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1. 发明申请

US20060074087A1 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
公开(公告)号：US20060074087A1
公开(公告)日：2006-04-06
申请号：US10542694
申请日：2004-01-27
申请人： Wallace Ashton , Charles Caldwell , Joseph Duffy , Robert Mathvink , Liping Wang , Ann Weber
发明人： Wallace Ashton , Charles Caldwell , Joseph Duffy , Robert Mathvink , Liping Wang , Ann Weber
IPC分类号： A61K31/519 , A61K31/503 , A61K31/498 , C07D487/02
CPC分类号： C07D471/04 , C07D217/06 , C07D217/26
摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

2. 发明申请

US20060052382A1 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 审中-公开
公开(公告)号：US20060052382A1
公开(公告)日：2006-03-09
申请号：US10540283
申请日：2003-12-16
申请人： Joseph Duffy , Scott Edmondson , Dooseop Kim , Brian Kirk , Liping Wang , Ann Weber
发明人： Joseph Duffy , Scott Edmondson , Dooseop Kim , Brian Kirk , Liping Wang , Ann Weber
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

3. 发明公开

US20230330631A1 SELECTIVE METAMATERIAL ABSORBER AND METHOD FOR FABRICATING THE SAME 审中-公开
公开(公告)号：US20230330631A1
公开(公告)日：2023-10-19
申请号：US17945597
申请日：2022-09-15
申请人： Jui-Yung Chang , Sydney Taylor , Liping Wang
发明人： Jui-Yung Chang , Sydney Taylor , Liping Wang
IPC分类号： B01J20/32 , B01J20/02 , B01J20/28 , B82Y40/00 , B82Y30/00
CPC分类号： B01J20/3236 , B01J20/0251 , B01J20/0218 , B01J20/28035 , B82Y40/00 , B01J20/3204 , B82Y30/00 , B01J2220/4806
摘要： A selective metamaterial absorber and method for fabricating the same is disclosed. The method includes deposing a first metal layer on a first surface of a substrate and on a plurality of nanowires extending outward from the first surface of the substrate, the plurality of nanowires forming an array on the first surface, the substrate further including a second surface opposite the first surface. The first metal layer may be deposed using conformally sputtering. The substrate and the plurality of nanowires may be composed of silicon, and the first metal layer may be composed of tungsten. The first metal layer may be composed of a material having a penetration depth for a wavelength range of interest. The first metal layer may be at least three times thicker than the penetration depth.

4. 发明申请

US20230010741A1 SEMICONDUCTOR-BASED SELECTIVE EMITTER FOR THERMOPHOTOVOLTAIC ENERGY CONVERSION AND METHOD FOR FABRICATING THE SAME 有权
公开(公告)号：US20230010741A1
公开(公告)日：2023-01-12
申请号：US17859987
申请日：2022-07-07
申请人： Liping Wang , Rajagopalan Ramesh , Qing Ni
发明人： Liping Wang , Rajagopalan Ramesh , Qing Ni
IPC分类号： H02S10/30 , H01L31/0216 , H01L31/028 , H01L31/056 , H01L31/18
摘要： A selective emitter for thermophotovoltaic energy conversion and method for fabricating the same is disclosed. The selective emitter includes a germanium wafer, and a reflective layer deposited on a first side of the germanium wafer. The reflective layer includes tungsten. The selective emitter also includes an anti-reflective layer deposited on a second side of the germanium wafer opposite the first side. The anti-reflective layer includes Si3N4. The method for fabricating a selective emitter for thermophotovoltaic energy conversion includes deposing a reflective layer on a first side of a germanium wafer, and deposing an anti-reflective layer on a second side of the germanium wafer, the first side being opposite the second side. The germanium wafer may be undoped. The reflective layer may be sputtered onto the germanium wafer. The anti-reflective layer may be deposited on the germanium wafer using plasma-enhanced chemical vapor deposition.

5. 发明申请

US20220390192A1 METAL BASED THERMAL DISSIPATOR HAVING ENHANCED THERMAL RADIATION, AND METHODS FOR PRODUCING THE SAME 有权
公开(公告)号：US20220390192A1
公开(公告)日：2022-12-08
申请号：US17835660
申请日：2022-06-08
申请人： Liping Wang , Payam Sabbaghi , Linshuang Long
发明人： Liping Wang , Payam Sabbaghi , Linshuang Long
IPC分类号： F28F21/08 , B22F7/08 , B22F1/145 , B22F1/05 , F28F3/04
摘要： A composite thermal dissipator and a method for fabricating the same is disclosed. The composite thermal dissipator includes a molded polydimethylsiloxane (PDMS) composite material composed of a powdered metal mixed with PDMS. The method for fabricating a composite thermal dissipator includes mixing a powdered copper into liquid PDMS to form a liquid mixture, and pouring the liquid mixture into a sacrificial wax mold. The sacrificial wax mold includes wax shaped to be complementary to the composite thermal dissipator. The method also includes curing the liquid mixture within the sacrificial wax mold, and removing the composite thermal dissipator from the sacrificial wax mold by melting away the wax.

6. 发明授权

US08957062B2 Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment 有权
标题翻译：取代的环丙基化合物，含有这些化合物的组合物和处理方法
公开(公告)号：US08957062B2
公开(公告)日：2015-02-17
申请号：US14110332
申请日：2012-04-05
申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
发明人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC分类号： C07D513/04 , C07D401/12 , C07D413/14 , C07D413/04 , C07D211/22 , C07D405/04 , C07D471/04 , C07D487/04 , C07D498/04 , A61K9/48 , C07D417/14 , C07D495/04
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。

7. 发明授权

US08848569B2 Method and device for power control in non-adaptive retransmission 有权
标题翻译：非自适应重传中功率控制的方法和装置
公开(公告)号：US08848569B2
公开(公告)日：2014-09-30
申请号：US13576397
申请日：2010-05-17
申请人： Lin Wang , Peng Zhang , Liping Wang
发明人： Lin Wang , Peng Zhang , Liping Wang
IPC分类号： H04L1/00 , H04W4/00 , G08C17/00
CPC分类号： H04L1/1822 , H04W52/20 , H04W52/221 , H04W52/362 , H04W52/48
摘要： The disclosure discloses a method and device for power control in non-adaptive retransmission. The solution thereof includes: when UE does not obtain a TPC adjustment value of a current HARQ process by parsing, determining a current power control mode; if the mode is an accumulation mode, determining whether the calculated sum of TPC adjustment values of each HARQ process is smaller than a given threshold, if yes, obtaining a transmission power by adding an increment adjustment value to a retransmission power, otherwise, calculating the transmission power of UE according to a formula in a protocol; if the mode is an absolute value mode, obtaining a transmission power by adding an increment adjustment value to a retransmission power. The solution can improve the SINR detected by an eNB and improve a retransmission success rate, thereby saving radio resources, facilitating utilization of radio resources and reduction of transmission delay, improving the throughput rate of an LTE system and improving the system performance.
摘要翻译：本公开公开了一种用于非自适应重传中的功率控制的方法和装置。其解决方案包括：当UE不通过解析获得当前HARQ进程的TPC调整值时，确定当前功率控制模式; 如果模式是累加模式，则确定所计算的每个HARQ过程的TPC调整值的和是否小于给定阈值，如果是，则通过将增量调整值与重发功率相加来获得发送功率，否则，计算 UE根据协议中的公式发送功率; 如果模式是绝对值模式，则通过将增量调整值与重发功率相加来获得发送功率。该方案可以提高基站检测到的SINR，提高重发成功率，节省无线资源，便于利用无线资源，减少传输延迟，提高LTE系统吞吐率，提高系统性能。

8. 发明授权

US08247415B2 Hydroxymethyl pyrrolidines as β3 adrenergic receptor agonists 有权
标题翻译：羟基甲基吡咯烷作为3肾上腺素能受体激动剂
公开(公告)号：US08247415B2
公开(公告)日：2012-08-21
申请号：US12417239
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： C07D237/30 , C07D239/90 , C07D221/02 , C07D277/60 , A61K31/502 , A61K31/517 , A61K31/435 , A61K31/428 , A61P13/10 , A61P13/06
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译：本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。

9. 发明申请

US20120157432A1 NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权
公开(公告)号：US20120157432A1
公开(公告)日：2012-06-21
申请号：US13392662
申请日：2010-08-17
申请人： Scott D. Edmondson , Richard Berger , Lehua Chang , Vincent j. Colandrea , Jeffrey J. Hale , Bart Harper , Nam Fung Kar , Bing Li , Greg J. Morriello , Christopher R. Moyes , Deyou Sha , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
发明人： Scott D. Edmondson , Richard Berger , Lehua Chang , Vincent j. Colandrea , Jeffrey J. Hale , Bart Harper , Nam Fung Kar , Bing Li , Greg J. Morriello , Christopher R. Moyes , Deyou Sha , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
IPC分类号： A61K31/4025 , A61K31/4155 , C07D403/12 , A61K31/497 , C07D413/14 , A61K31/4245 , C07D209/96 , A61K31/407 , C07D401/14 , A61K31/4439 , C07D487/04 , A61K31/519 , C07D401/12 , A61K31/454 , C07D221/20 , A61K31/438 , A61K31/4545 , C07D265/12 , A61K31/536 , A61K31/501 , A61K31/496 , A61P13/02 , C07D403/14
CPC分类号： C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

10. 发明申请

US20120093779A1 COMPLEX MICROBIAL PREPARATION FOR TREATING DIABETES AND PREPARATIVE METHOD AND USE THEREOF 审中-公开
标题翻译：用于治疗糖尿病的复杂微生物制剂及其制备方法及其用途
公开(公告)号：US20120093779A1
公开(公告)日：2012-04-19
申请号：US13257368
申请日：2010-11-03
申请人： Liping Wang
发明人： Liping Wang
IPC分类号： A61K35/74 , A61P3/10
CPC分类号： A61K35/74 , A61K35/742 , A61K35/747 , A61K36/06 , A61K36/064 , A61K2035/115 , C12N1/18 , C12N1/20 , A61K2300/00
摘要： A complex microbial preparation comprises (in vol. %): Photosynthetic bacterium (5-15%), Bacillus (10-20%), Yeasts (20-35%), Lactobacillus (30-45%) and Actinomycetes (3-10%). The preparative method of the complex microbial preparation involves first and second level complex fermentations. The first level complex fermentation involves: (a) separately inoculating the above-mentioned bacteria on first level culture media and culturing to obtain first level bacteria, (b) separately inoculating the obtained first level bacteria on second level culture media and culturing to obtain fermenting bacterial liquids, (c) mixing the five obtained fermenting bacterial liquids to obtain first level compound bacteria. The second level complex fermentation involves: adding sterile water, Lactobacillus plantarum, Lactobacillus acidophilus, Saccharomyces cerevisiae and brown sugar to the obtained first level compound bacteria, mixing uniformly in a same fermentor, and culturing to obtain second level complex microbial preparation. The complex microbial preparation is used in treatment for diabetes.
摘要翻译：复合微生物制剂包含（体积％）：光合细菌（5-15％），芽孢杆菌属（10-20％），酵母菌（20-35％），乳杆菌属（30-45％）和放线菌％）。复杂微生物制剂的制备方法涉及第一和第二级复合发酵。第一级复合发酵包括：（a）在第一级培养基上分别接种上述细菌并培养以获得一级细菌，（b）将获得的一级细菌分别接种在二级培养基上并培养以获得发酵细菌液体，（c）混合五种获得的发酵细菌液体以获得一级复合细菌。第二级复合发酵涉及：将无菌水，植物乳杆菌，嗜酸乳杆菌，酿酒酵母和红糖加入到所得一级复合菌中，在相同的发酵罐中均匀混合，培养获得二级复合微生物制剂。复杂的微生物制剂用于治疗糖尿病。

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