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1. 发明申请

WO2008116129A2 IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS 审中-公开
标题翻译：咪唑吡嗪类似物及其作为PI3激酶和MT抑制剂的用途
公开(公告)号：WO2008116129A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/057771
申请日：2008-03-21
申请人： WYETH , BURSAVICH, Matthew, Gregory , VENKATESAN, Aranapakam, Mudumbai , NOWAK, Pawel, Wojciech , LOMBARDI, Sabrina , GILBERT, Adam, Matthew , DEHNHARDT, Christoph, Martin , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren, Guillermo , BROOIJMANS, Natasja , AYRAL-KALOUSTIAN, Semiramis , CHEN, Zecheng , VERHEIJEN, Jeroen, Cunera , KAPLAN, Joshua , ZASK, Arie
发明人： BURSAVICH, Matthew, Gregory , VENKATESAN, Aranapakam, Mudumbai , NOWAK, Pawel, Wojciech , LOMBARDI, Sabrina , GILBERT, Adam, Matthew , DEHNHARDT, Christoph, Martin , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren, Guillermo , BROOIJMANS, Natasja , AYRAL-KALOUSTIAN, Semiramis , CHEN, Zecheng , VERHEIJEN, Jeroen, Cunera , KAPLAN, Joshua , ZASK, Arie
IPC分类号： C07D473/34 , A61K31/52 , A61P35/00
CPC分类号： C07D473/34
摘要： The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR -related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
摘要翻译：本发明涉及咪唑并嘧啶类似物，制备咪唑并嘧啶类似物的方法，包含咪唑并嘧啶类似物的组合物，以及用于治疗或预防PI3K相关病症的方法，其包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。本发明还涉及用于治疗或预防mTOR相关疾病的方法，包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。

2. 发明申请

WO2008115974A2 PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS 审中-公开
标题翻译：吡唑并嘧啶类似物及其作为MTOR激酶和PI3激酶抑制剂的用途
公开(公告)号：WO2008115974A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/057467
申请日：2008-03-19
申请人： WYETH , ZASK, Arie , NOWAK, Pawel, Wojciech , VERHEIJEN, Jeroen , CURRAN, Kevin, J. , KAPLAN, Joshua , MALWITZ, David , BURSAVICH, Matthew Gregory , COLE, Derek, Cecil , AYRAL-KALOUSTIAN, Semiramis , YU, Ker , RICHARD, David, James , LEFEVER, Mark
发明人： ZASK, Arie , NOWAK, Pawel, Wojciech , VERHEIJEN, Jeroen , CURRAN, Kevin, J. , KAPLAN, Joshua , MALWITZ, David , BURSAVICH, Matthew Gregory , COLE, Derek, Cecil , AYRAL-KALOUSTIAN, Semiramis , YU, Ker , RICHARD, David, James , LEFEVER, Mark
CPC分类号： C07D487/04
摘要： The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
摘要翻译：本发明涉及吡唑并嘧啶类似物，制备吡唑并嘧啶类似物的方法，包含吡唑并嘧啶类似物的组合物，以及用于治疗mTOR相关病症的方法，所述方法包括向有需要的受试者施用有效量的吡唑并嘧啶模拟。本发明还涉及治疗与PI3K相关的病症，包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。

3. 发明申请

WO2007075783A3 SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITOR 审中-公开
公开(公告)号：WO2007075783A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/048603
申请日：2006-12-20
申请人： WYETH , TSOU, Hwei-Ru , AYRAL-KALOUSTIAN, Semiramis , BIRNBERG, Gary, Harold , FLOYD, Middleton, Brawner , KAPLAN, Joshua , KUTTERER, Kristina, M.K. , LIU, Xiaoxiang , NILAKANTAN, Ramaswamy , OTTENG, Mercy, Adufa , TANG, Zhilian , ZASK, Arie , REICH, Marvin , TRAN, Tritan
发明人： TSOU, Hwei-Ru , AYRAL-KALOUSTIAN, Semiramis , BIRNBERG, Gary, Harold , FLOYD, Middleton, Brawner , KAPLAN, Joshua , KUTTERER, Kristina, M.K. , LIU, Xiaoxiang , NILAKANTAN, Ramaswamy , OTTENG, Mercy, Adufa , TANG, Zhilian , ZASK, Arie , REICH, Marvin , TRAN, Tritan
IPC分类号： C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04
摘要： This invention provides compounds of Formula (I), having the structure where G 1 , G 2 , G 3 , G 4 , A 1 , A 2 , Y 1 , Y 2 , L 1 , Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

4. 发明申请

WO2008137136A1 A SHOE HAVING A FORM FITTING CLOSURE STRUCTURE 审中-公开
标题翻译：具有形状贴合结构的鞋子
公开(公告)号：WO2008137136A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/005772
申请日：2008-05-02
申请人： NEW BALANCE ATHLETIC SHOE, INC. , KAPLAN, Joshua , MURPHY, Sean
发明人： KAPLAN, Joshua , MURPHY, Sean
IPC分类号： A43B5/00
CPC分类号： A43B23/07 , A43C1/04
摘要： A form fitting closure structure and method for an internal tightening of shoe facilitated the closure system to ensure the retention of the position of the shoe wearer's foot. The system comprises (1) an outer sole which is open to allow insertion of a foot and capable of being closed over the foot by a closure system, (2) an internal sock-like tightening structure that encases the instep of the foot and is affixed to the shoe's closure system. A method of providing a better fit of the shoe around the shoe wearer's foot by ensuring the retention of the position of the foot within the shoe is also disclosed.
摘要翻译：用于鞋内部紧固的形状配合闭合结构和方法促进了闭合系统，以确保鞋佩戴者的脚的位置的保持。该系统包括（1）外底，该外底敞开以允许插入脚并且能够通过闭合系统在脚上闭合，（2）内部袜子状紧固结构，其包围脚的脚背，并且是贴在鞋的封闭系统上。还公开了通过确保将脚的位置保持在鞋内部来提供鞋子围绕鞋佩戴者脚部更好的配合的方法。

5. 发明申请

WO2007103156A2 SYSTEM, APPARATUS AND METHOD FOR MANAGING PRELOADED CONTENT FOR REVIEW ON A HANDHELD DIGITAL MEDIA APPARATUS 审中-公开
标题翻译：用于管理手持式数字媒体装置的预测内容的系统，装置和方法
公开(公告)号：WO2007103156A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005316
申请日：2007-03-01
申请人： KAPLAN, Joshua , SCHLESSSINGER, Joseph , MACKENZIE, William , CAMGROS, Benjamin
发明人： KAPLAN, Joshua , SCHLESSSINGER, Joseph , MACKENZIE, William , CAMGROS, Benjamin
IPC分类号： G03F3/10
CPC分类号： H04N7/17318 , G06Q30/0601 , G06Q30/0645 , G06Q50/184 , G11B27/10 , G11B27/105 , H04L67/2847 , H04N1/0044 , H04N21/25891 , H04N21/41407 , H04N21/4335 , H04N21/44204 , H04N21/4627 , H04N21/6543 , H04N21/6582 , H04N21/8355 , H04N2201/3246
摘要： A portable digital media playback apparatus is disclosed. The device comes preloaded with a large number of digital media files for preview. After preview, the files are tagged with information that indicate that the user wishes to purchase the digital media file or purchase certain digital rights associated with the digital media file, such as for example, rental to play the media three times. When the portable device is synched back up with a library of digital media files available for purchase or rental, the files designated for purchase are downloaded to the portable device and files designated to be deleted are deleted from the portable device. In one embodiment, a user profile is created and includes a record of user events relating to the digital media files previewed or deleted or selected for purchase. The user profile is then provided to the content provider to compare it with the characteristics of additional digital media files available for preview. The content provider adopts a set of criteria for matches and with this policy or business rule creates a list of additional digital media files that are compatible with the user and which will be pushed down to the portable device the next time that the user synchs up. The user profile information from multiple users can be aggregated and stripped of the personal information to deliver valuable market research data to participants in the digital media marketplace. In another embodiment of the invention, the system is deployed in smartphones with secure digital flash memory cards upon which re-filtered and pre-formatted web pages are stored with a specialized web browsing application that accesses the operating system of the smartphone and accesses the flash memory card. The outcome is local web browsing of the pre-stored content with user registration and preferences being used to drive content delivery and update-frequency.
摘要翻译：公开了便携式数字媒体播放装置。该设备预装了大量数字媒体文件进行预览。在预览之后，这些文件被标记有指示用户希望购买数字媒体文件或购买与数字媒体文件相关联的某些数字权限的信息，例如租赁三次播放媒体。当便携式设备与可购买或出租的数字媒体文件库同步备份时，指定用于购买的文件被下载到便携式设备，并且从便携式设备中删除指定要删除的文件。在一个实施例中，创建用户简档并且包括与预览或删除或选择用于购买的数字媒体文件相关的用户事件的记录。然后将用户简档提供给内容提供商，以将其与可用于预览的附加数字媒体文件的特征进行比较。内容提供商采用一组用于匹配的标准，并且该策略或业务规则创建与用户兼容的附加数字媒体文件的列表，并且在下一次用户同步时被下载到便携式设备。来自多个用户的用户简档信息可以被聚合和剥离个人信息，以向数字媒体市场中的参与者提供有价值的市场研究数据。在本发明的另一个实施例中，该系统部署在具有安全数字闪存卡的智能电话机中，在其上使用访问智能电话的操作系统并访问闪存的专门的网页浏览应用程序存储重新过滤和预格式化的网页存储卡。结果是用户注册和偏好用于驱动内容传送和更新频率的预存储内容的本地Web浏览。

6. 发明公开

EP2125815A2 IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS 审中-公开
标题翻译： IMIDAZOLOPYRIMIDINANALOGA及其作为PI3激酶和mTOR抑制剂
公开(公告)号：EP2125815A2
公开(公告)日：2009-12-02
申请号：EP08744161.4
申请日：2008-03-21
申请人： Wyeth
发明人： BURSAVICH, Matthew, Gregory , VENKATESAN, Aranapakam, Mudumbai , NOWAK, Pawel, Wojciech , LOMBARDI, Sabrina , GILBERT, Adam, Matthew , DEHNHARDT, Christoph, Martin , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren, Guillermo , BROOIJMANS, Natasja , AYRAL-KALOUSTIAN, Semiramis , CHEN, Zecheng , VERHEIJEN, Jeroen, Cunera , KAPLAN, Joshua , ZASK, Arie
IPC分类号： C07D473/34 , A61K31/52 , A61P35/00
CPC分类号： C07D473/34
摘要： The present invention relates to Imidazolopyrimidine Analogs, of Formula Ib methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods foτ treating oτ preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR -related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.

7. 发明公开

EP2078021A2 PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS 审中-公开
标题翻译： PYRAZOLOPYRIMIDINANALOGA及其作为抑制剂mTOR激酶和PI3激酶
公开(公告)号：EP2078021A2
公开(公告)日：2009-07-15
申请号：EP08732460.4
申请日：2008-03-19
申请人： Wyeth
发明人： ZASK, Arie , NOWAK, Pawel, Wojciech , VERHEIJEN, Jeroen , CURRAN, Kevin, J. , KAPLAN, Joshua , MALWITZ, David , BURSAVICH, Matthew Gregory , COLE, Derek, Cecil , AYRAL-KALOUSTIAN, Semiramis , YU, Ker , RICHARD, David, James , LEFEVER, Mark
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P35/00 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.

8. 发明公开

EP1963273A2 SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITORS 审中-公开
标题翻译：取代的异喹啉-1,3（2H，4H） - 二酮，1-硫代-1,4-二氢-2H-异喹啉-3-酮和3,4-二氢-3（2H）-ISOQUINOLONE及其作为激酶抑制剂
公开(公告)号：EP1963273A2
公开(公告)日：2008-09-03
申请号：EP06847825.4
申请日：2006-12-20
申请人： Wyeth
发明人： TSOU, Hwei-Ru , AYRAL-KALOUSTIAN, Semiramis , BIRNBERG, Gary, Harold , FLOYD, Middleton, Brawner , KAPLAN, Joshua , KUTTERER, Kristina, M.K. , LIU, Xiaoxiang , NILAKANTAN, Ramaswamy , OTTENG, Mercy, Adufa , TANG, Zhilian , ZASK, Arie , REICH, Marvin , TRAN, Tritan
IPC分类号： C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04
CPC分类号： C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
摘要： This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

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