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1. 发明授权

US06180772B2 Nucleic acids encoding dominant negative I-&kgr;-B -&agr; polypeptides 失效
标题翻译：编码显性阳性I-kappa-B-α多肽的核酸
公开(公告)号：US06180772B2
公开(公告)日：2001-01-30
申请号：US09064713
申请日：1998-04-22
申请人： Warner C. Greene , Shao-Cong Sun , Parham Ganchi
发明人： Warner C. Greene , Shao-Cong Sun , Parham Ganchi
IPC分类号： C12N1512
CPC分类号： C07K14/4702 , A61K38/00
摘要： Methods and compositions for the inhibition of NF-&kgr;B activation are disclosed.
摘要翻译：公开了抑制NF-κB活化的方法和组合物

2. 发明授权

US07723021B2 Methods for treating lentivirus infections 有权
标题翻译：治疗慢病毒感染的方法
公开(公告)号：US07723021B2
公开(公告)日：2010-05-25
申请号：US11671991
申请日：2007-02-06
申请人： Warner C. Greene , Kimberly S. Stopak , Carlos M. deNoronha , Ya-Lin Chiu , Vanessa B. Soros , Wesley M. Yonemoto
发明人： Warner C. Greene , Kimberly S. Stopak , Carlos M. deNoronha , Ya-Lin Chiu , Vanessa B. Soros , Wesley M. Yonemoto
IPC分类号： C12Q1/00
CPC分类号： C12Q1/702 , G01N33/5008 , G01N33/56983 , G01N2333/155 , G01N2500/00
摘要： The present invention provides methods of identifying an agent that inhibits an activity of a lentiviral Vif protein. The present invention provides methods of identifying an agent that increases the level of active APOBEC3G in a cell. The present invention provides agents identified by a subject screening method; and further provides methods for treating lentivirus infections.
摘要翻译：本发明提供鉴定抑制慢病毒Vif蛋白活性的试剂的方法。本发明提供鉴定增加细胞中活性APOBEC3G水平的试剂的方法。本发明提供了通过受试者筛选方法鉴定的药剂; 并进一步提供治疗慢病毒感染的方法。

3. 发明授权

US07250251B2 Virion-based fusion assay 有权
标题翻译：基于Virion的融合测定
公开(公告)号：US07250251B2
公开(公告)日：2007-07-31
申请号：US10656803
申请日：2003-09-04
申请人： Warner C. Greene , Marielle Cavrois , Carlos de Noronha
发明人： Warner C. Greene , Marielle Cavrois , Carlos de Noronha
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , C07K2319/00 , C12N7/00 , C12N2740/16322 , C12Q1/6897
摘要： The present invention features methods and compositions relating to a virion-based fusion assay for detection of infection of a target cell by an enveloped retroviral virion such as HIV. The assay uses virions containing a chimeric viral protein comprising a viral accessory polypeptide (such as Vpr) fused to a reporter polypeptide (such as beta-lactamase). Fusion of the virion with a target cell membrane results in intracellular delivery of the chimeric protein to the target cell, which in turn provides for detection of a detectable signal mediated by the reporter polypeptide portion of the chimeric polypeptide. Significant detectable signal is only detected following intracellular delivery of the chimeric viral protein, thus providing for detection of productive viral entry to the exclusion of non-productive, endocytic entry of virions into the cell.
摘要翻译：本发明的特征在于与基于病毒体的融合测定相关的方法和组合物，用于通过包膜的逆转录病毒药物（例如HIV）检测靶细胞的感染。该测定使用含有嵌合病毒蛋白质的病毒体，其包含与报道多肽（例如β-内酰胺酶）融合的病毒辅助多肽（例如Vpr）。病毒粒子与靶细胞膜的融合导致嵌合蛋白质的细胞内递送至靶细胞，其又提供检测由嵌合多肽的报道多肽部分介导的可检测信号。仅在嵌合病毒蛋白质的细胞内递送后才检测到显着的可检测信号，从而提供检测生产性病毒进入以排除病毒体进入细胞的非生产性内吞进入。

4. 发明授权

US06339150B1 Mutant rex genes encoding transdominant repressors of HIV/HTLV replication 失效
标题翻译：编码HIV / HTLV复制的横显性阻遏物的突变型rex基因
公开(公告)号：US06339150B1
公开(公告)日：2002-01-15
申请号：US09137784
申请日：1998-08-21
申请人： Helmut Bachmayer , Ernst Boehnlein , Warner C. Greene , Joachim Hauber
发明人： Helmut Bachmayer , Ernst Boehnlein , Warner C. Greene , Joachim Hauber
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K38/00 , C07K16/1036 , C12N2740/10022 , C12N2740/10043 , C12N2740/14022 , C12N2740/14043 , C12N2740/16322 , G03C7/3013 , G03C7/36
摘要： Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example protect cells against the deleterious effects of viral, e.g. HIV-1, infection.
摘要翻译：衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II，在某些情况下，均为Rev和Rex功能，因此在多种病毒物种中活跃。这样的显性病毒突变体可用作抗病毒剂，例如保护细胞免受病毒的有害影响，例如， HIV-1，感染。

5. 发明授权

US08338180B2 Methods for treating lentivirus infections 有权
标题翻译：治疗慢病毒感染的方法
公开(公告)号：US08338180B2
公开(公告)日：2012-12-25
申请号：US10865663
申请日：2004-06-09
申请人： Warner C. Greene , Kimberly S. Stopak , Carlos M. C. deNoronha , Wesley M. Yonemoto
发明人： Warner C. Greene , Kimberly S. Stopak , Carlos M. C. deNoronha , Wesley M. Yonemoto
IPC分类号： C12N15/00 , C12N15/87 , C12N5/07
CPC分类号： C12Q1/702 , G01N33/5008 , G01N33/56983 , G01N2333/155 , G01N2500/00
摘要： The present invention provides methods of identifying an agent that inhibits an activity of a lentiviral Vif protein. The present invention provides methods of identifying an agent that increases the level of active APOBEC3G in a cell. The present invention provides agents identified by a subject screening method; and further provides methods for treating lentivirus infections.
摘要翻译：本发明提供鉴定抑制慢病毒Vif蛋白活性的试剂的方法。本发明提供鉴定增加细胞中活性APOBEC3G水平的试剂的方法。本发明提供了通过受试者筛选方法鉴定的药剂; 并进一步提供治疗慢病毒感染的方法。

6. 发明授权

US06664040B2 Compositions and methods for delivery of a molecule into a cell 失效
公开(公告)号：US06664040B2
公开(公告)日：2003-12-16
申请号：US09839329
申请日：2001-04-20
申请人： Michael P. Sherman , Warner C. Greene , Carlos M.C. de Noronha , Ulrich Schubert , Peter Henklein
发明人： Michael P. Sherman , Warner C. Greene , Carlos M.C. de Noronha , Ulrich Schubert , Peter Henklein
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/162 , A61K41/0038 , A61K47/62 , C12N15/87 , C12N2740/16322
摘要： Provided is a composition comprising a Vpr polypeptide conjugated to a therapeutic molecule. Preferably, the Vpr comprises synthetic Vpr. The therapeutic molecule can comprise any molecule capable of being conjugated to Vpr or a fragment thereof, including a polypeptide, a polynucleotide, and/or a toxin. The invention additionally provides a method for delivering a molecule into a cell. The method comprises contacting the cell with a conjugate comprising a Vpr polypeptide conjugated to the molecule. The invention further provides a method for modulating the expression of a transgene in a cell, a method for killing a target cell population in a subject, a method for increasing the sensitivity of cells to radiation therapy, and a method for inhibiting cell proliferation.

7. 发明授权

US06287809B1 Mutant rex transdominant repressors of HIV replication 失效
标题翻译： HIV复制的突变型rex跨阻抗抑制因子
公开(公告)号：US06287809B1
公开(公告)日：2001-09-11
申请号：US09224247
申请日：1998-12-30
申请人： Helmut Bachmayer , Ernst Boehnlein , Warner C. Greene , Joachim Hauber
发明人： Helmut Bachmayer , Ernst Boehnlein , Warner C. Greene , Joachim Hauber
IPC分类号： C12P2106
CPC分类号： C07K14/005 , A61K38/00 , C07K16/1036 , C12N2740/10022 , C12N2740/10043 , C12N2740/14022 , C12N2740/14043 , C12N2740/16322 , G03C7/3013 , G03C7/36
摘要： Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example protect cells against the deleterious effects of viral, e.g. HIV-1, infection.
摘要翻译：衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II，在某些情况下，均为Rev和Rex功能，因此在多种病毒物种中活跃。这样的显性病毒突变体可用作抗病毒剂，例如保护细胞免受病毒的有害影响，例如， HIV-1，感染。

8. 发明授权

US09956260B1 Treatment of HIV-1 infection and AIDS 有权
公开(公告)号：US09956260B1
公开(公告)日：2018-05-01
申请号：US13556054
申请日：2012-07-23
申请人： Warner C. Greene , Gilad Doitsh , Orlando Zepeda , Nicole Galloway
发明人： Warner C. Greene , Gilad Doitsh , Orlando Zepeda , Nicole Galloway
IPC分类号： A61K38/06 , A61K38/00
CPC分类号： A61K38/005 , A61K31/18 , A61K31/198 , A61K31/336 , A61K31/341 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4164 , A61K31/422 , A61K31/44 , A61K31/55 , A61K31/551 , A61K31/555 , A61K31/662 , A61K38/00 , A61K38/06 , A61K45/06
摘要： Provided herein are compositions and methods for the treatment of a patient having an HIV-1 infection and/or AIDS. More specifically this invention provides treatment of an HIV-1 infection and/or AIDS using small molecule compounds, such as inhibitors for the activation and/or activity of caspase-1. Inhibitors for the activation and/or activity of caspase-1 also prevent the cell death of CD4 T-cells in a population of CD4 T-cells comprising HIV-1 infected CD4 T-cells and uninfected CD4 T-cells, In addition, caspase-1 inhibitors inhibit inflammation, and pyroptosis.

9. 发明申请

US20100168004A1 METHODS AND COMPOSITIONS FOR THE SYNERGISTIC ACTIVATION OF LATENT HIV 有权
标题翻译：艾滋病知识脉络协同激活的方法与组成
公开(公告)号：US20100168004A1
公开(公告)日：2010-07-01
申请号：US12297034
申请日：2007-04-17
申请人： Samuel A.F. Williams , Warner C. Greene
发明人： Samuel A.F. Williams , Warner C. Greene
IPC分类号： A61K31/216 , A61K38/16 , A61P31/18
CPC分类号： A61K45/06 , A61K31/165 , A61K31/19 , A61K31/22 , C12N2740/16011 , A61K2300/00
摘要： The present invention provides methods and compositions useful for the elimination of latent HIV reservoirs that persist despite HAART. The methods and compositions overcome this latent barrier by inducing the replication of HIV in latently infected T cells while preventing the spread of the newly produced virions to uninfected cells by providing HAART simultaneously. Compositions of the invention comprise an activator of latent HIV expression, such as prostratin, and an inhibitor of histone deacetylase, such as TSA. A surprising finding of this invention is that the inhibitor of the histone deacetylase synergizes the effect of prostratin thus, allowing administering to a patient a lower, non-toxic dose of prostratin.
摘要翻译：本发明提供了用于消除尽管HAART持续存在的潜伏性HIV储库的方法和组合物。方法和组合物通过在潜伏感染的T细胞中诱导HIV的复制来克服这种潜在的障碍，同时通过同时提供HAART来防止新产生的病毒粒子扩散到未感染的细胞。本发明的组合物包含潜伏的HIV表达的激活剂，例如前列腺素和组蛋白脱乙酰酶抑制剂，例如TSA。本发明的令人惊奇的发现是，组蛋白脱乙酰酶的抑制剂可促进前列腺素的作用，从而允许给予患者较低的无毒剂量的前列腺素。

10. 发明授权

US06265538B1 Inhibitor of the inflammatory response induced by the TNFA and IL-1 有权
标题翻译：由TNFA和IL-1诱导的炎症反应的抑制剂
公开(公告)号：US06265538B1
公开(公告)日：2001-07-24
申请号：US09257703
申请日：1999-02-25
申请人： Warner C. Greene , Xin Lin , Romas Gelezuinas
发明人： Warner C. Greene , Xin Lin , Romas Gelezuinas
IPC分类号： A61K3800
CPC分类号： C12N9/1205
摘要： The present invention provides the molecular basis for cytokine induction of NF-&kgr;B-dependent immune and inflammatory responses, emphasizing a role for both NIK-NIK and NIK-IKK protein-protein interactions. A relatively small region of NIK selectively impairs the NIK-IKK interaction. The present invention provides a highly specific method for modulating NF-&kgr;B-dependent immune, inflammatory, and anti-apoptotic responses, based on interruption of the critical protein-protein interaction of NIK and IKK. The present invention provides methods for inhibiting NF-&kgr;B-dependent gene expression, using mutant NIK proteins. One embodiment of the present invention provides kinase-deficient NIK mutant proteins that inhibit activation of IKK. Another embodiment of the invention provides N-terminus NIK mutant proteins that bind IKK, thus inhibiting NIK/IKK interaction.
摘要翻译：本发明提供NF-κB依赖性免疫和炎症反应的细胞因子诱导的分子基础，强调NIK-NIK和NIK-IKK蛋白质 - 蛋白质相互作用的作用。 NIK相对较小的区域选择性地损害NIK-IKK相互作用。本发明基于NIK和IKK的关键蛋白质 - 蛋白质相互作用的中断，提供了调节NF-κB依赖性免疫，炎症和抗凋亡反应的高度特异性方法。本发明提供使用突变NIK蛋白抑制NF-κB依赖性基因表达的方法。本发明的一个实施方案提供抑制IKK活化的激酶缺陷型NIK突变蛋白。本发明的另一个实施方案提供结合IKK的N末端NIK突变蛋白，从而抑制NIK / IKK相互作用。

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