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1. 发明申请

WO2010089115A8 MULTISPECIFIC PEPTIDES 审中-公开
标题翻译：多功能肽
公开(公告)号：WO2010089115A8
公开(公告)日：2011-12-22
申请号：PCT/EP2010000689
申请日：2010-02-04
申请人： MEDICAL RES COUNCIL , WINTER GREGORY PAUL , HEINIS CHRISTIAN , BERNARD ELISE , LOAKES DAVID , TITE JOHN PAUL , VAYSBURD MARINA , TEUFEL DANIEL PAUL , RIECHMANN LUTZ
发明人： WINTER GREGORY PAUL , HEINIS CHRISTIAN , BERNARD ELISE , LOAKES DAVID , TITE JOHN PAUL , VAYSBURD MARINA , TEUFEL DANIEL PAUL , RIECHMANN LUTZ
IPC分类号： A61K47/48 , G01N33/68
CPC分类号： C12N15/1037 , A61K47/55 , A61K47/64 , A61K47/643 , C07K14/001 , C12N15/1044 , C12N15/1058 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/531
摘要： The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
摘要翻译：本发明涉及一种提供多特异性肽配体的方法，所述多特异性肽配体包含在三个或更多个氨基酸残基处共价连接到分子支架并能够结合两个或更多个单独靶标的多肽，包括以下步骤：（a）提供第一多肽的所有组成部分，每个多肽包含两个或更多个能够与分子支架共价连接的反应性基团，以及至少一个环，其包含两个或更多个氨基酸的序列，对应于两个所述反应性基团; （b）提供如（a）所述的第二组多肽; （c）将第一组合物中的一个或多个成员的至少一个环连接到第二组合物的一个或多个成员的至少一个环，以形成至少一个包含两个环的多肽，和（d）将复合多肽（ s）至少在三个氨基酸位置分子支架。

2. 发明申请

WO9958655A3 PHAGE DISPLAY SELECTION SYSTEM FOR FOLDED PROTEINS 审中-公开
标题翻译：用于折叠蛋白质的PHAGE显示选择系统
公开(公告)号：WO9958655A3
公开(公告)日：2000-01-27
申请号：PCT/GB9901526
申请日：1999-05-13
申请人： MEDICAL RES COUNCIL , RIECHMANN LUTZ , KRISTENSEN PETER , JESTIN JEAN LUC , WINTER GREGORY PAUL
发明人： RIECHMANN LUTZ , KRISTENSEN PETER , JESTIN JEAN-LUC , WINTER GREGORY PAUL
IPC分类号： C12N15/00 , C12N7/01 , C12N7/02 , C12N15/10 , C12N15/62 , C40B40/02
CPC分类号： C40B40/02 , C07K2319/02 , C07K2319/41 , C07K2319/43 , C07K2319/50 , C07K2319/70 , C07K2319/735 , C12N15/1037 , C12N15/62
摘要： The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.
摘要翻译：本发明涉及一种选择病毒的方法，包括以下步骤：（a）提供编码和显示融合多肽的病毒，所述融合多肽包含插入到病毒外壳蛋白多肽序列中的异源多肽，其中所述病毒包含位于显示的多肽内的可切割位点; （b）将病毒暴露于裂解剂; （c）扩增包含完整融合蛋白的病毒。

3. 发明专利

CA1341411C METHOD FOR PRODUCING FV FRAGMENTS IN EUKARYOTIC CELLS 未知
公开(公告)号：CA1341411C
公开(公告)日：2002-12-17
申请号：CA596914
申请日：1989-04-17
申请人： RIECHMANN LUTZ , OWENS RAYMOND JOHN , YARRANTON GEOFFREY THOMAS , BODMER MARK WILLIAM , WINTER GREGORY PAUL
发明人： RIECHMANN LUTZ , OWENS RAYMOND JOHN , YARRANTON GEOFFREY THOMAS , BODMER MARK WILLIAM , WINTER GREGORY PAUL
IPC分类号： G01N33/531 , A61K39/395 , A61K45/00 , A61K49/00 , A61K51/00 , C07K1/22 , C07K14/00 , C07K16/00 , C07K16/40 , C07K19/00 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577 , C12N15/62 , C12N15/63 , C12P21/00
摘要： The present invention provides a method for producing Fv fragments comprising transforming a eukaryotic host cell with a eukaryotic expression vector comprising an operon having a DNA sequence which encodes the variable domain only of an antibody light or heavy chain, culturing the transformed host cell under conditions which cause the protein encoded by the DNA sequence to be synthesized; and collecting the synthesized protein. The Fv fragments may be suitable for use as diagnostic or therapeutic agents.

4. 发明申请

WO0157065A2 COMBINATORIAL PROTEIN DOMAINS 审中-公开
标题翻译：组合蛋白质域
公开(公告)号：WO0157065A2
公开(公告)日：2001-08-09
申请号：PCT/GB0100445
申请日：2001-02-02
申请人： DIVERSYS LTD , RIECHMANN LUTZ , WINTER GREG
发明人： RIECHMANN LUTZ , WINTER GREG
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , C07K14/01 , C07K14/245 , C07K14/47 , C07K19/00 , C12N15/10 , C40B40/02 , C07K1/00
CPC分类号： C40B40/02 , C07K14/245 , C12N15/1037
摘要： The present invention relates to a chimaeric folded protein domain comprising two or more sequence segments from parent amino acid sequences that are not homologous, wherein each of said sequence segments: is not designed or selected to consist solely of a single complete protein structural element and is not designed or selected to consist solely of an entire protein domain; and, in isolation, shows no significant folding at the melting temperature of the chimaeric protein; as well as to methods for the selection of such domains; and to a chimaeric folded protein domain comprising two or more sequence segments which share common sequences or sequences from common regions in the protein fold of their parent amino acid sequences, wherein the said common region of the fold is not designed or selected to consist solely of one or more complete protein structural elements, and wherein each of said sequence segments: is not designed or selected to consist solely of an entire protein domain; and wherein, in isolation, each said sequence segment shows no significant folding at the melting temperature of the chimaeric protein; as well as to methods for the selection of such domains.
摘要翻译：本发明涉及嵌合折叠的蛋白质结构域，其包含两个或更多个不同源的母体氨基酸序列的序列片段，其中每个所述序列片段不被设计或选择为仅由单个完整蛋白质结构元件组成，并且是不设计或选择仅由整个蛋白质结构域组成; 并且，孤立地，在嵌合蛋白质的熔解温度下没有显示出显着的折叠; 以及选择这些域的方法; 以及包含两个或更多个序列片段的嵌合折叠的蛋白质结构域，所述两个或更多个序列片段与其母体氨基酸序列的蛋白质折叠中的共同区域共享共同序列或序列，其中所述折叠的所述共同区域不被设计或选择为仅由一个或多个完整的蛋白质结构元件，并且其中每个所述序列片段：未设计或选择为仅由整个蛋白质结构域组成; 并且其中，分离地，每个所述序列片段在所述嵌合蛋白质的解链温度下不显示显着的折叠; 以及选择这些域的方法。

5. 发明申请

WO0212277A3 HYBRID COMBINATORIAL PROTEINS MADE FROM RESHUFFLING OF DIFFERENTLY FOLDED DOMAINS 审中-公开
标题翻译：混合组合蛋白从不同的折叠域修复
公开(公告)号：WO0212277A3
公开(公告)日：2002-05-30
申请号：PCT/GB0103508
申请日：2001-08-03
申请人： DIVERSYS LTD , RIECHMANN LUTZ , WINTER GREG
发明人： RIECHMANN LUTZ , WINTER GREG
IPC分类号： C07K14/245 , C12N15/10 , C40B40/02 , C12N15/62 , C07K14/00
CPC分类号： C40B40/02 , C07K14/245 , C07K2319/00 , C12N15/1037
摘要： The present invention relates to a chimaeric folded protein domain comprising two or more sequence segments from parent amino acid sequences that are not homologous, wherein each of said sequence segments, in isolation, shows no significant folding at the melting temperature of the chimaeric protein; as well as to methods for the selection of such domains; and to a chimaeric folded protein domain comprising two or more sequence segments which share common sequences or sequences from common regions in the protein fold of their parent amino acid sequences, wherein, in isolation, each said sequence segment shows no significant folding at the melting temperature of the chimaeric protein; as well as to methods for the selection of such domains. The invention specifically relates to the application of said chimaeric protein domains for use in vaccination, wherein said chimaeric protein domains display conformational B cell epitopes of at least one of its parent amino acid sequences.
摘要翻译：本发明涉及一种嵌合折叠的蛋白质结构域，其包含两个或更多个不同源的母体氨基酸序列的序列片段，其中每个所述序列片段在嵌合蛋白质的解链温度下不显示出显着的折叠; 以及选择这些域的方法; 以及包含两个或更多个序列片段的嵌合折叠的蛋白质结构域，所述两个或更多个序列片段与其母体氨基酸序列的蛋白质折叠中的共同区域共享共同序列或序列，其中，每个所述序列片段在融解温度下不显示显着的折叠的嵌合蛋白; 以及选择这些域的方法。本发明具体涉及用于疫苗接种的所述嵌合蛋白结构域的应用，其中所述嵌合蛋白结构域显示其母体氨基酸序列中的至少一个的构象B细胞表位。

6. 发明专利

GB2216126B ANTIBODIES TO THE ANTIGEN CAMPATH-1 未知
公开(公告)号：GB2216126B
公开(公告)日：1992-06-03
申请号：GB8902978
申请日：1989-02-10
申请人： MEDICAL RES COUNCIL , WALDMANN HERMAN , CLARK MICHAEL RONALD , NAT RES DEV
发明人： CLARK MICHAEL RONALD , RIECHMANN LUTZ , WALDMANN HERMAN , WINTER GREGORY PAUL
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91

7. 发明专利

DK502189A 未知
公开(公告)号：DK502189A
公开(公告)日：1989-10-12
申请号：DK502189
申请日：1989-10-10
申请人： MEDICAL RES COUNCIL , WALDMANN HERMAN , CLARK MICHAEL RONALD
发明人： WALDMANN HERMAN , CLARK MICHAEL RONALD , WINTER GREGORY PAUL , RIECHMANN LUTZ
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C07K15/06 , C12N15/13

8. 发明专利

DK502189D0 未知
公开(公告)号：DK502189D0
公开(公告)日：1989-10-10
申请号：DK502189
申请日：1989-10-10
申请人： MEDICAL RES COUNCIL , WALDMANN HERMAN , CLARK MICHAEL RONALD
发明人： WALDMANN HERMAN , CLARK MICHAEL RONALD , WINTER GREGORY PAUL , RIECHMANN LUTZ
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C07K15/06

9. 发明专利

GB2216126A Antibodies to Campath-1 未知
公开(公告)号：GB2216126A
公开(公告)日：1989-10-04
申请号：GB8902978
申请日：1989-02-10
申请人： MEDICAL RES COUNCIL , WALDMANN HERMAN , CLARK MICHAEL RONALD
发明人： CLARK MICHAEL RONALD , RIECHMANN LUTZ , WALDMANN HERMAN , WINTER GREGORY PAUL
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91
摘要： An antibody which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region (CDR) foreign to the constant regions (e.g. of rat origin), which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin. The foreign CRD(s) is (are) selected from amino acid residues 31-35, 50-65, and 95-102 of the heavy chain (Fig 2a - not shown) and residues 24-34, 50-56 and 89-97 of the light chain (Fig. 26 - not shown).

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