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1. 发明申请

WO2007146616A3 DEVICES AND METHODS FOR DETECTION OF MARKERS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：用于检测具有或不具有RADICULOPATHY的轴向疼痛标记物的装置和方法
公开(公告)号：WO2007146616A3
公开(公告)日：2008-04-10
申请号：PCT/US2007070174
申请日：2007-06-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
发明人： MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
IPC分类号： A61B5/00 , A61B5/03 , A61B5/06 , A61B17/00 , A61B17/56 , C12Q1/00 , G01N33/94
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

2. 发明申请

WO2007146595A3 COMPOSITIONS AND METHODS FOR DIAGNOSIS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：用于诊断具有或不具有RADICULOPATHY的轴向疼痛的组合物和方法
公开(公告)号：WO2007146595A3
公开(公告)日：2008-09-12
申请号：PCT/US2007070019
申请日：2007-05-31
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , TRIEU HAI H , ROY JOSEE , GROSS JEFFREY M , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
发明人： MCKAY WILLIAM F , TRIEU HAI H , ROY JOSEE , GROSS JEFFREY M , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
IPC分类号： A61K51/00 , A61K49/00 , A61K49/06
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了与成像技术一起使用并且可用于诊断和监测具有或不具有神经根病变的轴痛的疼痛发生器的方法和组合以及用于筛选潜在地可用于治疗具有或不具有神经根病变的轴向疼痛的治疗化合物的方法和组合物。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。疼痛标记和变性标记包括神经元，血管，免疫和基质元件的标记。

3. 发明申请

WO2007146616B1 DEVICES AND METHODS FOR DETECTION OF MARKERS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：装置和方法用于检测具有或不具有放射性皮炎的轴向疼痛标记物
公开(公告)号：WO2007146616B1
公开(公告)日：2008-06-12
申请号：PCT/US2007070174
申请日：2007-06-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
发明人： MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
IPC分类号： A61B5/00 , A61B5/03 , A61B5/06 , A61B17/00 , A61B17/56 , C12Q1/00 , G01N33/94
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了用于诊断和监测有或没有神经根病的轴向疼痛的疼痛发生器的装置和相关方法和组合物，以及用于筛选可能用于治疗有或没有神经根病的轴向疼痛的试验化合物的方法。或者，退化的椎间盘可以在发生病理性疼痛症状之前进行监测和治疗。退化椎间盘的疼痛标记和标记包括神经元，血管，免疫和基质元素的标记。

4. 发明申请

WO2007130906A3 MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX 审中-公开
标题翻译：包含骨质疏松基质的可植入植入物
公开(公告)号：WO2007130906A3
公开(公告)日：2008-03-27
申请号：PCT/US2007067767
申请日：2007-04-30
申请人： WARSAW ORTHOPEDIC INC , CHARMNESS KATHY L , MCKAY WILLIAM F , DRAPEAU SUSAN J , SCARBOROUGH NELSON L
发明人： CHARMNESS KATHY L , MCKAY WILLIAM F , DRAPEAU SUSAN J , SCARBOROUGH NELSON L
IPC分类号： A61L27/24 , A61L27/36 , A61L27/56 , A61L27/58
CPC分类号： A61L27/20 , A61F2/28 , A61L27/24 , A61L27/3608 , A61L27/365 , A61L27/48
摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising one or more polysaccharides. Also described are methods for making and using such medical compositions.
摘要翻译：描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。固体可以包括颗粒胶原和颗粒脱矿质骨基质。液体载体包括含有一种或多种多糖的水性介质。还描述了制备和使用这种医药组合物的方法。

5. 发明申请

WO2010009111A4 A DRUG DEPOT IMPLANTABLE WITHIN A SYNOVIAL JOINT 审中-公开
标题翻译：一个可以在SYNOVIAL JOINT中嵌入的药剂DEPOT
公开(公告)号：WO2010009111A4
公开(公告)日：2010-06-10
申请号：PCT/US2009050520
申请日：2009-07-14
申请人： WARSAW ORTHOPEDIC INC , MEDTRONIC INC , KIMBLE TOYA D , DRAPEAU SUSAN J , MCKAY WILLIAM F , ZANELLA JOHN MYERS , TENBROEK ERICA M
发明人： KIMBLE TOYA D , DRAPEAU SUSAN J , MCKAY WILLIAM F , ZANELLA JOHN MYERS , TENBROEK ERICA M
IPC分类号： A61F2/38 , A61K9/00 , A61K9/20 , A61K47/34 , A61P19/02 , A61P29/00
CPC分类号： A61K9/0024
摘要： Methods and compositions for treating a tissue within a synovial joint in a patient in need of such treatment are provided. The methods and compositions involve inserting a drug depot through the synovial joint and attaching the drug depot to the inside of the synovial joint capsule so that the drug depot does not substantially interfere with movement of the joint, wherein said depot comprises a polymer and at least one pharmaceutical agent.
摘要翻译：提供了用于治疗需要这种治疗的患者的滑膜关节内的组织的方法和组合物。所述方法和组合物包括将药物贮库穿过滑膜接头并将药物贮库附着到滑膜关节囊的内部，使得药物贮库基本上不干扰关节的运动，其中所述药剂库包含聚合物并且至少一种药剂。

6. 发明申请

WO2010009111A3 A DRUG DEPOT IMPLANTABLE WITHIN A SYNOVIAL JOINT 审中-公开
标题翻译：在SYNOVIAL JOINT中的药物容器可植入
公开(公告)号：WO2010009111A3
公开(公告)日：2010-04-22
申请号：PCT/US2009050520
申请日：2009-07-14
申请人： WARSAW ORTHOPEDIC INC , MEDTRONIC INC , KIMBLE TOYA D , DRAPEAU SUSAN J , MCKAY WILLIAM F , ZANELLA JOHN MYERS , TENBROEK ERICA M
发明人： KIMBLE TOYA D , DRAPEAU SUSAN J , MCKAY WILLIAM F , ZANELLA JOHN MYERS , TENBROEK ERICA M
IPC分类号： A61F2/38 , A61K9/00 , A61K9/20 , A61K47/34 , A61P19/02 , A61P29/00
CPC分类号： A61K9/0024
摘要： Methods and compositions for treating a tissue within a synovial joint in a patient in need of such treatment are provided. The methods and compositions involve inserting a drug depot through the synovial joint and attaching the drug depot to the inside of the synovial joint capsule so that the drug depot does not substantially interfere with movement of the joint, wherein said depot comprises a polymer and at least one pharmaceutical agent.
摘要翻译：提供了用于治疗需要这种治疗的患者的滑液关节内组织的方法和组合物。所述方法和组合物涉及将药物贮库插入滑液关节并将药物贮库连接至滑液关节囊的内部，使得药物贮存库基本上不干扰关节的运动，其中所述贮库包含聚合物，并且至少一种药剂。

7. 发明申请

WO2007130848A3 COMPOSITIONS COMPRISING BIOMEMBRANE SEALING AGENT FOR TREATMENT OF NEURONAL INJURY, AND METHODS OF USE 审中-公开
标题翻译：包含用于治疗神经损伤的生物膜密封剂的组合物及其使用方法
公开(公告)号：WO2007130848A3
公开(公告)日：2008-01-24
申请号：PCT/US2007067580
申请日：2007-04-27
申请人： WARSAW ORTHOPEDIC INC , ROY JOSEE , MCKAY WILLIAM F , MARX JEFFERY C MD
发明人： ROY JOSEE , MCKAY WILLIAM F , MARX JEFFERY C MD
IPC分类号： A61K33/06 , A61K47/10
CPC分类号： A61K33/06 , A61K9/0019 , A61K31/56 , A61K31/65 , A61K31/765 , A61K47/10
摘要： The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent may be delivered by a method selected from the group consisting of an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。生物膜密封剂和/或生物活性剂可以通过选自静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，肠胃外给药，直接施用于或与病理状况的位点相邻，以及其任何组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

8. 发明申请

WO2007002339A3 OSTEOGRAFT TREATMENT TO PROMOTE OSTEOINDUCTION AND OSTEOGRAFT INCORPORATION 审中-公开
标题翻译： OSTEOGRAFT治疗促进骨质疏松和骨质疏松综合征
公开(公告)号：WO2007002339A3
公开(公告)日：2008-03-06
申请号：PCT/US2006024389
申请日：2006-06-21
申请人： WARSAW ORTHOPEDIC INC , GROSS JEFFREY M , MCKAY WILLIAM F , ZANELLA JOHN M
发明人： GROSS JEFFREY M , MCKAY WILLIAM F , ZANELLA JOHN M
IPC分类号： A61L27/54 , A61F2/28
CPC分类号： A61F2/28 , A61F2/4601 , A61F2/4644 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/3021 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30677 , A61F2002/3068 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0068 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/602 , A61L2300/64 , A61L2430/02
摘要： The invention provides a bone implant, or osteograft, with improved retention of bioactive agents within the surface of the osteograft. Pits or pits formed within the surface of the osteograft have porous plugs placed within them to retain fluid comprising bioactive agents. Pits can also be formed so that the dimensions of the pits facilitate retention of fluid within a pit by hydrostatic attraction of fluid molecules within the pit.
摘要翻译：本发明提供了骨移植物或骨移植物，其具有改善的生物活性剂在骨移植物表面内的保留性。在骨移植物表面内形成的凹坑或凹坑具有置于其内的多孔塞子以保持包含生物活性剂的流体。还可以形成凹坑，使得凹坑的尺寸通过液体分子在凹坑内的静水吸引而促进流体在凹坑内的保留。

9. 发明申请

WO2011094316A3 HIGHLY COMPRESSION RESISTANT MATRIX WITH POROUS SKELETON 审中-公开
标题翻译：高耐压矩阵与多孔的SKELETON
公开(公告)号：WO2011094316A3
公开(公告)日：2011-12-29
申请号：PCT/US2011022582
申请日：2011-01-26
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61L27/40 , A61F2/28 , A61L27/10 , A61L27/12 , A61L27/14 , A61L27/24 , A61L27/42 , A61L27/54 , A61L27/56
CPC分类号： A61F2/4644 , A61F2002/4648 , A61K9/0024 , A61K9/19 , A61K9/70 , A61K9/7007 , A61L27/425 , A61L27/56
摘要： A highly compression resistant matrix is provided for implantation at or near a target tissue site beneath the skin. The matrix comprises a polymer and a ceramic skeleton. The compression resistance provides retention of a volume that facilitates bone regeneration.
摘要翻译：提供高抗压基质用于植入在皮肤下方的靶组织部位处或附近。该基质包括聚合物和陶瓷骨架。抗压性提供了保持促进骨再生的体积。

10. 发明申请

WO2011094735A3 SURGICAL RETRACTOR INSTRUMENT SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：手术回缩器仪器系统及其使用方法
公开(公告)号：WO2011094735A3
公开(公告)日：2011-12-08
申请号：PCT/US2011023318
申请日：2011-02-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61B17/02 , A61B19/00 , G01L5/00
CPC分类号： A61B17/0206 , A61B2017/00017 , A61B2017/00115 , A61B2017/00128 , A61B2017/00398 , A61B2017/00539 , A61B2017/00544 , A61B2017/0212 , A61B2090/064 , A61B2090/065
摘要： A retractor system for percutaneous surgery in a patient includes first and second retractor portions positionable opposite one another in an incision of the patient. The system also includes at least one actuating member operable to provide an oscillating motion to at least one of the first and second retractor portions. The actuating member is in communication with a controller and is responsive to the controller to move and adjust at least one of the first and second retractor portions between a first position and a second position. The system also includes at least one pressure sensor and display and at least one timing circuit with display. In another form, a method is directed to retracting tissue for percutaneous access to a surgical site in a patient using the pressure sensors and display as will as the timing circuit and display to assure that the amount of pressure applied and the duration does not exceed pre-determined values.
摘要翻译：用于患者经皮手术的牵开器系统包括可在患者切口中彼此相对定位的第一和第二牵开器部分。该系统还包括至少一个致动构件，其可操作以向第一牵拉器部分和第二牵拉器部分中的至少一个提供摆动运动。致动构件与控制器连通并且响应于控制器在第一位置和第二位置之间移动和调节第一牵拉器部分和第二牵拉器部分中的至少一个。该系统还包括至少一个压力传感器和显示器以及至少一个具有显示器的定时电路。在另一种形式中，一种方法涉及使用压力传感器缩回用于经皮进入患者手术部位的组织，并且如同计时电路和显示器那样显示，以确保施加的压力量和持续时间不超过预先设定的时间 - 确定的值。

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