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1. 发明申请

WO2010030720A1 VALVE SWITCH MODULATION FOR REDUCING ERRORS DUE OSCILLATIONS OF THE INLET FLUID OF A PUMP SYSTEM 审中-公开
标题翻译：用于减少泵系统的入口流体的振荡的减少误差的阀开关调制
公开(公告)号：WO2010030720A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056434
申请日：2009-09-10
申请人： WATER TECHNOLOGIES CORPORATION , SHREVE, Joshua, A. , CIAVARINI, Steven, J.
发明人： SHREVE, Joshua, A. , CIAVARINI, Steven, J.
IPC分类号： G01N1/00
CPC分类号： B01F15/0479 , B01D15/14 , B01F15/0216 , G01N30/34 , G01N30/36 , G01N35/00871 , G01N35/1097 , G01N2030/347 , G01N2035/00544 , G05D11/133
摘要： Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.
摘要翻译：描述了在低压混合泵系统中减少液体组成误差的方法。表示所需流体混合物的每个组分的切换间隔的分组被提供给混合泵系统的进气口。对于每个分组，调制与分组中的至少一个分量相关联的切换时间。调制切换时间基于根据混合泵系统的进气响应的不期望的频率特性而特别选择的时间偏移。由如此调制的分组贡献的卷的平均值等于在混合泵系统的输出流中实现组分的期望比例的分量体积。调制切换时间可以减少或消除混合泵系统的输出流量中的组成误差。

2. 发明申请

WO2011085337A1 THERMAL CONTROL OF THERMAL CHAMBER IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY SYSTEMS 审中-公开
标题翻译：高性能液相色谱系统中热室的热控制
公开(公告)号：WO2011085337A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020725
申请日：2011-01-11
申请人： WATERS TECHNOLOGIES CORPORATION , SHREVE, Joshua, A. , CIAVARINI, Steven, J.
发明人： SHREVE, Joshua, A. , CIAVARINI, Steven, J.
IPC分类号： F25B21/02
CPC分类号： F25B21/02 , F25B2321/0212 , F25B2321/0251 , F25B2700/2103 , F25D2700/02 , F25D2700/12 , F25D2700/123 , G01N30/24 , G01N30/30 , G01N2030/303
摘要： A sample manager of a liquid chromatography system implements a thermal system that uses a dual-loop feedback control system to control temperature within a thermal chamber. The sample manager includes an external heatsink disposed externally to the thermal chamber, an internal heatsink disposed within the thermal chamber, and one or more thermoelectric devices thermally coupled to the external and internal heatsinks to transfer heat therebetween in response to a pulse-width modulated power signal. A first temperature sensor disposed within the thermal chamber continuously measures a chamber temperature. A second temperature sensor coupled to the internal heatsink within the thermal chamber continuously measures temperature at the internal heatsink. A feedback control system controls a duty cycle of the pulse-width modulated power signal in response to a target chamber temperature and real-time temperature measurements produced by the first and second temperature sensors.
摘要翻译：液相色谱系统的样品管理器实现了使用双回路控制系统来控制热室内的温度的热系统。样品管理器包括设置在热室的外部的外部散热器，设置在热室内的内部散热器，以及一个或多个热耦合到外部和内部散热器的热电装置，以响应于脉冲宽度调制功率信号。设置在热室内的第一温度传感器连续地测量腔室温度。耦合到热室内的内部散热器的第二温度传感器连续测量内部散热器的温度。反馈控制系统响应于目标腔室温度和由第一和第二温度传感器产生的实时温度测量值来控制脉冲宽度调制功率信号的占空比。

3. 发明申请

WO2010030723A1 INTAKE PROFILE FOR OPTIMIZED UTILIZATION OF MOTOR CHARACTERISTICS 审中-公开
标题翻译：采用轮廓优化电机特性
公开(公告)号：WO2010030723A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056438
申请日：2009-09-10
申请人： WATERS TECHNOLOGIES CORPORATION , SHREVE, Joshura, A. , CIAVARINI, Steven, J.
发明人： SHREVE, Joshura, A. , CIAVARINI, Steven, J.
IPC分类号： G01N1/00
CPC分类号： H02P8/14 , F04B17/03 , F04B49/065 , F04B2203/0207 , F04B2203/0209 , G01N30/34 , G01N2030/326
摘要： Systems and methods for operating a stepper motor of a pump at a desired low velocity include memory for storing information corresponding to an intake velocity profile. The intake velocity profile represents an optimized acceleration curve for operating the stepper motor over a range of motor velocities during an intake cycle. A processor of a system controller dynamically accesses the memory during the intake cycle to acquire the information representing the intake velocity profile and issues a series of pulses to the stepper motor based on this information. In response to the pulses, the stepper motor accelerates in accordance with the optimized acceleration curve represented by the intake velocity profile. The optimized acceleration curve is based on the available torque of the stepper motor across a range of motor velocities and enables the motor to operate with greater torque utilization and less margin than traditional linear acceleration profiles.
摘要翻译：用于以期望的低速度操作泵的步进电动机的系统和方法包括用于存储对应于进气速度曲线的信息的存储器。进气速度曲线表示在进气循环期间在一定范围的电机速度下操作步进电机的优化加速曲线。系统控制器的处理器在进气循环期间动态地访问存储器以获取表示进气速度分布的信息，并基于该信息向步进电动机发出一系列脉冲。响应于脉冲，步进电机根据由进气速度分布表示的优化加速度曲线加速。优化的加速曲线基于步进电机在电机速度范围内的可用扭矩，并使电机能够以更大的转矩利用率和比传统线性加速度曲线更小的裕度运行。

4. 发明申请

WO2002086437A1 METHODS AND APPARATUS FOR DETERMINING THE PRESENCE OR ABSENCE OF A FLUID LEAK 审中-公开
标题翻译：用于确定流体泄漏存在或不存在的方法和装置
公开(公告)号：WO2002086437A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/006540
申请日：2002-03-01
申请人： WATERS INVESTMENTS LIMITED , LUONGO, Joseph, A. , CIAVARINI, Steven, J. , TACCONI, Robert, Q. , RUBINO, Frank, A. , DUMAS, Robert, J.
发明人： LUONGO, Joseph, A. , CIAVARINI, Steven, J. , TACCONI, Robert, Q. , RUBINO, Frank, A. , DUMAS, Robert, J.
IPC分类号： G01M3/26
CPC分类号： G01M3/26 , F04B51/00 , F04B2201/0208 , F04B2205/05 , G01N30/32 , G01N2030/326
摘要： Method and apparatus for detecting leaks or defects, including component failure and adverse performance, in a fluid pumping system having a pumping chamber, piston (21), motor (35), inlet, outlet, inlet valve, switchable valve and detector (29). The inlet valve (37) is in fluid communication with the inlet (17) while the switchable valve (41) is in fluid communication with the outlet (19). A pressure measuring device (45) is in fluid communication with the pumping chamber (15) between the inlet valve and switchable valve so as to determine a minimal pressure together with first and second threshold pressures measured at first and second times that correspond to first and second threshold pressure signals. A control means (51) calculates the slope of a line representing the difference of such first and second threshold pressure signals over time so as to compare the slope to a threshold decay value, or to compare the minimal pressure to minimal acceptable values, thus defining pump defects.
摘要翻译：具有泵送室，活塞（21），电动机（35），入口，出口，入口阀，可切换阀和检测器（29）的流体泵送系统中检测泄漏或缺陷（包括部件故障和不利性能）的方法和装置，。入口阀（37）与入口（17）流体连通，而可切换阀（41）与出口（19）流体连通。压力测量装置（45）与入口阀和可切换阀之间的泵送室（15）流体连通，以便确定最小压力以及在第一和第二时间测量的第一和第二阈值压力，其对应于第一和第二阀值第二阈值压力信号。控制装置（51）计算表示这种第一和第二阈值压力信号随时间的差异的线的斜率，以便将斜率与阈值衰减值进行比较，或将最小压力与最小可接受值进行比较，从而定义泵缺陷。

5. 发明申请

WO2007109157A3 SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS 审中-公开
公开(公告)号：WO2007109157A3
公开(公告)日：2007-09-27
申请号：PCT/US2007/006679
申请日：2007-03-16
申请人： WATERS INVESTMENTS LIMITED , CIAVARINI, Steven, J. , PENSAK, Stanley, P. , FINCH, Jeffrey, W. , FADGEN, Keith , LIU, Hongji
发明人： CIAVARINI, Steven, J. , PENSAK, Stanley, P. , FINCH, Jeffrey, W. , FADGEN, Keith , LIU, Hongji
IPC分类号： B01D15/08
摘要： A solvent delivery subsystem (720) for a chromatographic device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump (715A) and an organic pump (715B) are mixed to fill a storage capillary (722) while a downstream point from the storage capillary (722) is vented to atmosphere. After the gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only aqueous pump (715A) runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system used feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

6. 发明申请

WO2006023828A2 DEVICES, SYSTEMS, AND METHODS FOR FLOW-COMPENSATING PUMP-INJECTOR SYCHRONIZATION 审中-公开
标题翻译：流体补偿泵 - 注射器同步的装置，系统和方法
公开(公告)号：WO2006023828A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/029734
申请日：2005-08-19
申请人： WATERS INVESTMENTS LIMITED , PENSAK, Stanley, P., Jr. , HEDEN, John , CIAVARINI, Steven, J. , LAMOUREUX, John , SOARES, Miguel
发明人： PENSAK, Stanley, P., Jr. , HEDEN, John , CIAVARINI, Steven, J. , LAMOUREUX, John , SOARES, Miguel
IPC分类号： B01L11/00
CPC分类号： G01N30/34 , G01N35/1097
摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream (52), to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system (30) to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.
摘要翻译：用于减轻与将低压分析物样品注入高压HPLC流体流（52）相关的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。优选实施例通过二元溶剂输送系统（30）的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

7. 发明申请

WO2015191390A1 METHOD TO REMOVE ION INTERFERENCES 审中-公开
标题翻译：删除离子干扰的方法
公开(公告)号：WO2015191390A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/034448
申请日：2015-06-05
申请人： WATER TECHNOLOGIES CORPORATION
发明人： GOLICK, Daniel , GEROMANOS, Scott , GORENSTEIN, Marc, V. , CIAVARINI, Steven, J. , FADGEN, Keith
IPC分类号： H01J49/26 , G01N30/72 , G01N30/86
CPC分类号： H01J49/0036 , G01N30/7233
摘要： A method of mass spectrometry is disclosed comprising mass analysing an eluent from a chromatography device and obtaining parent ion data sets and corresponding product ion data sets, and determining whether, in a first product ion data set, one or more product ions are present that are related to one or more parent ions in a corresponding first parent ion data set, based on the mass or mass to charge ratio and/or intensity of the one or more product ions and the one or more parent ions. If it is determined that the one or more product ions are present, the method further comprises removing the one or more product ions from one or more second product ion data sets to produce one or more second modified product ion data sets and/or removing ions other than the one or more product ions from the first product ion data set to produce a first modified product ion data set.
摘要翻译：公开了一种质谱方法，其包括质量分析色谱装置的洗脱液并获得母体离子数据集和相应的产物离子数据集，以及确定在第一产物离子数据集中是否存在一个或多个产物离子基于一个或多个产物离子和一个或多个母体离子的质量或质荷比和/或强度，与相应的第一亲本离子数据集中的一个或多个亲本离子相关。如果确定存在一种或多种产物离子，该方法还包括从一个或多个第二产物离子数据集中除去一种或多种产物离子以产生一个或多个第二修饰产物离子数据集和/或除去离子除了来自第一产品离子数据集的一个或多个产物离子以产生第一修饰产物离子数据集。

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