专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1995029712A1 IMPROVED BLOOD CONTACT SURFACES USING EXTRACELLULAR MATRIX SYNTHESIZED IN VITRO 审中-公开
标题翻译：改进的血液接触表面使用体外合成的细胞基质
公开(公告)号：WO1995029712A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005298
申请日：1995-04-28
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： W.L. GORE & ASSOCIATES, INC. , BRUCHMAN, William, C. , BEGOVAC, Paul, C.
IPC分类号： A61L27/00
CPC分类号： A61L27/507 , A61F2/06 , Y10S623/916
摘要： This invention is directed to improved blood contact devices such as vascular prostheses rendered substantially nonthrombogenic through addition of a preserved layer of extracellular subendothelial matrix. The preserved subendothelial matrix layer, which serves as the blood interface of the device, is analogous to the subendothelial matrix layer beneath the endothelium of native vascular surfaces. The device consists of a permanent synthetic base material, preferably porous expanded polytetrafluoroethylene, on which this biologic layer of subendothelial matrix is grown in situ. The biologic layer is produced using in vitro tissue culture methods whereby living cells synthesize and deposit extracellular matrix components, after which the cells are killed and/or removed and the subendothelial matrix layer preserved before implantation. A key aspect of this invention is that no living cells are present in the final configuration, so that the likelihood of recipient immunological response is minimized. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm or less.
摘要翻译：本发明涉及通过添加细胞外内皮下基质的保留层而改进的血液接触装置，例如基本上不引起血管假体的血液假体。用作装置血液界面的保留的内皮下基质层类似于天然血管表面内皮下面的内皮下基质层。该装置由永久性合成基础材料，优选多孔膨胀聚四氟乙烯组成，该生物层内皮下基质在其上原位生长。使用体外组织培养方法产生生物层，其中活细胞合成并沉积细胞外基质组分，之后细胞被杀死和/或去除，并且内皮下基质层在植入前保留。本发明的关键方面是在最终配置中不存在活细胞，使得受体免疫应答的可能性最小化。本发明导致对于需要直径为6mm或更小的动脉旁路特别有用的血管假体。

2. 发明申请

WO1995029713A1 IMPROVED BLOOD CONTACT SURFACES USING ENDOTHELIUM ON A SUBENDOTHELIAL EXTRACELLULAR MATRIX 审中-公开
标题翻译：使用内皮细胞的改良血液接触表面在细胞外细胞基质上
公开(公告)号：WO1995029713A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005299
申请日：1995-04-28
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： W.L. GORE & ASSOCIATES, INC. , BRUCHMAN, William, C. , BEGOVAC, Paul, C.
IPC分类号： A61L27/00
CPC分类号： A61L27/507 , A61F2/06 , A61L27/16 , C08L27/18
摘要： This invention relates to improved blood contact devices such as vascular prostheses rendered antithrombotic through the use of recipient endothelial cells grown on an appropriate subendothelial matrix. The subendothelial matrix layer, which serves as the substratum for growing endothelial cells, may be obtained from either natural donor vessels or from in vitro tissue culture sources. This subendothelial matrix is used in situ on the donor vessel, or is grown or applied to a synthetic component, preferably porous expanded polytetrafluoroethylene. Once this subendothelial matrix is prepared, recipient endothelial cells are seeded onto this matrix substratum, which then serves as the immediate blood contact surface. The endothelial cells may be applied as an intra-operative procedure, or grown on the subendothelial matrix substratum in vitro until the cells establish a confluent monolayer. A key aspect of this invention is that living, recipient endothelial cells are grown on the appropriate subendothelial matrix substratum, thereby providing a substantially nonthrombotic blood contact surface. Furthermore, the likelihood of recipient immunological response is minimized. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm or less.
摘要翻译：本发明涉及通过使用在合适的内皮下基质上生长的受体内皮细胞，改进的血液接触装置，例如血管假体呈现抗血栓形成。用作生长内皮细胞的底物的内皮下基质层可以从天然供体血管或体外组织培养来源获得。该内皮下基质在供体血管上原位使用，或生长或应用于合成成分，优选多孔膨胀聚四氟乙烯。一旦制备了该内皮下基质，将受体内皮细胞接种到该基质底物上，然后其作为即时血液接触表面。内皮细胞可以作为手术中的程序施用，或者在体外在内皮下基质底物上生长，直到细胞建立汇合的单层。本发明的一个关键方面是，活的受体内皮细胞在适当的内皮下基质基质上生长，从而提供基本上非血栓的血液接触表面。此外，受体免疫应答的可能性最小化。本发明导致对于需要直径为6mm或更小的动脉旁路特别有用的血管假体。

4. 发明公开

EP0757563A1 IMPROVED BLOOD CONTACT SURFACES USING EXTRACELLULAR MATRIX SYNTHESIZED IN VITRO 失效
标题翻译：血液接触面使用合成的体外细胞外基质
公开(公告)号：EP0757563A1
公开(公告)日：1997-02-12
申请号：EP95917749.0
申请日：1995-04-28
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： BRUCHMAN, William, C. , BEGOVAC, Paul, C.
IPC分类号： A61L27 , A61F2 , A61L33
CPC分类号： A61L27/507 , A61F2/06 , Y10S623/916
摘要： This invention is directed to improved blood contact devices such as vascular prostheses rendered substantially nonthrombogenic through addition of a preserved layer of extracellular subendothelial matrix. The preserved subendothelial matrix layer, which serves as the blood interface of the device, is analogous to the subendothelial matrix layer beneath the endothelium of native vascular surfaces. The device consists of a permanent synthetic base material, preferably porous expanded polytetrafluoroethylene, on which this biologic layer of subendothelial matrix is grown in situ. The biologic layer is produced using in vitro tissue culture methods whereby living cells synthesize and deposit extracellular matrix components, after which the cells are killed and/or removed and the subendothelial matrix layer preserved before implantation. A key aspect of this invention is that no living Cells are present in the final configuration, so that the likelihood of recipient immunological response is minimized. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm or less.

5. 发明公开

EP0757562A1 IMPROVED BLOOD CONTACT SURFACES USING ENDOTHELIUM ON A SUBENDOTHELIAL EXTRACELLULAR MATRIX 失效
标题翻译：血液接触表面USING内皮上的SUBENDOTELIALEN细胞外基质
公开(公告)号：EP0757562A1
公开(公告)日：1997-02-12
申请号：EP95917203.0
申请日：1995-04-28
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： BRUCHMAN, William, C. , BEGOVAC, Paul, C.
IPC分类号： A61L27 , A61F2 , A61L33
CPC分类号： A61L27/507 , A61F2/06 , A61L27/16 , C08L27/18
摘要： This invention relates to improved blood contact devices such as vascular prostheses rendered antithrombotic through the use of recipient endothelial cells grown on an appropriate subendothelial matrix. The subendothelial matrix layer, which serves as the substratum for growing endothelial cells, may be obtained from either natural donor vessels or from in vitro tissue culture sources. This subendothelial matrix is used in situ on the donor vessel, or is grown or applied to a synthetic component, preferably porous expanded polytetrafluoroethylene. Once this subendothelial matrix is prepared, recipient endothelial cells are seeded onto this matrix substratum, which then serves as the immediate blood contact surface. The endothelial cells may be applied as an intra-operative procedure, or grown on the subendothelial matrix substratum in vitro until the cells establish a confluent monolayer. A key aspect of this invention is that living, recipient endothelial cells are grown on the appropriate subendothelial matrix substratum, thereby providing a substantially nonthrombotic blood contact surface. Furthermore, the likelihood of recipient immunological response is minimized. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm or less.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式