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1. 发明申请

WO2006108135A2 LASER MICRODISSECTION AND MICROARRAY ANALYSIS OF BREAST TUMORS REVEAL ESTROGEN RECEPTOR RELATED GENES AND PATHWAYS 审中-公开
标题翻译：乳腺肿瘤的激光微观分析和微观分析相关基因和途径
公开(公告)号：WO2006108135A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/013004
申请日：2006-04-03
申请人： WANG, Yixin , LEHNHARDT, Susan , YU, Jack , JIANG, Yuqiu , YANG, Fei
发明人： YU, Jack , JIANG, Yuqiu , YANG, Fei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： About 70% to 80% of breast cancers express estrogen receptor-α (ERa), and estrogens play important roles in the development and growth of hormone-dependent tumors. Together with lymph node metastasis, tumor size and histological grade, ER status is considered one of the prognostic factors in breast cancer, and an indicator for hormonal treatment. 147 genes and 112 genes with significant P- value and having significant differential expression between ER+ and ER- tumors were identified from the LCM data set and bulk tissue data set, respectively. 61 genes were found to be common in both data sets, while 85 genes were unique to the LCM data set and 51 genes were present only in the bulk tumor data set. Pathway analysis with the 85 genes using Gene Ontology suggested that genes involved in endocytosis, ceramide generation, Ras/ERK/Ark cascade, and JAT- STAT pathway may play roles related to ER. The gene profiling with LCM-captured tumpr cells provides a unique approach to characterize and study epithelial tumor cells and to gain an insight into signaling pathways associated with ER.
摘要翻译：大约70％至80％的乳腺癌表达雌激素受体-a（ERα），雌激素在激素依赖性肿瘤的发育和生长中起重要作用。与淋巴结转移，肿瘤大小和组织学分级一起，ER状态被认为是乳腺癌的预后因素之一，也是激素治疗的指标。分别从LCM数据集和体组织数据集中分别鉴定了147个基因和112个具有显着P值且具有ER +和ER-肿瘤差异表达的基因。发现61个基因在两个数据集中都是常见的，而85个基因是LCM数据集所独有的，51个基因仅存在于肿瘤数据集中。使用Gene Ontology的85个基因的途径分析表明，参与内吞作用，神经酰胺生成，Ras / ERK / Ark级联和JAT-STAT通路的基因可能发挥与ER相关的作用。用LCM捕获的Tumpr细胞进行基因分析提供了一种独特的方法来表征和研究上皮肿瘤细胞，并获得与ER相关的信号传导途径的洞察。

2. 发明公开

EP1874960A2 LASER MICRODISSECTION AND MICROARRAY ANALYSIS OF BREAST TUMORS REVEAL ESTROGEN RECEPTOR RELATED GENES AND PATHWAYS 审中-公开
标题翻译：激光显微切割和乳腺肿瘤微阵列分析与雌激素受体相关基因和途径SHOW
公开(公告)号：EP1874960A2
公开(公告)日：2008-01-09
申请号：EP06749496.3
申请日：2006-04-03
申请人： Veridex, LLC , Lehnhardt, Susan , Yu, Jack , Jiang, Yuqiu , Yang, Fei
发明人： YU, Jack , JIANG, Yuqiu , YANG, Fei , WANG, Yixin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158

3. 发明申请

WO2006127537A3 THYROID FINE NEEDLE ASPIRATION MOLECULAR ASSAY 审中-公开
公开(公告)号：WO2006127537A3
公开(公告)日：2006-11-30
申请号：PCT/US2006/019615
申请日：2006-05-18
申请人： VERIDEX, LLC , JIANG, Yuqiu , BACKUS, John, W. , MAZUMDER, Abhijit , CHOWDARY, Dondapati , YANG, Fei , WANG, Yixin , JATKOE, Timothy
发明人： JIANG, Yuqiu , BACKUS, John, W. , MAZUMDER, Abhijit , CHOWDARY, Dondapati , YANG, Fei , WANG, Yixin , JATKOE, Timothy
IPC分类号： C12Q1/68 , G01N33/53
摘要： The present invention relates to methods, compositions and articles directed to diagnosing thyroid carcinoma, differentiating between thyroid carcinoma and benign thyroid diseases, testing indeterminate thyroid fine needle aspirate samples of thyroid nodules, and determining patient protocols and outcomes.

4. 发明申请

WO2013025373A1 SYSTEM AND METHOD FOR MUTING AUDIO ASSOCIATED WITH A SOURCE 审中-公开
标题翻译：用于静音与音源相关的系统和方法
公开(公告)号：WO2013025373A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/049485
申请日：2012-08-03
申请人： CISCO TECHNOLOGY, INC. , MAUCHLY, William, J. , KUNAPULI, Subrahmanyam, V. , YANG, Fei
发明人： MAUCHLY, William, J. , KUNAPULI, Subrahmanyam, V. , YANG, Fei
IPC分类号： H04M3/56 , H04N7/15
CPC分类号： H04M3/568 , H04M3/564 , H04M2203/5072 , H04M2203/509 , H04N7/15
摘要： In one embodiment, a method includes receiving audio at a plurality of microphones, identifying a sound source to be muted, processing the audio to remove sound received from the sound source at each of the microphones, and transmitting the processed audio. An apparatus is also disclosed.
摘要翻译：在一个实施例中，一种方法包括在多个麦克风处接收音频，识别要被静音的声源，处理音频以移除在每个麦克风处从声源接收的声音，以及发送所处理的音频。还公开了一种装置。

5. 发明申请

WO2010042855A1 IMPROVED MONITOR OF HEART FAILURE USING BIOIMPEDANCE 审中-公开
标题翻译：改善使用生物利益的心脏失败的监测器
公开(公告)号：WO2010042855A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060223
申请日：2009-10-09
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , PATTERSON, Robert , YANG, Fei
发明人： PATTERSON, Robert , YANG, Fei
IPC分类号： A61B5/02
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/4878 , A61N1/36521
摘要： In a method of monitoring pulmonary edema in a human being, an electrical current is injected between a first electrode located in or around a heart and a housing of a medical device implanted in a chest region. A voltage potential is measured between a second electrode in a superior vena cava and a third electrode in the superior vena cava, where the voltage potential is created by the electrical current. Pulmonary edema is assessed based on an impedance value calculated from the electrical current and the voltage potential and a stored edema threshold impedance value.
摘要翻译：在监测人的肺水肿的方法中，在位于心脏中或周围的第一电极和植入胸部区域的医疗装置的壳体之间注入电流。在上腔静脉中的第二电极和上腔静脉中的第三电极之间测量电压电位，其中电压由电流产生。基于从电流和电压电位计算的阻抗值以及存储的水肿阈值阻抗值来评估肺水肿。

6. 发明申请

WO2009055699A1 METHODS FOR GENETIC MANIPULATION OF EXTREMOPHILES 审中-公开
标题翻译：用于遗传调控外源性的方法
公开(公告)号：WO2009055699A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081157
申请日：2008-10-24
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , ADAMS, Michael, W.W. , YANG, Fei , WESTPHELING, Janet
发明人： ADAMS, Michael, W.W. , YANG, Fei , WESTPHELING, Janet
IPC分类号： C12N15/74 , C12N15/90
CPC分类号： C12N15/74
摘要： Provided herein are methods for introducing a polynucleotide into an extremophile, such as Pyrococcus fitriosis, by conjugation with a member of the family Enterobacteriaceae. Also provided are genetically engineered extremophiles, such as Pyrococcus furiosiis, that include an exogenous polynucleotide integrated into genomic DNA.
摘要翻译：本文提供了通过与肠杆菌科的成员缀合将多核苷酸引入极端亲本（例如火球菌属）的方法。还提供了遗传工程化的极端亲子，例如激素裂殖酵母，其包括整合到基因组DNA中的外源多核苷酸。

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