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1. 发明申请

WO2010042855A1 IMPROVED MONITOR OF HEART FAILURE USING BIOIMPEDANCE 审中-公开
标题翻译：改善使用生物利益的心脏失败的监测器
公开(公告)号：WO2010042855A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060223
申请日：2009-10-09
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , PATTERSON, Robert , YANG, Fei
发明人： PATTERSON, Robert , YANG, Fei
IPC分类号： A61B5/02
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/4878 , A61N1/36521
摘要： In a method of monitoring pulmonary edema in a human being, an electrical current is injected between a first electrode located in or around a heart and a housing of a medical device implanted in a chest region. A voltage potential is measured between a second electrode in a superior vena cava and a third electrode in the superior vena cava, where the voltage potential is created by the electrical current. Pulmonary edema is assessed based on an impedance value calculated from the electrical current and the voltage potential and a stored edema threshold impedance value.
摘要翻译：在监测人的肺水肿的方法中，在位于心脏中或周围的第一电极和植入胸部区域的医疗装置的壳体之间注入电流。在上腔静脉中的第二电极和上腔静脉中的第三电极之间测量电压电位，其中电压由电流产生。基于从电流和电压电位计算的阻抗值以及存储的水肿阈值阻抗值来评估肺水肿。

2. 发明申请

WO2006088805A2 PATHOLOGY ASSESSMENT WITH IMPEDANCE MEASUREMENTS USING CONVERGENT BIOELECTRIC LEAD FIELDS 审中-公开
标题翻译：使用融合式电子导联领域进行阻抗测量的病理评估
公开(公告)号：WO2006088805A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005060
申请日：2006-02-14
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , BELALCAZAR, Andres , PATTERSON, Robert
发明人： BELALCAZAR, Andres , PATTERSON, Robert
IPC分类号： A61B5/05
CPC分类号： A61B5/416 , A61B5/0537 , A61B5/4519
摘要： A method and apparatus for measuring impedance for pathology assessment in a living being using convergent bioelectric lead fields is disclosed, including injecting a current between first and second electrodes implanted in a body of a living being, where the first and second electrodes define a first electric lead field oriented between the first and second electrodes. A potential difference is measured between third and fourth electrodes implanted in the body, where the potential difference results from the current injected between the first and second electrodes. The third and fourth electrodes define a second electric lead field oriented between the third and fourth electrodes. The first and second electric lead fields converge near an assessment site within the body, but are substantially separated otherwise. An impedance value is calculated based on the potential difference and the current injection, and is used to assess a pathology near the assessment site.
摘要翻译：公开了一种用于测量在使用会聚生物电场领域的生物中的病理学评估阻抗的方法和装置，包括在植入生物体内的第一和第二电极之间注入电流，其中第一和第二电极限定第一电引线场定向在第一和第二电极之间。在植入体内的第三和第四电极之间测量电位差，其中电位差由注入在第一和第二电极之间的电流产生。第三和第四电极限定了定向在第三和第四电极之间的第二电引线场。第一和第二电引线场在体内的评估位点附近收敛，但是基本上彼此分离。基于电位差和电流注入计算阻抗值，并用于评估评估点附近的病理学。

3. 发明申请

WO2004047638A1 IMPEDANCE MONITORING FOR DETECTING PULMONARY EDEMA AND THORACIC CONGESTION 审中-公开
标题翻译：用于检测肺动脉高压和胸腔积液的阻抗监测
公开(公告)号：WO2004047638A1
公开(公告)日：2004-06-10
申请号：PCT/US2003/037549
申请日：2003-11-24
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , BELALCAZAR, Andres , PATTERSON, Robert , SHULT, Rebecca
发明人： BELALCAZAR, Andres , PATTERSON, Robert , SHULT, Rebecca
IPC分类号： A61B5/053
CPC分类号： A61B5/4869 , A61B5/053 , A61B5/4878
摘要： An implantable medical device (30) includes a housing (32) for the implantable device that is sized for implantation in a chest region of a patient and includes a housing electrode (46). A left ventricular lead port (36) is connectable to a proximal end of a lead (38) having first and second insulated conductors that extend from the proximal end of the lead to corresponding first and second electrodes (42a, 42b) near a distal end of the lead. An electrical impedance measurement circuit (34) is electrically connected to the left ventricular lead port (36) and the housing electrode (46). The circuit may inject current between the first lead electrode (42b) and the housing electrode (46), and measure a voltage potential, created by the current injection, between the second lead electrode (42a) and the housing electrode (46). The ratio of the measured voltage to injected current may be used for assessing pulmonary edema. The lead electrodes (42a, 42b) may be located in a left ventricular coronary vein.
摘要翻译：可植入医疗装置（30）包括用于可植入装置的壳体（32），其尺寸适于植入患者的胸部区域并且包括壳体电极（46）。左心室引导端口（36）可连接到引线（38）的近端，引线（38）的近端具有从引线的近端延伸到相应的第一和第二电极（42a，42b）的远端的第一和第二绝缘导体的领先。电阻抗测量电路（34）电连接到左心室引导端口（36）和外壳电极（46）。电路可以在第一引线电极（42b）和外壳电极（46）之间注入电流，并且测量在第二引线电极（42a）和外壳电极（46）之间由电流注入产生的电压。测量电压与注射电流的比值可用于评估肺水肿。引线电极（42a，42b）可以位于左心室冠状静脉中。

4. 发明公开

EP1848334A2 PATHOLOGY ASSESSMENT WITH IMPEDANCE MEASUREMENTS USING CONVERGENT BIOELECTRIC LEAD FIELDS 审中-公开
标题翻译：症状阻抗测量用会聚生物LEAD FIELDS评价
公开(公告)号：EP1848334A2
公开(公告)日：2007-10-31
申请号：EP06734952.2
申请日：2006-02-14
申请人： The Regents of the University of Minnesota
发明人： BELALCAZAR, Andres , PATTERSON, Robert
IPC分类号： A61B5/05
CPC分类号： A61B5/416 , A61B5/0537 , A61B5/4519
摘要： A method and apparatus for measuring impedance for pathology assessment in a living being using convergent bioelectric lead fields is disclosed, including injecting a current between first and second electrodes implanted in a body of a living being, where the first and second electrodes define a first electric lead field oriented between the first and second electrodes. A potential difference is measured between third and fourth electrodes implanted in the body, where the potential difference results from the current injected between the first and second electrodes. The third and fourth electrodes define a second electric lead field oriented between the third and fourth electrodes. The first and second electric lead fields converge near an assessment site within the body, but are substantially separated otherwise. An impedance value is calculated based on the potential difference and the current injection, and is used to assess a pathology near the assessment site.

5. 发明授权

EP1565108B1 IMPEDANCE MONITORING FOR DETECTING PULMONARY EDEMA AND THORACIC CONGESTION 有权
标题翻译：阻抗监测FOR发现乳腺癌肺水肿和收集
公开(公告)号：EP1565108B1
公开(公告)日：2010-01-06
申请号：EP03783759.8
申请日：2003-11-24
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： BELALCAZAR, Andres , PATTERSON, Robert , SHULT, Rebecca
IPC分类号： A61B5/053
CPC分类号： A61B5/4869 , A61B5/053 , A61B5/4878
摘要： An implantable medical device (30) includes a housing (32) for the implantable device that is sized for implantation in a chest region of a patient and includes a housing electrode (46). A left ventricular lead port (36) is connectable to a proximal end of a lead (38) having first and second insulated conductors that extend from the proximal end of the lead to corresponding first and second electrodes (42a, 42b) near a distal end of the lead. An electrical impedance measurement circuit (34) is electrically connected to the left ventricular lead port (36) and the housing electrode (46). The circuit may inject current between the first lead electrode (42b) and the housing electrode (46), and measure a voltage potential, created by the current injection, between the second lead electrode (42a) and the housing electrode (46). The ratio of the measured voltage to injected current may be used for assessing pulmonary edema. The lead electrodes (42a, 42b) may be located in a left ventricular coronary vein.

6. 发明公开

EP2348970A1 IMPROVED MONITOR OF HEART FAILURE USING BIOIMPEDANCE 审中-公开
标题翻译：改进MONITOR心力衰竭由生物阻抗监测
公开(公告)号：EP2348970A1
公开(公告)日：2011-08-03
申请号：EP09819976.3
申请日：2009-10-09
申请人： Regents of the University of Minnesota
发明人： PATTERSON, Robert , YANG, Fei
IPC分类号： A61B5/02
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/4878 , A61N1/36521
摘要： In a method of monitoring pulmonary edema in a human being, an electrical current is injected between a first electrode located in or around a heart and a housing of a medical device implanted in a chest region. A voltage potential is measured between a second electrode in a superior vena cava and a third electrode in the superior vena cava, where the voltage potential is created by the electrical current. Pulmonary edema is assessed based on an impedance value calculated from the electrical current and the voltage potential and a stored edema threshold impedance value.

7. 发明公开

EP1565108A1 IMPEDANCE MONITORING FOR DETECTING PULMONARY EDEMA AND THORACIC CONGESTION 有权
标题翻译：阻抗监测FOR发现乳腺癌肺水肿和收集
公开(公告)号：EP1565108A1
公开(公告)日：2005-08-24
申请号：EP03783759.8
申请日：2003-11-24
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： BELALCAZAR, Andres , PATTERSON, Robert , SHULT, Rebecca
IPC分类号： A61B5/053
CPC分类号： A61B5/4869 , A61B5/053 , A61B5/4878
摘要： An implantable medical device (30) includes a housing (32) for the implantable device that is sized for implantation in a chest region of a patient and includes a housing electrode (46). A left ventricular lead port (36) is connectable to a proximal end of a lead (38) having first and second insulated conductors that extend from the proximal end of the lead to corresponding first and second electrodes (42a, 42b) near a distal end of the lead. An electrical impedance measurement circuit (34) is electrically connected to the left ventricular lead port (36) and the housing electrode (46). The circuit may inject current between the first lead electrode (42b) and the housing electrode (46), and measure a voltage potential, created by the current injection, between the second lead electrode (42a) and the housing electrode (46). The ratio of the measured voltage to injected current may be used for assessing pulmonary edema. The lead electrodes (42a, 42b) may be located in a left ventricular coronary vein.

8. 发明申请

WO2021173443A1 ADHESIVE EYEBROW COVER 审中-公开
公开(公告)号：WO2021173443A1
公开(公告)日：2021-09-02
申请号：PCT/US2021/018809
申请日：2021-02-19
申请人： PATTERSON, Natalie , PATTERSON, Robert
发明人： PATTERSON, Natalie , PATTERSON, Robert
IPC分类号： A61F13/12 , A45D40/30 , A45D44/00 , A61F13/02 , A61F15/00 , B23B9/00
摘要： An eyebrow cover has a primary layer, an adhesive layer, an adhesive release liner, and a top release liner. The primary layer may be flexible so as to conform to an eyebrow and the structure of a user's face. The primary layer may be shaped so as to surround the eyebrow, minimizing excess coverage on the face while protecting the microblading procedure. Further, the adhesive layer may surround a non-adhesive portion of a lower surface of the primary layer. To protect the eyebrow cover, the adhesive release liner may releasably adhere to the adhesive layer.

9. 发明申请

WO2005110051A2 PORTABLE DEVICE FOR MONITORING ELECTROCARDIOGRAPHIC SIGNALS AND INDICES OF BLOOD FLOW 审中-公开
标题翻译：用于监测电子信号的便携式设备和血液流量指示
公开(公告)号：WO2005110051A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/016396
申请日：2005-05-10
申请人： TRANSOMA MEDICAL, INC. , BENDITT, David, G. , PATTERSON, Robert , LURIE, Keith, G.
发明人： BENDITT, David, G. , PATTERSON, Robert , LURIE, Keith, G.
IPC分类号： A61B5/00 , A61B5/02 , A61B5/0205 , A61B5/021 , A61B5/026 , A61B5/04 , A61B5/0464 , A61B5/05 , A61B5/053
CPC分类号： A61B5/026 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/021 , A61B5/0295 , A61B5/0464 , A61B5/0535 , A61B5/6837
摘要： Embodiments of the present invention are directed to a physiological monitoring device which is configured to record signals that reflect blood flow and/or blood pressure, and which may also record ECG signals. In one embodiment, a portable monitoring device comprises a plurality of impedance electrodes configured to be coupled to a patient's body and to generate an AC current with an electrical field to detect local electrical impedance of a portion of the patient's body encompassed by the electrical field, the local electrical impedance being a surrogate measure of local blood flow of the portion of the patient's body. At least a portion of the portable monitoring device is configured to be insertable subcutaneously into the patient's body.
摘要翻译：本发明的实施例涉及一种生理监测装置，其被配置为记录反映血流和/或血压的信号，并且还可以记录ECG信号。在一个实施例中，便携式监视设备包括多个阻抗电极，其被配置为耦合到患者的身体并且产生具有电场的AC电流以检测由电场包围的患者身体的一部分的局部电阻抗，局部电阻抗是患者身体部分局部血流量的替代量度。便携式监视装置的至少一部分被配置为可皮下地插入患者体内。

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