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1. 发明申请

WO2007146616A3 DEVICES AND METHODS FOR DETECTION OF MARKERS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：用于检测具有或不具有RADICULOPATHY的轴向疼痛标记物的装置和方法
公开(公告)号：WO2007146616A3
公开(公告)日：2008-04-10
申请号：PCT/US2007070174
申请日：2007-06-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
发明人： MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
IPC分类号： A61B5/00 , A61B5/03 , A61B5/06 , A61B17/00 , A61B17/56 , C12Q1/00 , G01N33/94
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

2. 发明申请

WO2007146595A3 COMPOSITIONS AND METHODS FOR DIAGNOSIS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：用于诊断具有或不具有RADICULOPATHY的轴向疼痛的组合物和方法
公开(公告)号：WO2007146595A3
公开(公告)日：2008-09-12
申请号：PCT/US2007070019
申请日：2007-05-31
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , TRIEU HAI H , ROY JOSEE , GROSS JEFFREY M , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
发明人： MCKAY WILLIAM F , TRIEU HAI H , ROY JOSEE , GROSS JEFFREY M , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
IPC分类号： A61K51/00 , A61K49/00 , A61K49/06
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了与成像技术一起使用并且可用于诊断和监测具有或不具有神经根病变的轴痛的疼痛发生器的方法和组合以及用于筛选潜在地可用于治疗具有或不具有神经根病变的轴向疼痛的治疗化合物的方法和组合物。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。疼痛标记和变性标记包括神经元，血管，免疫和基质元件的标记。

3. 发明申请

WO2007146616B1 DEVICES AND METHODS FOR DETECTION OF MARKERS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：装置和方法用于检测具有或不具有放射性皮炎的轴向疼痛标记物
公开(公告)号：WO2007146616B1
公开(公告)日：2008-06-12
申请号：PCT/US2007070174
申请日：2007-06-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
发明人： MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
IPC分类号： A61B5/00 , A61B5/03 , A61B5/06 , A61B17/00 , A61B17/56 , C12Q1/00 , G01N33/94
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了用于诊断和监测有或没有神经根病的轴向疼痛的疼痛发生器的装置和相关方法和组合物，以及用于筛选可能用于治疗有或没有神经根病的轴向疼痛的试验化合物的方法。或者，退化的椎间盘可以在发生病理性疼痛症状之前进行监测和治疗。退化椎间盘的疼痛标记和标记包括神经元，血管，免疫和基质元素的标记。

4. 发明申请

WO2008005676A3 INJECTABLE COLLAGEN MATERIAL 审中-公开
标题翻译：可注射胶原材料
公开(公告)号：WO2008005676A3
公开(公告)日：2008-02-21
申请号：PCT/US2007071292
申请日：2007-06-15
申请人： WARSAW ORTHOPEDIC INC , TRIEU HAI H , HADDOCK SEAN M , SIMONTON T ANDREW , GROSS JEFFREY M , KINNANE KEITH M
发明人： TRIEU HAI H , HADDOCK SEAN M , SIMONTON T ANDREW , GROSS JEFFREY M , KINNANE KEITH M
IPC分类号： A61K9/00 , A61K31/00 , A61L17/08
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/00 , A61K31/728 , A61L27/24 , A61L2400/06 , A61L2430/38
摘要： A collagen material is disclosed and can include a plurality of particles. Each particle can include an elongated, thin body having one or more arcuate portions and one or more straight portions. Further, each particle can include one or more fibers extending from the body. One or more fibers of one particle can engage the one or more fibers of one or more other particles to establish a matrix of material.
摘要翻译：公开了胶原材料并且可以包含多个颗粒。每个颗粒可以包括具有一个或多个弓形部分和一个或多个直线部分的细长主体。此外，每个颗粒可以包括从身体延伸的一种或多种纤维。一个颗粒的一个或多个纤维可以接合一个或多个其他颗粒的一个或多个纤维以建立材料的基质。

5. 发明申请

WO2007002339A3 OSTEOGRAFT TREATMENT TO PROMOTE OSTEOINDUCTION AND OSTEOGRAFT INCORPORATION 审中-公开
标题翻译： OSTEOGRAFT治疗促进骨质疏松和骨质疏松综合征
公开(公告)号：WO2007002339A3
公开(公告)日：2008-03-06
申请号：PCT/US2006024389
申请日：2006-06-21
申请人： WARSAW ORTHOPEDIC INC , GROSS JEFFREY M , MCKAY WILLIAM F , ZANELLA JOHN M
发明人： GROSS JEFFREY M , MCKAY WILLIAM F , ZANELLA JOHN M
IPC分类号： A61L27/54 , A61F2/28
CPC分类号： A61F2/28 , A61F2/4601 , A61F2/4644 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/3021 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30677 , A61F2002/3068 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0068 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/602 , A61L2300/64 , A61L2430/02
摘要： The invention provides a bone implant, or osteograft, with improved retention of bioactive agents within the surface of the osteograft. Pits or pits formed within the surface of the osteograft have porous plugs placed within them to retain fluid comprising bioactive agents. Pits can also be formed so that the dimensions of the pits facilitate retention of fluid within a pit by hydrostatic attraction of fluid molecules within the pit.
摘要翻译：本发明提供了骨移植物或骨移植物，其具有改善的生物活性剂在骨移植物表面内的保留性。在骨移植物表面内形成的凹坑或凹坑具有置于其内的多孔塞子以保持包含生物活性剂的流体。还可以形成凹坑，使得凹坑的尺寸通过液体分子在凹坑内的静水吸引而促进流体在凹坑内的保留。

6. 发明申请

WO2007127666A2 VENTED DIRECTIONAL DELIVERY CANNULA WITH OPENINGS OF DIFFERENT SHAPE FOR USE WITH FLOWABLE MATERIALS AND METHOD FOR USE THEREOF 审中-公开
标题翻译：具有不同形状的开口的可通过流动的材料使用的方向传送肛门及其使用方法
公开(公告)号：WO2007127666A2
公开(公告)日：2007-11-08
申请号：PCT/US2007066964
申请日：2007-04-19
申请人： WARSAW ORTHOPEDIC INC , GROSS JEFFREY M , SERBOUSEK JON C
发明人： GROSS JEFFREY M , SERBOUSEK JON C
CPC分类号： A61B17/8811
摘要： ABSTRACT In one preferred aspect, a cannula is provided that has openings of different shape to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different shape into a patient.
摘要翻译：摘要在一个优选的方面，提供具有不同形状的开口的插管，以允许外科医生选择性地控制可流动材料通过插管并进入患者的分布模式。在另一方面，提供了一种方法，用于选择性地控制可流动材料通过具有不同形状的开口的套管到患者体内的分布模式。

7. 发明申请

WO2007126989A3 VENTED DIRECTIONAL DELIVERY CANNULA 审中-公开
公开(公告)号：WO2007126989A3
公开(公告)日：2008-04-24
申请号：PCT/US2007007815
申请日：2007-03-29
申请人： WARSAW ORTHOPEDIC INC , GROSS JEFFREY M , SERBOUSEK JON
发明人： GROSS JEFFREY M , SERBOUSEK JON
IPC分类号： A61M25/14
CPC分类号： A61B17/8811
摘要： In one preferred aspect, a cannula is provided that has openings of different size to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a cannula is provided that has openings of different shape to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different size into a patient. In yet another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different shape into a patient.
摘要翻译：在一个优选的方面，提供具有不同尺寸的开口的插管，以允许外科医生选择性地控制可流动材料通过插管并进入患者的分布模式。在另一方面，提供具有不同形状的开口的插管，以允许外科医生选择性地控制可流动材料通过插管并进入患者体内的分布模式。在另一方面，提供了一种方法，用于选择性地控制可流动材料通过具有不同尺寸开口的插管到患者体内的分布模式。在另一方面，提供了一种用于选择性地控制可流动材料通过具有不同形状的开口的套管到患者体内的分布模式的方法。

8. 发明申请

WO2007127666B1 CANNULA WITH OPENINGS OF DIFFERENT SHAPE FOR DELIVERING FLOWABLE MATERIALS AND METHOD FOR USE THEREOF 审中-公开
标题翻译：具有不同形状的开口用于递送可流动材料的肛门及其使用方法
公开(公告)号：WO2007127666B1
公开(公告)日：2008-02-28
申请号：PCT/US2007066964
申请日：2007-04-19
申请人： WARSAW ORTHOPEDIC INC , GROSS JEFFREY M , SERBOUSEK JON C
发明人： GROSS JEFFREY M , SERBOUSEK JON C
IPC分类号： A61B17/88
CPC分类号： A61B17/8811
摘要： In one preferred aspect, a cannula is provided that has openings of different shape to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different shape into a patient.
摘要翻译：在一个优选的方面，提供具有不同形状的开口的插管，以允许外科医生选择性地控制通过插管并进入患者的可流动材料的分布模式。在另一方面，提供了一种方法，用于选择性地控制可流动材料通过具有不同形状的开口的套管到患者体内的分布模式。

9. 发明申请

WO2008036580A3 COMPRESSION MOLDING METHOD FOR MAKING BIOMATERIAL COMPOSITES 审中-公开
标题翻译：用于制备生物材料复合材料的压缩成型方法
公开(公告)号：WO2008036580A3
公开(公告)日：2009-04-30
申请号：PCT/US2007078606
申请日：2007-09-17
申请人： WARSAW ORTHOPEDIC INC , HADDOCK SEAN M , KINNANE KEITH M , GROSS JEFFREY M , LYU SUPING , LOY BRIAN A , HOBOT CHRISTOPHER M , SPARER RANDALL V
发明人： HADDOCK SEAN M , KINNANE KEITH M , GROSS JEFFREY M , LYU SUPING , LOY BRIAN A , HOBOT CHRISTOPHER M , SPARER RANDALL V
IPC分类号： B29C43/00 , A61L27/36 , A61L27/40 , A61L27/46 , A61L27/54 , B29C45/00
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/3683 , A61L27/58 , C08L67/04
摘要： A process for making an implantable material comprising a composite of a biocompatible polymer and a bioactive agent. The composite combines desirable mechanical properties of polymers and the bioactivity of tissue or one or more component of tissue. More particularly, but not exclusively, the invention relates to methods for the manufacture of implantable materials, devices and components via a powder molding process.
摘要翻译：一种用于制造可植入材料的方法，其包括生物相容性聚合物和生物活性剂的复合物。该复合物结合聚合物的所需机械性能和组织的生物活性或组织的一种或多种组分。更具体地但不排他地，本发明涉及通过粉末成型工艺制造可植入材料，装置和部件的方法。

10. 发明专利

AU2007244933A1 Cannula with openings of different shape for delivering flowable materials and method for use thereof 未知
公开(公告)号：AU2007244933A1
公开(公告)日：2007-11-08
申请号：AU2007244933
申请日：2007-04-19
申请人： WARSAW ORTHOPEDIC INC
发明人： GROSS JEFFREY M , SERBOUSEK JON C
IPC分类号： A61B17/88

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