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    • 3. 发明申请
    • DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING
    • 用于连续葡萄糖监测的装置,系统,方法和工具
    • US20090131778A1
    • 2009-05-21
    • US12275145
    • 2008-11-20
    • Arvind N. JinaBeelee ChuaJanet TamadaMichael J. TierneyShashi P. Desai
    • Arvind N. JinaBeelee ChuaJanet TamadaMichael J. TierneyShashi P. Desai
    • A61B5/145
    • A61B5/14532A61B5/14514A61B5/14865
    • One aspect of the invention provides a glucose monitor having a plurality of tissue piercing elements, each tissue piercing element having a distal opening, a proximal opening and interior space extending between the distal and proximal openings; a sensing volume in fluid communication with the proximal openings of the tissue piercing elements; sensing fluid extending into the sensing volume; and a glucose sensor adapted to detect a concentration of glucose in the sensing fluid within the sensing volume. Another aspect of the invention provides A method of in vivo monitoring of an individual's interstitial fluid glucose concentration comprising: inserting distal ends of a plurality of tissue piercing elements through a stratum corneum area of the individual's skin, the tissue piercing elements each comprising a distal opening, a proximal opening, and an interior space extending between the distal and proximal opening; allowing interstitial fluid to flow into the interior space of the tissue piercing elements to substantially fill the interior space; filling substantially the entire interior space of the sensing area; and sensing a glucose concentration of the sensing fluid.
    • 本发明的一个方面提供一种具有多个组织刺穿元件的葡萄糖监测器,每个组织刺穿元件具有远端开口,在远端和近端开口之间延伸的近端开口和内部空间; 与组织刺穿元件的近端开口流体连通的感测体积; 感测流体延伸到感测体积中; 以及适于检测感测体积内的感测流体中的葡萄糖浓度的葡萄糖传感器。 本发明的另一方面提供了一种体内监测个体间质液葡萄糖浓度的方法,包括:将多个组织刺穿元件的远端穿过个体皮肤的角质层区域,所述组织刺穿元件各自包括远端开口 ,近端开口和在远端和近端开口之间延伸的内部空间; 允许间质液体流入组织刺穿元件的内部空间以基本上填充内部空间; 基本上填充感测区域的整个内部空间; 并感测感测流体的葡萄糖浓度。