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1. 发明申请

WO0038579A2 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINEL LYMPH NODES 审中-公开
标题翻译：安全定位和标记CAVITY和SENTINEL LYMPH NODES的装置和方法
公开(公告)号：WO0038579A2
公开(公告)日：2000-07-06
申请号：PCT/US9930619
申请日：1999-12-23
申请人： VIVANT MEDICAL INC , SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
发明人： SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B19/00 , A61K49/00 , A61B8/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和前哨淋巴结标记装置，标记递送装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置，对患者的至少创伤和毒性。组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以将所描述的特征与标记装置和递送装置组合。

2. 发明申请

WO0038579A9 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINEL LYMPH NODES 审中-公开
标题翻译：安全定位和标记CAVITY和SENTINEL LYMPH NODES的装置和方法
公开(公告)号：WO0038579A9
公开(公告)日：2001-09-13
申请号：PCT/US9930619
申请日：1999-12-23
申请人： VIVANT MEDICAL INC , SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
发明人： SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B19/00 , A61K49/00 , A61B8/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和前哨淋巴结标记装置，标记递送装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置，对患者的至少创伤和毒性。组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以将所描述的特征与标记装置和递送装置组合。

3. 发明申请

WO0038579B1 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINEL LYMPH NODES 审中-公开
标题翻译：用于安全定位和标记腔和淋巴结的装置和方法
公开(公告)号：WO0038579B1
公开(公告)日：2001-01-18
申请号：PCT/US9930619
申请日：1999-12-23
申请人： VIVANT MEDICAL INC , SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
发明人： SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B19/00 , A61K49/00 , A61B8/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和哨兵淋巴结标记装置，标记物输送装置和方法。更具体地说，在插入身体后，腔标记装置和方法使得能够通过射线照相，乳房X线照相，回声或其他非侵入性成像技术来确定腔的中心，方向和周边。公开了一种用于将前哨淋巴结定位在哺乳动物体内以确定癌细胞是否已扩散到其中的组合物和方法。该组合物优选为由载液和某种类型的造影剂组成的液体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。这种组合物能够（1）在病变中或其周围沉积并迁移并累积在相关的前哨淋巴结中，以及（2）通过任何数量的非侵入性技术进行远程检测。还公开了一种用于通过以下步骤来远程检测哨兵节点的位置的方法：（1）在病变中或周围放置远程可检测的流体以便迁移到相关联的哨点节点并在相关联的哨兵节点中累积;以及（2）用对患者的创伤和毒性最小。该组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以结合标记装置和递送装置所描述的任何特征。

4. 发明专利

CA2356890C DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINEL LYMPH NODES 未知
公开(公告)号：CA2356890C
公开(公告)日：2010-12-07
申请号：CA2356890
申请日：1999-12-23
申请人： VIVANT MEDICAL INC
发明人： SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61K49/00 , A61B6/12 , A61B8/00 , A61B17/00 , A61B19/00 , A61L31/02 , A61L31/04 , A61L31/14 , A61L31/16 , A61L31/18
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

5. 发明专利

AT460116T 未知
公开(公告)号：AT460116T
公开(公告)日：2010-03-15
申请号：AT04077087
申请日：1999-12-23
申请人： VIVANT MEDICAL INC
发明人： SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B8/00 , A61B19/00 , A61K49/00
摘要： A subcutaneous cavity marking device has detectable marker(s) attached to filler(s). Independent claims are included for the following: (a) the above device where the body includes resilient biocompatible material; (b) the above device where the body includes non bioabsorbable suture material and the marker is radiopaque; (c) the above device where the marker is not bioabsorbable and the body is bioabsorbable; (d) a composition having non-toxic non-radioactive microparticles for migrating from an insertion site to a lymph node in under 3 hours. The particles are detectable non-invasively; (e) a cavity marking delivery device having a delivery device in a lumen of a cartridge. The cartridge slides on a disengaging arm; (f) a delivery device having an ejector coupled to an elongate member. The ejector disengages a marking device seated on the member; (g) delivery systems including (f); (h) kits including (a), (b), (c), (d) or (f); (i) marking a tissue cavity using devices as in (a) and (f); (j) marking a tissue cavity using a delivery device to access the cavity and then deploy a remotely detectable device; (k) delivering a marking device into a cavity using a medical instrument probe to install an outer sheath, delivering the device through the sheath and then withdrawing the sheath; (l) delivering a marking device into a cavity using a medical instrument cannula having a side window. The device is ejected through the window by advancing a shaft that remains within the cannula; (m) marking a cavity by inserting a marking device through a small opening; the device expands to mark the borders of the larger cavity; (n) locating a sentinel lymph node by injecting a composition similar to (d); (o) making a cavity marking device by rolling or folding a sheet of bioabsorbable material around a marker; (p) making a cavity marking device by cutting a filler body material to shape, making a hole partway through the material and inserting marker(s) into the hole; (q) locating a sentinel lymph node comprising: (1) injecting a non-invasively detectable, non-radioactive, migratory contrast agent into the region of a cavity or lesion; (2) allowing the contrast agent to migrate to a sentinel lymph node; and (3) identifying the sentinel lymph node by non-invasively detecting the contrast agent in the sentinel lymph node. Preferred Features: The microparticles may be carbon or silicon dioxide.

6. 发明专利

DE69942132D1 未知
公开(公告)号：DE69942132D1
公开(公告)日：2010-04-22
申请号：DE69942132
申请日：1999-12-23
申请人： VIVANT MEDICAL INC
发明人： SIRIMANNE LAKSEN D , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B8/00 , A61B19/00 , A61K49/00
摘要： A subcutaneous cavity marking device has detectable marker(s) attached to filler(s). Independent claims are included for the following: (a) the above device where the body includes resilient biocompatible material; (b) the above device where the body includes non bioabsorbable suture material and the marker is radiopaque; (c) the above device where the marker is not bioabsorbable and the body is bioabsorbable; (d) a composition having non-toxic non-radioactive microparticles for migrating from an insertion site to a lymph node in under 3 hours. The particles are detectable non-invasively; (e) a cavity marking delivery device having a delivery device in a lumen of a cartridge. The cartridge slides on a disengaging arm; (f) a delivery device having an ejector coupled to an elongate member. The ejector disengages a marking device seated on the member; (g) delivery systems including (f); (h) kits including (a), (b), (c), (d) or (f); (i) marking a tissue cavity using devices as in (a) and (f); (j) marking a tissue cavity using a delivery device to access the cavity and then deploy a remotely detectable device; (k) delivering a marking device into a cavity using a medical instrument probe to install an outer sheath, delivering the device through the sheath and then withdrawing the sheath; (l) delivering a marking device into a cavity using a medical instrument cannula having a side window. The device is ejected through the window by advancing a shaft that remains within the cannula; (m) marking a cavity by inserting a marking device through a small opening; the device expands to mark the borders of the larger cavity; (n) locating a sentinel lymph node by injecting a composition similar to (d); (o) making a cavity marking device by rolling or folding a sheet of bioabsorbable material around a marker; (p) making a cavity marking device by cutting a filler body material to shape, making a hole partway through the material and inserting marker(s) into the hole; (q) locating a sentinel lymph node comprising: (1) injecting a non-invasively detectable, non-radioactive, migratory contrast agent into the region of a cavity or lesion; (2) allowing the contrast agent to migrate to a sentinel lymph node; and (3) identifying the sentinel lymph node by non-invasively detecting the contrast agent in the sentinel lymph node. Preferred Features: The microparticles may be carbon or silicon dioxide.

7. 发明专利

CA2356890A1 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINEL LYMPH NODES 未知
公开(公告)号：CA2356890A1
公开(公告)日：2000-07-06
申请号：CA2356890
申请日：1999-12-23
申请人： VIVANT MEDICAL INC
发明人： WILSON PETER M , CONSTON STANLEY R , SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B19/00 , A61K49/00 , A61B8/00
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type o f contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in th e associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting th e location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method ma y serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

8. 发明专利

AT280537T 未知
公开(公告)号：AT280537T
公开(公告)日：2004-11-15
申请号：AT99968528
申请日：1999-12-23
申请人： VIVANT MEDICAL INC
发明人： SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B19/00 , A61K49/00 , A61B8/00
摘要： A subcutaneous cavity marking device has detectable marker(s) attached to filler(s). Independent claims are included for the following: (a) the above device where the body includes resilient biocompatible material; (b) the above device where the body includes non bioabsorbable suture material and the marker is radiopaque; (c) the above device where the marker is not bioabsorbable and the body is bioabsorbable; (d) a composition having non-toxic non-radioactive microparticles for migrating from an insertion site to a lymph node in under 3 hours. The particles are detectable non-invasively; (e) a cavity marking delivery device having a delivery device in a lumen of a cartridge. The cartridge slides on a disengaging arm; (f) a delivery device having an ejector coupled to an elongate member. The ejector disengages a marking device seated on the member; (g) delivery systems including (f); (h) kits including (a), (b), (c), (d) or (f); (i) marking a tissue cavity using devices as in (a) and (f); (j) marking a tissue cavity using a delivery device to access the cavity and then deploy a remotely detectable device; (k) delivering a marking device into a cavity using a medical instrument probe to install an outer sheath, delivering the device through the sheath and then withdrawing the sheath; (l) delivering a marking device into a cavity using a medical instrument cannula having a side window. The device is ejected through the window by advancing a shaft that remains within the cannula; (m) marking a cavity by inserting a marking device through a small opening; the device expands to mark the borders of the larger cavity; (n) locating a sentinel lymph node by injecting a composition similar to (d); (o) making a cavity marking device by rolling or folding a sheet of bioabsorbable material around a marker; (p) making a cavity marking device by cutting a filler body material to shape, making a hole partway through the material and inserting marker(s) into the hole; (q) locating a sentinel lymph node comprising: (1) injecting a non-invasively detectable, non-radioactive, migratory contrast agent into the region of a cavity or lesion; (2) allowing the contrast agent to migrate to a sentinel lymph node; and (3) identifying the sentinel lymph node by non-invasively detecting the contrast agent in the sentinel lymph node. Preferred Features: The microparticles may be carbon or silicon dioxide.

9. 发明专利

AU5696099A Percutaneous tissue removal device 未知
公开(公告)号：AU5696099A
公开(公告)日：2000-03-21
申请号：AU5696099
申请日：1999-09-01
申请人： VIVANT MEDICAL INC
发明人： SIRIMANNE D LAKSEN , SUTTON DOUGLAS S , FAWZI NATALIE V , BUSH MARY ELIZABETH , MOORMAN JACK W
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/28 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00
摘要： This is a device for percutaneous tissue sampling or excision. In particular, it uses a rotating cutter which produces a helically cut, discrete tissue mass that is removable through a comparatively much smaller access member. The tissue mass is easily reconstructed to its original form and orientation once taken from the body for further study.

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