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1. 发明专利

JPS62296890A RECOMBINANT DNA PRODUCT AND ITS PRODUCTION 失效
公开(公告)号：JPS62296890A
公开(公告)日：1987-12-24
申请号：JP7397087
申请日：1987-03-27
申请人： WINTER GREGORY PAUL
发明人： WINTER GREGORY PAUL
IPC分类号： C07K14/195 , A61K39/395 , C07K14/005 , C07K16/00 , C07K16/46 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/91

2. 发明专利

GB2188638B RECOMBINANT DNA PRODUCT AND METHODS 未知
公开(公告)号：GB2188638B
公开(公告)日：1990-05-23
申请号：GB8707252
申请日：1987-03-26
申请人： WINTER GREGORY PAUL
发明人： WINTER GREGORY PAUL
IPC分类号： C07K14/195 , A61K39/395 , C07K14/005 , C07K16/00 , C07K16/46 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/91

3. 发明专利

CA1341411C METHOD FOR PRODUCING FV FRAGMENTS IN EUKARYOTIC CELLS 未知
公开(公告)号：CA1341411C
公开(公告)日：2002-12-17
申请号：CA596914
申请日：1989-04-17
申请人： RIECHMANN LUTZ , OWENS RAYMOND JOHN , YARRANTON GEOFFREY THOMAS , BODMER MARK WILLIAM , WINTER GREGORY PAUL
发明人： RIECHMANN LUTZ , OWENS RAYMOND JOHN , YARRANTON GEOFFREY THOMAS , BODMER MARK WILLIAM , WINTER GREGORY PAUL
IPC分类号： G01N33/531 , A61K39/395 , A61K45/00 , A61K49/00 , A61K51/00 , C07K1/22 , C07K14/00 , C07K16/00 , C07K16/40 , C07K19/00 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577 , C12N15/62 , C12N15/63 , C12P21/00
摘要： The present invention provides a method for producing Fv fragments comprising transforming a eukaryotic host cell with a eukaryotic expression vector comprising an operon having a DNA sequence which encodes the variable domain only of an antibody light or heavy chain, culturing the transformed host cell under conditions which cause the protein encoded by the DNA sequence to be synthesized; and collecting the synthesized protein. The Fv fragments may be suitable for use as diagnostic or therapeutic agents.

4. 发明申请

WO2010089115A8 MULTISPECIFIC PEPTIDES 审中-公开
标题翻译：多功能肽
公开(公告)号：WO2010089115A8
公开(公告)日：2011-12-22
申请号：PCT/EP2010000689
申请日：2010-02-04
申请人： MEDICAL RES COUNCIL , WINTER GREGORY PAUL , HEINIS CHRISTIAN , BERNARD ELISE , LOAKES DAVID , TITE JOHN PAUL , VAYSBURD MARINA , TEUFEL DANIEL PAUL , RIECHMANN LUTZ
发明人： WINTER GREGORY PAUL , HEINIS CHRISTIAN , BERNARD ELISE , LOAKES DAVID , TITE JOHN PAUL , VAYSBURD MARINA , TEUFEL DANIEL PAUL , RIECHMANN LUTZ
IPC分类号： A61K47/48 , G01N33/68
CPC分类号： C12N15/1037 , A61K47/55 , A61K47/64 , A61K47/643 , C07K14/001 , C12N15/1044 , C12N15/1058 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/531
摘要： The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
摘要翻译：本发明涉及一种提供多特异性肽配体的方法，所述多特异性肽配体包含在三个或更多个氨基酸残基处共价连接到分子支架并能够结合两个或更多个单独靶标的多肽，包括以下步骤：（a）提供第一多肽的所有组成部分，每个多肽包含两个或更多个能够与分子支架共价连接的反应性基团，以及至少一个环，其包含两个或更多个氨基酸的序列，对应于两个所述反应性基团; （b）提供如（a）所述的第二组多肽; （c）将第一组合物中的一个或多个成员的至少一个环连接到第二组合物的一个或多个成员的至少一个环，以形成至少一个包含两个环的多肽，和（d）将复合多肽（ s）至少在三个氨基酸位置分子支架。

5. 发明专利

GB2188638A CHIMERIC ANTIBODIES 未知
公开(公告)号：GB2188638A
公开(公告)日：1987-10-07
申请号：GB8707252
申请日：1987-03-26
申请人： WINTER GREGORY PAUL
发明人： WINTER GREGORY PAUL
IPC分类号： C07K14/195 , A61K39/395 , C07K14/005 , C07K16/00 , C07K16/46 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/91 , C07K15/00
摘要： An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced by site-directed mutagenesis using long oligonucleotides.

6. 发明申请

WO2008052933A3 PREVENTION OF AGGREGATION OF IMMUNOGLOBULIN LIGHT OR HEAVY CHAINS 审中-公开
标题翻译：防止聚集免疫球蛋白轻链或重链
公开(公告)号：WO2008052933A3
公开(公告)日：2008-11-13
申请号：PCT/EP2007061514
申请日：2007-10-26
申请人： DOMANTIS LTD , DE WILDT RUDOLF M T , JAMES LEO C , JONES PHILIP C , SCHON OLIVER , WINTER GREGORY PAUL
发明人： DE WILDT RUDOLF M T , JAMES LEO C , JONES PHILIP C , SCHON OLIVER , WINTER GREGORY PAUL
IPC分类号： C07K16/42 , C07K7/00 , C07K14/315 , C07K16/22 , C07K16/24 , C12N15/12 , C12N15/63
CPC分类号： C07K16/22 , C07K16/241 , C07K16/42 , C07K2317/31 , C07K2317/567 , C07K2317/569
摘要： The present invention provides an inhibitor of the aggregation of immunoglobulin chains (or immunoglobulin VL or CHl domains). In preferred embodiments, the inhibitor comprises or consists of a polypeptide which comprises or consists of (a) an amino acid sequence corresponding to the amino acid sequence of the FRl region of an immunoglobulin light chain variable domain, or part thereof which includes amino acid residue 12, (b) an amino acid sequence corresponding to the amino acid sequence of the immunoglobulin-binding domain of bacterial superantigen Protein L, or part thereof, and/or (c) an amino acid sequence corresponding to the amino acid sequence of the immunoglobulin-binding domain of streptococcal protein G (SpG), or part thereof, or a variant, fusion or derivative thereof, or a fusion of a said variant or derivative thereof which retains the ability of the parent polypeptide to inhibit aggregation of immunoglobulin chains, or domains thereof. The invention further provides a non-naturally occurring antibody, or antigen-binding fragment, fusion or derivative thereof comprising a light chain variable domain, or a fusion of a said fragment or derivative, wherein the FRl region of the light chain variable domain is modified (e.g. mutated) so as to inhibit, at least in part, the ability of the antibody, fragment, fusion or derivative to form aggregates. Most preferably, the light chain variable domain is modified at position 12 of the FR1 region by replacing the naturally occurring amino acid (e.g. serine in ? light chains) with proline.
摘要翻译：本发明提供免疫球蛋白链（或免疫球蛋白VL或CH1结构域）聚集的抑制剂。在优选的实施方案中，抑制剂包含或由多肽组成，该多肽包含（a）对应于免疫球蛋白轻链可变结构域的FR1区的氨基酸序列的氨基酸序列或其部分，其部分包括氨基酸残基 12，（b）对应于细菌超抗原蛋白L的免疫球蛋白结合结构域的氨基酸序列或其部分的氨基酸序列，和/或（c）对应于免疫球蛋白的氨基酸序列的氨基酸序列链球菌蛋白G（SpG）或其部分或其变体，融合物或衍生物或其所述变体或衍生物的融合物的结合结构域，其保留母体多肽抑制免疫球蛋白链的聚集的能力，或其领域。本发明还提供非天然存在的抗体或其抗原结合片段，其融合物或衍生物，其包含轻链可变区或所述片段或衍生物的融合物，其中轻链可变结构域的FR1区域被修饰（例如突变），以至少部分地抑制抗体，片段，融合物或衍生物形成聚集体的能力。最优选地，通过用脯氨酸替代天然存在的氨基酸（例如轻链中的丝氨酸），轻链可变结构域在FR1区的第12位被修饰。

7. 发明申请

WO9958655A3 PHAGE DISPLAY SELECTION SYSTEM FOR FOLDED PROTEINS 审中-公开
标题翻译：用于折叠蛋白质的PHAGE显示选择系统
公开(公告)号：WO9958655A3
公开(公告)日：2000-01-27
申请号：PCT/GB9901526
申请日：1999-05-13
申请人： MEDICAL RES COUNCIL , RIECHMANN LUTZ , KRISTENSEN PETER , JESTIN JEAN LUC , WINTER GREGORY PAUL
发明人： RIECHMANN LUTZ , KRISTENSEN PETER , JESTIN JEAN-LUC , WINTER GREGORY PAUL
IPC分类号： C12N15/00 , C12N7/01 , C12N7/02 , C12N15/10 , C12N15/62 , C40B40/02
CPC分类号： C40B40/02 , C07K2319/02 , C07K2319/41 , C07K2319/43 , C07K2319/50 , C07K2319/70 , C07K2319/735 , C12N15/1037 , C12N15/62
摘要： The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.
摘要翻译：本发明涉及一种选择病毒的方法，包括以下步骤：（a）提供编码和显示融合多肽的病毒，所述融合多肽包含插入到病毒外壳蛋白多肽序列中的异源多肽，其中所述病毒包含位于显示的多肽内的可切割位点; （b）将病毒暴露于裂解剂; （c）扩增包含完整融合蛋白的病毒。

8. 发明申请

WO9740141A3 ISOLATION OF ENZYMES 审中-公开
标题翻译：酶的分离
公开(公告)号：WO9740141A3
公开(公告)日：1998-01-08
申请号：PCT/GB9701153
申请日：1997-04-25
申请人： MEDICAL RES COUNCIL , NERI DARIO , DEMARTIS SALVATORE , HUBER ADRIAN , VITI FRANCESCA , TAWFIK DAN S , WINTER GREGORY PAUL
发明人： NERI DARIO , DEMARTIS SALVATORE , HUBER ADRIAN , VITI FRANCESCA , TAWFIK DAN S , WINTER GREGORY PAUL
IPC分类号： C12N15/09 , C07K14/47 , C07K14/72 , C12N9/00 , C12N9/10 , C12N9/12 , C12N15/10 , C40B40/02 , C12N15/00 , C12N15/62
CPC分类号： C12N15/1086 , C07K14/4728 , C07K14/72 , C07K2319/00 , C12N9/00 , C12N9/0002 , C12N9/1088 , C12N9/1205 , C12N15/1037 , C40B40/02
摘要： The present invention relates to a method of isolating an enzyme having a desired chemical or biological activity, the method comprising linking the enzyme to a substrate for the enzyme, reacting the enzyme and substrate such that a product is produced which remains linked to the enzyme and isolating the enzyme by selectively isolating the product linked to the enzyme.

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