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1. 发明专利

JP2009512716A Hiv-1 capsid assembly of small molecule inhibitors 审中-公开
公开(公告)号：JP2009512716A
公开(公告)日：2009-03-26
申请号：JP2008536867
申请日：2006-10-23
申请人：ユニバーシティ・オブ・アラバマ・アット・バーミンガムUniversity Of Alabama At Birmingham
发明人：ピーター・プレバリッジ・ジュニア
IPC分类号： C07C251/86 , A61K31/16 , A61K31/18 , A61K31/192 , A61K31/36 , A61K31/4025 , A61K31/404 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/428 , A61K31/4402 , A61K31/4409 , A61K31/473 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/655 , A61K45/00 , A61P31/18 , A61P37/04 , A61P43/00 , C07C311/21 , C07C311/49 , C07C323/37 , C07C323/56 , C07D209/34 , C07D213/36 , C07D213/53 , C07D221/16 , C07D233/60 , C07D235/08 , C07D239/50 , C07D277/20 , C07D277/40 , C07D277/82 , C07D317/68 , C07D409/04 , C07D417/06
CPC分类号： A61K31/5375 , A61K31/55
摘要：本発明は、化学ライブラリー(DIVERSet
登録商標ライブラリー)により同定される低分子阻害剤を使用するHIV感染の新規な治療方法を提供する。これらの低分子阻害剤は特異的にHIV-1キャプシドタンパク質に結合し、それによりキャプシド構築を阻害することができる。本発明の低分子阻害剤はHIV感染の治療の薬剤標的となる可能性がある。

2. 发明专利

AU1282297A Targeted adenovirus vectors 未知
公开(公告)号：AU1282297A
公开(公告)日：1997-06-27
申请号：AU1282297
申请日：1996-12-06
申请人： UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION THE
发明人： CURIEL DAVID
IPC分类号： C12N15/09 , A61K31/522 , A61K38/00 , A61K39/235 , A61K48/00 , A61P35/00 , C07K14/075 , C07K16/08 , C12N7/00 , C12N7/02 , C12N15/861
摘要： The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene using a two-plasmid rescue system for derivation of adenoviral fiber recombinants.

3. 发明专利

AU4717600A Regulation of Alzheimer's disease related proteins and uses thereof 未知
公开(公告)号：AU4717600A
公开(公告)日：2000-11-02
申请号：AU4717600
申请日：2000-07-12
申请人： UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION THE
发明人： WILSON DAVID M , BINDER LESTER I
IPC分类号： A61K45/00 , A61P25/28 , C07K1/107 , G01N33/68

5. 发明申请

WO2019055609A9 BIOMARKERS AND METHODS FOR ASSESSING MYOCARDIAL INFARCTION AND SERIOUS INFECTION RISK IN RHEUMATOID ARTHRITIS PATIENTS 审中-公开
公开(公告)号：WO2019055609A9
公开(公告)日：2019-03-21
申请号：PCT/US2018/050817
申请日：2018-09-13
申请人： CURTIS, Jeff , FORD, Kerri , UNIVERSITY OF ALABAMA AT BIRMINGHAM , CRESCENDO BIOSCIENCE, INC.
发明人： CURTIS, Jeff , FORD, Kerri
IPC分类号： G01N33/53 , G01N33/68
摘要： Provided herein are methods for assessing risk of infection or cardiovascular disease (CVD) in a subject with an inflammatory disease, e.g., rheumatoid arthritis. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers with or without additional clinical variables to assess infection and CVD risk. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.

6. 发明申请

WO2009009207A2 THERMOPLASTIC COMPOSITE/METAL LAMINATE STRUCTURES AND METHODS OF MAKING THERMOPLASTIC COMPOSITE/METAL LAMINATE STRUCTURES 审中-公开
标题翻译：热塑性复合材料/金属层合结构及制备热塑性复合材料/金属层合结构的方法
公开(公告)号：WO2009009207A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/061233
申请日：2008-04-23
申请人： UNIVERSITY OF ALABAMA AT BIRMINGHAM , KUKHARNI, Rahul R. , CHAWLA, Kristan K. , VAIDYA, Uday K.
发明人： KUKHARNI, Rahul R. , CHAWLA, Kristan K. , VAIDYA, Uday K.
CPC分类号： B32B15/14 , B32B15/20 , B32B2260/021 , B32B2260/046 , B32B2262/0253 , B32B2262/0261 , B32B2262/0269 , B32B2262/101 , B32B2262/103 , B32B2262/106 , B32B2262/14 , B32B2307/54 , B32B2307/72
摘要： Long fiber thermoplastic composite/metal laminate structures, methods of making long fiber thermoplastic composite/metal laminate structures, and the like, are disclosed.
摘要翻译：公开了长纤维热塑性复合材料/金属层压结构，制造长纤维热塑性复合材料/金属层压结构的方法等。

7. 发明申请

WO2008118226A2 SYSTEMS AND METHODS FOR RANDOMIZING SENSOR POSITIONS IN SENSOR ARRAYS 审中-公开
标题翻译：传感器阵列传感器位置的系统和方法
公开(公告)号：WO2008118226A2
公开(公告)日：2008-10-02
申请号：PCT/US2007/086280
申请日：2007-12-03
申请人： UNIVERSITY OF ALABAMA AT BIRMINGHAM , CALLAHAN, Dale , WANG, Percy, F.
发明人： CALLAHAN, Dale , WANG, Percy, F.
IPC分类号： G11B5/596
CPC分类号： H04R1/083 , G01H3/125 , H04R1/406 , H04R2201/401
摘要： The present disclosure generally pertains to systems and methods for randomizing sensor positions in sensor arrays in order to reduce artifacts, such as ghost artifacts, in the data sampled by the arrays. In one exemplary embodiment of the present disclosure, a sensor array is used to sense a parameter, such as light or acoustic energy. Each sensor of the array is movable under the control of a controller, which tracks the position of the sensors as they are moved. At least one sample is taken while the sensors are in a first randomized pattern. The sensors are then randomly moved to new positions in order to form a new randomized pattern. At least one additional sample is taken after the sensors have been moved to the new randomized pattern. The data defining the multiple samples can be combined (e.g., averaged) to define a composite sample. The composite sample can be based on any number of samples taken while the sensors are in any number of randomized positions.
摘要翻译：本公开通常涉及用于随机化传感器阵列中的传感器位置的系统和方法，以便减少由阵列采样的数据中的伪像，例如重影伪像。在本公开的一个示例性实施例中，传感器阵列用于感测诸如光或声能的参数。阵列的每个传感器在控制器的控制下是可移动的，该控制器跟踪传感器移动时的位置。当传感器处于第一随机化模式时，至少采取一个样本。然后将传感器随机移动到新位置，以形成新的随机化模式。在传感器移动到新的随机模式之后，至少再抽取一个样本。定义多个样本的数据可以组合（例如，平均）以定义复合样本。复合样品可以基于在传感器处于任意数量的随机位置时所采集的任何数量的样品。

8. 发明申请

WO1997008180A1 METHOD TO IMPROVE THE BIOLOGICAL AND ANTIVIRAL ACTIVITY OF PROTEASE INHIBITORS 审中-公开
标题翻译：提高蛋白酶抑制剂生物活性和抗病毒活性的方法
公开(公告)号：WO1997008180A1
公开(公告)日：1997-03-06
申请号：PCT/US1996013721
申请日：1996-08-30
申请人： UNIVERSITY OF ALABAMA AT BIRMINGHAM , SCHINAZI, Raymond, F.
发明人： UNIVERSITY OF ALABAMA AT BIRMINGHAM , SOMMADOSSI, Jean-Pierre
IPC分类号： C07H17/08
CPC分类号： A61K31/706 , A61K31/00 , A61K31/70 , A61K31/7048 , Y02A50/411 , A61K2300/00
摘要： Methods for improving the cellular uptake of protease inhibitors (e.g., HIV protease inhibitor), alone or in the presence of one or more additional therapeutic agents, in protease inhibitor-based therapies, involving administration of one or more AAG-binding compounds, such as macrolide or lincosamide antibiotics, which have sufficient binding affinity for AAG to competitively bind AAG in the presence of the protease inhibitor.
摘要翻译：用于改善蛋白酶抑制剂（例如，HIV蛋白酶抑制剂）在蛋白酶抑制剂的疗法中单独或在一种或多种另外的治疗剂存在下的细胞摄取的方法，涉及施用一种或多种AAG结合化合物，例如大环内酯或林可素类抗生素，其具有对AAG的足够的结合亲和力，以在蛋白酶抑制剂存在下竞争性地结合AAG。

9. 发明申请

WO1996039036A1 COMPOSITION AND METHODS FOR CREATING SYNGENEIC RECOMBINANT VIRUS-PRODUCING CELLS 审中-公开
标题翻译：用于创建合成重组病毒生产细胞的组合物和方法
公开(公告)号：WO1996039036A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008885
申请日：1996-06-05
申请人： THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION , GARVER, Robert, I. , CURIEL, David, T.
发明人： THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION
IPC分类号： A01N63/00
CPC分类号： C12N15/86 , A61K48/00 , C12N7/00 , C12N2710/10343 , C12N2710/10362 , C12N2740/13052
摘要： Replication-defective viruses and means for intracellular replication thereof are described which are useful for gene therapy. Human cells can be changed into recombinant replication-defective virus particle-producing cells by the simultaneous delivery to those cells of two different nucleic acids: the first being a replication-defective viral genome, the second being a nucleic acid that complements the viral sequences deleted from the first nucleic acid so as to result in the production of new infective virus. The first nucleic acid can be delivered by the replication-defective virus itself or, as a nucleic acid that is not part of the virus. In a preferred embodiment, the replication-defective virus includes elements to maintain the two nucleic acids in combination during transduction.
摘要翻译：描述了用于基因治疗的复制缺陷病毒及其细胞内复制的方法。可以通过同时递送到两种不同核酸的那些细胞，将人细胞改变成重组复制缺陷型病毒颗粒产生细胞：第一种是复制缺陷型病毒基因组，第二种是补充病毒序列缺失的核酸从第一核酸引起新的感染性病毒的产生。第一核酸可以由复制缺陷型病毒本身或作为不是病毒的一部分的核酸递送。在优选的实施方案中，复制缺陷型病毒包括在转导期间组合维持两种核酸的元件。

10. 发明申请

WO1996018398A1 TREATMENT OF TOXOPLASMOSIS 审中-公开
标题翻译：治疗牙菌斑
公开(公告)号：WO1996018398A1
公开(公告)日：1996-06-20
申请号：PCT/US1995016343
申请日：1995-12-14
申请人： THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION
发明人： THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION , EL KOUNI, Mahmoud, H. , GUARCELLO Vincent , NAGUIB, Fardos, N., M.
IPC分类号： A61K31/52
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/522 , A61K45/06 , Y02A50/411 , Y02A50/414
摘要： Pharmaceutical compositions comprising purine analogs and uses for the compositions in treating parasite infections and other diseases or conditions are described.
摘要翻译：描述了包含嘌呤类似物的药物组合物和用于治疗寄生虫感染和其它疾病或病症的组合物的用途。

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