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1. 发明专利

JP2014050404A Method and composition to generate dna probes having unique sequence, labeling of dna probes and use of the probes 审中-公开
标题翻译：用于生成具有独特序列的DNA探针的方法和组合，DNA探针的标记和探针的使用
公开(公告)号：JP2014050404A
公开(公告)日：2014-03-20
申请号：JP2013228145
申请日：2013-11-01
申请人： Veridex Llc , ベリデックス・リミテッド・ライアビリティ・カンパニーVeridex,LLC
发明人： CONNELLY MARK CARLE , FOULK BRAD , KAGAN MICHAEL T , SWENNENHUIS JOOST F , TERSTAPPEN LEON W M M , TIBBE ARJAN G J , VERRANT JOHN A
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/53 , G01N37/00
CPC分类号： C12Q1/6886 , C12Q1/34 , C12Q1/6811 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2533/101 , C12Q2531/113 , C12Q2521/301 , C12Q2563/131 , C12Q2563/103
摘要： PROBLEM TO BE SOLVED: To provide a method and a composition to obtain DNA probes having a unique sequence, in the field of identification of DNA sequences, genes or chromosomes.SOLUTION: A composition comprises any double stranded DNA containing a unique sequence from which repetitive sequences are eliminated according to the method described in this invention. The invention relates to preservation of cells that are identified after immunomagnetic selection and fluorescent labeling, in order to further investigate the cells of interest. The invention also relates to genetic analysis of cells that are identified after immunomagnetic selection and fluorescent labeling.
摘要翻译：要解决的问题：提供在DNA序列，基因或染色体鉴定领域中获得具有独特序列的DNA探针的方法和组合物。解决方案：组合物包含含有独特序列的任何双链DNA，其中重复根据本发明描述的方法消除序列。本发明涉及在免疫磁性选择和荧光标记之后鉴定的细胞的保存，以便进一步研究感兴趣的细胞。本发明还涉及在免疫磁性选择和荧光标记之后鉴定的细胞的遗传分析。

2. 发明专利

JP2012175976A Method and composition to generate unique sequence dna probe, labeling of dna probe, and use of the probe 审中-公开
标题翻译：用于生成独特序列DNA探针的方法和组合，DNA探针的标记和探针的使用
公开(公告)号：JP2012175976A
公开(公告)日：2012-09-13
申请号：JP2012099354
申请日：2012-04-25
申请人： Veridex Llc , ベリデックス・リミテッド・ライアビリティ・カンパニーVeridex,LLC
发明人： CONNELLY MARK CARLE , FOULK BRAD , KAGAN MICHAEL T , SWENNENHUIS JOOST F , TERSTAPPEN LEON W M M , TIBBE ARJAN G J , VERRANT JOHN A
IPC分类号： C12Q1/68 , C12M1/34 , C12N15/09 , C12Q1/04 , G01N33/53 , G01N33/543 , G01N37/00
CPC分类号： C12Q1/6886 , C12Q1/34 , C12Q1/6811 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2533/101 , C12Q2531/113 , C12Q2521/301 , C12Q2563/131 , C12Q2563/103
摘要： PROBLEM TO BE SOLVED: To provide a method and composition to obtain Unique Sequence DNA probes.SOLUTION: The composition comprises of any double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated. Rare circulating cells are analyzed by combining phenotypic and genotypic multiparametic analysis of an individually isolated target cell. For the investigation of cells of interest, the cells identified after immunomagnetic selection and fluorescent labeling are preserved for cytogenetic analysis of the cells identified after immunomagnetic selection and fluorescent labeling.
摘要翻译：要解决的问题：提供获得Unique Sequence DNA探针的方法和组合物。解决方案：组合物包含含有重复序列的唯一序列的任何双链DNA。通过组合单独分离的靶细胞的表型和基因型多参数分析来分析稀有的循环细胞。为了研究感兴趣的细胞，在免疫磁选择和荧光标记之后鉴定的细胞被保留用于免疫磁性选择和荧光标记后鉴定的细胞的细胞遗传学分析。版权所有（C）2012，JPO＆INPIT

3. 发明申请

WO2013016600A3 METHODS FOR DIAGNOSING CANCER BY CHARACTERIZATION OF TUMOR CELLS ASSOCIATED WITH PLEURAL OR SEROUS FLUIDS 审中-公开
标题翻译：通过与PLEURAL或SEROUS FLUIDS相关的肿瘤细胞表征来诊断癌症的方法
公开(公告)号：WO2013016600A3
公开(公告)日：2013-04-18
申请号：PCT/US2012048452
申请日：2012-07-27
申请人： UNIV PENNSYLVANIA , VERIDEX LLC , ALBELDA STEVEN M , SCHWED DANIEL , RAO GALLA CHANDRA , CONNELLY MARK , FOULK BRAD
发明人： ALBELDA STEVEN M , SCHWED DANIEL , RAO GALLA CHANDRA , CONNELLY MARK , FOULK BRAD
IPC分类号： G01N33/574 , G01N15/00
CPC分类号： G01N33/574 , C12Q1/6841 , G01N1/40 , G01N1/4077 , G01N33/57488 , G01N2333/705
摘要： A method for diagnosing or differentially diagnosing a cancer characterized by the presence of cancer cells in the pleural fluid of a mammalian subject, the method comprising contacting a sample of pleural fluid of the subject with colloidal magnetic particles coupled to a ligand which binds to a determinant on a cancer cell, but does not bind above a baseline threshold to other cellular and non-cellular components in pleural fluid; subjecting the pleural fluid-magnetic particle mixture to a magnetic field to produce a cell fraction enriched in ligand coupled-magnetic particle-bound cancer cells, if present in the pleural fluid; and analyzing the enriched fraction for the number of cancer cells in the pleural fluid. In certain aspects, this method involves preparing the pleural fluids for the above-noted method steps by, e.g., dilution of unprocessed pleural fluid. In certain aspect, the pleural fluid is subjected to the diagnostic method within 24 hours of withdrawal from the subject. This method has advantages to present diagnostic procedures for identifying malignant pleural effusions. The tumor cells present in pleural fluid can be characterized with cellular and molecular markers to determine prognostic and predictive factors.
摘要翻译：一种用于诊断或差异诊断癌症的方法，其特征在于哺乳动物受试者的胸膜液中存在癌细胞，所述方法包括将受试者的胸膜液样品与结合至决定簇的配体偶联的胶体磁性颗粒但不能在基础阈值以上结合胸膜液中的其他细胞和非细胞成分; 使胸膜液 - 磁性颗粒混合物进行磁场以产生富含配体偶联磁性颗粒结合的癌细胞（如果存在于胸膜液中）的细胞部分; 并分析胸膜液中癌细胞数量的富集部分。在某些方面，该方法包括通过例如稀释未加工的胸膜液来制备上述方法步骤的胸膜液。在某些方面，在从受试者撤出的24小时内对胸膜液进行诊断。该方法具有鉴定恶性胸腔积液的诊断方法的优点。存在于胸膜液中的肿瘤细胞可用细胞和分子标记进行表征，以确定预后和预测因素。

4. 发明专利

MX2010010465A METODO PARA LA DETECCION DE IGF1R/CHR 15 EN CELULAS TUMORALES CIRCULANTES MEDIANTE HIBRIDACION FLUORESCENTE IN SITU. 未知
公开(公告)号：MX2010010465A
公开(公告)日：2010-10-20
申请号：MX2010010465
申请日：2009-03-25
申请人： VERIDEX LLC
发明人： FOULK BRAD , TERSTAPPEN LEON W M M
IPC分类号： C12Q1/68
摘要： La presente invención describe los métodos y la composición de las sondas para un ensayo de FISH automatizado de una muestra de sangre que contiene células tumorales circulantes que expresan el gen de IGF-1R. El ensayo proporciona un análisis genético de las posibles células tumorales circulantes que han sido identificadas después de una selección inmunomagnética y la marcación fluorescente. Mediante el uso de sondas únicas sin repeticiones para el locus de IGF-1R y una sonda de referencia del cromosoma 15, se detectaron las líneas celulares que expresaban una cantidad anómala de señales de IGF-1R y Cr 15, que incluía una línea celular con un bajo nivel de amplificación de IGF1R. La capacidad de examinar en forma directa el perfil genético de IGF-1R en las células tumorales circulantes puede proporcionar un medio automatizado para evaluar la enfermedad y la respuesta del paciente al tratamiento.

5. 发明专利

BRPI0910038A2 método para detecção de igf1r/chr 15 em células tumorais circulantes com o uso de fish (hibridização in situ fluorescente) 未知
公开(公告)号：BRPI0910038A2
公开(公告)日：2015-12-29
申请号：BRPI0910038
申请日：2009-03-25
申请人： VERIDEX LLC
发明人： FOULK BRAD , TERSTAPPEN LEON W M M
IPC分类号： C12Q1/68

6. 发明公开

EP2279266A4 A METHOD FOR DETECTING IGF1R/CHR 15 CIRCULATING TUMOR CELLS USING FISH 有权
标题翻译：检测方法的循环IGF1R / CHR-15肿瘤细胞使用的鱼
公开(公告)号：EP2279266A4
公开(公告)日：2011-08-10
申请号：EP09725711
申请日：2009-03-25
申请人： VERIDEX LLC
发明人： FOULK BRAD , TERSTAPPEN LEON W M M
IPC分类号： C12Q1/68
CPC分类号： G01N33/57492 , C12Q1/6841 , C12Q1/6886 , C12Q2600/156 , G01N2333/71

7. 发明专利

CA2717975A1 A METHOD FOR DETECTING IGF1R/CHR 15 CIRCULATING TUMOR CELLS USING FISH 未知
公开(公告)号：CA2717975A1
公开(公告)日：2009-10-01
申请号：CA2717975
申请日：2009-03-25
申请人： VERIDEX LLC
发明人： FOULK BRAD , TERSTAPPEN LEON W M M
IPC分类号： C12Q1/68
摘要： The present invention describes methods and probe composition for an automated FISH assay of a blood sample containing circulating tumor cells expressing the IGF-IR gene. The assay provides genetic analysis of suspect circulating tumor cells that have been identified after immunomagnetic selection and fluorescent labeling. Using unique, repeat-free probes to the IGF-IR locus and a chromosome 15 reference probe, cell lines expressing an aberrant number of IGF-IR and Chr 15 signals were detected, including one cell line with a low level of IGF-IR amplification. The ability to directly examine the genetic profile of IGF-IR on circulating tumor cells may provide an automated means for assessing disease and patient response to therapy.

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