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1. 发明申请

US20120014547A1 Hearing Instrument 审中-公开
标题翻译：听力仪器
公开(公告)号：US20120014547A1
公开(公告)日：2012-01-19
申请号：US12806197
申请日：2009-11-03
申请人： Walter P. Sjursen , Michael DeSalvo , Hassan A. Mohamed , Michael C. Pereira , Daniel Nelsen , Son Luong , David Baker , Thomas Stuart
发明人： Walter P. Sjursen , Michael DeSalvo , Hassan A. Mohamed , Michael C. Pereira , Daniel Nelsen , Son Luong , David Baker , Thomas Stuart
IPC分类号： H04R25/00
CPC分类号： H04R25/602 , H04R25/65 , H04R25/654
摘要： A hearing instrument may include an enclosure adapted for behind-the-ear placement that houses a microphone for converting an acoustical input signal to an electrical signal and a sound processing circuit for processing the electrical signal; an earpiece adapted for in-the-canal placement that includes a receiver for converting the processed electrical signal to an acoustical output signal; a replaceable battery housed in the enclosure for powering the microphone, sound processing circuit and receiver; and an electrical cable extending from the enclosure that electrically couples the processed electrical signal from the sound processing circuit to the receiver. The enclosure includes a top portion and a bottom portion. The top portion and the bottom portion pivot about a hinge point at one end of the enclosure to open and closed positions. In the open position, the battery is accessible for replacement. A latch mechanism at the other end of the enclosure secures the top portion to the bottom portion in the closed position. The bottom portion may be detached from the top portion and may be replaced by the user.
摘要翻译：助听器可以包括适于耳后放置的外壳，其容纳用于将声输入信号转换为电信号的麦克风和用于处理电信号的声音处理电路; 用于管道内放置的耳机，其包括用于将经处理的电信号转换为声输出信号的接收器; 容纳在外壳中的可替换电池为麦克风，声音处理电路和接收器供电; 以及从外壳延伸的电缆，其将经处理的电信号从声音处理电路电耦合到接收器。外壳包括顶部和底部。顶部部分和底部部分围绕围绕壳体的一端处的铰链点枢转到打开和关闭位置。在打开位置，电池可以更换。在外壳的另一端处的闩锁机构将封闭位置的顶部固定到底部。底部可以从顶部分离，并且可以由使用者代替。

2. 发明申请

US20170318832A1 Frozen Tea Treat with Non-Synthetic Ingredients and Method of Making the Same 审中-公开
公开(公告)号：US20170318832A1
公开(公告)日：2017-11-09
申请号：US15147540
申请日：2016-05-05
申请人： Dionne Laslo-Baker , Joahua Baker , David Baker
发明人： Dionne Laslo-Baker , Joahua Baker , David Baker
IPC分类号： A23G9/42 , A23F3/40 , A23G9/34
CPC分类号： A23G9/42 , A23F3/40 , A23G9/083 , A23G9/34 , A23G9/503 , A23V2002/00
摘要： The invention relates to ice lollys comprising a frozen liquid tea based composition comprising: water, tea powder or tea concentrate, methyl glucoside coconut oil ester, guar, gellan or pectin gum, and USDA certified organic non-genetically modified organism (non-GMO) grown fruit or vegetables in the form of a concentrate of liquid, puree, or powder. The processing and subsequent packaging allows the composition to be processed without heating and/or pasteurization but remain shelf stable in the frozen form.

3. 发明授权

US08578769B2 Flow sensors 有权
标题翻译：流量传感器
公开(公告)号：US08578769B2
公开(公告)日：2013-11-12
申请号：US13129047
申请日：2009-11-12
申请人： Martyn John Hucker , Graham Andrew Johnson , David Baker , Amir Rezai
发明人： Martyn John Hucker , Graham Andrew Johnson , David Baker , Amir Rezai
IPC分类号： G01F15/06 , G01F1/68 , G01D21/00
CPC分类号： G01P1/02 , F16B35/041 , G01F1/684 , G01P5/00
摘要： A flow sensor and fastener assembly, is disclosed which includes at least the following modules: a sensor housing and a fastener element; wherein: the sensor housing is adapted to receive a flow-based sensor, e.g. a MEMS airflow sensor; the sensor housing includes a connection for transmitting sensing signals from a fitted flow-based sensor; the fastener element includes a head and a shank, at least part of the shank being externally threaded; the fastener element includes a bore extending through the whole length of the fastener element; and the bore is shaped at the head end of the fastener element to provide a sensor housing receiving part.
摘要翻译：公开了一种流量传感器和紧固件组件，其包括至少以下模块：传感器壳体和紧固元件; 其中：所述传感器壳体适于接收基于流体的传感器，例如，一个MEMS气流传感器; 传感器壳体包括用于从拟合的基于流体的传感器传输感测信号的连接; 所述紧固元件包括头部和柄部，所述柄部的至少一部分是外螺纹的; 紧固件元件包括延伸穿过紧固元件的整个长度的孔; 并且所述孔在所述紧固件元件的头端处成形，以提供传感器壳体接收部分。

4. 发明授权

US08343487B2 Large-scale production of soluble hyaluronidase 有权
标题翻译：大规模生产可溶性透明质酸酶
公开(公告)号：US08343487B2
公开(公告)日：2013-01-01
申请号：US13385919
申请日：2012-03-13
申请人： David Baker , Louis H. Bookbinder
发明人： David Baker , Louis H. Bookbinder
IPC分类号： A61K38/46 , A61K38/54 , A61K48/00 , C12P21/06 , C12N9/24 , C12N9/26 , C12N5/00 , C12N15/00 , C07K1/00
CPC分类号： C12N9/2408 , C12Y302/01035 , C12Y302/01036
摘要： Provided are methods for preparing culture medium that contains soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium.
摘要翻译：提供了制备含有可溶性透明质酸酶的培养基的方法。该方法使用含有编码可溶性透明质酸酶的多种核酸活性拷贝的细胞和多种饲料和温度变化，从而将编码的可溶性透明质酸酶分泌到细胞培养基中。

5. 发明授权

US08340951B2 Synthetic enzymes derived from computational design 有权
标题翻译：衍生自计算设计的合成酶
公开(公告)号：US08340951B2
公开(公告)日：2012-12-25
申请号：US12334360
申请日：2008-12-12
申请人： David Baker , Alexandre Zanghellini , Lin Jiang , Andrew Wollacott , Daniela Grabs-Röthlisberger , Eric Althoff
发明人： David Baker , Alexandre Zanghellini , Lin Jiang , Andrew Wollacott , Daniela Grabs-Röthlisberger , Eric Althoff
IPC分类号： G06G7/58 , C12N9/14 , C07K14/00 , C07K17/00
CPC分类号： C12N9/88 , G06F19/24
摘要： Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.
摘要翻译：本文公开了用于计算设计酶的技术。这些技术可用于设计天然存在的酶的变体，以及不具有天然对应物的新酶。这些技术基于首先鉴定促进所需反应所需的功能性反应位点。然后，使用散列算法来鉴定能够支持所需功能位点的潜在的蛋白质主链结构（即支架）。这些技术用于设计出显示醛醇反应催化功能的32种不同的蛋白质序列，其中31种在序列表中定义。提供了这31种不同合成醛缩酶的细节，包括如何将这些合成醛缩酶与天然存在的醛缩酶相区分。

6. 发明申请

US20120283295A1 INDAZOLE DERIVATIVES AND THEIR USE FOR BLOCKADING VOLTAGE DEPENDENT SODIUM CHANNELS 审中-公开
标题翻译：吲哚衍生物及其用于阻断电压依赖性钠通道的用途
公开(公告)号：US20120283295A1
公开(公告)日：2012-11-08
申请号：US13499517
申请日：2010-09-30
申请人： Cristina Garcia Posada , David Selwood , John Garthwaite , David Baker , Lisa Clutterbuck
发明人： Cristina Garcia Posada , David Selwood , John Garthwaite , David Baker , Lisa Clutterbuck
IPC分类号： A61K31/4245 , C07D417/14 , A61K31/427 , A61P29/00 , A61P27/06 , A61P25/00 , A61P25/28 , A61P25/16 , C07D413/14 , A61K31/4439
CPC分类号： C07D413/14 , C07D417/14
摘要： The invention provides an indazole derivative of formula (1), or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1, R2, R3 and R4 are as defined herein. The indazole derivatives are capable of blockading voltage dependent sodium channels and they are useful in the treatment or prevention of normal tension glaucoma, multiple sclerosis, a motorneurone disease, stroke, spinal cord injury, Alzheimer's disease, Parkinson's disease or pain.
摘要翻译：本发明提供式（1）的吲唑衍生物或其药学上可接受的盐或N-氧化物，其中R 1，R 2，R 3和R 4如本文所定义。吲唑衍生物能够阻断电压依赖性钠通道，并且它们可用于治疗或预防正常张力性青光眼，多发性硬化，运动神经元疾病，中风，脊髓损伤，阿尔茨海默病，帕金森病或疼痛。

7. 发明申请

US20120129159A1 METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES 有权
标题翻译：蛋白质标记的方法和组合使用LIPOIC ACID LIGASES
公开(公告)号：US20120129159A1
公开(公告)日：2012-05-24
申请号：US13267761
申请日：2011-10-06
申请人： Alice Y. Ting , David Baker , Florian Richter , Lucas Nivon , Daniel Shao-Chen Liu
发明人： Alice Y. Ting , David Baker , Florian Richter , Lucas Nivon , Daniel Shao-Chen Liu
IPC分类号： C12P21/00 , C12Q1/68 , C07D265/38 , C12N9/00
CPC分类号： C12N9/1241 , C12N9/93 , C12N15/102 , C12Y207/07063 , G01N33/532 , G01N33/533 , G01N2333/9015
摘要： The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase.
摘要翻译：本公开提供其用于在体外或体内标记肽和蛋白质的组合物和方法。本文描述的方法使用硫辛酸连接酶或其突变体，以及由硫辛酸连接酶和硫辛酸连接酶突变体识别的硫辛酸类似物（例如包含再溶血部分的硫辛酸类似物）。本文还提供了通过由硫辛酸连接酶介导的反应来成像蛋白质 - 蛋白质相互作用的方法。

8. 发明申请

US20120100594A1 ENZYME CATALYSTS FOR DIELS-ALDER REACTIONS 有权
标题翻译：用于DIELS-ALDER反应的酶催化剂
公开(公告)号：US20120100594A1
公开(公告)日：2012-04-26
申请号：US13130260
申请日：2009-11-19
申请人： David Baker , Alexandre Zangellini , Justin Siegel , Jennifer St. Clair
发明人： David Baker , Alexandre Zangellini , Justin Siegel , Jennifer St. Clair
IPC分类号： C12N9/10
CPC分类号： C12N9/90 , C12N9/16 , C12P5/002 , C12Y301/08002 , C12Y503/03001
摘要： The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity.
摘要翻译：本发明提供了用于Diels-Alder反应的酶催化剂，包括分子间Diels-Alder反应，以及用于制备这种酶催化剂的蛋白质支架。在其他方面，本发明提供了制备酶催化剂的方法，包括通过重新计算设计。因此，本发明提供能够催化所需Diels-Alder反应的酶催化剂，包括具有指定或期望的立体选择性。

9. 发明授权

US08038132B2 Hydraulic bushing 有权
标题翻译：液压套管
公开(公告)号：US08038132B2
公开(公告)日：2011-10-18
申请号：US11507313
申请日：2006-08-21
申请人： Jay Thornhill , Robert Goudie , Richard Butch Brown , Mark Morman , Bill Burk , Hal Henry , Daniel Wittler , Robert Ferguson , David Stewart , Andrew Franzen , David Baker
发明人： Jay Thornhill , Robert Goudie , Richard Butch Brown , Mark Morman , Bill Burk , Hal Henry , Daniel Wittler , Robert Ferguson , David Stewart , Andrew Franzen , David Baker
IPC分类号： F16F13/00
CPC分类号： F16F13/1463
摘要： A hydraulic bushing assembly includes an inner tube, an elastomeric bushing disposed around the inner tube, an insert disposed around the elastomeric bushing and an outer tube disposed around the insert. The elastomeric bushing and the insert define a pair of chambers which are connected by a passageway defined by the insert. A pair of intermediate tubes are disposed in the elastomeric bushing at opposite axial ends of the insert.
摘要翻译：液压衬套组件包括内管，围绕内管设置的弹性衬套，围绕弹性衬套设置的插入件和围绕插入件设置的外管。弹性衬套和插入件限定一对室，其通过由插入件限定的通道连接。一对中间管在插入件的相对的轴向端部处设置在弹性衬套中。

10. 发明申请

US20110220180A1 ELECTRICAL CONNECTORS FOR SOLAR MODULES 有权
标题翻译：太阳能模块电气连接器
公开(公告)号：US20110220180A1
公开(公告)日：2011-09-15
申请号：US12796466
申请日：2010-06-08
申请人： Barry Cinnamon , David Baker , Wilson W. Leong , Alexander W. Au
发明人： Barry Cinnamon , David Baker , Wilson W. Leong , Alexander W. Au
IPC分类号： H01L31/048 , H01R13/60
CPC分类号： H01L31/0201 , F24S20/67 , F24S25/20 , F24S25/61 , F24S2025/014 , F24S2025/6004 , H01L31/048 , H01L31/05 , H01R13/73 , H02S20/23 , H02S30/10 , H02S40/34 , H02S40/36 , Y02B10/12 , Y02B10/20 , Y02E10/47 , Y02E10/50
摘要： A solar module is disclosed that has one or more integrated electrical connectors. In addition, a solar module electrical connector holder is disclosed that has resilient wing portions and axial portions that mate with a first connector window in a frame of a solar module and allow the position of an electrical connector to be moved one of vertically, horizontally and angularly with respect to the frame. In addition, a solar module frame is disclosed that has a first connector window in one of the side frame members that is capable of accepting an electrical connection so that the electrical connection is integrated into the frame of the solar module.
摘要翻译：公开了一种具有一个或多个集成电连接器的太阳能模块。此外，公开了一种具有弹性翼部分和与太阳能模块的框架中的第一连接器窗口配合的轴向部分的太阳能模块电连接器保持器，并允许电连接器的位置垂直，水平和相对于框架成角度地。此外，公开了一种太阳能模块框架，其在一个侧框架构件中具有能够接受电连接的第一连接器窗口，使得电连接被集成到太阳能模块的框架中。

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