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1. 发明授权

US4877965A Fluorometer 失效
标题翻译：荧光计
公开(公告)号：US4877965A
公开(公告)日：1989-10-31
申请号：US751746
申请日：1985-07-01
申请人： Walter B. Dandliker , Howard S. Barr , Henry S. Katzenstein , Keith R. Watson
发明人： Walter B. Dandliker , Howard S. Barr , Henry S. Katzenstein , Keith R. Watson
IPC分类号： G01N21/64 , G02B21/16
CPC分类号： G01N21/6408 , G02B21/16 , G01N21/6456 , G01N21/6458 , G01N2201/1087
摘要： A fluorometer for measuring a particular fluorescence emanating from a specimen and operating in accordance with the following method. Producing a burst of concentrated light energy and directing the concentrated light energy toward the specimen to produce a fluorescence from the specimen including the particular fluorescence. Preferably producing an image of the fluorescence. Detecting the fluorescence and producing a signal in accordance with the fluorescence. Controlling the passage of the image of the fluorescence for detecting within a particular time period so as to optimize the detection of the particular fluorescence. Timing the operation to sequence the detection of the fluorescence within the particular time period after the production of the burst of concentrated light energy. Scanning the fluorescence from the specimen for forming signals representative of the fluorescence from the specimen. Analyzing the signals to enhance the portion of the signal representing the particular fluorescence relative to the portion of the signal.
摘要翻译：一种荧光计，用于测量从样品发出的特定荧光并根据以下方法进行操作。产生集中的光能的突发，并将集中的光能引导到样品以从包括特定荧光的样品产生荧光。优选地产生荧光图像。根据荧光检测荧光并产生信号。控制在特定时间段内用于检测的荧光图像的通过，以便优化特定荧光的检测。计算在产生聚集的光能的突发之后的特定时间段内对荧光的检测进行排序的操作。扫描来自样品的荧光，以形成代表来自样品荧光的信号。分析信号以增强表示相对于信号部分的特定荧光的信号部分。

2. 再颁专利

USRE34782E Fluorometer 失效
标题翻译：荧光计
公开(公告)号：USRE34782E
公开(公告)日：1994-11-08
申请号：US969794
申请日：1992-10-12
申请人： Walter B. Dandliker , Howard S. Barr , Henry S. Katzenstein , Keith R. Watson
发明人： Walter B. Dandliker , Howard S. Barr , Henry S. Katzenstein , Keith R. Watson
IPC分类号： G01N21/64 , G02B21/16
CPC分类号： G01N21/6408 , G02B21/16 , G01N21/6456 , G01N21/6458 , G01N2201/1087
摘要： A fluorometer for measuring a particular fluorescence emanating from a specimen and operating in accordance with the following method. Producing a burst of concentrated light energy and directing the concentrated light energy toward the specimen to produce a fluorescence from the specimen including the particular fluorescence. Preferably producing an image of the fluorescence. Detecting the fluorescence and producing a signal in accordance with the fluorescence. Controlling the passage of the image of the fluorescence for detecting within a particular time period so as to optimize the detection of the particular fluorescence. Timing the operation to sequence the detection of the fluorescence within the particular time period after the production of the burst of concentrated light energy. Scanning the fluorescence from the specimen for forming signals representative of the fluorescence from the specimen. Analyzing the signals to enhance the portion of the signal representing the particular fluorescence relative to the portion of the signal.
摘要翻译：一种荧光计，用于测量从样品发出的特定荧光并根据以下方法进行操作。产生集中的光能的突发，并将集中的光能引导到样品以从包括特定荧光的样品产生荧光。优选地产生荧光图像。根据荧光检测荧光并产生信号。控制在特定时间段内用于检测的荧光图像的通过，以便优化特定荧光的检测。计算在产生聚集的光能的突发之后的特定时间段内对荧光的检测进行排序的操作。扫描来自样品的荧光，以形成代表来自样品荧光的信号。分析信号以增强表示相对于信号部分的特定荧光的信号部分。

3. 发明授权

US4900824A Perfluoro hexamethylenetetramine useful in synthetic blood 失效
标题翻译：全氟六亚甲基四胺可用于合成血液
公开(公告)号：US4900824A
公开(公告)日：1990-02-13
申请号：US312038
申请日：1989-02-17
申请人： Walter B. Dandliker , W. Keith R. Watson , Thomas C. Drees
发明人： Walter B. Dandliker , W. Keith R. Watson , Thomas C. Drees
IPC分类号： A61K9/00 , C07C23/38 , C07D487/18
CPC分类号： A61K9/0026 , C07C23/38 , C07D487/18
摘要： A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity; the invention enables preparation of an improved blood substitute, with improved O.sub.2 carrying capacity and stability, as well as lessened anaphylactoid reaction.
摘要翻译：血液替代品采用氟或全氟化合物的组合，其能够在乳化剂存在下形成在室温下稳定并具有增强的携氧能力的乳化剂; 本发明能够制备改进的血液替代物，具有改善的O 2承载能力和稳定性，以及减少的过敏反应。

4. 发明授权

US5243044A Compounds of perfluoro[3,3,3]propellene and perfluoro hexamethylenetetramine 失效
标题翻译：全氟[3,3,3]丙烯和全氟六亚甲基四胺的化合物
公开(公告)号：US5243044A
公开(公告)日：1993-09-07
申请号：US312028
申请日：1989-02-17
申请人： Walter B. Dandliker , W. Keith R. Watson , Thomas C. Drees
发明人： Walter B. Dandliker , W. Keith R. Watson , Thomas C. Drees
IPC分类号： A61K9/00 , C07C23/38 , C07D487/18
CPC分类号： A61K9/0026 , C07C23/38 , C07D487/18 , Y10S514/832 , Y10S514/833
摘要： A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity; the invention enables preparation of an improved blood substitute, with improved O.sub.2 carrying capacity and stability, as well as lessened anaphylactoid reaction.
摘要翻译：血液替代品采用氟或全氟化合物的组合，其能够在乳化剂存在下形成在室温下稳定并具有增强的携氧能力的乳化剂; 本发明能够制备改进的血液替代物，具有改善的O 2承载能力和稳定性，以及减少的过敏反应。

5. 发明授权

US5434191A Artificial blood containing perfluoro chemicals in presence of emulsifying agents 失效
标题翻译：含有全氟化学物质的人造血液存在乳化剂
公开(公告)号：US5434191A
公开(公告)日：1995-07-18
申请号：US110733
申请日：1993-08-23
申请人： Walter B. Dandliker , W. Keith R. Watson , Thomas C. Drees
发明人： Walter B. Dandliker , W. Keith R. Watson , Thomas C. Drees
IPC分类号： A61K9/00 , C07C23/38 , C07D487/18 , A61K31/025 , A61K31/395
CPC分类号： A61K9/0026 , C07C23/38 , C07D487/18 , Y10S514/832 , Y10S514/833
摘要： A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity; the invention enables preparation of an improved blood substitute, with improved O.sub.2 carrying capacity and stability, as well as lessened anaphylactoid reaction.
摘要翻译：血液替代品采用氟或全氟化合物的组合，其能够在乳化剂存在下形成在室温下稳定并具有增强的携氧能力的乳化剂; 本发明能够制备改进的血液替代物，具有改善的O 2承载能力和稳定性，以及减少的过敏反应。

6. 发明授权

US5122540A Method and composition for treating warts and throat soreness with DMSO and citric acid 失效
标题翻译：用DMSO和柠檬酸治疗疣和咽喉酸痛的方法和组合物
公开(公告)号：US5122540A
公开(公告)日：1992-06-16
申请号：US468890
申请日：1990-01-22
申请人： W. Keith R. Watson , Walter B. Dandliker
发明人： W. Keith R. Watson , Walter B. Dandliker
IPC分类号： A61K31/19 , A61K47/20
CPC分类号： A61K9/0014 , A61K31/19 , A61K47/20 , Y10S514/936 , Y10S514/947
摘要： A solution of DMSO and a body reactive agent (such as citric acid) is provided, and is typically topically applied to the body, as to a wart or to the skin of the throat.
摘要翻译：提供DMSO和身体反应剂（例如柠檬酸）的溶液，并且典型地局部施用于身体，疣或咽喉的皮肤。

7. 发明授权

US07371524B2 Substituted azaporphyrins as fluorescence labels 失效
标题翻译：取代的氮杂卟啉作为荧光标记
公开(公告)号：US07371524B2
公开(公告)日：2008-05-13
申请号：US10866361
申请日：2004-06-14
申请人： Walter B. Dandliker , Mao Lin Hsu , William P. Murphy, Jr.
发明人： Walter B. Dandliker , Mao Lin Hsu , William P. Murphy, Jr.
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53 , G01N33/533 , G01N31/00 , C07H19/04 , A01N61/00 , A01N43/04
CPC分类号： C07D487/22 , C07H21/04 , G01N33/582 , Y10S435/968
摘要： The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According to the present invention, detectably labeled marker components are provided that comprise a fluorescent moiety coupled to two small solubilizing groups, one on each side of the molecular plane, said fluorescent moiety having substituents to control net charge so as to reduce or remove the problems of solvent sensitivity and nonspecific binding.
摘要翻译：本发明涉及标记组分，荧光探针，寡核苷酸，杂交测定和使用这些产物的免疫测定，以及制备这些产品的方法。根据本发明，提供可检测标记的标记物组分，其包含与两个小增溶基团偶联的荧光部分，分子平面每侧一个，所述荧光部分具有用于控制净电荷的取代基，以减少或消除问题的溶剂敏感性和非特异性结合。

8. 发明授权

US5880287A Polyoxyhydrocarbyl related products and methods for fluorescence assays 失效
标题翻译：聚氧烃基相关产品和荧光测定方法
公开(公告)号：US5880287A
公开(公告)日：1999-03-09
申请号：US476544
申请日：1995-06-07
申请人： Walter B. Dandliker , Robert Francis Devlin , Peter Olaf Gustaf Arrhenius , Mao-Lin Hsu
发明人： Walter B. Dandliker , Robert Francis Devlin , Peter Olaf Gustaf Arrhenius , Mao-Lin Hsu
IPC分类号： G01N33/533 , A61K41/00 , A61K47/48 , A61K49/00 , C07D209/14 , C07D209/60 , C07D215/12 , C07D241/38 , C07D277/64 , C07D309/34 , C07D311/58 , C07D335/02 , C07D409/06 , C07D421/06 , C07D487/22 , C07J43/00 , C07J51/00 , C09B47/00 , C09B47/04 , C09B47/073 , C09B47/08 , C09B47/24 , C09B69/00 , G01N33/52 , G01N33/58 , C09B23/00 , C07D513/02
CPC分类号： A61K41/0057 , A61K47/48215 , A61K49/0015 , A61K49/0021 , A61K49/0026 , A61K49/0028 , A61K49/003 , A61K49/0032 , C07D487/22 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/045 , C09B47/073 , C09B47/08 , C09B47/24 , C09B69/00 , G01N33/52 , G01N33/533 , G01N33/582 , G01N2333/19
摘要： Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy. Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine. The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.
摘要翻译：提供了没有聚集和血清结合的荧光染料。这些染料适用于荧光免疫测定，体内成像和体内肿瘤治疗。提供荧光免疫测定方法，其使用不含聚集和血清结合的荧光染料。因此，这样的免疫测定方法对生物流体如血清，血浆，全血和尿液的测定特别有用。本发明涉及包含连接到包含荧光团部分的可检测标记的标记组分的寡核苷酸的组合物，其包含与能够与两个轴向配体和两个聚氧化烃部分配位的中心原子配位的基本上平面的多齿大环配体，轴向配体到中心原子。本发明还涉及使用这种组合物的核酸杂交和扩增方法。

9. 发明授权

US5302349A Transient-state luminescence assay apparatus 失效
标题翻译：瞬态发光测定装置
公开(公告)号：US5302349A
公开(公告)日：1994-04-12
申请号：US490770
申请日：1990-03-06
申请人： Walter B. Dandliker , June K. Dandliker , Jacques C. Levin
发明人： Walter B. Dandliker , June K. Dandliker , Jacques C. Levin
IPC分类号： G01N21/64
CPC分类号： G01N21/6445 , G01N21/6408 , G01N21/6428
摘要： Light, pulsed or continuous at a particular wavelength (e.g. 780 nm), fluoresces a specimen. The specimen may be combinations of an antigen (e.g. rubella) labelled with a fluorescent dye, unlabeled antigen or hapten and an antibody reactive with the antigen or hapten. The light polarized in a first direction (e.g. z-axis) parallel to the electric field of the incident light and in a second direction (e.g. x-axis) perpendicular to the first direction is measured. A second specimen is then provided with the antigen and the antibody but without the dye. The same light as discussed above excites the second specimen and polarizes the light. The light polarized in the first (z-axis) and second (x-axis) directions in the second specimen is measured. These measurements are processed in a microprocessor with the measurements in the z and x directions in the first specimen to identify the antigen or, when the antigen is known, to identify the concentration of the antigen in the first specimen. When the light is pulsed, the measurements are made in a time window beginning after the initiation, and terminating before the end, of the fluorescence of the combination of the dye, the antibody and the antigen. Determinations as discussed above but without unlabeled antigen or hapten may be made of the antibody instead of the antigen. When the light is continuous, it is modulated. Measurements are made of the phase shifts in the polarized light in the z and x directions as a result of the light modulations and the decay of the fluorescence.
摘要翻译：在特定波长（例如780nm）下的光，脉冲或连续的荧光发射样品。标本可以是用荧光染料标记的抗原（例如风疹），未标记的抗原或半抗原和与抗原或半抗原反应的抗体的组合。测量在与入射光的电场平行的第一方向（例如z轴）并且垂直于第一方向的第二方向（例如，x轴）偏振的光。然后向抗体和抗体提供第二个标本，但没有染料。与上述相同的光激发第二个样品并使光线偏振。测量在第二样本中在第一（z轴）和第二（x轴）方向偏振的光。这些测量在微处理器中处理，其中在第一样本中的z和x方向上的测量以识别抗原，或者当抗原已知时，以鉴定第一样品中抗原的浓度。当光被脉冲时，测量在起始之后开始的时间窗口中，并且在结束之前终止染料，抗体和抗原的组合的荧光。如上所述但没有未标记的抗原或半抗原的测定可以由抗体代替抗原制成。当光线连续时，它被调制。测量由于光调制和荧光衰减而在z和x方向的偏振光中的相移。

10. 发明授权

US5641878A Porphyrin, azaporphyrin, and related fluorescent dyes free of aggregation and serum binding 失效
标题翻译：卟啉，azaporphyrin和相关的荧光染料无聚集和血清结合
公开(公告)号：US5641878A
公开(公告)日：1997-06-24
申请号：US333603
申请日：1994-11-02
申请人： Walter B. Dandliker , Mao-Lin Hsu
发明人： Walter B. Dandliker , Mao-Lin Hsu
IPC分类号： A61K49/00 , C07D487/22 , C09B47/00 , C09B47/08 , C09B47/24 , G01N33/58 , C09B47/30
CPC分类号： A61K49/0021 , A61K49/0052 , A61K49/0054 , C07D487/22 , C09B47/00 , C09B47/08 , C09B47/24 , G01N33/582 , G01N2333/19
摘要： Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy. The dyes are particularly useful in fluorescence immunoassays of biological samples containing serum. Such dyes have two polyoxyhydrocarbyl moities, one located on either side of a planar molecular structure such as a porphyrin derivative, azaporphyrin derivative, corrin derivative, sapphyrin derivative or porphycene derivative.
摘要翻译：提供了没有聚集和血清结合的荧光染料。这些染料适用于荧光免疫测定，体内成像和体内肿瘤治疗。染料在含有血清的生物样品的荧光免疫测定中特别有用。这样的染料具有两个聚氧化烃基，一个位于平面分子结构的两侧，例如卟啉衍生物，氮杂卟啉衍生物，cor啉衍生物，卟啉衍生物或卟吩衍生物。

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