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1. 发明申请

WO2009120758A1 ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES 审中-公开
标题翻译：用于多种模式的VIVO TOMOGRAPHIC成像的动物持有人
公开(公告)号：WO2009120758A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038213
申请日：2009-03-25
申请人： VISEN MEDICAL, INC. , YARED, Wael, I. , WILSON, Andrew, K.
发明人： YARED, Wael, I. , WILSON, Andrew, K.
IPC分类号： A61B6/04 , A61D3/00
CPC分类号： A61B6/045 , A61B5/7285 , A61B6/0421 , A61B6/485 , A61B6/508 , A61B6/583 , A61B8/543 , A61B2503/40
摘要： The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations. The animal holder optionally also includes a system for providing the animal with inhalation anesthesia, for example, isoflurane, and is designed to fit into identical receptacles inside or outside the imaging workstation(s) that provide heating to minimize or prevent animal hypothermia.
摘要翻译：本发明有助于在相同或不同的物理位置的多个单一模态或多模态成像工作站上运输固定的被麻醉的小动物，而不损失对象位置信息。动物持有人与临床前动物成像站如micro-CT，micro-MR，micro-PET，micro-SPECT和FMT兼容。动物保持器被配置为通过（例如，装配在这些器械的）各个成像室中来容纳，并且由与所使用的所有成像模式兼容的材料制成。在某些实施例中，集成的一组基准标记井容纳在多个平面中同时由几种模态拾取的标记的分配。然后，基准标记在标准图像处理或图像分析软件中进行对准，具有简单的图像平移和旋转操作，而不需要更高级的缩放，失真或其他操作。动物保持器可选地还包括用于向动物提供吸入麻醉的系统，例如异氟烷，并且被设计成装配在提供加热以使动物体温过低最小化或防止动物低体温的成像工作站内部或外部的相同容器中。

2. 发明公开

EP2265181A1 ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES 有权转让
标题翻译：动物HOLDER层析成像与多个方法和程序体内成像
公开(公告)号：EP2265181A1
公开(公告)日：2010-12-29
申请号：EP09724324.0
申请日：2009-03-25
申请人： Visen Medical, Inc.
发明人： YARED, Wael, I. , WILSON, Andrew, K.
IPC分类号： A61B6/04 , A61D3/00
CPC分类号： A61B6/045 , A61B5/7285 , A61B6/0421 , A61B6/485 , A61B6/508 , A61B6/583 , A61B8/543 , A61B2503/40
摘要： The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations. The animal holder optionally also includes a system for providing the animal with inhalation anesthesia, for example, isoflurane, and is designed to fit into identical receptacles inside or outside the imaging workstation(s) that provide heating to minimize or prevent animal hypothermia.

3. 发明授权

EP2265181B1 ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES AND METHOD 有权转让
标题翻译：动物HOLDER层析成像与多个方法和程序体内成像
公开(公告)号：EP2265181B1
公开(公告)日：2016-11-16
申请号：EP09724324.0
申请日：2009-03-25
申请人： VisEn Medical, Inc.
发明人： YARED, Wael, I. , WILSON, Andrew, K.
IPC分类号： A61B6/04 , A61D3/00
CPC分类号： A61B6/045 , A61B5/7285 , A61B6/0421 , A61B6/485 , A61B6/508 , A61B6/583 , A61B8/543 , A61B2503/40

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