专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007111669A2 COMBINED X-RAY AND OPTICAL TOMOGRAPHIC IMAGING SYSTEM 审中-公开
标题翻译：组合X射线和光学图像成像系统
公开(公告)号：WO2007111669A2
公开(公告)日：2007-10-04
申请号：PCT/US2006048785
申请日：2006-12-21
申请人： VISEN MEDICAL INC , YARED WAEL I
发明人： YARED WAEL I
CPC分类号： A61B6/032 , A61B5/0035 , A61B5/0059 , A61B5/0064 , A61B5/1077 , A61B6/4014 , A61B6/4417 , A61B6/482 , A61B6/485 , A61B6/508 , A61B6/5247 , A61B2503/40 , A61B2560/0223
摘要： The invention relates to a combined x-ray and optical (light-based) tomographic imaging system that provides functional information at greater resolution than can be achieved by optical tomography alone. The system is configured with one or more x-ray sources, x-ray detectors, light sources, and light detectors arranged on a gantry which rotates about an imaging chamber containing the object to be imaged. The system thereby allows both x-ray radiation and light to be directed into the object at multiple locations. Processing methods of the invention go beyond simple co-registration of images obtained from two or more imaging techniques. Both x-ray data and light data are used together in optical tomographic reconstruction to create the tomographic image, thereby allowing a more accurate and/or higher resolution final image.
摘要翻译：本发明涉及一种组合的x射线和光学（基于光的）断层成像系统，其以比仅通过光学层析成像可以实现的更高的分辨率提供功能信息。该系统配置有一个或多个X射线源，X射线检测器，光源和布置在围绕包含待成像对象的成像室旋转的台架的光检测器。因此，该系统允许x射线辐射和光在多个位置被引导到物体中。本发明的处理方法超出了从两种或更多种成像技术获得的图像的简单共同配准。 X射线数据和光数据在光学层析成像重建中一起使用以产生断层图像，从而允许更准确和/或更高分辨率的最终图像。

2. 发明申请

WO2011038006A1 SYSTEMS AND METHODS FOR VIRTUAL INDEX-MATCHING OF DIFFUSIVE MEDIA 审中-公开
标题翻译：虚拟媒体虚拟索引的系统与方法
公开(公告)号：WO2011038006A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/049831
申请日：2010-09-22
申请人： VISEN MEDICAL, INC. , RIPOLL, Lorenzo, Jorge , YARED, Wael, I. , KEMPNER, Joshua
发明人： RIPOLL, Lorenzo, Jorge , YARED, Wael, I. , KEMPNER, Joshua
IPC分类号： A61B5/00 , G01N21/47 , G06T11/00
CPC分类号： A61B5/0073 , A61B6/037 , A61B2562/146 , G01N21/6456 , G01N21/6486 , G01N2021/1787
摘要： The invention relates to systems and methods for tomographic imaging of a subject comprising diffuse media by converting measurements of electromagnetic radiation, e.g., fluorescent light, obtained in free space exterior to the subject into data that would be measured if the subject were surrounded by an infinite and homogeneous diffusive medium, e.g., a medium with optical properties equal to the average optical properties of the subject. After applying a transformation to convert measurements to virtually-matched values, propagation of light is simulated from the index-matched surface to a set of virtual detectors exterior to the subject and arranged in a geometrically advantageous fashion, for example, in a planar array, thereby facilitating the use of fast reconstruction techniques.
摘要翻译：本发明涉及用于通过将被测体外部获得的电磁辐射（例如，荧光）的测量值转换为被测量物体被无限量包围的数据的数据的扩散介质的层析成像系统和方法。和均匀扩散介质，例如具有等于受试者的平均光学性质的光学性质的介质。在应用变换以将测量值转换为虚拟匹配值之后，将光的传播从目标匹配表面模拟到对象外部的一组虚拟检测器，并以几何有利的方式布置，例如在平面阵列中，从而有助于使用快速重建技术。

3. 发明申请

WO2007111669A3 COMBINED X-RAY AND OPTICAL TOMOGRAPHIC IMAGING SYSTEM 审中-公开
公开(公告)号：WO2007111669A3
公开(公告)日：2007-10-04
申请号：PCT/US2006/048785
申请日：2006-12-21
申请人： VISEN MEDICAL, INC. , YARED, Wael, I.
发明人： YARED, Wael, I.
IPC分类号： A61B5/00 , A61B6/03 , G06T11/00 , G01N21/64
摘要： The invention relates to a combined x-ray and optical (light-based) tomographic imaging system that provides functional information at greater resolution than can be achieved by optical tomography alone. The system is configured with one or more x-ray sources, x-ray detectors, light sources, and light detectors arranged on a gantry which rotates about an imaging chamber containing the object to be imaged. The system thereby allows both x-ray radiation and light to be directed into the object at multiple locations. Processing methods of the invention go beyond simple co-registration of images obtained from two or more imaging techniques. Both x-ray data and light data are used together in optical tomographic reconstruction to create the tomographic image, thereby allowing a more accurate and/or higher resolution final image.

4. 发明申请

WO2011025950A3 SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGING IN DIFFUSE MEDIA USING A HYBRID INVERSION TECHNIQUE 审中-公开
公开(公告)号：WO2011025950A3
公开(公告)日：2011-03-03
申请号：PCT/US2010/046973
申请日：2010-08-27
申请人： VISEN MEDICAL, INC. , RIPOLL LORENZO, Jorge , YARED, Wael, I. , KEMPNER, Joshua
发明人： RIPOLL LORENZO, Jorge , YARED, Wael, I. , KEMPNER, Joshua
IPC分类号： G01N21/64 , G06T11/00
摘要： The invention relates to systems and methods for tomographic imaging in diffuse media employing a fast reconstruction technique. A hybrid Fourier approach is presented that enables the fast tomographic reconstruction of large datasets. In certain embodiments, the invention features methods of i n vivo fluorescence molecular tomographic (FMT) reconstruction of signals, reporters and/or agents (i.e., contrast agents or probes) in a diffusive medium (e.g., a mammalian subject). The method preserves the three-dimensional fluorophore distribution and quantitative nature of the FMT approach while substantially accelerating its computation speed, allowing FMT imaging of larger anatomies.

5. 发明申请

WO2011025950A2 SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGING IN DIFFUSE MEDIA USING A HYBRID INVERSION TECHNIQUE 审中-公开
标题翻译：使用混合反演技术在差别媒体中进行图像成像的系统和方法
公开(公告)号：WO2011025950A2
公开(公告)日：2011-03-03
申请号：PCT/US2010046973
申请日：2010-08-27
申请人： VISEN MEDICAL INC , RIPOLL LORENZO JORGE , YARED WAEL I , KEMPNER JOSHUA
发明人： RIPOLL LORENZO JORGE , YARED WAEL I , KEMPNER JOSHUA
IPC分类号： A61B6/00 , A61B5/055 , A61B5/1455 , A61B8/13 , G06K9/00
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/0071 , A61B5/0086 , A61B5/14556 , A61B5/41 , A61B5/7257 , A61B6/508 , G06T11/006 , G06T2211/424
摘要： The invention relates to systems and methods for tomographic imaging in diffuse media employing a fast reconstruction technique. A hybrid Fourier approach is presented that enables the fast tomographic reconstruction of large datasets. In certain embodiments, the invention features methods of in vivo fluorescence molecular tomographic (FMT) reconstruction of signals, reporters and/or agents (i.e., contrast agents or probes) in a diffusive medium (e.g., a mammalian subject). The method preserves the three-dimensional fluorophore distribution and quantitative nature of the FMT approach while substantially accelerating its computation speed, allowing FMT imaging of larger anatomies.
摘要翻译：本发明涉及采用快速重建技术的扩散介质中的断层成像系统和方法。提出了一种混合傅立叶方法，可以实现大型数据集的快速层析成像。在某些实施方案中，本发明的特征在于扩散介质（例如哺乳动物受试者）中的信号，记录和/或代理（即造影剂或探针）的体内荧光分子层析（FMT）重建方法。该方法保持了FMT方法的三维荧光团分布和定量性质，同时大大加快了其计算速度，允许更大的解剖结构的FMT成像。

6. 发明申请

WO2009120758A1 ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES 审中-公开
标题翻译：用于多种模式的VIVO TOMOGRAPHIC成像的动物持有人
公开(公告)号：WO2009120758A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038213
申请日：2009-03-25
申请人： VISEN MEDICAL, INC. , YARED, Wael, I. , WILSON, Andrew, K.
发明人： YARED, Wael, I. , WILSON, Andrew, K.
IPC分类号： A61B6/04 , A61D3/00
CPC分类号： A61B6/045 , A61B5/7285 , A61B6/0421 , A61B6/485 , A61B6/508 , A61B6/583 , A61B8/543 , A61B2503/40
摘要： The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations. The animal holder optionally also includes a system for providing the animal with inhalation anesthesia, for example, isoflurane, and is designed to fit into identical receptacles inside or outside the imaging workstation(s) that provide heating to minimize or prevent animal hypothermia.
摘要翻译：本发明有助于在相同或不同的物理位置的多个单一模态或多模态成像工作站上运输固定的被麻醉的小动物，而不损失对象位置信息。动物持有人与临床前动物成像站如micro-CT，micro-MR，micro-PET，micro-SPECT和FMT兼容。动物保持器被配置为通过（例如，装配在这些器械的）各个成像室中来容纳，并且由与所使用的所有成像模式兼容的材料制成。在某些实施例中，集成的一组基准标记井容纳在多个平面中同时由几种模态拾取的标记的分配。然后，基准标记在标准图像处理或图像分析软件中进行对准，具有简单的图像平移和旋转操作，而不需要更高级的缩放，失真或其他操作。动物保持器可选地还包括用于向动物提供吸入麻醉的系统，例如异氟烷，并且被设计成装配在提供加热以使动物体温过低最小化或防止动物低体温的成像工作站内部或外部的相同容器中。

7. 发明申请

WO2009055095A1 IMAGING SYSTEMS FEATURING WAVEGUIDING COMPENSATION 审中-公开
标题翻译：成像系统特征波形补偿
公开(公告)号：WO2009055095A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/065648
申请日：2008-06-03
申请人： VISEN MEDICAL, INC. , YARED, Wael, I. , MOHAJERANI, Pouyan , KEMPNER, Joshua
发明人： YARED, Wael, I. , MOHAJERANI, Pouyan , KEMPNER, Joshua
IPC分类号： A61B5/00
CPC分类号： G06T11/005 , A61B5/0071 , A61B5/0073 , A61B5/415 , G01N21/4795 , G01N21/6456 , G01N2021/6439 , G01N2021/6491 , G06T11/003
摘要： There are systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.
摘要翻译：存在用于改变图像以补偿异质弥漫组织中的一种或多种物理和/或超级特性（例如光学吸收和/或散射）的变化的系统和方法，从而衰减组织波导的影响。这些方法能够正确识别证明电磁辐射的波导的发射图像区域，并且能够补偿这种波导的发射图像。该方法保留了FMT方法的深度定位精度，并改善了目标区域的光学重构，同时从所获取的数据集中消除了荧光的杂散成分。还提供了探针浓度映射的校准方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式