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1. 发明授权

US06524301B1 Guidewire with an intermediate variable stiffness section 有权
标题翻译：导丝具有中间可变刚度部分
公开(公告)号：US06524301B1
公开(公告)日：2003-02-25
申请号：US09748294
申请日：2000-12-21
申请人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
发明人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
IPC分类号： A61M2500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09133
摘要： The invention is directed to an guide wire for intraluminal deployment of a medical device within a patient, the guide wire having an elongate core member with an intermediate core section comprising a plurality of contiguous segments in alignment with the longitudinal axis of the core member with alternating flexible and rigid core segments, so that the articulated section bends in a discontinuous, discrete manner when advanced through a curved blood vessel or other body lumen within the patient. When an obstruction on a vessel wall causes the catheter or other coaxial device to be impeded, the guide wire and intermediate core section may alternately be advanced and retracted a short distance through the catheter distal tip causing a “nodding” motion of the catheter tip while the catheter is pushed through the vessel, so as to avoid and bypass the vessel obstruction.
摘要翻译：本发明涉及一种用于在患者体内腔内部署医疗装置的导丝，所述导丝具有细长的芯部件，所述细长的芯部件具有中间的芯部分，所述中间纤芯部分包括与所述芯部件的纵向轴线对准的多个连续部分，柔性和刚性的芯段，使得铰接部分在通过患者体内的弯曲血管或其他体腔前进时以不连续的离散方式弯曲。当血管壁上的阻塞物导致导管或其它同轴装置被阻碍时，引导线和中间芯部分可以交替地前进并缩回穿过导管远端的短距离，导致导管末端的“点头”运动，同时导管被推过血管，以避免和绕过血管阻塞。

2. 发明授权

US06638266B2 Guidewire with an intermediate variable stiffness section 有权
公开(公告)号：US06638266B2
公开(公告)日：2003-10-28
申请号：US10310392
申请日：2002-12-05
申请人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
发明人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
IPC分类号： A61M2500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09133
摘要： The invention is directed to an guide wire for intraluminal deployment of a medical device within a patient, the guide wire having an elongate core member with an intermediate core section comprising a plurality of contiguous segments in alignment with the longitudinal axis of the core member with alternating flexible and rigid core segments, so that the articulated section bends in a discontinuous, discrete manner when advanced through a curved blood vessel or other body lumen within the patient. When an obstruction on a vessel wall causes the catheter or other coaxial device to be impeded, the guide wire and intermediate core section may alternately be advanced and retracted a short distance through the catheter distal tip causing a “nodding” motion of the catheter tip while the catheter is pushed through the vessel, so as to avoid and bypass the vessel obstruction.

3. 发明申请

US20080146967A1 Polymer coated guidewire 有权
标题翻译：聚合物涂层导丝
公开(公告)号：US20080146967A1
公开(公告)日：2008-06-19
申请号：US10631275
申请日：2003-07-31
申请人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
发明人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
IPC分类号： A61M25/00
CPC分类号： A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M25/09 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under fluoroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间断的，连续的或呈螺旋状的形式，用于在透视成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

4. 发明授权

US06673025B1 Polymer coated guidewire 有权
标题翻译：聚合物涂层导丝
公开(公告)号：US06673025B1
公开(公告)日：2004-01-06
申请号：US09441698
申请日：1999-11-16
申请人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
发明人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

5. 发明授权

US07455646B2 Polymer coated guide wire 有权
标题翻译：聚合物涂层导丝
公开(公告)号：US07455646B2
公开(公告)日：2008-11-25
申请号：US11768794
申请日：2007-06-26
申请人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
发明人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61M25/09 , A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

6. 发明授权

US07494474B2 Polymer coated guidewire 有权
标题翻译：聚合物涂层导丝
公开(公告)号：US07494474B2
公开(公告)日：2009-02-24
申请号：US10631275
申请日：2003-07-31
申请人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
发明人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M25/09 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under fluoroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间断的，连续的或呈螺旋状的形式，用于在透视成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

7. 发明授权

US07678129B1 Locking component for an embolic filter assembly 失效
标题翻译：栓塞过滤器组件的锁定部件
公开(公告)号：US07678129B1
公开(公告)日：2010-03-16
申请号：US10805455
申请日：2004-03-19
申请人： Douglas H. Gesswein , David K. Wrolstad , David H. Burkett , Robert C. Esselstein , Kathern J. Lind , Pablito Buan , Robert C. Hazelden , Thomas Tokarchik, III , Ryan Grandfield , Aaron Baldwin , Wayne E. Cornish , Philip S. Yip
发明人： Douglas H. Gesswein , David K. Wrolstad , David H. Burkett , Robert C. Esselstein , Kathern J. Lind , Pablito Buan , Robert C. Hazelden , Thomas Tokarchik, III , Ryan Grandfield , Aaron Baldwin , Wayne E. Cornish , Philip S. Yip
IPC分类号： A61M290/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A locking component for locking a medical device onto a guide wire. Such medical devices include, for example, an embolic filter assembly used to capture embolic material that may be created and released into a patient's vasculature during a stenting or angioplasty procedure. The embolic filter assembly tracks along the guide wire, and is delivered to a treatment site where it is locked in place and deployed. The locking component enables the filter assembly to lock onto any standard guide wire, and does not require a modified guide wire that has a specially-designed fitting or stop to accomplish the locking function.
摘要翻译：用于将医疗装置锁定在导丝上的锁定部件。这样的医疗装置包括例如用于捕获栓塞材料的栓塞过滤器组件，其可以在支架置入或血管成形术过程期间产生并释放到患者的脉管系统中。栓塞过滤器组件沿着导丝跟踪，并且被输送到其被锁定就位并展开的治疗部位。锁定组件使过滤器组件能够锁定到任何标准导丝上，并且不需要具有专门设计的接头或止挡件的改进的导丝来实现锁定功能。

8. 发明授权

US08308753B2 Locking component for an embolic filter assembly 有权
标题翻译：栓塞过滤器组件的锁定部件
公开(公告)号：US08308753B2
公开(公告)日：2012-11-13
申请号：US12713054
申请日：2010-02-25
申请人： Douglas H. Gesswein , David K. Wrolstad , David H. Burkett , Robert C. Esselstein , Kathern J. Lind , Pablito Buan , Robert C. Hazelden , Thomas Tokarchik, III , Ryan Grandfield , Aaron Baldwin , Wayne E. Cornish , Philip Yip
发明人： Douglas H. Gesswein , David K. Wrolstad , David H. Burkett , Robert C. Esselstein , Kathern J. Lind , Pablito Buan , Robert C. Hazelden , Thomas Tokarchik, III , Ryan Grandfield , Aaron Baldwin , Wayne E. Cornish , Philip Yip
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A locking component for locking a medical device onto a guide wire. Such medical devices include, for example, an embolic filter assembly used to capture embolic material that may be created and released into a patient's vasculature during a stenting or angioplasty procedure. The embolic filter assembly tracks along the guide wire, and is delivered to a treatment site where it is locked in place and deployed. The locking component enables the filter assembly to lock onto any standard guide wire, and does not require a modified guide wire that has a specially-designed fitting or stop to accomplish the locking function.
摘要翻译：用于将医疗装置锁定在导丝上的锁定部件。这样的医疗装置包括例如用于捕获栓塞材料的栓塞过滤器组件，其可以在支架置入或血管成形术程序期间产生并释放到患者的脉管系统中。栓塞过滤器组件沿着导丝跟踪，并且被输送到其被锁定就位并展开的治疗部位。锁定组件使过滤器组件能够锁定到任何标准导丝上，并且不需要具有专门设计的接头或止挡件的改进的导丝来实现锁定功能。

9. 发明授权

US07879065B2 Locking component for an embolic filter assembly 有权
标题翻译：栓塞过滤器组件的锁定部件
公开(公告)号：US07879065B2
公开(公告)日：2011-02-01
申请号：US11698549
申请日：2007-01-26
申请人： Douglas H. Gesswein , David K. Wrolstad , David H. Burkett , Robert C. Esselstein , Kathern J. Lind , Pablito Buan , Robert C. Hazelden , Thomas Tokarchik, III , Ryan Grandfield , Aaron Baldwin , Wayne E. Cornish , Philip S. Yip
发明人： Douglas H. Gesswein , David K. Wrolstad , David H. Burkett , Robert C. Esselstein , Kathern J. Lind , Pablito Buan , Robert C. Hazelden , Thomas Tokarchik, III , Ryan Grandfield , Aaron Baldwin , Wayne E. Cornish , Philip S. Yip
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A locking component for locking a medical device onto a guide wire. Such medical devices include, for example, an embolic filter assembly used to capture embolic material that may be created and released into a patient's vasculature during a stenting or angioplasty procedure. The embolic filter assembly tracks along the guide wire, and is delivered to a treatment site where it is locked in place and deployed. The locking component enables the filter assembly to lock onto any standard guide wire, and does not require a modified guide wire that has a specially-designed fitting or stop to accomplish the locking function.
摘要翻译：用于将医疗装置锁定在导丝上的锁定部件。这样的医疗装置包括例如用于捕获栓塞材料的栓塞过滤器组件，其可以在支架置入或血管成形术程序期间产生并释放到患者的脉管系统中。栓塞过滤器组件沿着导丝跟踪，并且被输送到其被锁定就位并展开的治疗部位。锁定组件使过滤器组件能够锁定到任何标准导丝上，并且不需要具有专门设计的接头或止挡件的改进的导丝来实现锁定功能。

10. 发明授权

US06494891B1 Ultrasonic angioplasty transmission member 有权
标题翻译：超声波血管成形术传播部件
公开(公告)号：US06494891B1
公开(公告)日：2002-12-17
申请号：US09474953
申请日：1999-12-30
申请人： Wayne E. Cornish , Robert C. Esselstein , Sepehr Fariabi , Henry Nita
发明人： Wayne E. Cornish , Robert C. Esselstein , Sepehr Fariabi , Henry Nita
IPC分类号： A61B1732
CPC分类号： A61B17/22012 , A61B2017/22015 , A61B2017/22018
摘要： The ultrasonic angioplasty transmission wire has regions of reduced cross-sectional diameter to improve flexibility of the ultrasonic angioplasty transmission wire and to compensate for degradation of longitudinal displacement due to acoustic losses along the length of the ultrasonic angioplasty transmission wire. One or more constraining members are disposed on the ultrasonic angioplasty transmission wire at one or more of the regions of reduced cross-sectional diameter where transverse vibration of ultrasonic energy transmitted by the ultrasound transmission wire is amplified, to constrain transverse vibration at these areas to reduce stress and reduce fracturing, while allowing longitudinal movement. The transmission wire has an elongated shaft including, in atomic percent, from about 28 to about 52 percent nickel, from about 48 to about 52 percent titanium, and up to about 20 percent of at least one alloying element selected from the group consisting of palladium, chromium, and hafnium.
摘要翻译：超声波血管成形术传输线具有减小的横截面直径的区域，以改善超声波血管成形术传输线的柔性，并且补偿由于沿着超声波血管成形术传输线的长度的声学损失引起的纵向位移的退化。一个或多个约束构件设置在超声波血管成形术传输线上的一个或多个减小横截面直径的区域中，其中由超声波传输线传输的超声能量的横向振动被放大，以限制这些区域的横向振动，以减少应力和减少压裂，同时允许纵向移动。传输线具有细长轴，原子百分比包括约28至约52％的镍，约48至约52％的钛，以及至多一种选自钯的至少一种合金元素的至多约20％，铬和铪。

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