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1. 发明授权

US4585775A Substituted pyrido (1,2-c)imidazo(1,2-a)benzimidazoles, processes for their preparation, their use and pharmaceutical preparations based on these compounds 失效
标题翻译：取代的吡啶（1,2-c）咪唑并（1,2-a）苯并咪唑，其制备方法及其用途和基于这些化合物的药物制剂
公开(公告)号：US4585775A
公开(公告)日：1986-04-29
申请号：US650106
申请日：1984-09-13
申请人： Volker Hitzel , Gerhard Rackur , Martin Bickel
发明人： Volker Hitzel , Gerhard Rackur , Martin Bickel
IPC分类号： C07D471/10 , A61K31/435 , A61P1/04 , C07D213/38 , C07D213/53 , C07D401/06 , C07D471/14 , A61K31/44 , C07D471/12
CPC分类号： C07D213/53 , C07D213/38 , C07D401/06 , C07D471/14 , Y02P20/55
摘要： The invention relates to compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen, alkyl, trifluoromethyl, halogen, alkoxycarbonyl, alkoxy or alkanoyl, R.sup.3, R.sup.4 and R.sup.5 are identical or different and are hydrogen, methyl, alkoxy or alkoxyethoxy, and R is hydrogen or a group SR.sup.6, in which R.sup.6 is the lone, unpaired electron of the 12-sulfenyl radical, hydrogen, optionally substituted alkyl, alkenyl, alkynyl, alkanoyl, optionally mono- or poly-substituted benzoyl, fuoryl, phenacyl, phenoxyacetyl, phenylacetyl or another conventional thiol-protective group, and to physiologically acceptable salts thereof, and to processes for their preparation, to their use as a gastric acid secretion inhibitor and to pharmaceutical preparations based on these compounds.
摘要翻译：本发明涉及式（I）的化合物，其中R 1和R 2相同或不同，为氢，烷基，三氟甲基，卤素，烷氧基羰基，烷氧基或烷酰基，R 3，R 4和R 5相同或不同，氢，甲基，烷氧基或烷氧基乙氧基，R是氢或基团SR6，其中R6是12-亚磺酰基的单体不成对电子，氢，任选取代的烷基，烯基，炔基，烷酰基，任选单或多取代苯甲酰基，富酰基，苯甲酰甲基，苯氧基乙酰基，苯乙酰基或另一种常规硫醇保护基，及其生理上可接受的盐，及其制备方法，用作胃酸分泌抑制剂和基于这些化合物的药物制剂。

2. 发明授权

US06717008B2 Derivatives of C2-substituted indan-1-ol compounds, methods for their preparation and use 有权
标题翻译： C2取代的茚满-1-醇化合物的衍生物，其制备和使用方法
公开(公告)号：US06717008B2
公开(公告)日：2004-04-06
申请号：US10231365
申请日：2002-08-30
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： C07C30900
CPC分类号： C07C317/20 , C07C323/17 , C07C2602/08
摘要： Derivatives of C2-substituted indan-1-ol compounds, processes for their preparation and their use are disclosed. In particular, the invention relates to compounds of the formula I and to their physiologically acceptable salts and physiologically functional derivatives. The compounds are suitable, for example, for use as anorectics.
摘要翻译：公开了C2-取代的茚满-1-醇化合物的衍生物，其制备方法及其应用。特别地，本发明涉及式I化合物及其生理上可接受的盐和生理功能衍生物。这些化合物适用于例如用作止痛剂。

3. 发明授权

US06410577B1 Substituted 8,8a-dihydro-3ah-indeno[1,2-d]thiazoles, processes for their preparation and their use as medicaments 有权
公开(公告)号：US06410577B1
公开(公告)日：2002-06-25
申请号：US09790905
申请日：2001-02-23
申请人： Gerhard Jaehne , Hans-Jochen Lang , Matthias Gossel , Martin Bickel
发明人： Gerhard Jaehne , Hans-Jochen Lang , Matthias Gossel , Martin Bickel
IPC分类号： C07D27760
摘要： The invention relates to substituted 8,8a-dihydro-3aH-indeno[1,2-d]thiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.

4. 发明授权

US06207689B1 Polycyclic thiazol-2-ylidene amines, processes for their preparation and their use as medicaments 有权
公开(公告)号：US06207689B1
公开(公告)日：2001-03-27
申请号：US09500464
申请日：2000-02-09
申请人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
发明人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
IPC分类号： A61K31428
CPC分类号： C07D277/60 , C07D513/04
摘要： The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example as anorectics and in the treatment or prophylaxis of type II diabetes.

5. 发明授权

US06187801B1 Polycyclic thiazole systems, processes for their preparation and pharmaceuticals comprising these compounds 有权
标题翻译：多环噻唑系统，其制备方法和包含这些化合物的药物
公开(公告)号：US06187801B1
公开(公告)日：2001-02-13
申请号：US09501210
申请日：2000-02-10
申请人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
发明人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
IPC分类号： A61K31428
CPC分类号： C07D277/60 , C07D277/84 , C07D417/04 , C07D417/06
摘要： The invention relates to polycyclic thiazole systems and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
摘要翻译：本发明涉及多环噻唑体系及其生理上耐受的盐和生理功能衍生物。描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。所述化合物例如适合作为抗精神病药。

6. 发明授权

US5726305A Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates 失效
公开(公告)号：US5726305A
公开(公告)日：1998-03-10
申请号：US675155
申请日：1996-07-03
申请人： Klaus Weidmann , Karl-Heinz Baringhaus , Georg Tschank , Martin Bickel
发明人： Klaus Weidmann , Karl-Heinz Baringhaus , Georg Tschank , Martin Bickel
IPC分类号： A61K31/47 , A61P1/16 , A61P11/00 , A61P17/00 , A61P37/00 , A61P43/00 , C07D215/48 , C07D215/60 , C07K5/078 , C07D215/14 , C07D215/20
CPC分类号： C07K5/06139 , C07D215/48
摘要： The invention relates to substituted quinoline-2-carboxylic acid amides of the formula I ##STR1## their preparation and their use, and intermediates which are formed in the preparation of the compounds of the formula I. The compounds according to the invention are used as inhibitors of prolyl 4-hydroxylase and as pharmaceuticals (medicaments) for treatment of fibrotic diseases.

7. 发明授权

US5512586A Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides 失效
标题翻译：基于吡啶-2,4-和2,5-二羧酸酰胺的药物
公开(公告)号：US5512586A
公开(公告)日：1996-04-30
申请号：US367770
申请日：1995-01-03
申请人： Martin Bickel , Dietrich Brocks , Harald Burghard , Volkmar Gunzler , Stephan Henke , Hartmut Hanauske-Abel , Jurgen Mohr , Georg Tschank
发明人： Martin Bickel , Dietrich Brocks , Harald Burghard , Volkmar Gunzler , Stephan Henke , Hartmut Hanauske-Abel , Jurgen Mohr , Georg Tschank
IPC分类号： C07D213/81 , C07D213/82 , C07D401/14 , C07D409/14 , C07D417/14 , A61K31/455 , A61K31/445
CPC分类号： C07D213/81 , C07D213/82 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, 3.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.
摘要翻译：本发明涉及式Ⅰ的吡啶-2,4-和二羧酸衍生物，其中R1，R2,33，R4和X具有给定的含义，制备方法的这些化合物及其用途，特别是用于影响胶原和胶原样物质代谢的药物或Clq的生物合成。

8. 发明授权

US5240921A Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, processes for their preparation and their use 失效
标题翻译：环丙基吡啶-2,4-和-2,5-二羧酸二异氰酸酯，其制备方法及其用途
公开(公告)号：US5240921A
公开(公告)日：1993-08-31
申请号：US571107
申请日：1990-08-23
申请人： Ekkehard Baader , Martin Bickel , Volkmar Gunzler-Pukall
发明人： Ekkehard Baader , Martin Bickel , Volkmar Gunzler-Pukall
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61P17/16 , A61P37/06 , C07D213/81 , C07D213/82 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D213/81
摘要： The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can accordingly be employed as fibrosuppressants and immunosuppressants.
摘要翻译：本发明涉及式I（I）的环状吡啶-2,4-和-2,5-二羧酸二酰胺，其中n和X具有给定的含义。根据本发明的化合物抑制脯氨酸羟化酶和赖氨酸羟化酶，因此可以用作纤维抑制剂和免疫抑制剂。

9. 发明授权

US4825036A Device for directing optical rays 失效
标题翻译：用于引导光线的装置
公开(公告)号：US4825036A
公开(公告)日：1989-04-25
申请号：US176441
申请日：1988-04-01
申请人： Martin Bickel , Albrecht Baum
发明人： Martin Bickel , Albrecht Baum
IPC分类号： B23K26/02 , B23K26/10 , B23K26/08
CPC分类号： B23K26/10 , B23K26/02 , B23K26/042
摘要： In the context of a device for directing optical rays along a given path comprising a ray deflecting means there is a pivoting ray exit member, which simultaneously pivotally entrains the deflecting mirror and is arranged to pivot with the mirror about a third axis. The ray exit member is able to pivot about a first axis and the mirror pivots about a second axis and both are mounted on a rotary housing. The first and the second axes are parallel to each other and are located in the reflecting surface of the mirror. By means of a threaded rod and a return spring the ray exit member is turned and its pivoting motion is transmitted via an abutment to the mirror. The distance of the abutment from the first axis is half the size of the distance from the second axis in order thus to pivot the mirror through an angle which is half as large as the pivotal sweep of the ray exit member with the result that the central ray setting in the small exit opening is adhered to. This pivotal motion serves to correct the position when moving the ray along a given line. If the line onto which the ray is to be directed is curved in three dimensions the ray exit member is so swept with the mirror around the third axis that the ray is also kept perpendicular to the point at which the ray is to be directed.
摘要翻译：在用于沿着包括射线偏转装置的给定路径引导光线的装置的上下文中，存在枢转的射线出射构件，其同时枢转夹带偏转镜并且被布置成使得反射镜围绕第三轴线枢转。射线出射构件能够围绕第一轴线枢转，并且镜子围绕第二轴线枢转并且两者都安装在旋转壳体上。第一和第二轴彼此平行并且位于反射镜的反射表面中。通过螺纹杆和复位弹簧，射线出射构件被转动，并且其枢转运动通过邻接件传递到反射镜。邻接部分与第一轴线的距离是从第二轴线的距离的大小的一半，以便使镜子枢转通过与射线出口部件的枢转扫掠一半一样大的角度，结果是中心粘附在小出口的光线设置。当沿着给定的线移动射线时，该枢转运动用于校正位置。如果射线要被引导的线在三维弯曲，则射线出射构件被围绕第三轴扫射，镜子也保持垂直于射线要被定向的点。

10. 发明授权

US4661636A 6-sulfoxyphenol derivatives, their preparation and their use as cytoprotective agents 失效
标题翻译： 6-磺基苯酚衍生物，其制备及其作为细胞保护剂的用途
公开(公告)号：US4661636A
公开(公告)日：1987-04-28
申请号：US648139
申请日：1984-09-07
申请人： Heinrich C. Englert , Hans-Jochen Lang , Dieter Mania , Martin Bickel
发明人： Heinrich C. Englert , Hans-Jochen Lang , Dieter Mania , Martin Bickel
IPC分类号： A61K31/10 , A61K31/11 , A61K31/135 , A61K31/18 , A61K31/415 , A61K31/60 , A61P1/04 , A61P3/00 , C07C45/56 , C07C67/00 , C07C311/15 , C07C313/00 , C07C315/00 , C07C315/04 , C07C317/00 , C07C317/22 , C07C317/32 , C07C317/46 , C07C323/66 , C07D233/02 , C07D325/00 , C07D327/02 , C07D339/00 , C07C149/00 , C07C149/32
CPC分类号： C07D233/02 , C07C309/00 , C07C313/04 , C07C317/00 , C07C45/565
摘要： Compounds of the formula I ##STR1## where R.sup.1 is hydrogen, lower alkyl, lower alkoxy, amino or dialkylamino; R.sup.2 and R.sup.3 are O-alkyl, N-dialkyl or S-alkyl, or R.sup.2 and R.sup.3 together represent --X--(CH.sub.2).sub.m --X, a carbonyl group or an imino group NR, and m is 2-6; where R.sup.4 is lower alkyl, cycloalkyl, alkenyl or dialkylamino, and where R.sup.5 is lower alkyl or cycloalkyl, and where n is 1 or 2, have excellent cytoprotective effects.They are prepared by reacting compounds II ##STR2## with formaldehyde or a reagent producing formaldehyde.
摘要翻译：式I的化合物其中R 1是氢，低级烷基，低级烷氧基，氨基或二烷基氨基; R 2和R 3是O-烷基，N-二烷基或S-烷基，或者R 2和R 3一起表示-X-（CH 2）m -X，羰基或亚氨基NR，m是2-6; 其中R 4是低级烷基，环烷基，烯基或二烷基氨基，其中R 5是低级烷基或环烷基，并且其中n是1或2，具有优异的细胞保护作用。它们通过使化合物II与甲醛或产生甲醛的试剂反应制备。

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