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1. 发明授权

US06430438B1 Cardiac rhythm management system with atrial shock timing optimization 失效
标题翻译：心律节律管理系统与心房休克时序优化
公开(公告)号：US06430438B1
公开(公告)日：2002-08-06
申请号：US09316741
申请日：1999-05-21
申请人： Victor T. Chen , Jay A. Warren , Gary T. Seim , David B. Krig , Jesse W. Hartley , Jeffrey E. Stahmann
发明人： Victor T. Chen , Jay A. Warren , Gary T. Seim , David B. Krig , Jesse W. Hartley , Jeffrey E. Stahmann
IPC分类号： A61N139
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/3627 , A61N1/3682 , A61N1/395 , A61N1/3987
摘要： A cardiac rhythm management system includes atrial shock timing optimization. Because an atrial tachyarrhythmia, such as atrial fibrillation typically causes significant variability in the ventricular heart rate, resulting in potentially proarrhythmic conditions. The system avoids delivering atrial cardioversion/defibrillation therapy during potentially proarrhythmic conditions because doing so could result in dangerous ventricular arrhythmias. Using Ventricular Rate Regularization (“VRR”) techniques, the system actively stabilizes the ventricular heart rate to obtain less potentially proarrhythmic conditions for delivering the atrial tachyarrhythmia therapy. The intrinsic ventricular heart rate is stabilized at a variable VRR-indicated rate, computed using an infinite impulse response (IIR) filter, and based on the underlying intrinsic ventricular heart rate. The system withholds delivery of atrial cardioversion/defibrillation therapy until the intervals between ventricular beats (“V-V intervals”) meet certain criteria that decrease the chance that the atrial cardioversion/defibrillation therapy will induce a ventricular arrhythmia.
摘要翻译：心律管理系统包括心房休克时序优化。因为房性心律失常，例如心房颤动，通常会导致心室心率的显着变异，导致潜在的心律失常症状。该系统避免在潜在的心律失常症状期间进行心房复律/除颤治疗，因为这样做可能导致危险的室性心律失常。使用心室率正常化（“VRR”）技术，该系统主动地稳定心室心率以获得较少的用于递送心房快速性心律失常治疗的潜在致心律失常状况。使用无限脉冲响应（IIR）滤波器，并且基于潜在的内部心室心率计算，内在心室心率以可变的VRR指示速率被稳定。系统禁止心房复律/除颤治疗，直到心室搏动之间的间隔（“V-V间隔”）符合某些标准，可降低心房复律/除颤疗法诱发室性心律失常的机会。

2. 发明授权

US07120490B2 Cardiac rhythm management system with atrial shock timing optimization 失效
公开(公告)号：US07120490B2
公开(公告)日：2006-10-10
申请号：US10211414
申请日：2002-08-02
申请人： Victor T. Chen , Jay A. Warren , Gary T. Seim , David B. Krig , Jesse W. Hartley , Jeffrey E. Stahmann
发明人： Victor T. Chen , Jay A. Warren , Gary T. Seim , David B. Krig , Jesse W. Hartley , Jeffrey E. Stahmann
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/3627 , A61N1/3682 , A61N1/395 , A61N1/3987
摘要： A cardiac rhythm management system includes atrial shock timing optimization. Because an atrial tachyarrhythmia, such as atrial fibrillation typically causes significant variability in the ventricular heart rate, resulting in potentially proarrhythmic conditions. The system avoids delivering atrial cardioversion/defibrillation therapy during potentially proarrhythmic conditions because doing so could result in dangerous ventricular arrhythmias. Using Ventricular Rate Regularization (“VRR”) techniques, the system actively stabilizes the ventricular heart rate to obtain less potentially proarrhythmic conditions for delivering the atrial tachyarrhythmia therapy. The intrinsic ventricular heart rate is stabilized at a variable VRR-indicated rate, computed using an infinite impulse response (IIR) filter, and based on the underlying intrinsic ventricular heart rate. The system withholds delivery of atrial cardioversion/defibrillation therapy until the intervals between ventricular beats (“V—V intervals”) meet certain criteria that decrease the chance that the atrial cardioversion/defibrillation therapy will induce a ventricular arrhythmia.

3. 发明授权

US07016732B2 Cardiac rhythm management system with remotely activated capture verification for CHF and other patients 有权
公开(公告)号：US07016732B2
公开(公告)日：2006-03-21
申请号：US10338270
申请日：2003-01-07
申请人： Jay A. Warren , Jeffrey E. Stahmann
发明人： Jay A. Warren , Jeffrey E. Stahmann
IPC分类号： A61N1/365 , A61B5/04
CPC分类号： A61N1/371 , A61N1/3627
摘要： A cardiac rhythm management device capable of delivering multiple uni-chamber stimulation pulses to a patient's heart and suitable for verifying capture independently for each uni-chamber stimulation pulse. The uni-chamber capture verification mode of the cardiac rhythm management device may be activated via telemetry or by applying a magnetic field proximate the device. During the capture verification mode, bi-chamber pacing, for example, may precede or follow uni-chamber pacing to allow for pacing support. Also, the energy levels of the pacing stimulus over several beats may be varied, thereby verifying the programmed safety margins.

4. 发明授权

US06564100B2 Cardiac rhythm management system with remotely activated capture verification for CHF and other patients 有权
公开(公告)号：US06564100B2
公开(公告)日：2003-05-13
申请号：US09731124
申请日：2000-12-06
申请人： Jay A. Warren , Jeffrey E. Stahmann
发明人： Jay A. Warren , Jeffrey E. Stahmann
IPC分类号： A61N137
CPC分类号： A61N1/371 , A61N1/3627
摘要： A cardiac rhythm management device capable of delivering multiple uni-chamber stimulation pulses to a patient's heart and suitable for verifying capture independently for each uni-chamber stimulation pulse. The uni-chamber capture verification mode of the cardiac rhythm management device may be activated via telemetry or by applying a magnetic field proximate the device. During the capture verification mode, bi-chamber pacing, for example, may precede or follow uni-chamber pacing to allow for pacing support. Also, the energy levels of the pacing stimulus over several beats may be varied, thereby verifying the programmed safety margins.

5. 发明授权

US09149637B2 Adaptive confirmation of treatable arrhythmia in implantable cardiac stimulus devices 有权
标题翻译：可植入心脏刺激装置中可治疗心律失常的自适应确认
公开(公告)号：US09149637B2
公开(公告)日：2015-10-06
申请号：US12826241
申请日：2010-06-29
申请人： Jay A. Warren , Rick Sanghera , Venugopal Allavatam
发明人： Jay A. Warren , Rick Sanghera , Venugopal Allavatam
IPC分类号： A61N1/39 , A61N1/365 , A61N1/362 , A61B5/0464
CPC分类号： A61N1/3987 , A61B5/0464 , A61N1/3622 , A61N1/3925 , A61N1/3943 , A61N1/3956
摘要： Methods and devices for adjusting therapy delivery decisions in an implantable cardiac stimulus device by observing cardiac activity following an initial identification of a treatable condition. In some examples, cardiac activity that appears benign is quantified and a therapy confirmation threshold is adjusted according to how much apparently benign cardiac activity is seen after an initial identification of a treatable condition. In other examples, a new threshold is applied following the initial identification of treatable condition, removing historical data preceding the initial identification from subsequent therapy delivery decisions.
摘要翻译：用于通过在初始识别可治疗病症后观察心脏活动来调整可植入心脏刺激装置中的治疗递送决定的方法和装置。在一些实例中，显示良性的心脏活动被定量，并且根据在可治疗病症的初始鉴定之后看到多少明显良性的心脏活动来调整治疗确认阈值。在其他示例中，在可治疗条件的初始识别之后应用新阈值，从随后的治疗递送决定中移除初始识别之前的历史数据。

6. 发明授权

US08565878B2 Accurate cardiac event detection in an implantable cardiac stimulus device 有权
标题翻译：在可植入心脏刺激装置中精确的心脏事件检测
公开(公告)号：US08565878B2
公开(公告)日：2013-10-22
申请号：US12399901
申请日：2009-03-06
申请人： Venugopal Allavatam , Surekha Palreddy , Rick Sanghera , Jay A. Warren
发明人： Venugopal Allavatam , Surekha Palreddy , Rick Sanghera , Jay A. Warren
IPC分类号： A61N1/36
CPC分类号： A61N1/3987 , A61B5/0245 , A61B5/0452 , A61B5/04525 , A61B5/726 , A61N1/365 , A61N1/3704
摘要： Methods, systems, and devices for signal analysis in an implanted cardiac monitoring and treatment device such as an implantable cardioverter defibrillator. In some illustrative examples, detected events are analyzed to identify changes in detected event amplitudes. When detected event amplitudes are dissimilar from one another, a first set of detection parameters may be invoked, and, when detected event amplitudes are similar to one another, a second set of detection parameters may be invoked. Additional methods determine whether the calculated heart rate is “high” or “low,” and then may select a third set of detection parameters for use when the calculated heart rate is high.
摘要翻译：植入式心脏监测和治疗装置如植入式心律转复除颤器中的信号分析方法，系统和装置。在一些说明性示例中，分析检测到的事件以识别检测到的事件振幅的变化。当检测到的事件幅度彼此不同时，可以调用第一组检测参数，并且当检测到的事件幅度彼此相似时，可以调用第二组检测参数。另外的方法确定计算的心率是“高”还是“低”，然后可以选择第三组检测参数，以便在计算心率高时使用。

7. 发明授权

US08160697B2 Method for adapting charge initiation for an implantable cardioverter-defibrillator 有权
公开(公告)号：US08160697B2
公开(公告)日：2012-04-17
申请号：US11042911
申请日：2005-01-25
申请人： Jay A. Warren , Gust H. Bardy
发明人： Jay A. Warren , Gust H. Bardy
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3621 , A61N1/3943 , A61N1/3956
摘要： Adaptive methods for initiating charging of the high power capacitors of an implantable medical device for therapy delivery after the patient experiences a non-sustained arrhythmia. The adaptive methods adjust persistence criteria used to analyze an arrhythmia prior to initiating a charging sequence to deliver therapy.

8. 发明授权

US07996082B2 Method and devices for performing cardiac waveform appraisal 有权
标题翻译：用于进行心脏波形鉴定的方法和装置
公开(公告)号：US07996082B2
公开(公告)日：2011-08-09
申请号：US11781687
申请日：2007-07-23
申请人： Surekha Palreddy , Jay A. Warren , James W. Phillips
发明人： Surekha Palreddy , Jay A. Warren , James W. Phillips
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0422 , A61B5/04525 , A61B5/7207 , A61B5/7239 , A61N1/3622 , A61N1/368
摘要： Implementations of various technologies described herein are directed toward a sensing architecture for use in cardiac rhythm management devices. The sensing architecture may provide a method and means for certifying detected events by the cardiac rhythm management device. Moreover, by exploiting the enhanced capability to accurately identifying only those sensed events that are desirable, and preventing the use of events marked as suspect, the sensing architecture can better discriminate between rhythms appropriate for device therapy and those that are not.
摘要翻译：本文描述的各种技术的实现针对用于心律管理装置的感测架构。感测架构可以提供用于通过心律管理装置认证检测到的事件的方法和装置。此外，通过利用增强的能力来准确地仅识别那些感兴趣的事件，并且防止使用标记为可疑的事件，感测体系结构可以更好地区分适合于设备治疗的节律和不适合于设备治疗的节律。

9. 发明授权

US07991459B2 Method for defining signal templates in implantable cardiac devices 有权
标题翻译：在可植入心脏装置中定义信号模板的方法
公开(公告)号：US07991459B2
公开(公告)日：2011-08-02
申请号：US11941781
申请日：2007-11-16
申请人： Surekha Palreddy , Jay A. Warren , Alan H. Ostroff
发明人： Surekha Palreddy , Jay A. Warren , Alan H. Ostroff
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/0472
摘要： Template formation methods for use in implantable cardiac rhythm management devices. In an illustrative method, a signal is captured in an implanted cardiac rhythm management device, and parameters for analysis of the captured signal are then defined. Then, in the example, additional signals can be captured and used to either verify or discard the captured signal defined parameters. The template formation methods provide for creating a robust template to compare with sensed cardiac complexes. Devices and systems configured to perform template formation and verification methods are also shown.
摘要翻译：用于植入式心律管理装置的模板形成方法。在说明性方法中，在植入的心律管理装置中捕获信号，然后定义用于分析捕获信号的参数。然后，在该示例中，可以捕获附加信号并用于验证或丢弃所捕获的信号定义参数。模板形成方法提供了创建一个可靠的模板来与感觉到的心脏复合物进行比较。还显示了配置为执行模板形成和验证方法的设备和系统。

10. 发明申请

US20110098775A1 Adaptive Waveform Appraisal in an Implantable Cardiac System 有权
标题翻译：植入式心脏系统中的自适应波形评估
公开(公告)号：US20110098775A1
公开(公告)日：2011-04-28
申请号：US12913647
申请日：2010-10-27
申请人： Venugopal Allavatam , Rick Sanghera , Jay A. Warren
发明人： Venugopal Allavatam , Rick Sanghera , Jay A. Warren
IPC分类号： A61N1/08
CPC分类号： A61B5/04012 , A61N1/37 , A61N1/3706 , A61N1/3987
摘要： Methods and implantable devices for cardiac signal analysis. The methods and devices make use of waveform appraisal techniques to distinguish event detections into categories for suspect events and waveform appraisal passing events. When adjustments are made to the data entering analysis for waveform appraisal, the waveform appraisal thresholds applied are modified as well. For example, when the data analysis window for waveform appraisal changes in length, a waveform appraisal threshold is modified. Other changes, including changes in sensing characteristics with which waveform appraisal operates may also result in changes to the waveform appraisal threshold including changes in gain, sensing vector, activation of other devices, implantee posture and other examples which are explained.
摘要翻译：用于心脏信号分析的方法和可植入装置。方法和设备利用波形评估技术将事件检测区分为可疑事件和波形评估传递事件的类别。当对输入波形评估分析的数据进行调整时，也会修改应用的波形评估阈值。例如，当波形评估的数据分析窗口长度变化时，波形评估阈值被修改。其他变化，包括波形评估操作的检测特性的变化也可能导致波形评估阈值的变化，包括增益，感测向量，其他设备的激活，植入者姿势以及其他所示示例的变化。

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