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1. 发明申请

WO2018236789A1 TECHNIQUES FOR DETERMINING EQUILIBRATION AND STABILITY IN SCIENTIFIC INSTRUMENT SYSTEMS 审中-公开
公开(公告)号：WO2018236789A1
公开(公告)日：2018-12-27
申请号：PCT/US2018/038170
申请日：2018-06-19
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： BEALS, Peyton C. , ANDREWS, Richard W. , SUNRAY, Barry , BINNEY, Steven M.
IPC分类号： G01N30/88 , G01N30/86
摘要： A method of performing experiments on samples (102) may include receiving from a computer (116) criteria defining a starting state for performing an experiment in a system (100) including a scientific instrument (104) and one or more detectors (112); determining whether the starting state is established in the system (100); and, responsive to the starting state being established, allowing the experiment, that analyzes a sample (102) using the scientific instrument (104), to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter such as system pressure, column temperature or detector signal, for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

2. 发明申请

WO2021030245A1 MIXER FOR CHROMATOGRAPHY SYSTEM 审中-公开
公开(公告)号：WO2021030245A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/045581
申请日：2020-08-10
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： BEALS, Peyton C. , CORMIER, Sylvain Gilles , ANDREWS, Richard W.
IPC分类号： B01F5/06 , B01F13/00 , B01F13/10 , G01N30/02
摘要： Described is a mixer (1) for a chromatography system. The mixer (1) includes an inlet manifold channel (10), an outlet manifold channel (50) and a plurality of transfer channels (20A-20I ). The inlet manifold channel (10) has an inlet (13) at a proximal end (11) of the inlet manifold channel (10) for receiving an inlet flow (13). The transfer channels (20A-20I) are fluidly connected between the inlet (10) and outlet (50) manifold channels. The respective fluid connections are distributed along each of the inlet and outlet manifolds channels. The transfer channels (20A-20I) have different volumes. The mixer may be formed of a plurality of layer and the layers may be diffusion bonded to each other.

3. 发明申请

WO2016160157A1 MULTI-INJECTION MODE VALVE MODULE 审中-公开
标题翻译：多注入模式阀模块
公开(公告)号：WO2016160157A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/018218
申请日：2016-02-17
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： CORMIER, Sylvain , ANDREWS, Richard W. , BEALS, Peyton C.
IPC分类号： G01N30/22 , G01N30/24 , G06F11/30
CPC分类号： G01N30/32 , G01N30/34 , G01N30/88 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N2030/328 , G01N2030/347 , G01N2030/889
摘要： A chromatography system has an associated system volume and a sample dispersion volume. The chromatography system comprises a pump pumping a flow of gradient, a sample manager for introducing a sample into the flow of gradient, and a valve manager fluidically coupled to the pump and to the sample manager. The valve manager includes at least one valve. A first valve of the at least one valve has a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve. The first valve has at least two different, automatically selectable positions. A first position of the at least two different automatically selectable positions operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position.
摘要翻译：色谱系统具有相关系统体积和样品分散体积。色谱系统包括泵送梯度流的泵，用于将样品引入梯度流的样品管理器，以及流体耦合到泵和样品管理器的阀门管理器。阀门管理器包括至少一个阀。所述至少一个阀的第一阀具有多个端口，所述多个端口包括从所述泵接收梯度流的入口端口和所述梯度流通过所述出口端口离开所述第一阀的出口。第一阀具有至少两个不同的自动选择位置。当第一阀自动切换到第一位置时，所述至少两个不同的自动可选位置的第一位置用于改变色谱系统的系统和样品分散体积之一。

4. 发明公开

EP4013539A1 MIXER FOR CHROMATOGRAPHY SYSTEM 审中-实审
公开(公告)号：EP4013539A1
公开(公告)日：2022-06-22
申请号：EP20760716.9
申请日：2020-08-10
申请人： Waters Technologies Corporation
发明人： BEALS, Peyton C. , CORMIER, Sylvain Gilles , ANDREWS, Richard W.
IPC分类号： B01F5/06 , B01F13/00 , B01F13/10 , G01N30/02

5. 发明公开

EP3278099A1 MULTI-INJECTION MODE VALVE MODULE 审中-实审
标题翻译：多注射模式阀模块
公开(公告)号：EP3278099A1
公开(公告)日：2018-02-07
申请号：EP16773640.4
申请日：2016-02-17
申请人： Waters Technologies Corporation
发明人： CORMIER, Sylvain , ANDREWS, Richard W. , BEALS, Peyton C.
IPC分类号： G01N30/22 , G01N30/24 , G06F11/30
CPC分类号： G01N30/32 , G01N30/34 , G01N30/88 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N2030/328 , G01N2030/347 , G01N2030/889
摘要： A chromatography system has an associated system volume and a sample dispersion volume. The chromatography system comprises a pump pumping a flow of gradient, a sample manager for introducing a sample into the flow of gradient, and a valve manager fluidically coupled to the pump and to the sample manager. The valve manager includes at least one valve. A first valve of the at least one valve has a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve. The first valve has at least two different, automatically selectable positions. A first position of the at least two different automatically selectable positions operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position.

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