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1. 发明申请

US20090203977A1 METHOD OF SCREENING FOR CANCER USING PARAMETERS OBTAINED BY THE DETECTION OF EARLY INCREASE IN MICROVASCULAR BLOOD CONTENT 审中-公开
标题翻译：通过检测微血管内容物中早期检测获得的参数来筛选癌症的方法
公开(公告)号：US20090203977A1
公开(公告)日：2009-08-13
申请号：US12350955
申请日：2009-01-08
申请人： Vadim Backman , Hemant Roy , Andrew Gomes , Sarah Ruderman , Jeremy Rogers
发明人： Vadim Backman , Hemant Roy , Andrew Gomes , Sarah Ruderman , Jeremy Rogers
IPC分类号： A61B5/1459
CPC分类号： A61B5/4255 , A61B1/31 , A61B5/0075 , A61B5/0084 , A61B5/0261 , A61B5/1459 , A61B2560/0443 , A61B2562/0242
摘要： The present invention, in one aspect, relates to screening test for tumors or lesions using what is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue and in tissues that precede the development of such lesions or tumors. While the abnormal tissue can be a lesion or tumor, the abnormal tissue can also be tissue that precedes formation of a lesion or tumor, such as a precancerous adenoma, aberrant crypt foci, tissues that precede the development of dysplastic lesions that themselves do not yet exhibit dysplastic phenotype, and tissues in the vicinity of these lesions or pre-dysplastic tissues.
摘要翻译：本发明在一个方面涉及使用所谓的“微血管供血的早期增加”（EIBS）来筛选肿瘤或病变的试验，其存在于接近但本身不属于异常组织的组织中和在这种损伤或肿瘤的发展之前的组织中。虽然异常组织可以是病变或肿瘤，但是异常组织也可以是在形成病变或肿瘤之前的组织，例如癌前腺瘤，异常隐窝灶，在发育不良的病变之前的组织，其本身还没有表现出发育不良的表型，以及这些损伤或发育不良前组织附近的组织。

2. 发明授权

US07652772B2 Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy 有权
标题翻译：低相干增强后向散射光谱的系统，方法和装置
公开(公告)号：US07652772B2
公开(公告)日：2010-01-26
申请号：US11803029
申请日：2007-05-11
申请人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu , Vladimir Turzhitsky , Jeremy Rogers
发明人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu , Vladimir Turzhitsky , Jeremy Rogers
IPC分类号： G01B9/02
CPC分类号： G01J3/4412 , G01J3/02 , G01J3/0221 , G01J3/0224 , G01J3/10 , G01N21/31 , G01N21/47 , G01N2021/4709
摘要： Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.
摘要翻译：本申请中描述了低相干增强后向散射光谱的系统，方法和装置。一个实施例包括提供包括具有低相干性的至少一个光谱分量的入射光，其中入射光将在体内照射在目标物体上。记录至少一个光谱分量中的一个或多个光束分量和至少一个后向散射光的后向散射角度的角度分量的强度，其中后向散射光将从目标物体上入射光的照射反向散射，并且其中后向散射角是入射光传播方向和反向散射光传播方向之间的角度。分析至少一个光谱分量的强度和背散射光的至少一个后向散射角度，以获得反向散射光的一个或多个光学标记，以评估所述性质。

3. 发明授权

US08131348B2 Systems, methods and apparatuses of elastic light scattering spectroscopy and low coherence enhanced backscattering spectroscopy 有权
标题翻译：弹性光散射光谱的系统，方法和装置以及低相干性增强后向散射光谱
公开(公告)号：US08131348B2
公开(公告)日：2012-03-06
申请号：US11803418
申请日：2007-05-14
申请人： Vadim Backman , Hemant Roy , Brand Randall , Yang Liu , Jeremy Rogers , Vladimir Turzhitsky
发明人： Vadim Backman , Hemant Roy , Brand Randall , Yang Liu , Jeremy Rogers , Vladimir Turzhitsky
IPC分类号： A61B6/00 , G01J3/40
CPC分类号： G01J3/4412 , A61B1/00096 , A61B1/00179 , A61B1/00188 , A61B1/0051 , A61B1/018 , A61B1/0623 , A61B1/07 , A61B5/0084 , A61B5/7257 , G01J3/02 , G01J3/0208 , G01J3/0221 , G01J3/0224 , G01J3/10 , G01N21/21 , G01N21/474 , G01N2021/4709 , G01N2021/4745 , G01N2201/1293
摘要： Systems, methods, and apparatuses of elastic light scattering spectroscopy and low-coherence enhanced backscattering spectroscopy are described here. An apparatus couple-able to a light source and a target object, to facilitate light transmission between the light source and the target object, the apparatus comprises: a probe to emit incident light that is partially coherent obtained from the light source onto the target object and to receive interacted light, the interacted light to be backscattered light from illumination of the incident light on the target object, the probe comprising: a delivery channel having at least one delivery optical fiber with a distal end portion couple-able to the light source and a proximal end portion suited to couple the incident light to the target object, a collection channel having a first collection optical fiber suited to collect substantially co-polarized backscattered light and a second collection optical fiber suited to collect substantially cross-polarized backscattered light.
摘要翻译：这里描述弹性光散射光谱和低相干增强后向散射光谱的系统，方法和装置。一种能够对光源和目标物体进行耦合的装置，以便于在光源和目标物体之间的光传输，所述装置包括：将从光源发射的部分相干的入射光发射到目标物体上的探测器并且为了接收相互作用的光，所述相互作用的光从所述目标物体上的入射光的照射中反向散射光，所述探针包括：输送通道，其具有至少一个递送光纤，所述输送光纤具有可耦合到所述光源的远端部分以及适于将入射光耦合到目标物体的近端部分，具有适于收集基本上共偏振的背散射光的第一收集光纤的收集通道和适于收集基本上交叉偏振的背散射光的第二收集光纤。

4. 发明申请

US20100262020A1 PROBE APPARATUS FOR RECOGNIZING ABNORMAL TISSUE 审中-公开
标题翻译：用于识别异常组织的探针装置
公开(公告)号：US20100262020A1
公开(公告)日：2010-10-14
申请号：US12684837
申请日：2010-01-08
申请人： Vadim Backman , Bradley Gould , Andrew Cittadine , Jeremy Rogers , Hemant Roy
发明人： Vadim Backman , Bradley Gould , Andrew Cittadine , Jeremy Rogers , Hemant Roy
IPC分类号： A61B6/00
CPC分类号： A61B5/0084
摘要： The present invention relates to probe apparatuses and component combinations thereof that are used to recognize possibly abnormal living tissue using a detected early increase in microvascular blood supply and corresponding applications. In one embodiment there is disclosed an apparatus that emits broadband light obtained from a light source onto microvasculature of tissue disposed within a human body and receives interacted light that is obtained from interaction of the broadband light with the microvasculature for transmission to a receiver. Different further embodiments include combinations of optical fibers, polarizers and lenses that assist in the selection of a predetermined depth profile of interacted light. In another embodiment, a kit apparatus is described that has various probe tips and/or light transmission elements that provide for various combinations of predetermined depth profiles of interacted light. In a further embodiment, a method of making a spectral data probe for depth range detection selectivity for detection of blood within microvasculature of tissue is described.
摘要翻译：本发明涉及用于利用检测到的微血管血液供应的早期增加和相应应用来识别可能的异常活体组织的探针装置及其组分组合。在一个实施例中，公开了一种将从光源发射的宽带光发射到设置在人体内的组织的微血管上的装置，并且接收从宽带光与微血管系统的相互作用获得的相互作用的光，以便传输到接收器。不同的另外的实施例包括有助于选择相互作用的光的预定深度分布的光纤，偏振器和透镜的组合。在另一个实施例中，描述了具有各种探针尖端和/或光透射元件的套件装置，其提供了相互作用的光的预定深度分布的各种组合。在另一个实施方案中，描述了制备用于深度范围检测选择性的光谱数据探针以检测组织微血管内的血液的方法。

5. 发明申请

US20090009759A1 Systems, methods and apparatuses of elastic light scattering spectroscopy and low coherence enhanced backscattering spectroscopy 有权
标题翻译：弹性光散射光谱的系统，方法和装置以及低相干性增强后向散射光谱
公开(公告)号：US20090009759A1
公开(公告)日：2009-01-08
申请号：US11803418
申请日：2007-05-14
申请人： Vadim Backman , Hemant Roy , Brand Randall , Yang Liu , Jeremy Rogers , Vladimir Turzaitsky
发明人： Vadim Backman , Hemant Roy , Brand Randall , Yang Liu , Jeremy Rogers , Vladimir Turzaitsky
IPC分类号： A61B1/00 , G01N21/47
CPC分类号： G01J3/4412 , A61B1/00096 , A61B1/00179 , A61B1/00188 , A61B1/0051 , A61B1/018 , A61B1/0623 , A61B1/07 , A61B5/0084 , A61B5/7257 , G01J3/02 , G01J3/0208 , G01J3/0221 , G01J3/0224 , G01J3/10 , G01N21/21 , G01N21/474 , G01N2021/4709 , G01N2021/4745 , G01N2201/1293
摘要： Systems, methods, and apparatuses of elastic light scattering spectroscopy and low-coherence enhanced backscattering spectroscopy are described here. An apparatus couple-able to a light source and a target object, to facilitate light transmission between the light source and the target object, the apparatus comprises: a probe to emit incident light that is partially coherent obtained from the light source onto the target object and to receive interacted light, the interacted light to be backscattered light from illumination of the incident light on the target object, the probe comprising: a delivery channel having at least one delivery optical fiber with a distal end portion couple-able to the light source and a proximal end portion suited to couple the incident light to the target object, a collection channel having a first collection optical fiber suited to collect substantially co-polarized backscattered light and a second collection optical fiber suited to collect substantially cross-polarized backscattered light.
摘要翻译：这里描述弹性光散射光谱和低相干增强后向散射光谱的系统，方法和装置。一种能够对光源和目标物体进行耦合的装置，以便于在光源和目标物体之间的光传输，所述装置包括：将从光源发射的部分相干的入射光发射到目标物体上的探测器并且为了接收相互作用的光，所述相互作用的光从所述目标物体上的入射光的照射中反向散射光，所述探针包括：输送通道，其具有至少一个递送光纤，所述输送光纤具有可耦合到所述光源的远端部分以及适于将入射光耦合到目标物体的近端部分，具有适于收集基本上共偏振的背散射光的第一收集光纤的收集通道和适于收集基本上交叉偏振的背散射光的第二收集光纤。

6. 发明申请

US20150292036A1 CANCER SCREENING BY DETECTION OF ULTRASTRUCTURAL AND MOLECULAR MARKERS 有权
标题翻译：通过检测超声和分子标记来筛选癌症
公开(公告)号：US20150292036A1
公开(公告)日：2015-10-15
申请号：US14747596
申请日：2015-06-23
申请人： Vadim Backman , Hariharan Subramanian , Dhwanil Damania , Hemant Roy , Dhananjay Kunte , Mart Angelo De la Cruz
发明人： Vadim Backman , Hariharan Subramanian , Dhwanil Damania , Hemant Roy , Dhananjay Kunte , Mart Angelo De la Cruz
IPC分类号： C12Q1/68 , G01N21/41 , G01N21/64
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , G01N21/41 , G01N21/64 , G01N21/6486 , G01N33/57407 , G01N33/57411 , G01N33/57419 , G01N33/57484
摘要： The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.
摘要翻译：本发明涉及癌症的检测或其发展风险的评估。特别地，本发明通过鉴定受试者中的超微结构和分子标记来提供组合物和方法检测场致癌作用。

7. 发明授权

US07800746B2 Method for identifying refractive-index fluctuations of a target 有权
$Method for identifying refractive-index fluctuations of a target$
标题翻译：用于识别目标的折射率波动的方法
公开(公告)号：US07800746B2
公开(公告)日：2010-09-21
申请号：US11891877
申请日：2007-08-13
申请人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
发明人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
IPC分类号： G01N21/41
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.
摘要翻译：在本申请中描述了用于识别目标的折射率波动的系统和方法。一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

8. 发明申请

US20070129615A1 Apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content 审中-公开
标题翻译：使用检测微血管血液含量的早期增加识别异常组织的装置
公开(公告)号：US20070129615A1
公开(公告)日：2007-06-07
申请号：US11604659
申请日：2006-11-27
申请人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu
发明人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu
IPC分类号： A61B5/00
CPC分类号： A61B5/0261 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/1459 , A61B2560/0443 , A61B2562/0242 , G01N33/48
摘要： The present invention relates to probe apparatuses and component combinations thereof that are used to recognize possibly abnormal living tissue using a detected early increase in microvascular blood supply and corresponding applications. In one embodiment there is disclosed an apparatus that emits broadband light obtained from a light source onto microvasculature of tissue disposed within a human body and receives interacted light that is obtained from interaction of the broadband light with the microvasculature for transmission to a receiver. Different further embodiments include combinations of optical fibers, polarizers and lenses that assist in the selection of a predetermined depth profile of interacted light. In another embodiment, a kit apparatus is described that has various probe tips and/or light transmission elements that provide for various combinations of predetermined depth profiles of interacted light. In a further embodiment, a method of making a spectral data probe for a depth range detection selectivity for detection of blood within microvasculature of tissue is described.
摘要翻译：本发明涉及用于利用检测到的微血管血液供应的早期增加和相应应用来识别可能的异常活体组织的探针装置及其组分组合。在一个实施例中，公开了一种将从光源发射的宽带光发射到设置在人体内的组织的微血管上的装置，并且接收从宽带光与微血管系统的相互作用获得的相互作用的光，以便传输到接收器。不同的另外的实施例包括有助于选择相互作用的光的预定深度分布的光纤，偏振器和透镜的组合。在另一个实施例中，描述了具有各种探针尖端和/或光透射元件的套件装置，其提供了相互作用的光的预定深度分布的各种组合。在另一个实施方案中，描述了制备用于检测组织微血管内的血液的深度范围检测选择性的光谱数据探针的方法。

9. 发明申请

US20080278713A1 Method for identifying refractive-index fluctuations of a target 有权
$Method for identifying refractive-index fluctuations of a target$
标题翻译：用于识别目标的折射率波动的方法
公开(公告)号：US20080278713A1
公开(公告)日：2008-11-13
申请号：US11891877
申请日：2007-08-13
申请人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
发明人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
IPC分类号： G01N21/41 , G01N21/55
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.
摘要翻译：在本申请中描述了用于识别目标的折射率波动的系统和方法。一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

10. 发明授权

US09090933B2 Cancer screening by detection of ultrastructural and molecular markers 有权
标题翻译：通过检测超微结构和分子标记进行癌症筛查
公开(公告)号：US09090933B2
公开(公告)日：2015-07-28
申请号：US14202919
申请日：2014-03-10
申请人： Vadim Backman , Hariharan Subramanian , Dhwanil Damania , Hemant Roy , Dhananjay Kunte , Mart Angelo De la Cruz
发明人： Vadim Backman , Hariharan Subramanian , Dhwanil Damania , Hemant Roy , Dhananjay Kunte , Mart Angelo De la Cruz
IPC分类号： C12Q1/68 , C12Q1/00 , C12Q1/02 , G01N1/28 , G01N21/41 , G01N33/574 , G01N21/64
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , G01N21/41 , G01N21/64 , G01N21/6486 , G01N33/57407 , G01N33/57411 , G01N33/57419 , G01N33/57484
摘要： The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.
摘要翻译：本发明涉及癌症的检测或其发展风险的评估。特别地，本发明通过鉴定受试者中的超微结构和分子标记来提供组合物和方法检测场致癌作用。

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