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    • 3. 发明授权
    • Loudspeaker with tapered slot coupler and sound reproduction system
    • 扬声器带锥形槽耦合器和声音再现系统
    • US5943431A
    • 1999-08-24
    • US812766
    • 1997-03-06
    • Alan WeissThomas Brown
    • Alan WeissThomas Brown
    • H04R1/34H04R25/00
    • H04R1/345
    • In accordance with the invention, there is provided a tapered slot coupler combined with a loudspeaker for providing a high degree of uniform angular sound distribution in the horizontal plane, and a sharp cut-off above the horizontal plane through the coupler-speaker combination. It also sends a greater amount of sound energy to the furthest point of the domain and diminishing energy in direction to the interior of the domain as one comes closer and closer to the sound source. A sound reproduction system cooperating with the coupler-speaker combination has a receiving domain for receiving the sound, a perimeter defining the domain, and a plurality of tapered slot high and medium frequency coupler-speakers disposed proximal to the perimeter facing the domain, and a plurality of low frequency loudspeakers also disposed along the perimeter facing the domain, wherein the high/medium frequency loudspeakers are of the tapered slot coupler-speaker combination type. The invention includes sound-energy generating apparatus operative for feeding sound energy to the speakers.
    • 根据本发明,提供了一种与扬声器组合的锥形槽式联接器,用于在水平面中提供高度均匀的角度声音分布,以及通过耦合器 - 扬声器组合在水平面上方的锐利截止。 它还向该领域的最远点发送更大量的声能,并且随着越来越接近声源而朝向内部内部的方向减少能量。 与耦合器 - 扬声器组合协作的声音再现系统具有用于接收声音的接收区域,界定该区域的周边,以及靠近面向该区域的周边设置的多个锥形槽高和中频耦合器扬声器,以及 多个低频扬声器也沿着面向域的周边设置,其中高/中频扬声器是锥形槽耦合器 - 扬声器组合型。 本发明包括可操作以将声能馈送到扬声器的声能发生装置。
    • 5. 发明申请
    • Diluent, methods of manufacture and use
    • 稀释剂,制造和使用方法
    • US20060121627A1
    • 2006-06-08
    • US11325899
    • 2006-01-05
    • John LynchAlan Weiss
    • John LynchAlan Weiss
    • G01N33/543
    • G01N33/54393
    • The use of diluent to reduce non-specific drug binding (NSB) provides a simple, flexible and biocompatible way to reduce chemical entity (such as drugs, drug candidates and other small molecules) NSB so that bioassay results may more closely predict the behavior of these compounds in vitro. Additionally, the use of diluent as the chemical entity diluent enhances the predictive nature of data emanating from high throughput drug assays such as Caco-2 drug transport assays, plasma protein drug binding assays, PAMPA assays, permeability assays, and drug solubility assays. The diluent is made by either filtering a selected plasma through an ultrafiltration membrane having nominal molecular weight cutoff of about 30 kD, preferably about 10 kD or below or by selectively adding individual components of a plasma or serum that do not contribute to non-specific binding.
    • 使用稀释剂来减少非特异性药物结合(NSB)提供了一种简单,灵活和生物相容的方法来减少化学实体(如药物,药物候选物和其他小分子)NSB,以便生物测定结果可以更加密切地预测 这些化合物在体外。 另外,使用稀释剂作为化学实体稀释剂增强了从高通量药物测定(例如Caco-2药物转运测定法,血浆蛋白质药物结合测定法,PAMPA测定法,渗透性测定法和药物溶解度测定)中发出的数据的预测性质。 稀释剂通过将选定的血浆过滤通过具有约30kD,优选约10kD或更低的标称分子量截留值的超滤膜或通过选择性加入不对非特异性结合有贡献的血浆或血清的各成分来制备 。