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1. 发明申请

US20070027117A1 Novel glucocorticoid receptor ligands for the treatment of metabolic disorders 失效
标题翻译：用于治疗代谢紊乱的新型糖皮质激素受体配体
公开(公告)号：US20070027117A1
公开(公告)日：2007-02-01
申请号：US11491337
申请日：2006-07-21
申请人： Richard Bishop , Russell Cink , Bradley Gates , Lars Hagberg , Peer Jacobsen , Philip Kym , Chunqiu Lai , Marvin Leanna , James Link , Steven Richards , Noah Tu , Tom von Geldern
发明人： Richard Bishop , Russell Cink , Bradley Gates , Lars Hagberg , Peer Jacobsen , Philip Kym , Chunqiu Lai , Marvin Leanna , James Link , Steven Richards , Noah Tu , Tom von Geldern
IPC分类号： A61K31/66 , A61K31/56
CPC分类号： C07J1/00 , Y10S514/866 , Y10S514/909
摘要： This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.
摘要翻译：本发明涉及作为肝脏选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及使用这些化合物来调节代谢的方法，特别是降低血清葡萄糖水平，胰岛素水平或脂质水平，和/或减轻体重。

2. 发明授权

US4299189A Dipping device 失效
标题翻译：浸渍装置
公开(公告)号：US4299189A
公开(公告)日：1981-11-10
申请号：US147157
申请日：1980-05-06
申请人： Lars Hagberg , Ake Jonsen
发明人： Lars Hagberg , Ake Jonsen
IPC分类号： B05C3/10 , B65G49/04 , B65G49/02
CPC分类号： B65G49/025 , B05C3/10 , B65G49/0413
摘要： A device for dipping plates (40) in a liquid (70) includes a plurality of elements (20) which form a number of disc-like devices secured at a certain distance from each other on a rotatable shaft (30). Each element is provided with several evenly spaced recesses for receiving the plates and each plate received rests in at least two recesses. The elements are partially immersed in the liquid. The drive mechanism rotates the shaft in steps and the recesses, together with the plates contained in them, then pass through the liquid. During the pauses between the elements rotating, a feeder device (51) pushes the plates into the recesses (21') in the elements from a feeder table (52), whereas the dipped plates are moved by an ejector device (61) to a receiving device (62. The receiving device has a number of compartments (64) with surfaces (60) located above one another, and these compartments are gradually moved into position for receiving the dipped plates. A control and computing device deducts the number of plates delivered from the number of compartments in the receiving device, so that the storage capacity of the latter will not be exceeded.
摘要翻译：用于将板（40）浸在液体（70）中的装置包括多个元件（20），其形成在旋转轴（30）上彼此固定一定距离的多个盘状装置。每个元件设置有几个均匀间隔的凹部，用于接纳板，并且每个板在至少两个凹部中接收。元件部分浸入液体中。驱动机构使轴逐步旋转，并且凹部与其中包含的板一起通过液体。在旋转元件之间的暂停期间，馈送装置（51）将板推入来自进料台（52）的元件中的凹槽（21'），而浸渍板通过喷射器装置（61）移动到接收装置（62）。接收装置具有多个具有彼此位于上方的表面（60）的隔室（64），并且这些隔间逐渐移动到用于接收浸渍板的位置。控制和计算装置扣除板数从接收设备中的隔间数量传送，从而不会超过后者的存储容量。

3. 发明授权

US4118149A Output regulation in hydraulic and hydropneumatic systems 失效
标题翻译：液压和液压气动系统的输出调节
公开(公告)号：US4118149A
公开(公告)日：1978-10-03
申请号：US764472
申请日：1977-01-31
申请人： Lars Hagberg
发明人： Lars Hagberg
IPC分类号： F04B49/06 , F04B49/20 , G05D7/03 , F16D31/02
CPC分类号： F04B49/20 , G05D7/03
摘要： Apparatus for regulating the output of a system feed with a fluid medium irrespective of the instantaneous pressure in the system comprising a regulating device including an adjustable throttling connected in the inlet line of the system. A preset non-return valve is connected downstream of the throttling and a spring loaded non-return valve is connected in series with the preset non-return valve and is fitted with a leakage connection extending to a reservoir tank. A control line is connected between the pre-set non-return valve and the spring loaded non-return valve and it senses pressure drop at the throttling so that when the pressure drop reaches a predetermined value the non-return valve opens so that fluid medium is transferred and pressure in the control line increases. A central device is connected in the control line for regulating a quantity of flow to the primary line and the control device comprises a spring loaded piston actuated by increased pressure in the control line.
摘要翻译：用于通过流体介质调节系统进料的输出的装置，而与系统中的瞬时压力无关，包括调节装置，该调节装置包括连接在系统的入口管线中的可调节流。预调节止回阀连接在节流器的下游，弹簧加载的止回阀与预设的止回阀串联连接，并配有延伸到储罐的泄漏连接。控制线连接在预设的止回阀和弹簧加载的止回阀之间，并且其感测节流时的压降，使得当压降达到预定值时，止回阀打开，使得流体介质被控制线上的压力增加。一个中央装置连接在控制管线中，用于调节到一条线路的流量，并且该控制装置包括由控制线路中增加的压力致动的弹簧加载的活塞。

4. 发明申请

US20100210524A1 NOVEL ESTROGEN RECEPTOR LIGANDS 审中-公开
标题翻译：新颖的雌激素受体配体
公开(公告)号：US20100210524A1
公开(公告)日：2010-08-19
申请号：US12452678
申请日：2008-07-21
申请人： Theresa Apelqvist , Joakim Löfstedt , Thomas Norin , Mattias Wennerstål , Xiongyu Wu , Lars Hagberg
发明人： Theresa Apelqvist , Joakim Löfstedt , Thomas Norin , Mattias Wennerstål , Xiongyu Wu , Lars Hagberg
IPC分类号： A61K31/122 , C07C49/747 , C07C255/47 , A61K31/277 , C07C251/44 , A61K31/15 , C07C233/33 , A61K31/167 , C07D333/38 , A61K31/381 , C07D307/46 , A61K31/341 , C07D277/34 , A61K31/426 , C07D207/333 , A61K31/40 , C07C69/78 , A61K31/235 , C07D261/08 , A61K31/42 , C07C211/45 , A61K31/136 , C07D231/56 , A61K31/416 , C07D407/10 , C07D209/52 , A61K31/403 , C07C311/08 , A61K31/18 , C07C311/21 , A61K31/663 , A61K31/565 , A61K38/23 , A61K31/59 , A61P35/00 , A61P37/06 , A61P25/00 , A61P19/00 , A61P19/10 , A61P3/04 , A61P3/06 , A61P9/00 , A61P15/00
CPC分类号： C07C49/747 , C07C45/513 , C07C45/62 , C07C45/63 , C07C45/65 , C07C45/66 , C07C45/673 , C07C45/676 , C07C45/68 , C07C45/69 , C07C45/71 , C07C45/72 , C07C45/78 , C07C49/753 , C07C49/84 , C07C69/63 , C07C225/22 , C07C233/33 , C07C251/44 , C07C255/47 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2602/22 , C07C2602/30 , C07D207/333 , C07D209/44 , C07D209/94 , C07D231/56 , C07D261/08 , C07D277/24 , C07D277/34 , C07D307/46 , C07D307/52 , C07D333/16 , C07D333/22 , C07D333/38 , C07C49/633
摘要： The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are as defined in the specification. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯，酰胺，溶剂合物或其盐，包括这种酯或酰胺的盐，以及这种酯，酰胺或盐的溶剂合物，其中W，X， Y，Z，R 1，R 2，R 7，R 8，R 9，R 10，R 11，R 12，R 13，R 14，R 15和R 16如说明书中所定义。本发明还提供了这样的化合物在治疗或预防与雌激素受体活性相关的疾病或病症相关的病症中的用途。

5. 发明授权

US09586891B2 Estrogen receptor ligands 有权
标题翻译：雌激素受体配体
公开(公告)号：US09586891B2
公开(公告)日：2017-03-07
申请号：US14234916
申请日：2012-08-02
申请人： Aiping Cheng , Neeraj Garg , Lars Krüger , Joakim Löfstedt , Eva Koch , Konrad Koehler , Lars Hagberg , Daniel Nöteberg
发明人： Aiping Cheng , Neeraj Garg , Lars Krüger , Joakim Löfstedt , Eva Koch , Konrad Koehler , Lars Hagberg , Daniel Nöteberg
IPC分类号： C07C251/48 , A61K31/381 , C07D261/08 , C07D207/327 , C07D213/58 , C07D215/12 , C07D217/14 , C07D231/12 , C07D233/64 , C07D235/16 , C07D277/30 , C07D277/34 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/87 , C07D317/60 , C07D333/20 , C07D409/10 , C07D413/10 , C07C209/68 , A61K31/155 , A61K31/341 , A61K31/416 , A61K31/42 , A61K31/4418 , A61K31/47 , A61K31/472 , C07D215/14 , C07D217/16 , C07D333/24
CPC分类号： A61K31/472 , A61K31/155 , A61K31/165 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/365 , A61K31/381 , A61K31/402 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/44 , A61K31/4418 , A61K31/47 , C07C209/68 , C07C251/48 , C07D207/327 , C07D213/58 , C07D215/12 , C07D215/14 , C07D217/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/16 , C07D261/08 , C07D277/30 , C07D277/34 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/87 , C07D317/60 , C07D333/20 , C07D333/24 , C07D409/10 , C07D413/10 , C07C211/65
摘要： Compounds of formula (I) or a pharmaceutically acceptable ester, amide, carbamate or salt thereof, including a salt of such an ester, amide or carbamate in which R1 to R9 have meanings as defined in the Specification, are useful as estrogen receptor ligands.
摘要翻译：式（I）化合物或其药学上可接受的酯，酰胺，氨基甲酸酯或其盐，包括其中R 1至R 9具有如本说明书中所定义的含义的酯，酰胺或氨基甲酸酯的盐，可用作雌激素受体配体。

6. 发明授权

US08710243B2 Estrogen receptor ligands 有权
标题翻译：雌激素受体配体
公开(公告)号：US08710243B2
公开(公告)日：2014-04-29
申请号：US13500471
申请日：2010-10-06
申请人： Lars Hagberg , Sandra Gordon , Aiping Cheng , Theresa Apelqvist , Patrik Rhönnstad , Mattias Wennerstål
发明人： Lars Hagberg , Sandra Gordon , Aiping Cheng , Theresa Apelqvist , Patrik Rhönnstad , Mattias Wennerstål
IPC分类号： C07D209/12
CPC分类号： C07D207/32 , C07D409/04 , C07D413/04 , C07D417/04
摘要： The invention provides a compound of formula(I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity. Formula(I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined in the specification.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯，酰胺，溶剂化物或其盐，包括这种酯或酰胺的盐，以及这种酯，酰胺或盐的溶剂合物。本发明还提供了这样的化合物在治疗或预防与与雌激素受体活性相关的疾病或病症相关的病症中的用途。式（I）其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10如说明书中所定义。

7. 发明申请

US20120202861A1 NOVEL ESTROGEN RECEPTOR LIGANDS 有权
标题翻译：新颖的雌激素受体配体
公开(公告)号：US20120202861A1
公开(公告)日：2012-08-09
申请号：US13500471
申请日：2010-10-06
申请人： Mattias Wennerstål , Patrik Rhönnstad , Aiping Cheng , Sandra Gordon , Theresa Apelqvist , Lars Hagberg
发明人： Mattias Wennerstål , Patrik Rhönnstad , Aiping Cheng , Sandra Gordon , Theresa Apelqvist , Lars Hagberg
IPC分类号： A61K31/427 , G01N33/566 , A61K31/422 , A61K31/404 , C07D417/04 , C07D413/04 , C07D409/04 , A61P19/08 , A61P19/10 , A61P3/06 , A61P9/00 , A61P3/04 , A61P13/02 , A61P25/22 , A61P25/24 , A61P15/00 , A61P25/20 , A61P27/16 , A61P25/16 , A61P25/28 , A61P29/00 , A61P9/12 , A61P27/02 , A61P11/00 , A61P35/00 , A61P17/02 , C12Q1/68
CPC分类号： C07D207/32 , C07D409/04 , C07D413/04 , C07D417/04
摘要： The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity. Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined in the specification.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯，酰胺，溶剂化物或其盐，包括这种酯或酰胺的盐，以及这种酯，酰胺或盐的溶剂合物。本发明还提供了这样的化合物在治疗或预防与与雌激素受体活性相关的疾病或病症相关的病症中的用途。式（I）其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10如说明书中所定义。

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