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1. 发明申请

WO2013134215A1 STATIC BACK PRESSURE REGULATOR 审中-公开
标题翻译：静态压力调节器
公开(公告)号：WO2013134215A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029035
申请日：2013-03-05
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： SHREVE, Joshua A. , MURPHY, Charles T. , KEENAN, Paul , HILL, Ryan , CORMIER, Sylvain
IPC分类号： G05D7/01
CPC分类号： F16K15/063 , B01D15/40 , F16K1/38 , F16K1/42 , F16K15/021 , F16K15/044 , F16K25/005 , F16K25/04 , G01N30/32 , G05D16/103 , Y10T137/7925
摘要： The invention generally provides a static back pressure regulator. In exemplary embodiments, the static back pressure regulator includes a seat that defines part of a fluid pathway, a poppet, a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway, and a calibration element configured to adjust a force applied to the poppet by the spring. The calibration element can include a through hole that forms part of the fluid pathway. The poppet can include a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat.
摘要翻译：本发明通常提供一种静态背压调节器。在示例性实施例中，静态背压调节器包括限定流体通道的一部分的座，提升阀，弹簧，其布置成将提升阀朝向座椅偏置以限制流过流体通路的流体流动;以及校准元件，春天施加在提升阀上的力。校准元件可以包括形成流体通路的一部分的通孔。提升阀可以包括延伸到校准元件的通孔中的第一引导部分，并且防止提升阀相对于座椅的倾翻。

2. 发明申请

WO2016160157A1 MULTI-INJECTION MODE VALVE MODULE 审中-公开
标题翻译：多注入模式阀模块
公开(公告)号：WO2016160157A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/018218
申请日：2016-02-17
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： CORMIER, Sylvain , ANDREWS, Richard W. , BEALS, Peyton C.
IPC分类号： G01N30/22 , G01N30/24 , G06F11/30
CPC分类号： G01N30/32 , G01N30/34 , G01N30/88 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N2030/328 , G01N2030/347 , G01N2030/889
摘要： A chromatography system has an associated system volume and a sample dispersion volume. The chromatography system comprises a pump pumping a flow of gradient, a sample manager for introducing a sample into the flow of gradient, and a valve manager fluidically coupled to the pump and to the sample manager. The valve manager includes at least one valve. A first valve of the at least one valve has a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve. The first valve has at least two different, automatically selectable positions. A first position of the at least two different automatically selectable positions operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position.
摘要翻译：色谱系统具有相关系统体积和样品分散体积。色谱系统包括泵送梯度流的泵，用于将样品引入梯度流的样品管理器，以及流体耦合到泵和样品管理器的阀门管理器。阀门管理器包括至少一个阀。所述至少一个阀的第一阀具有多个端口，所述多个端口包括从所述泵接收梯度流的入口端口和所述梯度流通过所述出口端口离开所述第一阀的出口。第一阀具有至少两个不同的自动选择位置。当第一阀自动切换到第一位置时，所述至少两个不同的自动可选位置的第一位置用于改变色谱系统的系统和样品分散体积之一。

3. 发明申请

WO2009146290A1 DEVICE AND METHOD FOR CONNECTING FLUID CONDUITS 审中-公开
标题翻译：用于连接流体流量的装置和方法
公开(公告)号：WO2009146290A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/044880
申请日：2009-05-21
申请人： WATERS TECHNOLOGIES CORPORATION , MURPHY, James, P. , MICHIENZI, Joseph , PRENTICE, David , CORMIER, Sylvain
发明人： MURPHY, James, P. , MICHIENZI, Joseph , PRENTICE, David , CORMIER, Sylvain
IPC分类号： F16L25/00
CPC分类号： G01N30/6004 , B01L3/565 , G01N30/7233 , G01N2030/6013
摘要： A connector for connecting a first conduit to a second conduit including a body having a passageway therethrough, a first cavity and a second cavity, a first sealing member, a second sealing member, a first compression, a second compression fitting, a first set of one or more keys and one or more mated key ways for preventing rotation of the first conduit when the first sealing member is compressed, and a second set of one or more keys and one or more mated key ways for preventing rotation of the second conduit when the second sealing member is compressed, wherein each of the first cavity and the second cavity in the body is configured to receive one of the sealing members or a detachable holder configured to receive one of the sealing members.
摘要翻译：一种用于将第一导管连接到第二导管的连接器，所述第二导管包括具有穿过其的通道的主体，第一腔和第二腔，第一密封构件，第二密封构件，第一压缩构件，第二压缩配件，第一组一个或多个键和一个或多个配合的钥匙方式，用于当第一密封构件被压缩时防止第一导管的旋转;以及第二组一个或多个键和一个或多个配合的键槽，用于防止第二导管旋转时所述第二密封构件被压缩，其中所述主体中的所述第一空腔和所述第二空腔中的每一个构造成容纳所述密封构件中的一个或构造成容纳所述密封构件中的一个的可拆卸保持器。

4. 发明申请

WO2019229697A1 HIGH RESOLUTION AND SEMI-PREPARATIVE RECYCLING CHROMATOGRAPHY SYSTEM FOR ISOLATION AND PREPARATION OF UNKNOWN TRACE IMPURITIES IN PHARMACEUTICAL PRODUCTS 审中-公开
公开(公告)号：WO2019229697A1
公开(公告)日：2019-12-05
申请号：PCT/IB2019/054489
申请日：2019-05-30
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： GRITTI, Fabrice , CORMIER, Sylvain
IPC分类号： B01D15/18 , G01N30/44 , G01N30/46 , G01N30/88 , B01D15/24
摘要： The disclosure relates to a recycling chromatography method that includes injecting a sample into a mobile phase flow stream of a chromatography system to create a combined flow stream. The sample includes an API and at least one impurity. The chromatography system includes a first column and a column in series, a first valve in fluid communication with the first and second chromatographic columns, a heater in communication with the first and second chromatographic columns, a fraction collector in fluid communication with the first and second chromatographic columns, and a second valve positioned before the fraction collector. The combined flow stream is recycled from the first chromatographic column to the second chromatographic column and vice versa by switching the first valve until a baseline resolution is achieved to separate the at least one impurity from the API. The at least one impurity is collected in the fraction collector.

5. 发明申请

WO2017192792A1 METHOD AND APPARATUS FOR INJECTING A CHROMATOGRAPHIC SAMPLE 审中-公开
标题翻译：注射色谱样品的方法和设备
公开(公告)号：WO2017192792A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030950
申请日：2017-05-04
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： GILAR, Martin , ANDREWS, Richard, W. , BEALS, Peyton, C. , MCDONALD, Thomas , FADGEN, Keith , KORNFELD, Jordan , GERHARDT, Geoff , CORMIER, Sylvain
IPC分类号： G01N30/20
摘要： A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.
摘要翻译：用于将稀释样品注入色谱系统的方法包括合并样品流和稀释剂流以形成稀释样品流。稀释样品的稀释比等于样品和稀释剂的体积流量之和除以样品的体积流量。稀释的样品在注入色谱系统流程之前储存在保持元件中。在相对于色谱流动的低压下进行样品稀释，从而允许使用较低压力的样品和稀释剂注射器。其他好处包括压缩性降低和由于较低压力操作导致的泄漏减少。该方法避免了由于例如样品损失，样品沉淀和样品吸附到样品瓶而可能引入误差的手动技术相关的问题。

6. 发明申请

WO2014014622A1 HIGH PRESSURE FITTING FOR SUPERCRITICAL FLUID CHROMATOGRAPHY 审中-公开
标题翻译：用于超临界流体色谱的高压配件
公开(公告)号：WO2014014622A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/047460
申请日：2013-06-25
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： BELANGER, Jonathan L. , CORMIER, Sylvain , TRUDEAU, Steven D. , KEENAN, Paul , MCCORMICK, Daniel J.
IPC分类号： B01D15/08
CPC分类号： F16L15/04 , B01D15/10 , B01D15/22 , B01D15/40 , F16J15/0806 , F16J15/102 , F16L19/0212 , G01N30/60 , G01N30/6004 , G01N30/6026
摘要： Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.
摘要翻译：描述了具有减少的腐蚀和侵蚀的流动相配件。配件包括联接体，压缩螺钉，压缩构件和衬垫。联接体在一端具有螺纹孔，锥形腔，窄孔和流体通道。压缩螺杆具有轴向孔以接收管和与联接体的螺纹孔接合的螺纹外表面。压缩构件设置在锥形空腔中并且具有轴向开口以使管和锥形表面接合以使锥形空腔的表面接合。垫圈设置在狭窄的孔中并且具有与第一内表面接触的一个表面并且具有平行的表面以容纳管的端面。流动相沿着包括管，垫圈中的开口和流体通道的路径流动。

7. 发明申请

WO2017161216A1 ROTARY INJECTION VALVE WITH INTERNAL SAMPLE LOAD CHANNEL 审中-公开
标题翻译：带内部样品负载通道的旋转注射阀
公开(公告)号：WO2017161216A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022858
申请日：2017-03-17
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： CORMIER, Sylvain
IPC分类号： G01N30/06 , G01N30/16 , G01N30/18 , G01N30/20 , G01N30/22 , G01N30/24
摘要： A rotary injection valve used in chromatography includes a stator having a stator sealing surface and a sample load channel disposed inside the stator body below the stator sealing surface. The valve can have a reduced number of ports thereby allowing faster integration of the valve into a chromatographic system. Flow restriction is reduced compared to valves that use an external sample loop for a similar volume of sample. The lack of stator ports for the sample load channel eliminates the potential for carryover created by external valve couplings. Another advantage is the reduction of surface wear achieved by locating the sample load channel below the stator sealing surface.
摘要翻译：在色谱中使用的旋转式进样阀包括具有定子密封表面的定子和位于定子主体内定子密封表面下方的样品负载通道。该阀可以具有减少的端口数量，从而允许阀门更快地集成到色谱系统中。与对于相似体积的样品使用外部样品环的阀相比，流量限制减少。样品负载通道缺少定子端口，消除了由外部阀门耦合产生的夹带的可能性。另一个优点是通过将样品载荷通道定位在定子密封表面下方来减少表面磨损。

8. 发明申请

WO2016089515A1 SYSTEM AND METHOD FOR PERFORMING A CHROMATOGRAPHY INJECTION SEQUENCE USING A SINGLE INJECTION VALVE 审中-公开
标题翻译：使用单一注射阀执行色谱注射序列的系统和方法
公开(公告)号：WO2016089515A1
公开(公告)日：2016-06-09
申请号：PCT/US2015/058571
申请日：2015-11-02
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： CORMIER, Sylvain
IPC分类号： G01N30/20
CPC分类号： G01N30/20 , G01N2030/202 , G01N2030/207
摘要： A rotary valve used in chromatography includes a stator with a plurality of stator ports arranged on the stator. The stator further includes a stator groove connected at one end to a first stator port and terminating between the first stator port and a second stator port adjacent to the first stator port. A rotor, rotatably fitted to the stator, has a plurality of arcuate channels arranged in an asymmetrical pattern on the rotor. Each rotor channel connects to one or more of the stator ports. Different connections of the rotor channels to the stator ports produce at least three different positions for the injection valve. The three different positions provide a complete chromatography sample injection sequence using only a single valve.
摘要翻译：用于色谱的旋转阀包括具有布置在定子上的多个定子口的定子。定子还包括定子槽，其一端连接到第一定子口并且终止在第一定子口与邻近第一定子口的第二定子口之间。可旋转地装配到定子的转子具有在转子上以不对称图案布置的多个弧形通道。每个转子通道连接到一个或多个定子口。转子通道与定子端口的不同连接为喷射阀产生至少三个不同的位置。三个不同的位置提供了仅使用单个阀的完整的色谱分析样品注射顺序。

9. 发明申请

WO2013133920A1 HIGH PRESSURE FITTING FOR A LIQUID CHROMATOGRAPHY SYSTEM 审中-公开
标题翻译：液相色谱系统的高压配件
公开(公告)号：WO2013133920A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/024347
申请日：2013-02-01
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： JOUDREY, Kurt , CORMIER, Sylvain , USOWICZ, James , BERG, Emily J. , SEITH, Christopher
IPC分类号： F16L19/00
CPC分类号： F16L19/061 , G01N30/6026
摘要： A fitting for coupling fluidic paths, such as high pressure fluidic paths in liquid chromatography systems, includes a compression nut, a tube assembly and a compression member. The compression nut has a threaded outer surface to engage a threaded bore of a receiving port and the tube assembly has an outer surface and an end face to contact a sealing surface of the receiving port. The compression member is pre-staked to the outer surface of the tube assembly at a predetermined distance from the end face and has a tapered surface to engage a surface of the receiving port. The predetermined distance permits the tube assembly to be inserted into the receiving port so that the end face makes contact with the sealing surface without the tapered surface engaging a surface of the receiving port and so that the threaded outer surface of the compression nut engages the threaded bore.
摘要翻译：用于耦合流体路径（例如液相色谱系统中的高压流体路径）的配件包括压缩螺母，管组件和压缩构件。压缩螺母具有螺纹外表面以接合接收端口的螺纹孔，并且管组件具有外表面和端面以接触接收端口的密封表面。压缩构件预先固定在距离端面一预定距离的管组件的外表面上，并且具有锥形表面以接合接收端口的表面。预定距离允许管组件插入到接收端口中，使得端面与密封表面接触，而锥形表面接合接收端口的表面，并且使得压缩螺母的螺纹外表面接合螺纹孔。

10. 发明申请

WO2011106162A1 ON-LINE SAMPLING FORM A PROCESS SOURCE 审中-公开
标题翻译：在线采样方式来源
公开(公告)号：WO2011106162A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/024292
申请日：2011-02-10
申请人： WATERS TECHNOLOGIES CORPORATION , CORMIER, Sylvain
发明人： CORMIER, Sylvain
IPC分类号： G01N21/53
CPC分类号： G01N30/20 , G01N1/38 , G01N30/18 , G01N35/1097 , G01N2030/201 , G01N2030/202 , Y10T137/0318 , Y10T137/85978
摘要： An online sample manager of a liquid chromatography system includes a fluidic tee having a first inlet port, a second inlet port, and an outlet port. A diluent pump moves diluent from a diluent source to the first inlet port of the fluidic tee. A valve has a fluidic intake port connected to a process source for acquiring a process sample therefrom. A pumping system moves the acquired process sample from the valve into the second inlet port of the fluidic tee where the process sample merges with the diluent arriving at the first inlet port to produce a diluted process sample that flows out from the outlet port of the fluidic tee.
摘要翻译：液相色谱系统的在线样品管理器包括具有第一入口端口，第二入口端口和出口端口的流体三通管。稀释剂泵将稀释剂从稀释剂源移动到流体三通的第一入口端口。阀具有连接到用于从其获取处理样品的处理源的流体入口。泵送系统将获取的过程样品从阀门移动到流体三通的第二入口端口，其中过程样品与到达第一入口端口的稀释剂合并，以产生从流体出口端口流出的稀释过程样品开球。

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