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1. 发明授权

US06593366B2 Ionic polymers as anti-infective agents 有权
公开(公告)号：US06593366B2
公开(公告)日：2003-07-15
申请号：US10081022
申请日：2002-02-21
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K3122
CPC分类号： A61K31/785 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

2. 发明授权

US06187762B1 Polyvalent polymers for the treatment of rotavirus infection 失效
标题翻译：用于治疗轮状病毒感染的多价聚合物
公开(公告)号：US06187762B1
公开(公告)日：2001-02-13
申请号：US09286351
申请日：1999-04-05
申请人： W. Harry Mandeville, III , John S. Petersen , Venkata R. Garigapati , Thomas X. Neenan
发明人： W. Harry Mandeville, III , John S. Petersen , Venkata R. Garigapati , Thomas X. Neenan
IPC分类号： A61K3170
CPC分类号： C07H13/04 , C07D309/10 , C07H15/04 , C08F246/00
摘要： The present invention includes polymerizable monomers comprising a fucoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotavirus infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The glycoside moieties can be, for example, fucoside moieties or sialic acid moieties. The polymer can be a homopolyrner or a co-polymer. In one embodiment, the polymer is a copolymer comprising a glycoside-bearing monomer and a hydrophobic monomer. In another embodiment, the polymer to be administered comprises two or more different glycoside-bearing monomers.
摘要翻译：本发明包括包含岩藻糖苷部分的可聚合单体。在一个实施方案中，单体具有可聚合官能团，例如烯键，通过间隔基团例如亚烷基或其中一个或多个碳原子被杂原子，例如氧，氮或硫原子。本发明还包括包含一种或多种可以抑制或预防哺乳动物轮状病毒感染的岩藻糖苷部分的聚合物，例如侧壁ucoside部分。这样的聚合物可以包括例如本发明的单体。聚合物可以是均聚物或共聚物，并且可以具有例如聚丙烯酰胺，聚丙烯酸酯或聚苯乙烯主链。在另一个实施方案中，本发明包括通过向哺乳动物施用治疗有效量的包含一个或多个糖苷部分的聚合物，例如侧链糖苷部分，来治疗哺乳动物例如人的轮状病毒感染的方法。糖苷部分可以是例如岩藻糖苷部分或唾液酸部分。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含含糖苷单体和疏水性单体的共聚物。在另一个实施方案中，待施用的聚合物包含两种或更多种不同的含糖苷单体。

3. 发明授权

US6034129A Ionic polymers as anti-infective agents 失效
公开(公告)号：US6034129A
公开(公告)日：2000-03-07
申请号：US670764
申请日：1996-06-24
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K31/785 , A61P31/04 , A61P31/10 , A61P33/00 , A61P33/04 , A61K31/14 , A61K31/16 , A61K31/74
CPC分类号： A61K31/785
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

4. 发明授权

US6007803A Ionic polymers as toxin binding agents 失效
标题翻译：离子聚合物作为毒素结合剂
公开(公告)号：US6007803A
公开(公告)日：1999-12-28
申请号：US934495
申请日：1997-09-19
申请人： W. Harry Mandeville, III , Thomas X. Neenan
发明人： W. Harry Mandeville, III , Thomas X. Neenan
IPC分类号： A61K31/785 , A61P31/00 , A61P43/00
CPC分类号： A61K31/785
摘要： A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译：一种用于治疗哺乳动物（例如人）中致病性毒素的方法，包括用治疗有效量的包含连接到聚合物主链上的阳离子基团的聚合物来治疗哺乳动物。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。

5. 发明授权

US06767549B2 Ionic polymers as anti-infective agents 有权
标题翻译：离子聚合物作为抗感染剂
公开(公告)号：US06767549B2
公开(公告)日：2004-07-27
申请号：US10374014
申请日：2003-02-25
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K3114
CPC分类号： A61K31/785 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译：一种用于治疗哺乳动物例如人的微生物感染的方法，包括用治疗有效量的包含通过脂肪族间隔基连接到聚合物主链的氨基或铵基团的聚合物来治疗哺乳动物。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。

6. 发明授权

US06692732B2 Ionic polymers as toxin-binding agents 有权
标题翻译：离子聚合物作为毒素结合剂
公开(公告)号：US06692732B2
公开(公告)日：2004-02-17
申请号：US10324623
申请日：2002-12-19
申请人： Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
发明人： Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
IPC分类号： A61K3174
CPC分类号： A61K31/785 , Y02A50/465 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译：一种用于治疗哺乳动物（例如人）中致病性毒素的方法，包括用治疗有效量的包含连接到聚合物主链上的阳离子基团的聚合物来治疗哺乳动物。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。

7. 发明授权

US06565895B2 Bismuth compounds for the treatment and prevention of mucositis 有权
公开(公告)号：US06565895B2
公开(公告)日：2003-05-20
申请号：US09877723
申请日：2001-06-08
申请人： Philip J. Goddard , Jeffrey D. Klinger , Pradeep K. Dhal , W. Harry Mandeville, III , Richard J. Fitzpatrick , Thomas X. Neenan
发明人： Philip J. Goddard , Jeffrey D. Klinger , Pradeep K. Dhal , W. Harry Mandeville, III , Richard J. Fitzpatrick , Thomas X. Neenan
IPC分类号： A61K3324
CPC分类号： A61K33/12 , A61K31/28 , A61K31/60 , A61K33/24 , A61K33/245 , Y10S514/901 , Y10S514/902 , Y10S514/925 , Y10S514/928 , A61K31/715 , A61K31/00 , A61K2300/00
摘要： The invention relates to the unexpected discovery that bismuth-containing compounds are effective in the treatment of oral mucositis in a mammal. Thus, the invention relates, in one aspect to a method of treating oral mucositis comprising administering an effective amount of a pharmaceutically acceptable bismuth-containing compound, such as a bismuth salt or bismuth complex. In a preferred embodiment, the bismuth compound is an organic or inorganic salt such as, bismuth subsalicylate, bismuth subgallate, bismuth aluminate, bismuth citrate, bismuth subcitrate, bismuth carbonate, bismuth subcarbonate, tripotassium dicitrato bismuthate, bismuth nitrate, bismuth subnitrate, bismuth tartrate and mixtures thereof, preferably, bismuth subsalicylate and bismuth subgallate.

8. 发明授权

US06290947B1 Ionic polymers as toxin-binding agents 有权
标题翻译：离子聚合物作为毒素结合剂
公开(公告)号：US06290947B1
公开(公告)日：2001-09-18
申请号：US09597343
申请日：2000-06-19
申请人： Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
发明人： Richard Fitzpatrick , Chad Cori Huval , Caroline Isabelle Bacon Kurtz , W. Harry Mandeville, III , Thomas X. Neenan
IPC分类号： A61K3174
CPC分类号： A61K31/785 , Y02A50/465 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译：一种用于治疗哺乳动物（例如人）中致病性毒素的方法，包括用治疗有效量的包含连接到聚合物主链上的阳离子基团的聚合物来治疗哺乳动物。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。

9. 发明授权

US5925379A Interpenetrating polymer networks for sequestration of bile acids 失效
标题翻译：用于螯合胆汁酸的互穿聚合物网络
公开(公告)号：US5925379A
公开(公告)日：1999-07-20
申请号：US826197
申请日：1997-03-27
申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
发明人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
IPC分类号： A61K31/74 , A61K31/785 , A61K9/10 , A61K47/32
CPC分类号： A61K31/74 , A61K31/785 , Y10S514/824 , Y10S525/903
摘要： The present invention relates to a method for removing bile salts from a patient, comprising the step of administering to the patient a therapeutically effective amount of a polymer network composition comprising a cationic polymer. In one embodiment, the polymer network is an interpenetrating polymer network. In another embodiment, the polymer network is a semi-interpenetrating polymer network.
摘要翻译：本发明涉及一种从患者中除去胆汁盐的方法，包括向患者施用治疗有效量的包含阳离子聚合物的聚合物网络组合物的步骤。在一个实施方案中，聚合物网络是互穿聚合物网络。在另一个实施方案中，聚合物网络是半互穿聚合物网络。

10. 发明授权

US5891862A Polyvalent polymers for the treatment of rotavirus infection 失效
标题翻译：用于治疗轮状病毒感染的多价聚合物
公开(公告)号：US5891862A
公开(公告)日：1999-04-06
申请号：US717265
申请日：1996-09-20
申请人： W. Harry Mandeville, III , John S. Petersen , Venkata R. Garigapati , Thomas X. Neenan
发明人： W. Harry Mandeville, III , John S. Petersen , Venkata R. Garigapati , Thomas X. Neenan
IPC分类号： C07H5/06 , A61K31/785 , A61P31/12 , C07D309/10 , C07H13/04 , C07H15/04 , C07H15/12 , C07H15/14 , C08F20/58 , C08F246/00 , A61K31/70 , C07H19/00
CPC分类号： C07H13/04 , C07D309/10 , C07H15/04 , C08F246/00
摘要： The present invention includes polymerizable monomers comprising a fucoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotavirus infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The glycoside moieties can be, for example, fucoside moieties or sialic acid moieties. The polymer can be a homopolymer or a co-polymer. In one embodiment, the polymer is a copolymer comprising a glycoside-bearing monomer and a hydrophobic monomer. In another embodiment, the polymer to be administered comprises two or more different glycoside-bearing monomers.
摘要翻译：本发明包括包含岩藻糖苷部分的可聚合单体。在一个实施方案中，单体具有可聚合官能团，例如烯键，通过间隔基团例如亚烷基或其中一个或多个碳原子被杂原子，例如氧，氮或硫原子。本发明还包括包含一种或多种可以抑制或预防哺乳动物轮状病毒感染的岩藻糖苷部分的聚合物，例如侧壁ucoside部分。这样的聚合物可以包括例如本发明的单体。聚合物可以是均聚物或共聚物，并且可以具有例如聚丙烯酰胺，聚丙烯酸酯或聚苯乙烯主链。在另一个实施方案中，本发明包括通过向哺乳动物施用治疗有效量的包含一个或多个糖苷部分的聚合物，例如侧链糖苷部分，来治疗哺乳动物例如人的轮状病毒感染的方法。糖苷部分可以是例如岩藻糖苷部分或唾液酸部分。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含含糖苷单体和疏水单体的共聚物。在另一个实施方案中，待施用的聚合物包含两种或更多种不同的含糖苷的单体。

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