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1. 发明申请

WO2006066103B1 OPHTHALMIC IMPLANT FOR TREATMENT OF GLAUCOMA 审中-公开
标题翻译：用于治疗玻璃体的OPHTHALMIC植入物
公开(公告)号：WO2006066103B1
公开(公告)日：2006-10-26
申请号：PCT/US2005045675
申请日：2005-12-16
申请人： ISCIENCE SURGICAL CORP , STEGMANN ROBERT , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN , PINSON CANDICE D , YAMAMOTO RONALD
发明人： STEGMANN ROBERT , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN , PINSON CANDICE D , YAMAMOTO RONALD
IPC分类号： A61F9/007
CPC分类号： A61F9/00781
摘要： An implant (11) is placed within Schlemm's canal of the eye and provides tension to the trabecular meshwork. The tension (12) is continuous and increases the aqueous outflow without the necessity of administering cholinergic drugs to treat glaucoma.
摘要翻译：植入物（11）放置在眼睛的施莱姆（Schlemm）运河内，为小梁网提供张力。张力（12）是连续的，并且增加水流出物，而不需要施用胆碱能药物治疗青光眼。

2. 发明申请

WO0038579A2 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINEL LYMPH NODES 审中-公开
标题翻译：安全定位和标记CAVITY和SENTINEL LYMPH NODES的装置和方法
公开(公告)号：WO0038579A2
公开(公告)日：2000-07-06
申请号：PCT/US9930619
申请日：1999-12-23
申请人： VIVANT MEDICAL INC , SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
发明人： SIRIMANNE D LAKSEN , FAWZI NATALIE V , SUTTON DOUGLAS S , LEBOVIC GAIL S , CONSTON STANLEY R , WILSON PETER M , MORRISSEY ANNE B , BUSH MARY ELIZABETH
IPC分类号： A61B17/00 , A61B19/00 , A61K49/00 , A61B8/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和前哨淋巴结标记装置，标记递送装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置，对患者的至少创伤和毒性。组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以将所描述的特征与标记装置和递送装置组合。

3. 发明专利

GB201815035D0 Ophthalmic drug compositions 未知
公开(公告)号：GB201815035D0
公开(公告)日：2018-10-31
申请号：GB201815035
申请日：2018-09-14
申请人： BLEY ROBERT STEVEN , CONSTON STANLEY R , NGUYEN TIEN T , YAMAMOTO RONALD K , LUNSFORD JOHN P , MARTINEZ DILLON DANIEL , PHAN LOC X

4. 发明专利

GB201815034D0 Ophthalmic delivery device 未知
公开(公告)号：GB201815034D0
公开(公告)日：2018-10-31
申请号：GB201815034
申请日：2018-09-14
申请人： BLEY ROBERT STEVEN , CONSTON STANLEY R , NGUYEN TIEN T , YAMAMOTO RONALD K , LUNSFORD JOHN P , MARTINEZ DILLON DANIEL , PHAN LOC X

5. 发明申请

WO2012051575A3 DEVICE FOR OCULAR ACCESS 审中-公开
标题翻译： OCULAR ACCESS的设备
公开(公告)号：WO2012051575A3
公开(公告)日：2012-06-14
申请号：PCT/US2011056433
申请日：2011-10-14
申请人： ISCIENCE INTERVENTIONAL CORP , HAMMACK AMY LEE , CONSTON STANLEY R , YAMAMOTO RONALD
发明人： HAMMACK AMY LEE , CONSTON STANLEY R , YAMAMOTO RONALD
IPC分类号： A61F9/00 , A61F9/007
CPC分类号： A61F9/0017 , A61F9/00727 , A61M5/46 , A61M5/486 , A61M2005/3103 , A61M2210/0612
摘要： The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.
摘要翻译：本发明提供了通过微创结膜手术来接近眼中的脉络膜间隙或视网膜下空间的装置。在部分解剖之后，例如在解剖眼睛的外巩膜层之后并且使用解剖内的装置来访问脉管外的空间或子视网膜空间，也可以使用装置。

6. 发明申请

WO2011150045A1 DEVICE FOR PLACING CIRCUMFERENTIAL IMPLANT IN SCHLEMM'S CANAL 审中-公开
标题翻译：用于在SCHLEMM's CANAL中放置循环植入物的装置
公开(公告)号：WO2011150045A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037882
申请日：2011-05-25
申请人： ISCIENCE INTERNATIONAL CORPORATION , YAMAMOTO, Ronald, K. , CONSTON, Stanley, R.
发明人： YAMAMOTO, Ronald, K. , CONSTON, Stanley, R.
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61B2090/306 , A61B2090/3945
摘要： A device (1, 9, 12, 15, 16) is provided to enable placing an implant within the full circumference of Schlemm's canal of an eye. The device comprises a flexible elongated solid element (2, 10) with a proximal end and a distal tip that transmits light such as one or more strands of a fiber optic. The device is characterized by selected mechanical characteristics (3, 11, 16, 17) to allow advancement within Schlemm's canal. The fiber optic element transmits light from a proximal connector to the distal tip to provide a lighted tip that may be viewed transclerally when the device is advanced along Schlemm's canal.
摘要翻译：提供了一种装置（1,9,12,15,16），以使得植入物能够放置在眼睛的施莱姆管的整个圆周内。该装置包括具有近端的柔性细长实体元件（2,10）和用于透射诸如光纤的一股或多股的光的远端。该装置的特征在于选择的机械特性（3,11,16,17），以允许在施莱姆运河内前进。光纤元件将光从近端连接器透射到远侧末端，以提供当器件沿着施莱姆氏管前进时可以经视观察的点亮尖端。

7. 发明申请

WO2009120960A2 MICROLITER INJECTOR 审中-公开
公开(公告)号：WO2009120960A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038556
申请日：2009-03-27
申请人： ISCIENCE INTERVENTIONAL CORPORATION , YAMAMOTO, Ronald , CONSTON, Stanley, R.
发明人： YAMAMOTO, Ronald , CONSTON, Stanley, R.
IPC分类号： A61M5/31
CPC分类号： A61M5/2459 , A61M5/286 , A61M5/288 , A61M5/3129 , A61M5/31505 , A61M5/31531 , A61M5/3291 , A61M5/34 , A61M5/347 , A61M2005/3107 , A61M2005/3118 , A61M2005/3121 , A61M2005/3131
摘要： Injectors are provided that may be pre-filled aseptically with an active biological agent into a sterile cavity and sealed in such a manner that the injectate may be readily expelled into the body. The injectors are particularly useful for injecting precisely measured small volumes of sterile agents.
摘要翻译：提供了可以将活性生物试剂无菌预填充到无菌腔中并以这样的方式密封的注射器，使得注射剂可以容易地排入体内。注射器对于注射精确测量的小体积的无菌试剂特别有用。

8. 发明申请

WO2005069831A2 INJECTOR FOR VISCOUS MATERIALS 审中-公开
标题翻译：注射器粘胶材料
公开(公告)号：WO2005069831A2
公开(公告)日：2005-08-04
申请号：PCT/US2005/001123
申请日：2005-01-12
申请人： ISCIENCE SURGICAL CORPORATION , MCKENZIE, John, R. , CONSTON, Stanley, R. , KUPIECKI, David, J.
发明人： MCKENZIE, John, R. , CONSTON, Stanley, R. , KUPIECKI, David, J.
IPC分类号： A61F9/00 , A61M5/145 , A61M5/168 , A61M5/315 , A61M37/00
CPC分类号： A61M5/1456 , A61F9/0017 , A61M5/16854 , A61M5/31511 , A61M5/31586 , A61M5/486
摘要： An injector is provided to deliver microquantities of viscous materials into the body, such as the eye, for surgical purposes. The injector comprises a syringe body with a plunger disposed therein coupled to a positive displacement mechanism capable of progressively advancing the plunger to precisely deliver microquantities of materials at a constant or predetermined delivery rate.
摘要翻译：提供注射器用于将粘性物质的微量量输送到体内，例如眼睛，用于外科用途。注射器包括注射器本体，其中设置有柱塞，其联接到能够逐渐前进柱塞的正位移机构，以以恒定或预定的输送速率精确地输送材料的微量。

9. 发明申请

WO2003045290A1 OPHTHALMIC MICROSURGICAL SYSTEM 审中-公开
标题翻译： OPHTHALMIC微观系统
公开(公告)号：WO2003045290A1
公开(公告)日：2003-06-05
申请号：PCT/US2002/037572
申请日：2002-11-21
申请人： ISCIENCE CORPORATION , CONSTON, Stanley, R. , YAMAMOTO, Ronald, K.
发明人： CONSTON, Stanley, R. , YAMAMOTO, Ronald, K.
IPC分类号： A61F9/007
CPC分类号： A61B17/32002 , A61B17/3421 , A61B2017/00867 , A61B2017/305 , A61B2017/320044 , A61B2090/306 , A61F9/00763 , A61F9/00781 , A61F9/0133
摘要： An ophthalmic microsurgical system is described for treatment of eye diseases, such as glaucoma, using minimally invasive surgical techniques. The microsurgical system includes a thin walled outer sheath microcannula 1 slidably disposed about an inner member 4, which extends slightly beyond the distal end of the microcannula 1. The inner member 4 may be straight or curved and may optionally include a surgical instrument and/or a sensor or signaling beacon. The microsurgical system is used in a surgical procedure for opening Schlemm's Canal to provide drainage of aqueous fluid in order to relieve excess intraocular that results from glaucoma an other diseases of the eye.
摘要翻译：描述了一种眼科显微外科系统，用于使用微创手术技术治疗诸如青光眼的眼部疾病。显微外科系统包括可滑动地设置在内部构件4周围的薄壁外护套微型插管1，其稍微延伸超出微型插管1的远端。内部构件4可以是直的或弯曲的，并且可以可选地包括外科器械和/或传感器或信号灯。显微手术系统用于打开施莱姆运河的外科手术，以提供含水液体的排水，以便缓解由青光眼引起的眼睛内其他疾病的眼睛过剩。

10. 发明申请

WO2002058591A2 DEVICES AND METHODS FOR INTERCONNECTING VESSELS 审中-公开
标题翻译：用于互连船舶的装置和方法
公开(公告)号：WO2002058591A2
公开(公告)日：2002-08-01
申请号：PCT/US2002/003919
申请日：2002-01-28
申请人： VASCONNECT, INC. , AKIN, Jodi , SALAHIEH, Amr , MACK, Michael , SHENNIB, Hani , DEMOND, Jackson , YAMAMOTO, Ronald, K. , CONSTON, Stanley, R.
发明人： AKIN, Jodi , SALAHIEH, Amr , MACK, Michael , SHENNIB, Hani , DEMOND, Jackson , YAMAMOTO, Ronald, K. , CONSTON, Stanley, R.
IPC分类号： A61F
CPC分类号： A61F2/064 , A61B17/11 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139
摘要： The present invention provides implantable devices and associated methods for interconnecting human vessels in a side-to-side or an end-to-side arrangement rapidly, safely and in a minimally invasive manner. The devices comprises at least a first segment, a second component, and a flow opening between the at least one segment and the second component when operatively used. The first segment is flexible and has physical and mechanical properties which allow it to be easily inserted into a vessel, to conformably seal with the inside wall of the vessel and to be resistant to dislodging from the vessel. The second component may comprise a second segment having the same or a similar configuration as the first segment or may be a tubular member which extends from the first segment. The first and second segments are flexible for easy insertion into an incision made within the side of each vessel. Upon release from a constricted state, each flexible segment subsequently conforms to the interior walls of a vessel to provide a sealing contact along the contact surface of the segment inserted within. The tubular member is configured to be inserted into a transected end of a vessel. The flow opening provides fluid interconnectivity between the vessels connected by the implanted devices. The devices are configured so as to: (1) not impede flow inside a vessel; (2) prevent leakage from the incisions within the vessels; and (3) apposition the vessels toward each other allowing the vessels to heal together so that flow in one vessel may flow to the other.
摘要翻译：本发明提供可植入装置（1）和相关方法，用于将人血管以侧向或端对侧的排列方式快速，安全和微创的方式相互连接。当操作使用时，装置至少包括第一段（2），第二段（3）和在至少一个段和第二组分之间的流动开口（4）。第一段是柔性的并且具有物理和机械性质，其允许其容易地插入容器中，以与容器的内壁一致地密封并且抵抗从容器移出的阻力。第二部件可以包括具有与第一部分相同或相似的构造的第二部分，或者可以是从第一部分延伸的管状部件。第一和第二段是柔性的，以便于插入到在每个容器的侧面内形成的切口中。当从收缩状态释放时，每个柔性段随后与容器的内壁一致，以沿着插入其中的段的接触表面提供密封接触。管状构件被构造成插入到容器的横截面中。流动开口在由注入的装置连接的容器之间提供流体互连。

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