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1. 发明授权

US06593366B2 Ionic polymers as anti-infective agents 有权
公开(公告)号：US06593366B2
公开(公告)日：2003-07-15
申请号：US10081022
申请日：2002-02-21
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K3122
CPC分类号： A61K31/785 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

2. 发明授权

US6034129A Ionic polymers as anti-infective agents 失效
公开(公告)号：US6034129A
公开(公告)日：2000-03-07
申请号：US670764
申请日：1996-06-24
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K31/785 , A61P31/04 , A61P31/10 , A61P33/00 , A61P33/04 , A61K31/14 , A61K31/16 , A61K31/74
CPC分类号： A61K31/785
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

3. 发明授权

US06767549B2 Ionic polymers as anti-infective agents 有权
标题翻译：离子聚合物作为抗感染剂
公开(公告)号：US06767549B2
公开(公告)日：2004-07-27
申请号：US10374014
申请日：2003-02-25
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K3114
CPC分类号： A61K31/785 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译：一种用于治疗哺乳动物例如人的微生物感染的方法，包括用治疗有效量的包含通过脂肪族间隔基连接到聚合物主链的氨基或铵基团的聚合物来治疗哺乳动物。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。

4. 发明授权

US5925379A Interpenetrating polymer networks for sequestration of bile acids 失效
标题翻译：用于螯合胆汁酸的互穿聚合物网络
公开(公告)号：US5925379A
公开(公告)日：1999-07-20
申请号：US826197
申请日：1997-03-27
申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
发明人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
IPC分类号： A61K31/74 , A61K31/785 , A61K9/10 , A61K47/32
CPC分类号： A61K31/74 , A61K31/785 , Y10S514/824 , Y10S525/903
摘要： The present invention relates to a method for removing bile salts from a patient, comprising the step of administering to the patient a therapeutically effective amount of a polymer network composition comprising a cationic polymer. In one embodiment, the polymer network is an interpenetrating polymer network. In another embodiment, the polymer network is a semi-interpenetrating polymer network.
摘要翻译：本发明涉及一种从患者中除去胆汁盐的方法，包括向患者施用治疗有效量的包含阳离子聚合物的聚合物网络组合物的步骤。在一个实施方案中，聚合物网络是互穿聚合物网络。在另一个实施方案中，聚合物网络是半互穿聚合物网络。

5. 发明授权

US06395777B2 Ionic polymers as anti-infective agents 有权
标题翻译：离子聚合物作为抗感染剂
公开(公告)号：US06395777B2
公开(公告)日：2002-05-28
申请号：US09493639
申请日：2000-01-28
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K3122
CPC分类号： A61K31/785 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译：一种用于治疗哺乳动物例如人的微生物感染的方法，包括用治疗有效量的包含通过脂肪族间隔基连接到聚合物主链的氨基或铵基团的聚合物来治疗哺乳动物。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含具有侧铵基团和疏水单体的单体的共聚物。

6. 发明授权

US07459151B2 Phosphate-binding polymers for oral administration 有权
标题翻译：用于口服给药的磷酸盐结合聚合物
公开(公告)号：US07459151B2
公开(公告)日：2008-12-02
申请号：US11295159
申请日：2005-12-06
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
IPC分类号： A61K31/74 , A61K31/785
CPC分类号： A61K31/662 , A61K31/785 , A61K31/795
摘要： Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
摘要翻译：提供磷酸盐结合聚合物用于从胃肠道除去磷酸盐。口服聚合物，可用于治疗高磷血症。

7. 发明授权

US07041280B2 Aryl boronate functionalized polymers for treating obesity 有权
公开(公告)号：US07041280B2
公开(公告)日：2006-05-09
申请号：US10187316
申请日：2002-06-27
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li , Steven Craig Polomoscanik
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li , Steven Craig Polomoscanik
IPC分类号： A61K31/80
CPC分类号： C08F8/42 , A61K31/74 , A61K31/785 , A61K47/58 , C08F8/44 , C08G65/331 , C08G73/0206 , C08G79/08 , C08F20/60 , C08F26/02
摘要： Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid.Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.

8. 发明授权

US06858592B2 Aryl boronic acids for treating obesity 有权
标题翻译：用于治疗肥胖症的芳基硼酸
公开(公告)号：US06858592B2
公开(公告)日：2005-02-22
申请号：US10187397
申请日：2002-06-27
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li
IPC分类号： A61K31/69 , A61K31/74 , A61K31/785 , A61P3/04 , A61P3/06 , C07F5/02
CPC分类号： C07F5/025 , A61K31/74 , A61K31/785
摘要： Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z′ are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—(CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5. R1 and R1′ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N+(R1a)—]. Each R1 is Structural Formula (I) is preferably —H. R1a is —H, alkyl, substituted alkyl, phenyl or substituted phenyl. Also disclosed is a method of treating obesity in a subject by administering an effective amount of a compound represented by Structural Formula (I) and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.
摘要翻译：公开了由结构式（I）表示的苯基硼酸化合物：Ar是取代或未取代的芳基.Z和Z'独立地是-O-。 -NH-或-S-X是吸电子基团.R是任选地包含一个或多个胺，铵，醚，硫醚或亚苯基连接基团的取代或未取代的直链烃基，Y是-H，胺， - [NH-（CH 2）q] r -NH 2，卤素，-CF 3，硫醇铵，醇，-COOH，-SO 3 H，-OSO 3 H或共价键合到R的末端的鏻基团。 NH-（CH 2）q] r -NH 2任选被N-烷基化或N，N-二烷基化，-NH 2在 - [NH-（CH 2）q] r -NH 2中任选地N-烷基化，N，N-二烷基化或N ，N，N-三烷基化.q为2至约10的整数，r为1至约5.R1的整数，R1'独立地为-H，脂族基团，取代的脂族基团，芳基或取代的芳基，或者一起是任选地包含胺连接基团[-N +（R 1a） - ] - 的C 2 -C 5取代或未取代的亚烷基。每个R1是结构式（I）优选-HR 1a是-H，烷基，取代的烷基，苯基或取代的苯基。还公开了通过给予有效量的由结构式（I）和包含该化合物和药学上可接受的载体或稀释剂的药物组合物。

9. 发明授权

US06433026B1 Process for removing bile salts from a patient and alkylated compositions therefor 有权
公开(公告)号：US06433026B1
公开(公告)日：2002-08-13
申请号：US09803647
申请日：2001-03-09
申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley
IPC分类号： A01N3318
摘要： The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.

10. 发明授权

US06299868B1 Fat-binding polymers 失效
标题翻译：脂肪结合聚合物
公开(公告)号：US06299868B1
公开(公告)日：2001-10-09
申请号：US09353329
申请日：1999-07-14
申请人： Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
发明人： Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
IPC分类号： A61K31795
CPC分类号： A61K45/06 , A61K31/785 , A61K2300/00
摘要： The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.
摘要翻译：本发明涉及一种治疗肥胖症的方法，一种减少膳食脂肪吸收的方法，以及用于治疗患者中的高甘油三酯血症的方法以及用于该方法或用于制备药物的具体聚合物。所述方法包括向哺乳动物（例如人）口服施用治疗有效量的一种或多种脂肪结合聚合物的步骤。本发明的脂肪结合聚合物的施用有利于在消化之前从身体去除脂肪，具有最小的副作用和低毒性。在一个优选的实施方案中，一种或多种脂肪结合聚合物与一种或多种脂肪酶抑制剂，例如脂抑素和四氢脂抑素组合施用。

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