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1. 发明授权

US06494891B1 Ultrasonic angioplasty transmission member 有权
标题翻译：超声波血管成形术传播部件
公开(公告)号：US06494891B1
公开(公告)日：2002-12-17
申请号：US09474953
申请日：1999-12-30
申请人： Wayne E. Cornish , Robert C. Esselstein , Sepehr Fariabi , Henry Nita
发明人： Wayne E. Cornish , Robert C. Esselstein , Sepehr Fariabi , Henry Nita
IPC分类号： A61B1732
CPC分类号： A61B17/22012 , A61B2017/22015 , A61B2017/22018
摘要： The ultrasonic angioplasty transmission wire has regions of reduced cross-sectional diameter to improve flexibility of the ultrasonic angioplasty transmission wire and to compensate for degradation of longitudinal displacement due to acoustic losses along the length of the ultrasonic angioplasty transmission wire. One or more constraining members are disposed on the ultrasonic angioplasty transmission wire at one or more of the regions of reduced cross-sectional diameter where transverse vibration of ultrasonic energy transmitted by the ultrasound transmission wire is amplified, to constrain transverse vibration at these areas to reduce stress and reduce fracturing, while allowing longitudinal movement. The transmission wire has an elongated shaft including, in atomic percent, from about 28 to about 52 percent nickel, from about 48 to about 52 percent titanium, and up to about 20 percent of at least one alloying element selected from the group consisting of palladium, chromium, and hafnium.
摘要翻译：超声波血管成形术传输线具有减小的横截面直径的区域，以改善超声波血管成形术传输线的柔性，并且补偿由于沿着超声波血管成形术传输线的长度的声学损失引起的纵向位移的退化。一个或多个约束构件设置在超声波血管成形术传输线上的一个或多个减小横截面直径的区域中，其中由超声波传输线传输的超声能量的横向振动被放大，以限制这些区域的横向振动，以减少应力和减少压裂，同时允许纵向移动。传输线具有细长轴，原子百分比包括约28至约52％的镍，约48至约52％的钛，以及至多一种选自钯的至少一种合金元素的至多约20％，铬和铪。

2. 发明授权

US06652472B2 Guidewire with smoothly tapered segment 有权
公开(公告)号：US06652472B2
公开(公告)日：2003-11-25
申请号：US10186858
申请日：2002-07-01
申请人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
发明人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A guidewire for intraluminal advancement of a medical device within a patient which has an elongate core member with a flexible body member disposed on a distal section thereof. In one embodiment, the distal section of the elongate core member has at least one flexible segment with at least one pair of opposed tapered or parallel faces. Preferably the flexible segment with the tapered or parallel faces is disposed at the distal end of the elongate core and forms a shapable segment.

3. 发明授权

US06464650B2 Guidewire with smoothly tapered segment 有权
标题翻译：导丝平滑锥形
公开(公告)号：US06464650B2
公开(公告)日：2002-10-15
申请号：US09224451
申请日：1998-12-31
申请人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
发明人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A guidewire for intraluminal advancement of a medical device within a patient which has an elongate core member with a flexible body member disposed on a distal section thereof. In one embodiment, the distal section of the elongate core member has at least one flexible segment with at least one pair of opposed tapered or parallel faces. Preferably the flexible segment with the tapered or parallel faces is disposed at the distal end of the elongate core and forms a shapable segment.
摘要翻译：一种用于管腔内推进医疗装置的导丝，其具有细长的芯部件，其具有设置在其远端部分上的柔性主体部件。在一个实施例中，细长芯部件的远端部分具有至少一个具有至少一对相对的锥形或平行面的柔性部分。优选地，具有锥形或平行面的柔性段设置在细长芯的远端并形成可成形段。

4. 发明授权

US06491648B1 Guidewire with tapered flexible core segment 有权
标题翻译：导丝带锥形柔性芯段
公开(公告)号：US06491648B1
公开(公告)日：2002-12-10
申请号：US09748299
申请日：2000-12-21
申请人： Wayne E. Cornish , Mark T. Richardson , Lawrence E. Brennan , Marc M. Jalisi , David M. Anderson , Mo Jafari , Sepehr Fariabi
发明人： Wayne E. Cornish , Mark T. Richardson , Lawrence E. Brennan , Marc M. Jalisi , David M. Anderson , Mo Jafari , Sepehr Fariabi
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A guidewire for guiding a medical device within a patient which has an elongate core member with a flexible body member disposed about and secured to a distal core section and a flexible core segment or flexible core segment which has a first pair of opposed faces which define a first transverse dimension that tapers from a first value to a second larger value and a second pair of opposed faces which define a second transverse dimension that tapers from a first value to a second smaller value.
摘要翻译：一种用于在具有细长芯部件的患者体内引导医疗装置的导丝，其具有设置在远端芯部周围并固定到远端芯部的柔性主体部件以及具有第一对相对面的柔性芯部或柔性芯部，从第一值逐渐变细到第二较大值的第一横向尺寸和限定从第一值到第二较小值逐渐变细的第二横向尺寸的第二对相对面。

5. 发明申请

US20120330406A1 DRUG DELIVERY ENDOVASCULAR STENT AND METHOD OF USE 审中-公开
标题翻译：药物递送内支架及其使用方法
公开(公告)号：US20120330406A1
公开(公告)日：2012-12-27
申请号：US13554296
申请日：2012-07-20
申请人： Douglas R. Savage , John E. Shulze , Ronald E. Betts , Sepehr Fariabi , Shih-Horng Su
发明人： Douglas R. Savage , John E. Shulze , Ronald E. Betts , Sepehr Fariabi , Shih-Horng Su
IPC分类号： A61F2/82 , B05D7/14
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译：披露了药物洗脱支架的改进及其制作方法。金属支架的表面被粗糙化以具有至少约20μin（0.5μm）的表面粗糙度和在约300-700μin（7.5-17.5μm）之间的表面粗糙度范围。粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。

6. 发明申请

US20090287294A1 Braid-Ball Embolic Devices 有权
标题翻译：编织球栓塞装置
公开(公告)号：US20090287294A1
公开(公告)日：2009-11-19
申请号：US12427620
申请日：2009-04-21
申请人： Arturo S. Rosqueta , Frank P. Becking , Maria G. Aboytes , Siddharth Loganathan , Chi Vu , Sepehr Fariabi
发明人： Arturo S. Rosqueta , Frank P. Becking , Maria G. Aboytes , Siddharth Loganathan , Chi Vu , Sepehr Fariabi
IPC分类号： A61F2/06 , B29C53/08 , B32B37/02
CPC分类号： A61B17/12159 , A61B17/12022 , A61B17/12031 , A61B17/12109 , A61B17/12113 , A61B17/12118 , A61B17/1215 , A61B17/12172 , A61B2017/00526 , A61B2017/00862 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054 , A61B2017/12068 , A61B2018/00416 , A61B2090/3966 , A61M29/02 , Y10T156/1051
摘要： Embolic implants, delivery systems and methods of manufacture and delivery are disclosed. The devices can be used for aneurysm treatment and/or parent vessel occlusion. Implant designs offer low profile compressibility for delivery to neurovasculature, while maintaining other necessary features such as density for occlusion purposes and desirable radial strength characteristics.
摘要翻译：公开了栓塞植入物，递送系统以及制造和递送方法。该装置可用于动脉瘤治疗和/或母体血管闭塞。植入物设计提供低调压缩性以递送至神经血管系统，同时保持其他必要特征，例如闭塞目的的密度和期望的径向强度特征。

7. 发明授权

US07244319B2 Superelastic guiding member 失效
公开(公告)号：US07244319B2
公开(公告)日：2007-07-17
申请号：US10291930
申请日：2002-11-11
申请人： Robert M. Abrams , Sepehr Fariabi
发明人： Robert M. Abrams , Sepehr Fariabi
IPC分类号： A61F2/86
CPC分类号： A61L31/14 , A61L31/022 , A61L2400/16 , A61M25/09 , A61M2025/09008 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266 , C22C14/00 , C22C30/00 , C22F1/006
摘要： An improved guiding member for use within a body lumen having a unique combination of superelastic characteristics. The superelastic alloy material has a composition consisting of about 30% to about 52% (atomic) titanium, and about 38% to 52% nickel and may have one or more elements selected from the group consisting of iron, cobalt, platinum, palladium, vanadium, copper, zirconium, hafnium and niobium. The alloy material is subjected to thermomechanical processing which includes a final cold working of about 10 to about 75% and then a heat treatment at a temperature between about 450° and about 600° C. and preferably about 475° to about 550° C. Before the heat treatment the cold worked alloy material is preferably subjected to mechanical straightening. The alloy material is preferably subjected to stresses equal to about 5 to about 50% of the room temperature ultimate yield stress of the material during the thermal treatment. The guiding member using such improved material exhibits a stress-induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of over 90 ksi for solid members and over 70 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation. An essentially whip free product is obtained.

8. 发明授权

US06592570B2 Superelastic guiding member 失效
公开(公告)号：US06592570B2
公开(公告)日：2003-07-15
申请号：US09884432
申请日：2001-06-18
申请人： Robert M. Abrams , Sepehr Fariabi
发明人： Robert M. Abrams , Sepehr Fariabi
IPC分类号： A61M2501
CPC分类号： A61M25/09 , A61L31/022 , A61L31/14 , A61L2400/16 , A61M2025/09008 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266 , C22C14/00 , C22C30/00 , C22F1/006
摘要： An improved guiding member for use within a body lumen having a unique combination of superelastic characteristics. The superelastic alloy material has a composition consisting of about 30% to about 52% (atomic) titanium, and about 38% to 52% nickel and may have one or more elements selected from the group consisting of iron, cobalt, platinum, palladium, vanadium, copper, zirconium, hafnium and niobium. The alloy material is subjected to thermomechanical processing which includes a final cold working of about 10 to about 75% and then a heat treatment at a temperature between about 450° and about 600° C. and preferably about 475° to about 550° C. Before the heat treatment the cold worked alloy material is preferably subjected to mechanical straightening. The alloy material is preferably subjected to stresses equal to about 5 to about 50% of the room temperature ultimate yield stress of the material during the thermal treatment. The guiding member using such improved material exhibits a stress-induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of over 90 ksi for solid members and over 70 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation. An essentially whip free product is obtained.

9. 发明授权

US5636641A High strength member for intracorporeal use 失效
标题翻译：用于体内使用的高强度成员
公开(公告)号：US5636641A
公开(公告)日：1997-06-10
申请号：US280209
申请日：1994-07-25
申请人： Sepehr Fariabi
发明人： Sepehr Fariabi
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/09 , A61B5/00
CPC分类号： A61M25/0012 , A61F2/958 , A61M25/0009 , A61M25/09 , A61F2210/0019 , A61M2025/09083
摘要： This invention is directed to an intracorporeal device formed of a high strength Co--Ni--Cr alloy and is particularly suitable for forming a composite product with a pseudoelastic member formed of NiTi alloy. Suitable intracorporeal products include guidewires and stents. The high strength alloy consists essentially of about 28 to about 65% cobalt, about 2 to about 40% nickel, about 5 to about 35% chromium, up to about 12% molybdenum, up to about 20% tungsten, up to about 20% iron and the balance inconsequential amounts of impurities and other alloying constituents, with a preferred alloy composition including about 30 to about 45% cobalt, about 25 to about 37% nickel, about 15 to about 25% chromium and about 5 to about 15% molybdenum. Intravascular devices such as guidewires, stents and the like can be formed of this high strength Co--Ni--Cr alloy.
摘要翻译：本发明涉及由高强度Co-Ni-Cr合金形成的体内器件，特别适用于形成具有由NiTi合金形成的假弹性体的复合产品。合适的体内产品包括导线和支架。高强度合金主要由约28至约65％的钴，约2-约40％的镍，约5-35％的铬，至多约十二％的钼，至多约20％的钨，至多约20％铁和余量是无关的量的杂质和其他合金成分，优选的合金组成包括约30至约45％的钴，约25至约37％的镍，约15至约25％的铬和约5至约15％的钼。诸如导线，支架等的血管内装置可以由这种高强度Co-Ni-Cr合金形成。

10. 发明授权

US09579424B2 Drug delivery endovascular stent and method of use 有权
标题翻译：药物输送血管内支架及其使用方法
公开(公告)号：US09579424B2
公开(公告)日：2017-02-28
申请号：US13554296
申请日：2012-07-20
申请人： Douglas R. Savage , John E. Shulze , Ronald E. Betts , Sepehr Fariabi , Shih-Horng Su
发明人： Douglas R. Savage , John E. Shulze , Ronald E. Betts , Sepehr Fariabi , Shih-Horng Su
IPC分类号： A61F2/82 , A61L31/02 , A61F2/91 , A61F2/915 , A61L31/16 , A61F2/848 , A61F2/89
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译：披露了药物洗脱支架的改进及其制作方法。金属支架的表面被粗糙化以具有至少约20μin（0.5μm）的表面粗糙度和在约300-700μin（7.5-17.5μm）之间的表面粗糙度范围。粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。

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