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1. 发明授权

US06663555B2 Permanent magnet keeper-shield assembly 失效
公开(公告)号：US06663555B2
公开(公告)日：2003-12-16
申请号：US10087442
申请日：2002-03-01
申请人： Robert Mitchiner , Thomas B. Kent , Caryn Peterson , Scott Raymond Rudge
发明人： Robert Mitchiner , Thomas B. Kent , Caryn Peterson , Scott Raymond Rudge
IPC分类号： A61N200
CPC分类号： A61N2/06 , A61K9/5094 , A61N1/406 , A61N2/004
摘要： A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field. Such a field may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet keeper-shield assembly includes a magnetically permeable keeper-shield with a bore dimensioned to hold the magnet. A screw driven actuator is used to push the magnet partially out of the keeper-shield. The actuator is assisted by several springs extending through the base of the keeper-shield.

2. 发明授权

US4129116A Solar air flow controller and system 失效
标题翻译：太阳能空气流量控制器和系统
公开(公告)号：US4129116A
公开(公告)日：1978-12-12
申请号：US735096
申请日：1976-10-22
申请人： Thomas B. Kent
发明人： Thomas B. Kent
IPC分类号： F24D11/00 , F24D19/10 , F24J3/02
CPC分类号： F24D19/109 , F24D11/007 , Y02B10/20 , Y02B10/70
摘要： An installation for utilizing solar energy for heating air and delivering heated air to a building or the like includes a solar heat collector, a heat storage unit, a blower for producing the desired air flow and ducting connecting the components to permit operation in various modes. A unitary controller is provided in the form of an enclosure containing a blower and having three air flow ports. Ducting extends between the first port and the collector, between the second port and the heat storage unit, between the third port and the building, and between the building, heat storage unit, and collector. Flow control and directing means unitized within the enclosure establish three different air transport loops through the blower for three different heat transfer modes. A first loop connects the blower, storage unit and collector to deliver heat from the collector to the storage unit. A second loop connects the blower, building and collector to deliver heat from the collector to the building. A third loop connects the blower, building and storage unit to deliver heat from the storage unit to the building. The flow control devices and actuators are all located in unitary fashion at the enclosure for simplicity, convenience and reliability.
摘要翻译：用于利用太阳能加热空气并将热空气输送到建筑物等的装置包括太阳能集热器，蓄热单元，用于产生期望空气流的鼓风机和连接部件以允许各种模式操作的管道。整体控制器以包含鼓风机并具有三个气流端口的外壳的形式提供。管道在第一端口和收集器之间，第二端口和蓄热单元之间，第三端口和建筑物之间以及建筑物，蓄热单元和收集器之间延伸。在外壳内组合的流量控制和引导装置通过三个不同的传热模式通过鼓风机建立三个不同的空气输送回路。第一回路连接鼓风机，存储单元和收集器，以将热量从收集器传送到存储单元。第二回路连接鼓风机，建筑物和收集器，以将热量从收集器传送到建筑物。第三回路连接鼓风机，建筑物和存储单元，以将热量从存储单元传递到建筑物。流量控制装置和致动器在外壳上均以单一方式定位，以简化，方便和可靠。

3. 发明授权

US07090636B2 Permanent magnet keeper-shield assembly 失效
标题翻译：永磁保护罩组件
公开(公告)号：US07090636B2
公开(公告)日：2006-08-15
申请号：US10734651
申请日：2003-12-12
申请人： Thomas B. Kent , Robert K. Mitchiner , Caryn Peterson , Scott Raymond Rudge , David Glover
发明人： Thomas B. Kent , Robert K. Mitchiner , Caryn Peterson , Scott Raymond Rudge , David Glover
IPC分类号： A61N2/00
CPC分类号： A61K9/5094
摘要： A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field that, in one embodiment, may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet keeper-shield assembly includes a magnetically permeable keeper-shield with a bore dimensioned to hold the magnet. A lever mechanism is used to push the magnet partially out of the keeper-shield. The actuator is assisted by several springs extending through the base of the keeper-shield.
摘要翻译：磁体保持器 - 屏蔽组合件，其适于保持和存储用于产生高梯度磁场的永磁体，在一个实施例中，该永久磁体可以穿透到深的靶向肿瘤部位以便吸引响应敏感的微载体。磁力保持器 - 屏蔽组件包括具有用于保持磁体的孔尺寸的导磁保持器屏蔽件。杠杆机构用于将磁体部分地推出保护罩。致动器由几个延伸穿过保护罩底部的弹簧辅助。

4. 发明授权

US06488615B1 Permanent magnet keeper-shield assembly 失效
标题翻译：永磁保护罩组件
公开(公告)号：US06488615B1
公开(公告)日：2002-12-03
申请号：US09538952
申请日：2000-03-31
申请人： Robert Mitchiner , Thomas B. Kent , Caryn Peterson , Scott Raymond Rudge
发明人： Robert Mitchiner , Thomas B. Kent , Caryn Peterson , Scott Raymond Rudge
IPC分类号： A61N200
CPC分类号： A61N2/06 , A61K9/5094 , A61N1/406 , A61N2/004
摘要： A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field. Such a field may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet keeper-shield assembly includes a magnetically permeable keeper-shield with a bore dimensioned to hold the magnet. A screw driven actuator is used to push the magnet partially out of the keeper-shield. The actuator is assisted by several springs extending through the base of the keeper-shield.
摘要翻译：一种适于保持和存储用于产生高梯度磁场的永磁体的磁力保持器 - 屏蔽组件。这样的一个领域可能会渗透到深入靶点的肿瘤部位，以便吸引响应敏感的微载体。磁力保持器 - 屏蔽组件包括具有用于保持磁体的孔尺寸的导磁保持器屏蔽件。螺丝驱动的致动器用于将磁体部分地推出保持器屏蔽。致动器由几个延伸穿过保护罩底部的弹簧辅助。

5. 发明授权

US06482436B1 Magnetically responsive composition 失效
标题翻译：磁响应组成
公开(公告)号：US06482436B1
公开(公告)日：2002-11-19
申请号：US09226818
申请日：1999-01-06
申请人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
发明人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
IPC分类号： A61K914
CPC分类号： A61K9/5094 , A61K9/0009 , A61K9/143 , A61K41/0052
摘要： A magnetically controllable, or guided, ferrocarbon particle composition and methods of use and production are disclosed. The composition may optionally carry biologically active substances that have been adsorbed onto the particle. The composition comprises composite, volume-compounded particles of 0.1 to 5.0 &mgr;m in size, and preferably between 0.5 and 5.0 &mgr;m, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles may be produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are optionally placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension.
摘要翻译：公开了磁控制或引导的碳碳颗粒组合物及其使用和生产方法。组合物可以任选地携带已经吸附到颗粒上的生物活性物质。组合物包含0.1〜5.0μm的复合体积复合粒子，优选为0.5〜5.0μm，含有1.0〜95.0质量％的碳，优选为20〜60％左右。颗粒可以通过机械研磨铁和碳粉末的混合物来制备。将获得的颗粒任选地放置在生物活性物质的溶液中以将物质吸附到颗粒上。组合物通常以悬浮液的形式施用。

6. 发明授权

US06200547B1 Magnetically responsive compositions for carrying biologically active substances and methods of production and use 失效
标题翻译：用于携带生物活性物质的磁响应组合物及其生产和使用方法
公开(公告)号：US06200547B1
公开(公告)日：2001-03-13
申请号：US09003286
申请日：1998-01-06
申请人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
发明人： Viktor A. Volkonsky , Sergei D. Dyuksherstnov , Sergi V. Chernyakov , Larry M. Allen , Thomas B. Kent
IPC分类号： A61K916
CPC分类号： A61K9/5094 , A61K9/0009 , A61K9/143
摘要： A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0.2 to 5.0 &mgr;m in size, and preferably between 0.5 and 5.0 &mgr;m, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc99, and antisense-C Myc oligonucleotide, an hematoporphyrin derivative, 6-mercaptopurine, Amphotericin B, and Camptothecin have been produced using this invention. Magnetic carrier particles having diagnostic quantities of adsorbed Re186 and Re188 have also been produced using this invention.
摘要翻译：公开了磁性可控或引导的载体组合物和使用和生产方法，用于将生物活性物质运送到在磁场控制下的体内治疗区域的组合物。该组合物包含尺寸为0.2-5.0μm的复合体积复合紫杉醇吸附颗粒，优选为0.5-5.0μm，含有1.0至95.0wt％的碳，优选为约20wt％至约60wt％。颗粒通过机械研磨铁和碳粉末的混合物来制备。将获得的颗粒置于生物活性物质的溶液中以将物质吸附到颗粒上。组合物通常以悬浮液的形式施用。已经使用本发明制备了具有治疗量的吸附的紫杉醇，多柔比星，Tc99和反义-CMyc寡核苷酸，血卟啉衍生物，6-巯基嘌呤，两性霉素B和喜树碱的磁性载体颗粒。具有吸附的Re186和Re188诊断量的磁性载体颗粒也已经使用本发明生产。

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