标题翻译：用于测量肌酸激酶活性的稳定的两部分试剂
公开(公告)号：US5716797A
公开(公告)日：1998-02-10
申请号：US585516
申请日：1996-01-16
申请人： Masakazu Danno , Toshiro Hanada
发明人： Masakazu Danno , Toshiro Hanada
IPC分类号： C12Q1/50
CPC分类号： C12Q1/50
摘要： A stable two-part liquid reagent composition for measuring creatine kinase activity contains, in the first part, adenosine 5'-adiphosphate, kexokinase or glucokinse, nicotinamide adenine dinucleotide (phosphate), glucose-6-phosphate dehydrogenase, and thioglycerol, 2-mercaptoethanol, or 2-mercaptoethanesulfonic acid or a salt thereof; and contains, the second part, creatine phosphate at a pH of 7.5 to 10.0. Glucose and magnesium ions can be included in either part or in both parts. The two-part composition is stable even after being stored for 3 months at 10.degree. C.
摘要翻译：用于测量肌酸激酶活性的稳定的两部分液体试剂组合物在第一部分中包含腺苷5'-磷脂，酮考昔酶或葡糖苷酸，烟酰胺腺嘌呤二核苷酸（磷酸），葡萄糖-6-磷酸脱氢酶和硫甘油，2-巯基乙醇，或2-巯基乙磺酸或其盐; 并且在第二部分含有pH 7.5至10.0的磷酸肌酸。葡萄糖和镁离子可以包括在任一部分或两部分中。即使在10℃保存3个月后，两部分组合物也是稳定的。

8. 发明授权

US4837331A Stabilization of tetrazolium salts with cyclodextrins 失效
标题翻译：用环糊精稳定四唑鎓盐
公开(公告)号：US4837331A
公开(公告)日：1989-06-06
申请号：US930094
申请日：1986-11-13
申请人： Kazuhiko Yamanishi , Toshiro Hanada
发明人： Kazuhiko Yamanishi , Toshiro Hanada
IPC分类号： G01N33/50 , C07D257/04 , C07D417/04 , C09B50/02 , C12Q1/26 , G01N31/22
CPC分类号： C07D257/04 , C09B50/02 , C12Q1/26
摘要： An aqueous solution containing a tetrazolium compound used for determining superoxide ions can be stabilized by adding .beta.-cyclodextrin and/or a derivative thereof and/or .gamma.-cyclodextrin.
摘要翻译：含有用于测定超氧化物离子的四唑鎓化合物的水溶液可以通过加入β-环糊精和/或其衍生物和/或γ-环糊精来稳定。

9. 发明授权

US4695539A Process for quantitative determination of substrate treated with oxidase 失效
标题翻译：用氧化酶处理的底物的定量测定方法
公开(公告)号：US4695539A
公开(公告)日：1987-09-22
申请号：US516241
申请日：1983-07-22
申请人： Yoshitsugu Sakata , Yoshibonu Miyashita , Tadashi Hamanaka , Hiroyuki Kodera , Yutaka Miki , Kazuhiko Yamanishi , Toshiro Hanada
发明人： Yoshitsugu Sakata , Yoshibonu Miyashita , Tadashi Hamanaka , Hiroyuki Kodera , Yutaka Miki , Kazuhiko Yamanishi , Toshiro Hanada
IPC分类号： G01N33/50 , C12Q1/26 , C12Q1/28 , C12Q1/54 , C12Q1/60 , C12Q1/62
CPC分类号： C12Q1/60 , C12Q1/26 , C12Q1/54 , C12Q1/62 , Y10S435/81
摘要： A substrate in a sample can be determined quantitatively by measuring colorimetrically superoxide ion generated by treating the sample with a specific oxidase corresponding to the substrate to be determined, said oxidase treatment and measuring of the generated superoxide ion being conducted by using a reagent composition comprising (a) an oxidase, (b) peroxidase, (c) a phenol and/or an amine, (d) a thiol compound, (e) a color producing reagent to be reduced, and if necessary (f) a chelating agent.
摘要翻译：样品中的底物可以通过测量通过用相应于所要测定的底物的特定氧化酶处理样品而产生的比色超氧化物离子来测定，所述氧化酶处理和所测得的超氧化物离子是通过使用包含（ a）氧化酶，（b）过氧化物酶，（c）苯酚和/或胺，（d）硫醇化合物，（e）待还原的着色剂，以及必要时（f）螯合剂。

10. 发明授权

US4673635A Triphenyl methane derivatives and method of quantitatively measuring an oxidative substance 失效
标题翻译：三苯甲烷衍生物和定量测定氧化物质的方法
公开(公告)号：US4673635A
公开(公告)日：1987-06-16
申请号：US683487
申请日：1984-12-19
申请人： Kazuhiko Yamanishi , Akinori Shintani , Satoru Okajima , Toshiro Hanada
发明人： Kazuhiko Yamanishi , Akinori Shintani , Satoru Okajima , Toshiro Hanada
IPC分类号： B41M5/136 , C09B11/00 , C09B11/12 , C09B11/14 , C12Q1/28 , C12Q1/26 , C12Q1/54 , C12Q1/60
CPC分类号： B41M5/1366 , C09B11/12 , C12Q1/28 , C12Q2326/40 , Y10S436/904 , Y10T436/206664
摘要： Disclosed herein is a novel compound which is excellent in solubility to water around a neutral range, stable in an aqueous solution state for a long period of time, and high in coloring sensitivity with a stable coloring development, and is represented by the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same as or different from one another, represent lower alkyl groups, and X.sub.1 and X.sub.2 both represent --O(CH.sub.2).sub.n SO.sub.3 M in which M is a hydrogen atom, an alkali metal ion or NH.sub.4.sup.+, and n is an integer of 2-4, or either of X.sub.1 and X.sub.2 represents --O(CH.sub.2).sub.n SO.sub.3 M in which M and n are the same meanings as given above and the other represents a hydrogen atom. This reagent is hardly susceptible of the influence of the serum components such as hemoglobin, bilirubin and so on due to its color having absorption on a longer wavelength side. Disclosed is also a method of quantitatively measuring an oxidative substance, particularly, hydrogen peroxide, by using this color test reagent.
摘要翻译：本文公开了一种新颖的化合物，其在中性范围内对水的溶解性优异，在水溶液状态下长时间稳定，着色敏感性高，稳定的显色性，并且由通式（ I）：其中R 1，R 2，R 3和R 4可以相同或不同，表示低级烷基，X 1和X 2均表示-O（CH 2）n SO 3 M，其中M 是氢原子，碱金属离子或NH 4 +，n是2-4的整数，或者X 1和X 2中的任一个表示-O（CH 2）n SO 3 M，其中M和n与上述相同，而另一个表示氢原子。该试剂由于其在长波长侧具有吸收的颜色，几乎不受血清成分如血红蛋白，胆红素等的影响。还公开了通过使用该颜色试验剂定量测定氧化物质，特别是过氧化氢的方法。

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