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1. 发明授权

US4346093A Heterocyclic oxypropanolamine compounds and pharmaceutical compositions 失效
公开(公告)号：US4346093A
公开(公告)日：1982-08-24
申请号：US117190
申请日：1980-01-31
申请人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Wolfgang Bartsch , Karl Dietmann
发明人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D251/72 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/00 , A61P9/08 , A61P9/12 , A61P25/02 , C07D209/04 , C07D209/08 , C07D209/42 , C07D209/43 , C07D231/56 , C07D233/00 , C07D235/02 , C07D235/06 , C07D235/26 , C07D235/28 , C07D249/08 , C07D249/18 , C07D401/12 , C07D405/12 , A61K31/41
CPC分类号： C07D209/08 , C07D209/42 , C07D235/26 , C07D249/18 , Y10S514/929
摘要： The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl, hydroxyalkyl, alkoxycarbonyl or alkanoyloxyalkyl radicals or together represent an alkylene radical, R.sub.4 is a hydrogen atom or a lower alkanoyl radical or an aroyl radical, R.sub.5 is a hydrogen atom or a lower alkyl radical or an aralkyl radical, R.sub.6 is a hydrogen atom or a lower alkyl radical, R.sub.7 is a hydrogen atom, a hydroxyl group or a lower alkyl radical, Z is a valency bond, a methylene radical or an oxygen or sulphur atom, Ar is a carbocyclic aryl radical or a pyridyl radical, R.sub.8, R.sub.9 and R.sub.10, which can be the same or different, are hydrogen or halogen atoms, hydroxyl groups, lower alkanoyl radicals, lower alkyl radicals, lower alkenyl radicals, lower alkoxy radicals, aralkoxy radicals, allyloxy radicals, lower alkylthio radicals, aminocarbonyl radicals, aminosulphonyl radicals or lower alkanoylamino radicals or R.sub.8 and R.sub.9 together represent a lower alkylenedioxy radical or R.sub.7 and R.sub.8 together represent a --CH.sub.2 --O-- radical and A is --X.sub.1 --Y.sub.1, in which X.sub.1 is a methylene or --NR.sub.11 -- radical, R.sub.11 being a hydrogen atom or a lower alkyl radical, and Y.sub.1 is a methylene radical or .dbd.C.dbd.Q, Q being an oxygen or sulphur atom; or A is --X.sub.2 .dbd.Y.sub.2 --, in which X.sub.2 and Y.sub.2, which can be the same or different and signify nitrogen atoms or .dbd.C(R.sub.12)-- groups, R.sub.12 being a hydrogen atom or a lower alkyl or an alkoxycarbonyl radical, and when --X.sub.2 .dbd.Y.sub.2 -- represents a --CH.dbd.N-- group and R.sub.1 is an alkyl or aralkyl radical, because of the ability of indazole to tautomerise, this can also be localized on the nitrogen atom represented by Y.sub.2, with the proviso that Y.sub.1 or Y.sub.2 is joined to .dbd.N--R.sub.1 in general formula (I), and, when Q is an oxygen atom or --X.sub.2 .dbd.Y.sub.2 -- represents --CR.sub.12 .dbd.CR.sub.12 -- and Z is a valency bond or when --X.sub.1 --Y.sub.1 -- represents ##STR2## and Z is an oxygen atom or a valency bond, either the two symbols R.sub.2 and R.sub.3 do not simultaneously represent hydrogen atoms or R.sub.7 and R.sub.8 together must form a --CH.sub.2 --O-- radical; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.Furthermore, the present invention is concerned with the use of these compounds for the treatment of cardiac and circulatory diseases.

2. 发明授权

US4146630A Blood pressure lowering and adrenergic .beta.-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers 失效
标题翻译：血压降低和ADRENERGIC“ - 抑制3-（4-苯甲酰氨基哌啶）丙基苯基醚
公开(公告)号：US4146630A
公开(公告)日：1979-03-27
申请号：US846057
申请日：1977-10-27
申请人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
发明人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D401/12 , A61K31/403 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/445 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D209/90 , C07D211/22 , C07D231/56
CPC分类号： C07D211/22 , C07D231/56
摘要： A 3-(4-phenoxymethylpiperidino)-propyl-phenyl-ether of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, lower alkyl, hydroxyalkyl, lower alkanoyloxyalkyl or --CO--Z,Z is hydroxy, lower alkyloxy or ##STR2## R.sub.6 and R.sub.7 each independently is hydrogen, lower alkyl or hydroxyalkyl,R.sub.3 is hydrogen or --O--R.sub.8,R.sub.8 is hydrogen, lower alkanoyl or aroyl optionally substituted by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, hydroxyl, alkylthio, nitrile, nitro or trifluoromethyl,R.sub.4 and R.sub.5 each independently is hydrogen, halogen, hydroxy, benzyloxy, lower alkyl, lower alkoxy, lower alkylthio, carboxy, benzyloxycarbonyl or lower alkoxycarbonyl,X and Y each independently is nitrogen or ##STR3## R.sub.9 is hydrogen, lower allkyl optionally substituted by --O--R.sub.8, or --CO--Z,or a pharmacologically acceptable salt thereof. The compounds lower blood pressure and inhibit adrenergic .beta.-receptors.

3. 发明授权

US4288442A Inhibiting adrenergic .beta.-receptors with piperidinopropyl derivatives 失效
标题翻译：用哌啶丙基衍生物抑制肾上腺素β受体
公开(公告)号：US4288442A
公开(公告)日：1981-09-08
申请号：US117172
申请日：1980-01-31
申请人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Gisbert Sponer , Wolfgang Schaumann
发明人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Gisbert Sponer , Wolfgang Schaumann
IPC分类号： C07D401/12 , A61K31/44 , A61K31/4427 , A61K31/4523 , A61K31/505 , A61P9/08 , A61P9/12 , A61P25/02 , C07C205/56 , C07D209/04 , C07D209/08 , C07D209/82 , C07D211/14 , C07D211/22 , C07D235/04 , C07D401/14 , A61K31/445
CPC分类号： C07D211/22 , C07C205/56
摘要： A piperidinopropyl derivative of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical, or together are an alkylene radical,R.sub.3 is hydrogen, hydroxy, or acyloxy,R.sub.4 is hydrogen or formyl,A together with the adjacent benzene ring and N-R.sub.4 forms a benzimidazolin-2-one, benzimidazoline-2-thione, oxindole, indazole carbazole, benztriazole, benzimidazole, indoline or indole moiety, andB is a heterocyclic radical or, under certain circumstances, a phenyl radical, either of which is optionally substituted by halogen, hydroxy, lower alkyl, hydroxy-lower alkyl, carboxamido-lower alkyl, lower alkoxy, amino, carboxamido, lower alkyl-carbonylamino, acyl or lower alkylsulphonylamino,or a pharmacologically acceptable salt thereof. The compounds inhibit adrenergic .beta.-receptors and lower blood pressure.
摘要翻译：其中R 1和R 2各自独立地是氢或低级烷基，或者一起是亚烷基，R 3是氢，羟基或酰氧基，R 4是氢或甲酰基，A和相邻的苯环和N-R4形成苯并咪唑啉-2-酮，苯并咪唑啉-2-硫酮，羟吲哚，吲唑咔唑，苯并三唑，苯并咪唑，二氢吲哚或吲哚部分，B为杂环基团，或在某些情况下为苯基羟基，低级烷基，羟基 - 低级烷基，甲酰胺基 - 低级烷基，低级烷氧基，氨基，甲酰氨基，低级烷基 - 羰基氨基，酰基或低级烷基磺酰基氨基，或其药理学上可接受的盐。这些化合物抑制肾上腺素能β受体和降低血压。

4. 发明授权

US4503067A Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions 失效
标题翻译：（4） - 氧丙醇胺化合物和治疗组合物
公开(公告)号：US4503067A
公开(公告)日：1985-03-05
申请号：US479921
申请日：1983-04-04
申请人： Fritz Wiedemann , Wolfgang Kampe , Max Thiel , Gisbert Sponer , Egon Roesch , Karl Dietmann
发明人： Fritz Wiedemann , Wolfgang Kampe , Max Thiel , Gisbert Sponer , Egon Roesch , Karl Dietmann
IPC分类号： A61K31/40 , A61K31/403 , A61P9/08 , A61P25/02 , C07D209/88 , C07D317/64 , C07D401/12 , C07D405/12 , C07D209/82
CPC分类号： C07D209/88 , C07D317/64
摘要： Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl;R.sub.2 is hydrogen, lower alkyl or arylalkyl;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen or lower alkyl, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--;X is a valency bond, --CH.sub.2 --, oxygen or sulfur;Ar is mono- or bicyclic aryl or pyridyl;R.sub.5 and R.sub.6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl;R.sub.5 and R.sub.6 together can represent methylenedioxy;and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.
摘要翻译：式（I）的羧基 - （4） - 氧丙醇胺化合物，其中R 1是氢，低级烷酰基或芳酰基; R2是氢，低级烷基或芳基烷基; R3是氢或低级烷基; R4是氢或低级烷基，或者当X是氧时，R4与R5一起可以代表-CH2-O-; X是价键，-CH 2 - ，氧或硫; Ar是单环或双环芳基或吡啶基; R5和R6分别选自氢，卤素，羟基，低级烷基，氨基羰基，低级烷氧基，芳烷氧基，低级烷硫基，低级烷基亚磺酰基或低级烷基磺酰基; R5和R6一起可以代表亚甲二氧基; 并且其与生理上可接受的酸的盐在治疗和预防循环和心脏疾病例如高血压和心绞痛方面是显着的。

5. 发明授权

US3998810A N-substituted 1-amino-3-phenoxy-propan-2-ol compounds and therapeutic compositions containing them 失效
标题翻译： N-取代的1-氨基-3-苯氧基丙-2-醇化合物和含有它们的治疗组合物
公开(公告)号：US3998810A
公开(公告)日：1976-12-21
申请号：US487423
申请日：1974-07-10
申请人： Fritz Wiedemann , Max Thiel , Kurt Stach , Karl Dietmann , Gisbert Sponer
发明人： Fritz Wiedemann , Max Thiel , Kurt Stach , Karl Dietmann , Gisbert Sponer
IPC分类号： A61K31/135 , A61K31/00 , A61K31/395 , A61K31/54 , A61K31/5415 , A61P9/00 , C07C67/00 , C07C213/00 , C07C217/30 , C07D209/82 , C07D209/86 , C07D223/24 , C07D223/28 , C07D279/24 , C07D279/28
CPC分类号： C07D209/86
摘要： New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;B is straight or branched chain alkylene or hydroxyalkylene of from 2 to 5 carbon atoms; andR.sub.3 is hydrogen or alkyl of up to 3 carbon atoms;And the physiologically compatible salts thereof; possess valuable cardiac and circulatory activity.

6. 发明授权

US4438128A Cardioactive aryloxypropanolamines 失效
公开(公告)号：US4438128A
公开(公告)日：1984-03-20
申请号：US273543
申请日：1981-06-15
申请人： Fritz Wiedemann , Wolfgang Kampe , Karl Dietmann , Gisbert Sponer
发明人： Fritz Wiedemann , Wolfgang Kampe , Karl Dietmann , Gisbert Sponer
IPC分类号： A61K31/38 , A61K31/045 , A61K31/135 , A61K31/138 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/473 , A61K31/495 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/522 , A61P9/00 , A61P9/04 , C07C217/32 , C07C217/72 , C07C217/78 , C07C219/06 , C07C219/08 , C07C219/14 , C07D209/48 , C07D213/74 , C07D215/46 , C07D217/22 , C07D219/12 , C07D231/06 , C07D231/20 , C07D231/32 , C07D231/38 , C07D231/46 , C07D231/52 , C07D231/56 , C07D237/20 , C07D239/42 , C07D239/54 , C07D239/545 , C07D239/557 , C07D239/56 , C07D239/84 , C07D239/95 , C07D241/44 , C07D249/18 , C07D333/36 , C07D473/16 , C07D473/32 , C07D473/34 , C07D487/00 , C07D487/04 , C07D231/54
CPC分类号： C07D473/16 , C07D209/48 , C07D213/74 , C07D215/46 , C07D217/22 , C07D219/12 , C07D231/06 , C07D231/20 , C07D231/32 , C07D231/38 , C07D231/52 , C07D231/56 , C07D237/20 , C07D239/42 , C07D239/545 , C07D239/557 , C07D239/56 , C07D239/84 , C07D239/95 , C07D333/36 , C07D473/34 , C07D487/04
摘要： The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl, cyano, carboxamido, hydroxyl, lower acyloxy, lower alkoxy, lower alkenyloxy or aryl lower alkoxy radicals, R.sub.5 and R.sub.6, which may be the same or different, are hydrogen atoms or lower alkyl radicals, X is a straight or branched alkylene chain containing 2 to 6 carbon atoms, A is a mono-, bi- or tricyclic heteroaromatic or hydroheteroaromatic radical or, when at least one of the symbols R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than a hydrogen atom, may also be a phenyl radical, with the proviso that when A is a uracil-6-yl radical, the 5-position of the uracil moiety does not contain a hydrogen atom, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, which may be the same or different, are mono- or divalent substituents selected from hydrogen, halogen, nitro, hydroxylamino, amino, lower acylamino, lower alkylamino, di-(lower alkyl)-amino, hydroxyethylamino, di-(hydroxyethyl)-amino, hydroxyl, lower alkoxy, allyloxy, methoxy lower alkoxy, cyano, carboxamido, carboxy, lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl, halomethyl, aminomethyl, lower acylaminomethyl, di-(lower alkyl)-aminomethyl, pyrrolidinomethyl, piperidinomethyl, di-(hydroxyethyl)-aminomethyl, morpholinomethyl, piperazinomethyl, 4-lower acylpiperazinomethyl, 4-lower alkylpiperazinomethyl, lower alkyl, lower alkenyl, 2-cyanoethyl, 2-(lower alkoxycarbonyl)-ethyl, 2-carboxyethyl, 2-hydroxyethyl, phenyl lower alkyl and phenyl, the phenyl radicals being optionally substituted with 1 or 2 hydroxyl or methoxy radicals, or from oxygen or sulphur; the optically-active forms and the racemic mixtures thereof, and the pharmacologically compatible salts thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

7. 发明授权

US4029783A N-substituted 1-amino-3-phenoxy-propan-2-ol compounds and therapeutic compositions containing them 失效
标题翻译： N-取代的1-氨基-3-苯氧基 - 丙-2-醇化合物和含有它们的治疗组合物
公开(公告)号：US4029783A
公开(公告)日：1977-06-14
申请号：US638874
申请日：1975-12-08
申请人： Fritz Wiedemann , Max Thiel , Kurt Stach , Karl Dietmann , Gisbert Sponer
发明人： Fritz Wiedemann , Max Thiel , Kurt Stach , Karl Dietmann , Gisbert Sponer
IPC分类号： C07D209/86 , A61K31/54 , C07D279/24
CPC分类号： C07D209/86
摘要： New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;B is straight or branched chain alkylene or hydroxyalkylene of from 2 to 5 carbon atoms; andR.sub.3 is hydrogen or alkyl of up to 3 carbon atoms;And the physiologically compatible salts thereof; possess valuable cardiac and circulatory activity.
摘要翻译：新的N-取代的1-氨基-3-苯氧基 - 丙-2-醇，其分子式为：其中R 1和R 2各自为氢或一起表示硫键，乙烯激进或价格债券; B是2至5个碳原子的直链或支链亚烷基或羟基亚烷基; 并且R 3是氢或至多3个碳原子的烷基; 及其生理适应性肥皂; 有价值的心脏和循环活动。

8. 发明授权

US4143149A Indazolyl-(4)-oxypropanolamine compounds and therapeutic compositions 失效
标题翻译：（4） - 异丙醇胺化合物和治疗组合物
公开(公告)号：US4143149A
公开(公告)日：1979-03-06
申请号：US790648
申请日：1977-04-25
申请人： Fritz Wiedemann , Wolfgang Kampe , Max Thiel , Wolfgang Bartsch , Egon Roesch
发明人： Fritz Wiedemann , Wolfgang Kampe , Max Thiel , Wolfgang Bartsch , Egon Roesch
IPC分类号： A61K31/415 , A61P9/00 , A61P25/02 , C07D231/56
CPC分类号： C07D231/56
摘要： New indazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; andR.sub.2 is straight-chain or branched lower alkyl which can be substituted by lower alkylthio;And the pharmacologically compatible salts thereof; are outstandingly effective adrenergic .beta.-receptor inhibitors and useful in the treatment or prevention of a recurrence of cardiac and circulatory diseases.

9. 发明授权

US4479962A Indazoloxypropanolamine derivatives and use in combating, and for the prophylaxis of, cardiac and circulatory diseases 失效
标题翻译： Indazoloxypropanolamine衍生物，用于对抗和预防心脏和循环系统疾病
公开(公告)号：US4479962A
公开(公告)日：1984-10-30
申请号：US403968
申请日：1982-08-02
申请人： Fritz Wiedemann , Helmut Michel , Wolfgang Weckerle , Egon Roesch , Klaus Strein
发明人： Fritz Wiedemann , Helmut Michel , Wolfgang Weckerle , Egon Roesch , Klaus Strein
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/433 , A61K31/495 , A61K31/496 , A61P9/04 , C07D209/08 , C07D209/12 , C07D209/32 , C07D209/42 , C07D209/43 , C07D209/44 , C07D209/88 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D235/26 , C07D241/40 , C07D241/42 , C07D249/18 , C07D285/14
CPC分类号： C07D285/14 , C07D209/08 , C07D209/88 , C07D231/56 , C07D235/06 , C07D235/08 , C07D235/26 , C07D241/42 , C07D249/18
摘要： The present invention provides heteroaryloxypropanolamines and pharmaceutical compositions containing them, for combating, and for the prophylaxis of, cardiac and circulatory diseases. The heteroaryloxypropanolamines of the present invention are of the general formula: ##STR1## wherein A is a bi- or tricyclic heteroaromatic radical, which is optionally partly hydrogenated, X is a straight-chained or branched alkylene chain containing 2 to 6 carbon atoms, R.sub.1 and R.sub.2, which can be the same or different, are hydrogen atoms or lower alkyl or benzyl radicals, R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms or lower alkyl, benzyl, formyl, lower alkanoyl, cyano, hydroxymethyl, lower alkoxycarbonyl or carbamoyl radicals or the divalent substituents sulfur or oxygen and R.sub.6, R.sub.7 and R.sub.8, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, nitro, amino, lower alkylthio or lower alkoxy radicals or R.sub.6 and R.sub.7 together represent an optionally unsaturated trimethylene chain; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.
摘要翻译：本发明提供含有它们的异丙氧基丙醇胺和含有它们的药物组合物，用于对抗和预防心脏和循环系统疾病。本发明的杂芳氧基丙酰胺具有以下通式：其中A是双环或三环杂芳族基，其任选地部分氢化，X是含有2-6个碳原子的直链或支链亚烷基链，R 1 和R 2可以相同或不同，为氢原子或低级烷基或苄基，R 3，R 4和R 5可相同或不同，为氢原子或低级烷基，苄基，甲酰基，低级烷酰基，氰基，羟甲基，低级烷氧基羰基或氨基甲酰基或二价取代基硫或氧，R 6，R 7和R 8可以相同或不同，为氢或卤原子，低级烷基，硝基，氨基，低级烷硫基或低级烷氧基或 R6和R7一起表示任选不饱和的三亚甲基链; 及其药理学上可接受的盐。本发明还提供了制备这些化合物的方法，以及含有它们的药物组合物。

10. 发明授权

US4171446A Indazole compounds 失效
标题翻译：吲唑化合物
公开(公告)号：US4171446A
公开(公告)日：1979-10-16
申请号：US790646
申请日：1977-04-25
申请人： Fritz Wiedemann , Wolfgang Kampe
发明人： Fritz Wiedemann , Wolfgang Kampe
IPC分类号： C07D231/56 , C07D301/00 , C07D405/12
CPC分类号： C07D231/56
摘要： Indazole compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkyl,R' is hydrogen or acyl, e.g., alkanoyl, andR.sub.2 is benzyl or a radical of the general formula ##STR2## in which X is a reactive residue and Y is hydroxyl or X and Y together represent oxygen and, when R' is an acyl radical, R.sub.2 can also be hydrogen:Are valuable intermediates for the preparation of pharmacologically active compounds, e.g., adrenergic .beta.-receptor active 3-indazolyl-(4)-oxy-propan-2-ol-amines.
摘要翻译：式（I）的吲唑化合物，其中R 1是氢或低级烷基，R'是氢或酰基，例如烷酰基，R 2是苄基或通式为“IMAGE”的基团，其中X是反应性残基，Y是羟基或X和Y一起代表氧，当R'是酰基时，R 2也可以是氢：

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