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1. 发明授权

US06200547B1 Magnetically responsive compositions for carrying biologically active substances and methods of production and use 失效
标题翻译：用于携带生物活性物质的磁响应组合物及其生产和使用方法
公开(公告)号：US06200547B1
公开(公告)日：2001-03-13
申请号：US09003286
申请日：1998-01-06
申请人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
发明人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
IPC分类号： A61K916
CPC分类号： A61K9/5094 , A61K9/0009 , A61K9/143
摘要： A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0.2 to 5.0 &mgr;m in size, and preferably between 0.5 and 5.0 &mgr;m, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc99, and antisense-C Myc oligonucleotide, an hematoporphyrin derivative, 6-mercaptopurine, Amphotericin B, and Camptothecin have been produced using this invention. Magnetic carrier particles having diagnostic quantities of adsorbed Re186 and Re188 have also been produced using this invention.
摘要翻译：公开了磁性可控或引导的载体组合物和使用和生产方法，用于将生物活性物质运送到在磁场控制下的体内治疗区域的组合物。该组合物包含尺寸为0.2-5.0μm的复合体积复合紫杉醇吸附颗粒，优选为0.5-5.0μm，含有1.0至95.0wt％的碳，优选为约20wt％至约60wt％。颗粒通过机械研磨铁和碳粉末的混合物来制备。将获得的颗粒置于生物活性物质的溶液中以将物质吸附到颗粒上。组合物通常以悬浮液的形式施用。已经使用本发明制备了具有治疗量的吸附的紫杉醇，多柔比星，Tc99和反义-CMyc寡核苷酸，血卟啉衍生物，6-巯基嘌呤，两性霉素B和喜树碱的磁性载体颗粒。具有吸附的Re186和Re188诊断量的磁性载体颗粒也已经使用本发明生产。

2. 发明授权

US06482436B1 Magnetically responsive composition 失效
标题翻译：磁响应组成
公开(公告)号：US06482436B1
公开(公告)日：2002-11-19
申请号：US09226818
申请日：1999-01-06
申请人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
发明人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
IPC分类号： A61K914
CPC分类号： A61K9/5094 , A61K9/0009 , A61K9/143 , A61K41/0052
摘要： A magnetically controllable, or guided, ferrocarbon particle composition and methods of use and production are disclosed. The composition may optionally carry biologically active substances that have been adsorbed onto the particle. The composition comprises composite, volume-compounded particles of 0.1 to 5.0 &mgr;m in size, and preferably between 0.5 and 5.0 &mgr;m, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles may be produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are optionally placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension.
摘要翻译：公开了磁控制或引导的碳碳颗粒组合物及其使用和生产方法。组合物可以任选地携带已经吸附到颗粒上的生物活性物质。组合物包含0.1〜5.0μm的复合体积复合粒子，优选为0.5〜5.0μm，含有1.0〜95.0质量％的碳，优选为20〜60％左右。颗粒可以通过机械研磨铁和碳粉末的混合物来制备。将获得的颗粒任选地放置在生物活性物质的溶液中以将物质吸附到颗粒上。组合物通常以悬浮液的形式施用。

3. 发明授权

US5549915A Magnetically responsive composition for carrying biologically active substances and methods of production 失效
标题翻译：用于携带生物活性物质的磁响应组合物和生产方法
公开(公告)号：US5549915A
公开(公告)日：1996-08-27
申请号：US188062
申请日：1994-01-26
申请人： Viktor A. Volkonsky , Sergei D. Dvukhsherstnov , Sergei V. Chernyakov
发明人： Viktor A. Volkonsky , Sergei D. Dvukhsherstnov , Sergei V. Chernyakov
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/18 , A61K9/50 , A61K31/704 , A61K41/00 , A61K45/00 , A61K47/02 , A61P35/00
CPC分类号： A61K9/5094 , A61K41/0052
摘要： A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded ferrocarbon particles of 0.2 to 5.0 .mu.m in size, and preferably between 1.0 and 4.0 .mu.m, containing 1.0 to 95.0% by volume of carbon, and preferably between about 20 and 50%. The particles are produced by a joint deformation of a mechanical mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to absorb the substance onto the particles. The combination is administered in suspension.
摘要翻译：公开了磁性可控或引导的载体组合物和使用和生产方法，用于将生物活性物质运送到在磁场控制下的体内治疗区域的组合物。该组合物包含尺寸为0.2至5.0μm，优选1.0至4.0μm的含有1.0至95.0体积％的碳，优选约20至50％的复合体积复合的碳化硅颗粒。颗粒通过铁和碳粉末的机械混合物的接合变形产生。将获得的颗粒置于生物活性物质的溶液中以将物质吸收到颗粒上。该组合被暂停使用。

4. 发明授权

US5705195A Magnetically responsive composition for carrying biologically active substances and methods of production and use 失效
标题翻译：用于携带生物活性物质的磁响应组合物及其生产和使用方法
公开(公告)号：US5705195A
公开(公告)日：1998-01-06
申请号：US480195
申请日：1995-06-07
申请人： Viktor A. Volkonsky , Sergei D. Dvukhsherstnov , Sergei V. Chernyakov
发明人： Viktor A. Volkonsky , Sergei D. Dvukhsherstnov , Sergei V. Chernyakov
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/18 , A61K9/50 , A61K31/704 , A61K41/00 , A61K45/00 , A61K47/02 , A61P35/00
CPC分类号： A61K9/5094 , A61K41/0052
摘要： A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded ferrocarbon particles of 0.2 to 5.0 .mu.m in size, and preferably between 1.0 and 4.0 .mu.m, containing 1.0 to 95.0% by volume of carbon, and preferably between about 20 and 50%. The particles are produced by a joint deformation of a mechanical mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to absorb the substance onto the particles. The combination is administered in suspension.
摘要翻译：公开了磁性可控或引导的载体组合物和使用和生产方法，用于将生物活性物质运送到在磁场控制下的体内治疗区域的组合物。该组合物包含尺寸为0.2至5.0μm，优选1.0至4.0μm的含有1.0至95.0体积％的碳，优选约20至50％的复合体积复合的碳化硅颗粒。颗粒通过铁和碳粉末的机械混合物的接合变形产生。将获得的颗粒置于生物活性物质的溶液中以将物质吸收到颗粒上。该组合被暂停使用。

5. 发明授权

US5651989A Magnetically responsive composition for carrying biologically active substances and methods of production and use 失效
标题翻译：用于携带生物活性物质的磁响应组合物及其生产和使用方法
公开(公告)号：US5651989A
公开(公告)日：1997-07-29
申请号：US480141
申请日：1995-06-07
申请人： Viktor A. Volkonsky , Sergei D. Dvukhsherstnov , Sergei V. Chernyakov
发明人： Viktor A. Volkonsky , Sergei D. Dvukhsherstnov , Sergei V. Chernyakov
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/18 , A61K9/50 , A61K31/704 , A61K41/00 , A61K45/00 , A61K47/02 , A61P35/00
CPC分类号： A61K9/5094 , A61K41/0052
摘要： A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded ferrocarbon particles of 0.2 to 5.0 .mu.m in size, and preferably between 1.0 and 4.0 .mu.m, containing 1.0 to 95.0% by volume of carbon, and preferably between about 20 and 50%. The particles are produced by a joint deformation of a mechanical mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to absorb the substance onto the particles. The combination is administered in suspension.
摘要翻译：公开了磁性可控或引导的载体组合物和使用和生产方法，用于将生物活性物质运送到在磁场控制下的体内治疗区域的组合物。该组合物包含尺寸为0.2至5.0μm，优选1.0至4.0μm的含有1.0至95.0体积％的碳，优选约20至50％的复合体积复合的碳化硅颗粒。颗粒通过铁和碳粉末的机械混合物的接合变形产生。将获得的颗粒置于生物活性物质的溶液中以将物质吸收到颗粒上。该组合被暂停使用。

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