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1. 发明授权

US08639323B2 System and apparatus to monitor biopacemaker maturation 有权
标题翻译：监测生物空间成熟的系统和仪器
公开(公告)号：US08639323B2
公开(公告)日：2014-01-28
申请号：US12917062
申请日：2010-11-01
申请人： Vinod Sharma , Deborah A. Jaye , Daniel Sigg
发明人： Vinod Sharma , Deborah A. Jaye , Daniel Sigg
IPC分类号： A61N1/08
CPC分类号： A61N1/362 , A61B5/021 , A61B5/026 , A61B5/0468 , A61B5/14503 , A61B5/14542 , A61B5/4848 , A61B5/686 , A61B5/7232 , A61K48/005 , A61N1/3702 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H15/00 , G16H40/63
摘要： The present invention includes systems, devices, and methods relating to the monitoring of the functional maturation of biological interventions effecting cardiac pacing; the systems, devices, and methods including an implantable electronic pulse generator delivering artificial cardiac pacing; a means for halting the electronic pulse generator delivering artificial cardiac pacing at predetermined data collection intervals; and a sensor for recording and storing data on one or more intrinsic physiological parameters of cardiac pacing during the predetermined data collection intervals.
摘要翻译：本发明包括与影响心脏起搏的生物干预功能成熟的监测有关的系统，装置和方法; 所述系统，装置和方法包括递送人造心脏起搏的可植入电子脉冲发生器; 用于停止以预定的数据采集间隔递送人造心脏起搏的电子脉冲发生器的装置; 以及用于在预定数据收集间隔期间记录和存储关于心脏起搏的一个或多个固有生理参数的数据的传感器。

2. 发明申请

US20120109231A1 SYSTEM AND APPARATUS TO MONITOR BIOPACEMAKER MATURATION 有权
标题翻译：系统和设备监控生物显微成像
公开(公告)号：US20120109231A1
公开(公告)日：2012-05-03
申请号：US12917062
申请日：2010-11-01
申请人： Vinod Sharma , Deborah A. Jaye , Daniel Sigg
发明人： Vinod Sharma , Deborah A. Jaye , Daniel Sigg
IPC分类号： A61N1/37
CPC分类号： A61N1/362 , A61B5/021 , A61B5/026 , A61B5/0468 , A61B5/14503 , A61B5/14542 , A61B5/4848 , A61B5/686 , A61B5/7232 , A61K48/005 , A61N1/3702 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H15/00 , G16H40/63
摘要： The present invention includes systems, devices, and methods relating to the monitoring of the functional maturation of biological interventions effecting cardiac pacing.
摘要翻译：本发明包括与影响心脏起搏的生物干预功能成熟的监测有关的系统，装置和方法。

3. 发明申请

US20060247697A1 Rate control during AF using cellular intervention to modulate AV node 有权
标题翻译：使用细胞干预调整AV节点的AF期间的速率控制
公开(公告)号：US20060247697A1
公开(公告)日：2006-11-02
申请号：US11116621
申请日：2005-04-28
申请人： Vinod Sharma , Daniel Sigg
发明人： Vinod Sharma , Daniel Sigg
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61K9/0019 , A61K31/221 , A61K38/177 , A61N1/0568
摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.
摘要翻译：生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。具体地，通用试剂用于调制心脏传导系统中的节点，包括使用一个和一组K + SUPER通道或等同物的组合的速率控制。具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。例如，可以使用Kv1.3通道作为生物通道。本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。

4. 发明申请

US20070087033A1 Self-fixating scaffolds 审中-公开
标题翻译：自固定脚手架
公开(公告)号：US20070087033A1
公开(公告)日：2007-04-19
申请号：US11250141
申请日：2005-10-14
申请人： Daniel Sigg , Prasanga Hiniduma-Lokuge , Vinod Sharma , John Sommer
发明人： Daniel Sigg , Prasanga Hiniduma-Lokuge , Vinod Sharma , John Sommer
IPC分类号： A61F2/00
CPC分类号： A61F2/02 , A61F2/2493 , A61F2250/0067
摘要： A self-fixating scaffold delivers therapeutic material to tissue for treating various diseases/conditions. A scaffold holds the therapeutic material and is implanted into the tissue. A fixation element anchors the scaffold in the tissue making the scaffold less likely to become dislodged.
摘要翻译：自固定支架将治疗材料递送至组织以治疗各种疾病/病症。支架固定治疗材料并植入组织。固定元件将支架锚定在组织中，使得支架不太可能脱落。

5. 发明授权

US08777874B2 Acoustic based cough detection 有权
标题翻译：声学咳嗽检测
公开(公告)号：US08777874B2
公开(公告)日：2014-07-15
申请号：US13114838
申请日：2011-05-24
申请人： Xusheng Zhang , Vinod Sharma , Eduardo N. Warman
发明人： Xusheng Zhang , Vinod Sharma , Eduardo N. Warman
IPC分类号： A61B7/00
CPC分类号： A61B5/0823 , A61B5/0205 , A61B5/11 , A61B5/686 , A61B2562/0204 , A61B2562/0219 , A61N1/3621 , A61N1/3627
摘要： The present disclosure is directed to the detection of coughs and coughing episodes using acoustic signals. In various examples, an implantable medical device processes an acoustic signal obtained from an acoustic sensor to determine whether a patient has coughed. In some examples, the implantable medical device also performs a cough severity assessment. In some examples, the cough severity assessment may include a determination of the depth of the cough, the duration of the coughing episode, or whether the cough was wet or dry.
摘要翻译：本公开涉及使用声信号检测咳嗽和咳嗽发作。在各种示例中，可植入医疗装置处理从声传感器获得的声信号，以确定患者是否已经咳嗽。在一些示例中，可植入医疗装置还执行咳嗽严重度评估。在一些实例中，咳嗽严重度评估可以包括确定咳嗽的深度，咳嗽发作的持续时间，或者咳嗽是湿还是干燥。

6. 发明授权

US08565898B2 Rate control during AF using cellular intervention to modulate AV node 有权
标题翻译：使用细胞干预调整AV节点的AF期间的速率控制
公开(公告)号：US08565898B2
公开(公告)日：2013-10-22
申请号：US11116621
申请日：2005-04-28
申请人： Vinod Sharma , Daniel C. Sigg
发明人： Vinod Sharma , Daniel C. Sigg
IPC分类号： A61N1/00 , A61K38/00 , A61K38/16
CPC分类号： A61N1/362 , A61K9/0019 , A61K31/221 , A61K38/177 , A61N1/0568
摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.
摘要翻译：生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。具体地，通用代理用于调制心脏传导系统中的节点，包括使用一个K +通道或等效物系的组合的速率控制。具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。例如，可以使用Kv1.3通道作为生物通道。本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。

7. 发明申请

US20110300107A1 Compositions and Methods to Treat Cardiac Pacing Conditions 有权
标题翻译：心脏起搏条件的组合和方法
公开(公告)号：US20110300107A1
公开(公告)日：2011-12-08
申请号：US13096135
申请日：2011-04-28
申请人： Vinod Sharma , Xiaohong Qiu
发明人： Vinod Sharma , Xiaohong Qiu
IPC分类号： A61K31/7088 , A61P9/00 , C12N5/10 , A61K35/00
CPC分类号： C12N15/86 , A61K35/13 , A61K48/005 , A61K48/0075 , C07K14/4705 , C12N2750/14143
摘要： The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.
摘要翻译：该方法可以包括向有需要的受试者施用有效量的HCN多核苷酸。 HCN多核苷酸包括编码具有通道活性的HCN多肽的核苷酸序列。 HCN多肽的氨基酸序列和参考多肽的氨基酸序列具有至少80％的同一性，其中参考多肽以选自氨基酸92-214的氨基酸开始，并以选自氨基酸的氨基酸结束 SEQ ID NO：8的723-1188。参考多肽的实例是SEQ ID NO：8的氨基酸214-723。 HCN多核苷酸可以是DNA或RNA。

8. 发明申请

US20090034128A1 Method and apparatus for independent piezoelectric excitation in the micro-actuator assemblies of a hard disk drive for improved drive reliability 审中-公开
标题翻译：用于硬盘驱动器的微致动器组件中的独立压电激励的方法和装置，用于提高驱动可靠性
公开(公告)号：US20090034128A1
公开(公告)日：2009-02-05
申请号：US11897936
申请日：2007-08-31
申请人： Vinod Sharma , Hyung Jai Lee
发明人： Vinod Sharma , Hyung Jai Lee
IPC分类号： G11B21/24
CPC分类号： G11B5/4826 , G11B5/4873 , G11B5/5552
摘要： A hard disk drive using a micro-actuator assembly to position a slider over a track on a rotating disk surface. The micro-actuator assembly includes a first piezoelectric device and a second piezoelectric device, both mechanically coupled to the slider. The first piezoelectric device includes a first terminal electrically coupled to a first voltage line and a second terminal electrically coupled to a ground line. The second piezoelectric device includes a third terminal electrically coupled to a ground line and a fourth terminal electrically coupled to a voltage line. A voltage applied to the first voltage line stimulates only the first piezoelectric device to alter a lateral position of the slider over the rotating disk surface, and a second voltage applied to the second voltage line stimulates only the second piezoelectric device to alter the lateral position of the slider over the rotating disk surface.
摘要翻译：使用微型致动器组件的硬盘驱动器将滑块定位在旋转盘表面上的轨道上。微致动器组件包括机械地联接到滑块的第一压电装置和第二压电装置。第一压电器件包括电耦合到第一电压线的第一端子和电耦合到接地线的第二端子。第二压电器件包括电耦合到接地线的第三端子和电耦合到电压线的第四端子。施加到第一电压线的电压仅刺激第一压电装置来改变滑块在旋转盘表面上的横向位置，并且施加到第二电压线的第二电压仅刺激第二压电装置改变第二压电装置的横向位置滑块越过旋转盘表面。

9. 发明申请

US20080259480A1 Glide test and calibration using flying height on demand 审中-公开
标题翻译：使用飞行高度进行滑行测试和校准
公开(公告)号：US20080259480A1
公开(公告)日：2008-10-23
申请号：US11787879
申请日：2007-04-17
申请人： Hoa Pham , Vinod Sharma , Sang Lee
发明人： Hoa Pham , Vinod Sharma , Sang Lee
IPC分类号： G11B5/455 , G11B15/64 , G11B5/56
CPC分类号： G11B5/455 , G11B5/60 , G11B5/6064
摘要： A glide head that can be used to certify disks of hard disk drives. The glide head includes a heater that can change the temperature of a slider surface of the head and vary the head flying height. The slider surface may induce the negative pressure so that the glide head more accurately simulates a head used in a production disk drive. A piezoelectric transducer may be coupled to the glide head so that contact between the head and a disk may be sensed and recorded in a disk certification routine.
摘要翻译：可用于认证硬盘驱动器磁盘的滑动头。滑行头包括可以改变头部的滑块表面的温度并改变头部飞行高度的加热器。滑块表面可以引起负压，使得滑动头更准确地模拟生产磁盘驱动器中使用的磁头。压电传感器可以耦合到滑动头，使得头和盘之间的接触可以被感测并记录在磁盘认证程序中。

10. 发明申请

US20080002302A1 Method and apparatus for head gimbal assembly with improved shock performance in hard disk drive 审中-公开
标题翻译：用于磁头万向节组装的方法和装置，具有改善的硬盘驱动器的冲击性能
公开(公告)号：US20080002302A1
公开(公告)日：2008-01-03
申请号：US11435271
申请日：2006-05-15
申请人： Hae-sung Kwon , Eo-Jin Hong , Yun-Sik Han , Vinod Sharma , Hyung Lee
发明人： Hae-sung Kwon , Eo-Jin Hong , Yun-Sik Han , Vinod Sharma , Hyung Lee
IPC分类号： G11B5/48
CPC分类号： G11B5/4826 , G11B5/40 , G11B5/5582
摘要： This invention stems from knowing that a head gimbal assembly has twice as much of its mass centered on its base plate as it has on its slider performs better in terms of resilience to mechanical shock than one with twice as much mass on the slider as on its base plate. The inventors realized that while these two configurations in normal operation are almost identical, during the impulse and after shocks, the slider with the smaller ratio of mass to the base plate performs better. The invention includes manufacturing methods for the head gimbal assembly, the head stack assembly, and the hard disk drive, as well as these items as products of their respective manufacturing processes.
摘要翻译：本发明源于知道头部万向节组件的质量是其基板的两倍，因为它的滑块在弹性回弹性方面比在滑块上具有两倍质量的弹性更好。底盘。发明人意识到，虽然这两种正常操作中的这两种配置几乎相同，但是在冲击和冲击之后，质量与基板之间的比例较小的滑块性能更好。本发明包括头部万向节组件，磁头组合组件和硬盘驱动器的制造方法，以及作为其各自制造工艺的产品的这些项目。

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