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1. 发明申请

US20080076819A1 INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权
标题翻译： 11-羟基脱氢酶脱氢酶1型酶的抑制剂
公开(公告)号：US20080076819A1
公开(公告)日：2008-03-27
申请号：US11697044
申请日：2007-04-05
申请人： Vince Yeh , Ravi Kurukulasuriya , David Madar , James Link
发明人： Vince Yeh , Ravi Kurukulasuriya , David Madar , James Link
IPC分类号： A61K31/40 , A61P3/04 , C07D207/00
CPC分类号： C07D401/14 , C07D207/26 , C07D207/267 , C07D401/12 , C07D403/12
摘要： A compound of formula (I): or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Methods of inhibiting 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. Methods of treating non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译：式（I）的化合物或其药学上可接受的盐，前药，前药的盐或其组合。抑制11-β-羟基类固醇脱氢酶1型酶的方法。治疗非胰岛素依赖型2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征等由过度糖皮质激素作用介导的疾病和病症的方法。

2. 发明申请

US20070179186A1 INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权
标题翻译： 11-羟基脱氢酶脱氢酶1型酶的抑制剂
公开(公告)号：US20070179186A1
公开(公告)日：2007-08-02
申请号：US11733636
申请日：2007-04-10
申请人： Jeffrey Rohde , Qi Shuai , James Link , Jyoti Patel , Jurgen Dinges , Bryan Sorensen , Hong Yong , Vince Yeh , Ravi Kurukulasuriya
发明人： Jeffrey Rohde , Qi Shuai , James Link , Jyoti Patel , Jurgen Dinges , Bryan Sorensen , Hong Yong , Vince Yeh , Ravi Kurukulasuriya
IPC分类号： A61K31/445 , A61K31/4015 , C07D211/06
CPC分类号： C07D207/277 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要： The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme, The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及作为11-β-羟基类固醇脱氢酶1型酶的抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖型 2型糖尿病，胰岛素抵抗，肥胖，脂质障碍，代谢综合征以及由过度糖皮质激素作用介导的其他疾病和病症。

3. 发明申请

US20060149070A1 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme 有权
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂
公开(公告)号：US20060149070A1
公开(公告)日：2006-07-06
申请号：US11326277
申请日：2006-01-05
申请人： Jeffrey Rohde , Qi Shuai , James Link , Jyoti Patel , Jurgen Dinges , Bryan Sorensen , Hong Yong , Vince Yeh , Ravi Kurukulasuriya
发明人： Jeffrey Rohde , Qi Shuai , James Link , Jyoti Patel , Jurgen Dinges , Bryan Sorensen , Hong Yong , Vince Yeh , Ravi Kurukulasuriya
IPC分类号： C07D211/06
CPC分类号： C07D207/277 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要： The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及作为11-β-羟基类固醇脱氢酶1型酶的抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途由过度的糖皮质激素作用。

4. 发明申请

US20060281773A1 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme 有权
公开(公告)号：US20060281773A1
公开(公告)日：2006-12-14
申请号：US11325965
申请日：2006-01-05
申请人： Jyoti Patel , Qi Shuai , James Link , Jeffrey Rohde , Jurgen Dinges , Bryan Sorensen , Martin Winn , Hong Yong , Vince Yeh
发明人： Jyoti Patel , Qi Shuai , James Link , Jeffrey Rohde , Jurgen Dinges , Bryan Sorensen , Martin Winn , Hong Yong , Vince Yeh
IPC分类号： A61K31/505 , A61K31/401 , A61K31/41 , A61K31/195 , A61K31/277
CPC分类号： C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

5. 发明授权

US07565734B2 Replaceable induction forging coil 失效
标题翻译：可更换感应锻造线圈
公开(公告)号：US07565734B2
公开(公告)日：2009-07-28
申请号：US11562321
申请日：2006-11-21
申请人： Jason D. Link , James Link
发明人： Jason D. Link , James Link
IPC分类号： B23P19/00 , B23K9/18
CPC分类号： B21J17/02 , H05B6/101 , Y10T29/49073 , Y10T29/53187 , Y10T29/532 , Y10T29/53243 , Y10T29/53257
摘要： An induction forging coil apparatus which makes induction forge coils easier and faster to change on a forge-line. The coil insert is a separate independent unit by itself which slides into the frame to connect to the frame via bus connections and other components. The coil insert is attached to the frame (another separate independent unit by itself) to complete the overall induction heating coil. The induction coil (with both units attached and operatively interconnected) can run on the forge line until it blows/fails, and instead of pulling the whole induction coil (both units attached) off-line to be rebuilt; the frame can be left on-line (or pulled off-line for a brief period of time if there is not enough room to reach the components due to the particular forge-line setup) to switch the failed insert with a new or rebuilt insert, by disconnecting the failed coil insert from the frame and then reconnecting the frame with the new or rebuilt coil insert.
摘要翻译：一种感应锻造线圈装置，其使感应锻造线圈在锻造线路上更容易和更快地改变。线圈插件本身是独立的独立单元，其通过总线连接和其它部件滑入框架以连接到框架。线圈插入件附接到框架（另外单独的独立单元）以完成整个感应加热线圈。感应线圈（两个单元连接和可操作地互连）可以在锻造线上运行，直到其发生/失效，而不是拉离整个感应线圈（两个单元附近）以进行重建; 如果由于特定的伪造线设置而没有足够的空间到达组件，则该框架可以保留在线（或者离线脱机），以便使用新的或重建的插入来切换失败的插入通过将故障的线圈插入件与框架断开，然后将框架与新的或重建的线圈插入件重新连接。

6. 发明申请

US20070027117A1 Novel glucocorticoid receptor ligands for the treatment of metabolic disorders 失效
标题翻译：用于治疗代谢紊乱的新型糖皮质激素受体配体
公开(公告)号：US20070027117A1
公开(公告)日：2007-02-01
申请号：US11491337
申请日：2006-07-21
申请人： Richard Bishop , Russell Cink , Bradley Gates , Lars Hagberg , Peer Jacobsen , Philip Kym , Chunqiu Lai , Marvin Leanna , James Link , Steven Richards , Noah Tu , Tom von Geldern
发明人： Richard Bishop , Russell Cink , Bradley Gates , Lars Hagberg , Peer Jacobsen , Philip Kym , Chunqiu Lai , Marvin Leanna , James Link , Steven Richards , Noah Tu , Tom von Geldern
IPC分类号： A61K31/66 , A61K31/56
CPC分类号： C07J1/00 , Y10S514/866 , Y10S514/909
摘要： This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.
摘要翻译：本发明涉及作为肝脏选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及使用这些化合物来调节代谢的方法，特别是降低血清葡萄糖水平，胰岛素水平或脂质水平，和/或减轻体重。

7. 发明申请

US20050245745A1 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme 审中-公开
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂
公开(公告)号：US20050245745A1
公开(公告)日：2005-11-03
申请号：US10834459
申请日：2004-04-29
申请人： James Link , Marina Pliushchev , Jeffrey Rohde , Dariusz Wodka
发明人： James Link , Marina Pliushchev , Jeffrey Rohde , Dariusz Wodka
IPC分类号： C07D205/04 , C07D211/06 , C07D211/46 , C07D213/74 , C07D295/15
CPC分类号： C07D295/15 , C07D205/04 , C07D211/46 , C07D213/74
摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征以及其它疾病和病症的用途由过度的糖皮质激素作用介导。

8. 发明申请

US20050245532A1 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application 审中-公开
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂及其治疗应用
公开(公告)号：US20050245532A1
公开(公告)日：2005-11-03
申请号：US10835132
申请日：2004-04-29
申请人： Ethan Hoff , James Link , Marina Pliushchev , Jeffrey Rohde , Martin Winn
发明人： Ethan Hoff , James Link , Marina Pliushchev , Jeffrey Rohde , Martin Winn
IPC分类号： A61K31/445 , A61K31/495 , A61K31/496
CPC分类号： A61K31/445 , A61K31/495 , A61K31/496
摘要： The present invention relates to the use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment or prophylactically treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及11-β-羟基类固醇脱氢酶1型酶抑制剂的用途。本发明还涉及11-β-羟基类固醇脱氢酶1型酶抑制剂用于治疗或预防性治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其它疾病的用途，以及过度糖皮质激素作用介导的病症。

9. 发明授权

US06878700B1 Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds 失效
标题翻译：细胞粘附抑制抗炎和免疫抑制化合物
公开(公告)号：US06878700B1
公开(公告)日：2005-04-12
申请号：US09541795
申请日：2000-03-31
申请人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00 , A61K31/33 , A61K31/415 , C07D221/02 , C07D265/30 , C07D319/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎性和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。

10. 发明申请

US20060148871A1 Metabolic stabilization of substituted adamantane 审中-公开
标题翻译：取代金刚烷的代谢稳定
公开(公告)号：US20060148871A1
公开(公告)日：2006-07-06
申请号：US11325956
申请日：2006-01-05
申请人： Jeffrey Rohde , Liping Pan , Marina Pliushchev , James Link
发明人： Jeffrey Rohde , Liping Pan , Marina Pliushchev , James Link
IPC分类号： A61K31/41 , A61K31/19 , A61K31/18
CPC分类号： A61K31/18 , A61K31/19 , A61K31/41
摘要： The present invention is directed to the method of increasing the metabolic stability of adamantane containing compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 (11-beta-HSD-1) enzyme. The stability is achieved by substitutions of the adamantane ring.
摘要翻译：本发明涉及增加含有金刚烷的化合物（其为11-β-羟基类固醇脱氢酶1型（11-β-HSD-1））的抑制剂的代谢稳定性的方法。稳定性通过金刚烷环的取代来实现。

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