专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010030723A1 INTAKE PROFILE FOR OPTIMIZED UTILIZATION OF MOTOR CHARACTERISTICS 审中-公开
标题翻译：采用轮廓优化电机特性
公开(公告)号：WO2010030723A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056438
申请日：2009-09-10
申请人： WATERS TECHNOLOGIES CORPORATION , SHREVE, Joshura, A. , CIAVARINI, Steven, J.
发明人： SHREVE, Joshura, A. , CIAVARINI, Steven, J.
IPC分类号： G01N1/00
CPC分类号： H02P8/14 , F04B17/03 , F04B49/065 , F04B2203/0207 , F04B2203/0209 , G01N30/34 , G01N2030/326
摘要： Systems and methods for operating a stepper motor of a pump at a desired low velocity include memory for storing information corresponding to an intake velocity profile. The intake velocity profile represents an optimized acceleration curve for operating the stepper motor over a range of motor velocities during an intake cycle. A processor of a system controller dynamically accesses the memory during the intake cycle to acquire the information representing the intake velocity profile and issues a series of pulses to the stepper motor based on this information. In response to the pulses, the stepper motor accelerates in accordance with the optimized acceleration curve represented by the intake velocity profile. The optimized acceleration curve is based on the available torque of the stepper motor across a range of motor velocities and enables the motor to operate with greater torque utilization and less margin than traditional linear acceleration profiles.
摘要翻译：用于以期望的低速度操作泵的步进电动机的系统和方法包括用于存储对应于进气速度曲线的信息的存储器。进气速度曲线表示在进气循环期间在一定范围的电机速度下操作步进电机的优化加速曲线。系统控制器的处理器在进气循环期间动态地访问存储器以获取表示进气速度分布的信息，并基于该信息向步进电动机发出一系列脉冲。响应于脉冲，步进电机根据由进气速度分布表示的优化加速度曲线加速。优化的加速曲线基于步进电机在电机速度范围内的可用扭矩，并使电机能够以更大的转矩利用率和比传统线性加速度曲线更小的裕度运行。

2. 发明申请

WO2011085337A1 THERMAL CONTROL OF THERMAL CHAMBER IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY SYSTEMS 审中-公开
标题翻译：高性能液相色谱系统中热室的热控制
公开(公告)号：WO2011085337A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020725
申请日：2011-01-11
申请人： WATERS TECHNOLOGIES CORPORATION , SHREVE, Joshua, A. , CIAVARINI, Steven, J.
发明人： SHREVE, Joshua, A. , CIAVARINI, Steven, J.
IPC分类号： F25B21/02
CPC分类号： F25B21/02 , F25B2321/0212 , F25B2321/0251 , F25B2700/2103 , F25D2700/02 , F25D2700/12 , F25D2700/123 , G01N30/24 , G01N30/30 , G01N2030/303
摘要： A sample manager of a liquid chromatography system implements a thermal system that uses a dual-loop feedback control system to control temperature within a thermal chamber. The sample manager includes an external heatsink disposed externally to the thermal chamber, an internal heatsink disposed within the thermal chamber, and one or more thermoelectric devices thermally coupled to the external and internal heatsinks to transfer heat therebetween in response to a pulse-width modulated power signal. A first temperature sensor disposed within the thermal chamber continuously measures a chamber temperature. A second temperature sensor coupled to the internal heatsink within the thermal chamber continuously measures temperature at the internal heatsink. A feedback control system controls a duty cycle of the pulse-width modulated power signal in response to a target chamber temperature and real-time temperature measurements produced by the first and second temperature sensors.
摘要翻译：液相色谱系统的样品管理器实现了使用双回路控制系统来控制热室内的温度的热系统。样品管理器包括设置在热室的外部的外部散热器，设置在热室内的内部散热器，以及一个或多个热耦合到外部和内部散热器的热电装置，以响应于脉冲宽度调制功率信号。设置在热室内的第一温度传感器连续地测量腔室温度。耦合到热室内的内部散热器的第二温度传感器连续测量内部散热器的温度。反馈控制系统响应于目标腔室温度和由第一和第二温度传感器产生的实时温度测量值来控制脉冲宽度调制功率信号的占空比。

3. 发明申请

WO2002086437A1 METHODS AND APPARATUS FOR DETERMINING THE PRESENCE OR ABSENCE OF A FLUID LEAK 审中-公开
标题翻译：用于确定流体泄漏存在或不存在的方法和装置
公开(公告)号：WO2002086437A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/006540
申请日：2002-03-01
申请人： WATERS INVESTMENTS LIMITED , LUONGO, Joseph, A. , CIAVARINI, Steven, J. , TACCONI, Robert, Q. , RUBINO, Frank, A. , DUMAS, Robert, J.
发明人： LUONGO, Joseph, A. , CIAVARINI, Steven, J. , TACCONI, Robert, Q. , RUBINO, Frank, A. , DUMAS, Robert, J.
IPC分类号： G01M3/26
CPC分类号： G01M3/26 , F04B51/00 , F04B2201/0208 , F04B2205/05 , G01N30/32 , G01N2030/326
摘要： Method and apparatus for detecting leaks or defects, including component failure and adverse performance, in a fluid pumping system having a pumping chamber, piston (21), motor (35), inlet, outlet, inlet valve, switchable valve and detector (29). The inlet valve (37) is in fluid communication with the inlet (17) while the switchable valve (41) is in fluid communication with the outlet (19). A pressure measuring device (45) is in fluid communication with the pumping chamber (15) between the inlet valve and switchable valve so as to determine a minimal pressure together with first and second threshold pressures measured at first and second times that correspond to first and second threshold pressure signals. A control means (51) calculates the slope of a line representing the difference of such first and second threshold pressure signals over time so as to compare the slope to a threshold decay value, or to compare the minimal pressure to minimal acceptable values, thus defining pump defects.
摘要翻译：具有泵送室，活塞（21），电动机（35），入口，出口，入口阀，可切换阀和检测器（29）的流体泵送系统中检测泄漏或缺陷（包括部件故障和不利性能）的方法和装置，。入口阀（37）与入口（17）流体连通，而可切换阀（41）与出口（19）流体连通。压力测量装置（45）与入口阀和可切换阀之间的泵送室（15）流体连通，以便确定最小压力以及在第一和第二时间测量的第一和第二阈值压力，其对应于第一和第二阀值第二阈值压力信号。控制装置（51）计算表示这种第一和第二阈值压力信号随时间的差异的线的斜率，以便将斜率与阈值衰减值进行比较，或将最小压力与最小可接受值进行比较，从而定义泵缺陷。

4. 发明申请

WO2007109157A3 SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS 审中-公开
公开(公告)号：WO2007109157A3
公开(公告)日：2007-09-27
申请号：PCT/US2007/006679
申请日：2007-03-16
申请人： WATERS INVESTMENTS LIMITED , CIAVARINI, Steven, J. , PENSAK, Stanley, P. , FINCH, Jeffrey, W. , FADGEN, Keith , LIU, Hongji
发明人： CIAVARINI, Steven, J. , PENSAK, Stanley, P. , FINCH, Jeffrey, W. , FADGEN, Keith , LIU, Hongji
IPC分类号： B01D15/08
摘要： A solvent delivery subsystem (720) for a chromatographic device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump (715A) and an organic pump (715B) are mixed to fill a storage capillary (722) while a downstream point from the storage capillary (722) is vented to atmosphere. After the gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only aqueous pump (715A) runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system used feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

5. 发明申请

WO2010030720A1 VALVE SWITCH MODULATION FOR REDUCING ERRORS DUE OSCILLATIONS OF THE INLET FLUID OF A PUMP SYSTEM 审中-公开
标题翻译：用于减少泵系统的入口流体的振荡的减少误差的阀开关调制
公开(公告)号：WO2010030720A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056434
申请日：2009-09-10
申请人： WATER TECHNOLOGIES CORPORATION , SHREVE, Joshua, A. , CIAVARINI, Steven, J.
发明人： SHREVE, Joshua, A. , CIAVARINI, Steven, J.
IPC分类号： G01N1/00
CPC分类号： B01F15/0479 , B01D15/14 , B01F15/0216 , G01N30/34 , G01N30/36 , G01N35/00871 , G01N35/1097 , G01N2030/347 , G01N2035/00544 , G05D11/133
摘要： Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.
摘要翻译：描述了在低压混合泵系统中减少液体组成误差的方法。表示所需流体混合物的每个组分的切换间隔的分组被提供给混合泵系统的进气口。对于每个分组，调制与分组中的至少一个分量相关联的切换时间。调制切换时间基于根据混合泵系统的进气响应的不期望的频率特性而特别选择的时间偏移。由如此调制的分组贡献的卷的平均值等于在混合泵系统的输出流中实现组分的期望比例的分量体积。调制切换时间可以减少或消除混合泵系统的输出流量中的组成误差。

6. 发明申请

WO2006023828A2 DEVICES, SYSTEMS, AND METHODS FOR FLOW-COMPENSATING PUMP-INJECTOR SYCHRONIZATION 审中-公开
标题翻译：流体补偿泵 - 注射器同步的装置，系统和方法
公开(公告)号：WO2006023828A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/029734
申请日：2005-08-19
申请人： WATERS INVESTMENTS LIMITED , PENSAK, Stanley, P., Jr. , HEDEN, John , CIAVARINI, Steven, J. , LAMOUREUX, John , SOARES, Miguel
发明人： PENSAK, Stanley, P., Jr. , HEDEN, John , CIAVARINI, Steven, J. , LAMOUREUX, John , SOARES, Miguel
IPC分类号： B01L11/00
CPC分类号： G01N30/34 , G01N35/1097
摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream (52), to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system (30) to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.
摘要翻译：用于减轻与将低压分析物样品注入高压HPLC流体流（52）相关的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。优选实施例通过二元溶剂输送系统（30）的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

7. 发明申请

WO2015191993A1 SYSTEM AND METHOD FOR ENHANCING CHARGE-STATE DETERMINATION IN ELECTROSPRAY MASS SPECTROMETRY 审中-公开
标题翻译：用于增强电喷雾质谱分析中的充电状态测定的系统和方法
公开(公告)号：WO2015191993A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035540
申请日：2015-06-12
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： GEROMANOS, Scott, J. , CIAVARINI, Steven, J.
IPC分类号： H01J49/10 , H01J49/14 , G01N30/72
CPC分类号： H01J49/0036 , G01N30/8675
摘要： A method of mass spectrometry comprises ionising a sample and obtaining mass spectral data relating to a plurality of ion detection events. The method then comprises applying match tolerances for mass to charge ratio (m/z), chromatographic retention time (t r ), and ion mobility drift time (t d ), to the ion detection events in order to determine possible charge state connections. The method also comprises constructing a tentative isotope chain and querying ion detection events for a match to the tentative isotope chain. Once a tentative isotope chain has been constructed, the method further comprises determining a corresponding theoretical molecular mass and a corresponding theoretical isotopic distribution, querying one or more lookup tables and returning one or more parameters (New X, New X', Δ New X') related to the fractional mass to charge ratio (f m/z ) and at least one of: ion mobility drift time (t d ); and nominal mass to charge ratio (N m/Z ), of the ion detection events, and using the one or more parameters (New X, New X', Δ New X') to determine a unique charge state of the ions.
摘要翻译：质谱法包括使样品电离并获得与多个离子检测事件相关的质谱数据。该方法然后包括将质量与电荷比（m / z），色谱保留时间（tr）和离子迁移率漂移时间（td）的匹配公差应用于离子检测事件，以便确定可能的电荷状态连接。该方法还包括构建临时同位素链和查询离子检测事件以与暂定同位素链匹配。一旦建立了临时同位素链，该方法还包括确定对应的理论分子质量和相应的理论同位素分布，查询一个或多个查找表并返回一个或多个参数（New X，New X'，ΔNew X' ）与分数质荷比（fm / z）和离子迁移率漂移时间（td）中的至少一个相关。和离子检测事件的标称质荷比（Nm / Z），并使用一个或多个参数（New X，New X'，ΔNew X'）来确定离子的独特电荷状态。

8. 发明申请

WO2018094396A1 TECHNIQUES FOR MASS ANALYZING A COMPLEX SAMPLE 审中-公开
公开(公告)号：WO2018094396A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/062811
申请日：2017-11-21
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： GEROMANOS, Scott, J. , DEVLIN, Curt , CIAVARINI, Steven, J.
IPC分类号： G06F19/18 , G06F19/24 , H01J49/00
摘要： Techniques and apparatus for analyzing mass spectrometry data are described. In one embodiment, for example, an apparatus may include logic to access a product ion data set generated via mass analyzing a sample comprising a target precursor, access precursor composition information for elements of the target precursor that includes nominal mass and mass defect information, determine nominal mass (NM)-mass defect (MD) relationship information for ion fragments associated with the target precursor based on the precursor composition information, determine one or more fragment upper boundaries and one or more fragment lower boundaries, extract candidate ion fragments from the ion fragments via applying the one or more fragment upper boundaries and the one or more fragment lower boundaries to the NM-MD relationship information, and determine target ion fragments from the plurality of candidate ion fragments based on fragmentation efficiency information associated with the candidate ion fragments. Other embodiments are described and claimed.

9. 发明申请

WO2015191999A1 ANALYSIS OF COMPLEX BIOLOGICAL MATRICES THROUGH TARGETING AND ADVANCED PRECURSOR AND PRODUCT ION ALIGNMENT 审中-公开
标题翻译：通过目标和先进的前体和产品离子对准分析复杂生物学基础
公开(公告)号：WO2015191999A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035555
申请日：2015-06-12
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： GEROMANOS, Scott, J. , CIAVARINI, Steven, J. , LANGRIDGE, James, I. , WILLIAMS, Brad, J. , NOLD, Michael, J.
IPC分类号： H01J49/10 , H01J49/14 , G01N30/72
CPC分类号： G01N33/6848 , G01N30/72 , H01J49/0031 , H01J49/421
摘要： A method of mass spectrometry comprises ionising a sample eluting from a separation device in order to generate a plurality of parent ions. Multiple cycles of operation are performed as the sample elutes from the separation device. Each cycle of operation comprises mass analysing the parent ions to obtain parent ion mass spectral data, and mass analysing fragment or product ions derived from the parent ion to obtain fragment or product ion mass spectral data. Each cycle of operation also comprises mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a first range to obtain first fragment or product ion mass spectral data, and mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a second different range to obtain second fragment or product ion mass spectral data. The method can provide a hybrid data independent acquisition (DIA) and data dependent acquisition (DDA) approach.
摘要翻译：质谱法包括将从分离装置洗脱的样品电离以产生多个母体离子。当样品从分离装置洗脱出来时，执行多个操作循环。每个操作循环包括对母体离子进行大量分析以获得母体离子质谱数据，以及质量分析从母体离子衍生的片段或产物离子，以获得片段或产物离子质谱数据。每个操作循环还包括质量分析衍生自具有质荷比在第一范围内的母离子的片段或产物离子，以获得第一片段或产物离子质谱数据，以及质量分析衍生自母体离子的片段或产物离子，电荷比在第二不同范围内，以获得第二片段或产物离子质谱数据。该方法可以提供混合数据独占采集（DIA）和数据相关采集（DDA）方法。

10. 发明申请

WO2015191980A1 INTELLIGENT TARGET-BASED ACQUISITION 审中-公开
标题翻译：基于智能目标的收购
公开(公告)号：WO2015191980A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035521
申请日：2015-06-12
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： GEROMANOS, Scott, J. , CIAVARINI, Steven, J. , CHEN, Weibin , HOUEL, Stephane
IPC分类号： H01J49/10 , H01J49/14 , G01N30/72
CPC分类号： H01J49/0036 , G01N30/72 , G01N30/8675 , G01N30/8679 , G01N30/8686 , G01N30/8693 , H01J49/0031
摘要： A method of mass spectrometry comprises ionising a sample eluting from a separation device in order to generate a plurality of parent ions. The method further comprises generating a target list of ions, which includes a predicted mass to charge ratio, a predicted chromatographic retention or elution time, and a predicted ion mobility drift time, derived from a model. Multiple cycles of operation are then performed as the sample elutes from the separation device. Each cycle of operation includes mass filtering the parent ions so that selected ions having mass to charge ratios within a first mass to charge ratio range are onwardly transmitted to a fragmentation or reaction device. The target list is then checked and the model is updated accordingly. The first mass to charge ratio range can then be adjusted in response to the updated model.
摘要翻译：质谱法包括将从分离装置洗脱的样品电离以产生多个母体离子。该方法还包括产生目标离子列表，其包括从模型导出的预测的质荷比，预测的色谱保留或洗脱时间以及预测的离子迁移率漂移时间。随着样品从分离装置洗脱出来，进行多个操作循环。每个操作循环包括对母离子进行质量过滤，使得在第一质荷比范围内具有质荷比的选定离子向上传递到碎裂或反应装置。然后检查目标列表，并相应地更新模型。然后可以响应于更新的模型来调整第一质量到充电比率范围。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式