专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110028461A1 HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权
标题翻译：羟丙基吡咯烷酮作为3型ADRENERGIC受体激动剂
公开(公告)号：US20110028461A1
公开(公告)日：2011-02-03
申请号：US12936275
申请日：2009-03-23
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
IPC分类号： A61K31/4439 , C07D417/14 , A61K31/502 , C07D413/14 , A61K31/5355 , A61P13/00 , A61P13/10
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
摘要： The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译：本发明提供式I化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。

2. 发明授权

US07589085B2 Tetrahydropyran heterocyclic cyclopentyl heteroaryl modulators of chemokine receptor activity 失效
标题翻译：趋化因子受体活性的四氢吡喃杂环环戊基杂芳基调节剂
公开(公告)号：US07589085B2
公开(公告)日：2009-09-15
申请号：US10567516
申请日：2004-08-06
申请人： Gabor Butora , Lihu Yang , Stephen D. Goble
发明人： Gabor Butora , Lihu Yang , Stephen D. Goble
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D405/12 , C07D417/12
摘要： The present invention is further directed to compounds of the formulas: (I) (II) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24 and R25 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
摘要翻译：本发明还涉及式（I）（II）（其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R15，R16，R17，R18，R19， R24和R25如本文所定义），其是趋化因子受体活性的调节剂，并且可用于预防或治疗某些炎性和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及作为自身免疫性病变如类风湿性关节炎和动脉粥样硬化。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及趋化因子受体的疾病中的用途。

3. 发明授权

US07700591B2 Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors 有权
标题翻译：趋化因子受体的苯并恶嗪基酰胺基环戊基 - 杂环调节剂
公开(公告)号：US07700591B2
公开(公告)日：2010-04-20
申请号：US11129512
申请日：2005-05-13
申请人： Stephen D. Goble , Sander G. Mills , Lihu Yang , Alexander Pasternak , Celine Bonnefous , Theodore M Kamenecka , Jean-Michel Vernier , John H. Hutchinson , Essa Hu , Steven Govek
发明人： Stephen D. Goble , Sander G. Mills , Lihu Yang , Alexander Pasternak , Celine Bonnefous , Theodore M Kamenecka , Jean-Michel Vernier , John H. Hutchinson , Essa Hu , Steven Govek
IPC分类号： A61K31/535 , C07D265/12 , C07D498/00
CPC分类号： C07D413/08 , C07D413/14 , C07D417/14
摘要： Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.
摘要翻译：通过使用苯并恶嗪的环氮通过酰胺部分连接到苯并恶嗪基的环戊基化合物，并进一步被杂环部分取代，由式I表示的化合物：其用于调节CCR-2趋化因子受体以预防或治疗炎症和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫性病态如类风湿性关节炎和动脉粥样硬化; 和包含这些化合物的药物组合物以及这些化合物和组合物的用途。

4. 发明申请

US20090253705A1 HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权
标题翻译：羟丙基吡咯烷酮作为3型ADRENERGIC受体激动剂
公开(公告)号：US20090253705A1
公开(公告)日：2009-10-08
申请号：US12417239
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： A61K31/506 , C07D417/12 , C07D403/12 , C07D495/04 , C07D401/12 , A61K31/427 , A61K31/428 , A61K31/517 , A61K31/501 , A61K31/502 , A61K31/4439 , A61K31/41 , A61K31/437 , A61P13/10
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译：本发明提供式（I）的化合物，其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。

5. 发明授权

US07557120B2 Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity 失效
标题翻译：氨基环戊烯基稠合异酰胺调节剂的趋化因子受体活性
公开(公告)号：US07557120B2
公开(公告)日：2009-07-07
申请号：US10543794
申请日：2004-02-23
申请人： Stephen D. Goble , Alexander Pasternak , Cheng Tang , Changyou Zhou , Lihu Yang
发明人： Stephen D. Goble , Alexander Pasternak , Cheng Tang , Changyou Zhou , Lihu Yang
IPC分类号： A61K31/437 , C07D471/02 , C07D471/14
CPC分类号： C07D471/06 , C07D487/06 , C07D513/06
摘要： The present invention is directed to compounds of formulae (I and II)(wherein A, D, E, X, l, m, n and R1 through R18 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
摘要翻译：本发明涉及可用作趋化因子受体活性调节剂的式（I和II）（其中A，D，E，X，l，m，n和R 1至R 18如本文所定义）的化合物。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂。

6. 发明授权

US07491737B2 Heterarylpiperidine modulators of chemokine receptor activity 失效
标题翻译：趋化因子受体活性的异基哌啶调节剂
公开(公告)号：US07491737B2
公开(公告)日：2009-02-17
申请号：US10528304
申请日：2003-10-24
申请人： Stephen D. Goble , Alexander Pasternak , Lihu Yang
发明人： Stephen D. Goble , Alexander Pasternak , Lihu Yang
IPC分类号： A61K31/454 , A61K31/4545
CPC分类号： C07D401/04 , C07D417/04 , C07D471/10
摘要： The present invention is directed to compounds of the formula (I): (wherein R1, R2, R3, R4, R5, R6, R10 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
摘要翻译：本发明涉及可用作趋化因子受体活性调节剂的式（I）：（其中R 1，R 2，R 3，R 4，R 5，R 6，R 10和n如本文所定义）的化合物。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂。

7. 发明授权

US07390803B2 Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity 失效
标题翻译：趋化因子受体活性的四氢吡喃基环戊基苄基酰胺调节剂
公开(公告)号：US07390803B2
公开(公告)日：2008-06-24
申请号：US10533326
申请日：2003-10-24
申请人： Gabor Butora , Sander G. Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen D. Goble
发明人： Gabor Butora , Sander G. Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen D. Goble
IPC分类号： A61K31/351 , A61K31/4523 , A61K31/5365 , C07D257/04 , C07D231/56
CPC分类号： C07D311/00 , C07C237/24 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07D211/58 , C07D211/96 , C07D305/08 , C07D307/22 , C07D309/14 , C07D311/02 , C07D311/68 , C07D311/74 , C07D313/04 , C07D319/06 , C07D333/36 , C07D335/02 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D491/04 , C07D491/107 , C07D493/08
摘要： The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2
摘要翻译：本发明涉及式（I）化合物（其中R 1，R 2，R 3，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， R 10，R 11，R 27，R 28，R 29， R 30，R 30，R 31，X，m，n，虚线在本文中定义），其可用作趋化因子受体活性的调节剂。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂

8. 发明授权

US06812234B2 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity 有权
标题翻译：趋化因子受体活性的四氢吡喃基环戊基四氢吡啶并吡啶调节剂
公开(公告)号：US06812234B2
公开(公告)日：2004-11-02
申请号：US10425167
申请日：2003-04-29
申请人： Richard Jiao , Gregori Morriello , Lihu Yang , Stephen D. Goble , Sander G. Mills , Alexander Pasternak , Changyou Zhou , Gabor Butora , Shankaran Kothandaraman , Deodialsingh Guiadeen , Christopher Moyes , Cheng Tang
发明人： Richard Jiao , Gregori Morriello , Lihu Yang , Stephen D. Goble , Sander G. Mills , Alexander Pasternak , Changyou Zhou , Gabor Butora , Shankaran Kothandaraman , Deodialsingh Guiadeen , Christopher Moyes , Cheng Tang
IPC分类号： A61K314375
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
摘要翻译：本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 7， R 9，R 10，X，n和虚线在本文中定义），其可用作趋化因子受体活性的调节剂。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂。

9. 发明授权

US08247415B2 Hydroxymethyl pyrrolidines as β3 adrenergic receptor agonists 有权
标题翻译：羟基甲基吡咯烷作为3肾上腺素能受体激动剂
公开(公告)号：US08247415B2
公开(公告)日：2012-08-21
申请号：US12417239
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： C07D237/30 , C07D239/90 , C07D221/02 , C07D277/60 , A61K31/502 , A61K31/517 , A61K31/435 , A61K31/428 , A61P13/10 , A61P13/06
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译：本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。

10. 发明授权

US07598243B2 Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity 失效
标题翻译：杂环环四氢异喹啉和四氢吡啶并吡啶调节剂的趋化因子受体活性
公开(公告)号：US07598243B2
公开(公告)日：2009-10-06
申请号：US10260008
申请日：2004-10-15
申请人： Gabor Butora , Stephen D. Goble , Alexander Pasternak , Lihu Yang , Changyou Zhou , Christopher R. Moyes
发明人： Gabor Butora , Stephen D. Goble , Alexander Pasternak , Lihu Yang , Changyou Zhou , Christopher R. Moyes
IPC分类号： A61K31/5377 , C07D413/08 , C07D413/14
CPC分类号： C07D401/08 , C07D217/06 , C07D401/12 , C07D401/14 , C07D413/08 , C07D471/04 , C07D491/08 , C07D519/00
摘要： The present invention is directed to compounds of the formula I: Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
摘要翻译：本发明涉及式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9，X，n和虚线如本文所定义，其可用作趋化因子受体的调节剂活动。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式