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1. 发明申请

WO2003089140A1 AUTOMATED HIGH VOLUME SLIDE STAINING SYSTEM 审中-公开
标题翻译：自动化高容量滑块系统
公开(公告)号：WO2003089140A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/011651
申请日：2003-04-15
申请人： VENTANA MEDICAL SYSTEMS, INC. , REINHARDT, Kurt , LEMME, Charles, D. , WARD, Glen , RICHARDS, William , SHOWALTER, Wayne
发明人： REINHARDT, Kurt , LEMME, Charles, D. , WARD, Glen , RICHARDS, William , SHOWALTER, Wayne
IPC分类号： B01L3/02
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus (20) includes a plurality of work stations (120, 140, 160, 180) arranged in a stack, and a transport/elevator (52) for transporting slides between the various work stations. In particular the device is for deparaffinizing, staining and coverslipping a plurality of biological specimen bearing slides (56), in a fully automated and integrated system.
摘要翻译：自动滑块处理装置（20）包括以堆叠方式布置的多个工作站（120,140,160,180）和用于在各个工作站之间传送滑块的运输/升降机（52）。特别地，该装置用于在完全自动化和集成的系统中脱蜡，染色和覆盖多个生物样品轴承滑块（56）。

2. 发明申请

WO2003091710A1 AUTOMATED MOLECULAR PATHOLOGY APPARATUS HAVING FIXED SLIDE PLATFORMS 审中-公开
标题翻译：具有固定滑动平台的自动分子病理学设备
公开(公告)号：WO2003091710A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012947
申请日：2003-04-28
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , BRYANT, David , CAMPBELL, Devon , GHUSSON, Andrew , REINHARDT, Kurt , RICHARDS, William , RIZZO, Vincent , SHOWALTER, Wayne
发明人： LEMME, Charles, D. , BRYANT, David , CAMPBELL, Devon , GHUSSON, Andrew , REINHARDT, Kurt , RICHARDS, William , RIZZO, Vincent , SHOWALTER, Wayne
IPC分类号： G01N21/00
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed positions, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions are brought to the slides. The apparatus includes a reagent support (1300), nozzle support (1100), and reagent dispensers (1302).
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂，洗涤和盖玻片溶液带到载玻片上。或者，将幻灯片保持在固定位置，同时将试剂，洗涤和盖玻片溶液带到载玻片上。该装置包括试剂支架（1300），喷嘴支架（1100）和试剂分配器（1302）。

3. 发明申请

WO2009009419A3 APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING 审中-公开
公开(公告)号：WO2009009419A3
公开(公告)日：2009-01-15
申请号：PCT/US2008/069151
申请日：2008-07-03
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , RICHARDS, William , WARD, Glen , ASHBY, Austin , GHUSSON, Andrew , JENSEN-LONG, Lisa , KNAPP, Kevin , KUGIZAKI, Rodney , LARSON, Alain , RICHARDS, Paul , SHOWALTER, Wayne , WILKINSON, Chad
发明人： LEMME, Charles, D. , RICHARDS, William , WARD, Glen , ASHBY, Austin , GHUSSON, Andrew , JENSEN-LONG, Lisa , KNAPP, Kevin , KUGIZAKI, Rodney , LARSON, Alain , RICHARDS, Paul , SHOWALTER, Wayne , WILKINSON, Chad
IPC分类号： G01N35/00
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate- supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.

4. 发明申请

WO2011008415A2 COVER TILE FOR TREATING A SUBSTRATE WITH A FLUID 审中-公开
标题翻译：用于处理具有流体的基板的盖子
公开(公告)号：WO2011008415A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/039229
申请日：2010-06-18
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , WARD, Glen , KRAM, Brian, H. , RICHARDS, William, L.
发明人： LEMME, Charles, D. , WARD, Glen , KRAM, Brian, H. , RICHARDS, William, L.
IPC分类号： G01N35/00 , G01N1/28
CPC分类号： G01N1/312 , G02B21/34
摘要： A cover tile/substrate construct that includes a cover tile having an upper surface, an opposing lower surface, a proximal edge, a distal edge, and a longitudinal direction extending from the proximal edge to the distal edge, wherein the lower surface defines a three-dimensional surface that includes a protrusion that extends in the longitudinal direction; a substantially planar substrate having an upper surface and an opposing lower surface; and wherein the cover tile is juxtaposed over the substrate so that the lower surface of the cover tile and the upper surface of the substrate together define a wedge-shaped capillary fluid flow gap and the longitudinally extended protrusion of the lower surface of the cover tile protrudes towards the upper surface of the substrate.
摘要翻译：一种覆盖瓦片/基底构造，其包括具有上表面，相对的下表面，近端边缘，远侧边缘和从近端边缘延伸到远端边缘的纵向方向的覆盖瓦，其中下表面限定三包括沿纵向方向延伸的突起的三维表面; 具有上表面和相对的下表面的基本平坦的基板; 并且其中所述覆盖瓦片并置在所述基板上，使得所述覆盖瓦片的下表面和所述基板的上表面一起限定楔形毛细流体流动间隙，并且所述盖板的下表面的纵向延伸的突出部突出朝向基板的上表面。

5. 发明申请

WO2006012498A1 METHOD AND APPARATUS FOR APPLYING FLUIDS TO A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于将液体应用于生物样品的方法和装置
公开(公告)号：WO2006012498A1
公开(公告)日：2006-02-02
申请号：PCT/US2005/026014
申请日：2005-07-21
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , REINHARDT, Kurt
发明人： LEMME, Charles, D. , REINHARDT, Kurt
IPC分类号： G01N33/53
CPC分类号： B01L3/0293 , B01L2300/0822 , B01L2400/0406 , B01L2400/0475 , G01N1/2813 , G01N1/30 , G01N1/312 , G01N33/543 , G01N33/54366 , Y10T436/112499
摘要： The invention is directed to a method of contacting a biological sample with a solution, comprising the steps of moving a curved surface wetted with the solution in proximity to the biological sample whereby the distance separating the wetted curved surface and the biological sample is sufficient to form a moving liquid meniscus layer between the two. The invention is also directed to an apparatus for contacting a biological sample suspected of containing a biomarker with a solution, comprising a platform for supporting a microscope slide having a biological sample thereon; a translating cap having a curved lower surface positioned above the platform, the curved lower surface being in proximity to a biological sample when in operation; means for moving the translating cap back and forth over the biological sample; and means for applying and removing liquid to and from the cap.
摘要翻译：本发明涉及一种使生物样品与溶液接触的方法，包括以下步骤：将溶液润湿的曲面移动到生物样品附近，由此分开润湿曲面和生物样品的距离足以形成两者之间移动的液体弯月面层。本发明还涉及一种用于将怀疑含有生物标志物的生物样品与溶液接触的装置，包括用于支撑其上具有生物样品的显微镜载片的平台; 平移盖，其具有位于所述平台上方的弯曲下表面，所述弯曲下表面在操作时接近生物样品; 用于将翻译盖来回移动到生物样品上的装置; 以及用于施加和去除帽子上的液体的装置。

6. 发明申请

WO2010078177A1 ROBOTIC PIPETTE SYSTEM 审中-公开
标题翻译：机载管系统
公开(公告)号：WO2010078177A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069348
申请日：2009-12-22
申请人： VENTANA MEDICAL SYSTEMS, INC. , LEMME, Charles, D. , RICHARDS, William
发明人： LEMME, Charles, D. , RICHARDS, William
IPC分类号： G01N35/00 , G01N35/10 , G01N1/31
CPC分类号： G01N35/1002 , G01N35/0099 , G01N35/025 , G01N2035/00039 , G01N2035/00138 , G01N2035/0434
摘要： A robotic pipette system is used to process specimen-bearing microscope slides. The system includes a filling station, carousels, and a transport apparatus that loads pipettes filled at the filling station into the carousels. The carousels position the pipettes above the specimen-bearing slides such that fluids dispensed from the pipettes are applied to the specimens. Each carousel can hold a series of pipettes that are used to perform a multi-step process.
摘要翻译：机器人移液器系统用于处理承载载玻片的载玻片。该系统包括一个加油站，转盘和运送装置，将装载在加油站的移液管装载到转盘中。转盘将移液器放置在载体载玻片上方，以便将从移液器分配的流体施加到样品上。每个转盘可以容纳一系列用于执行多步骤过程的移液器。

7. 发明申请

WO2002070778A1 APPARATUS AND METHOD FOR WEB COOLING IN A VACUUM COATING CHAMBER 审中-公开
标题翻译：用于在真空涂料室中进行网状冷却的装置和方法
公开(公告)号：WO2002070778A1
公开(公告)日：2002-09-12
申请号：PCT/US2002/005679
申请日：2002-02-27
申请人： APPLIED PROCESS TECHNOLOGIES , MADOCKS, John, E. , LEMME, Charles, D.
发明人： MADOCKS, John, E. , LEMME, Charles, D.
IPC分类号： C23C16/00
CPC分类号： C23C16/466 , C23C14/562
摘要： A chill drum (14) is modified to improve heat transfert between the drum and a flexible web substrate (20) disposed around the drum. The drum surface (22) contains a series of passages (44) and distribution holes (46). A working gas is injected into these passages and flows out of the distribution holes into the space between the web and drum. A cover (32) prevents working gas from escaping from frum passages in the area not covered by the web, and supplies the working gas to the passages at the drum cover. Once gas is in the passages, leakage only occurs from the edges of the web. The pressure in the passages remains essentially constant around the drum, producing uniform elevated pressures under the entire web. Elevated pressure behind the web significantly improves overall heat transfert, thereby allowing higher deposition rates and other process advantages.
摘要翻译：改变冷却鼓（14）以改善滚筒与布置在滚筒周围的柔性幅材基片（20）之间的热传递。鼓表面（22）包含一系列通道（44）和分配孔（46）。工作气体注入这些通道并从分配孔流出到卷筒和滚筒之间的空间中。盖（32）防止工作气体从未被卷筒纸覆盖的区域中的通道中逸出，并将工作气体供应到鼓罩上的通道。一旦气体在通道中，泄漏只从网的边缘发生。通道中的压力在鼓周围保持基本恒定，在整个幅材下产生均匀的升高的压力。幅材后面的高压显着地改善了总体传热，从而允许更高的沉积速率和其它工艺优点。

8. 发明授权

EP1771730B1 METHOD AND APPARATUS FOR APPLYING FLUIDS TO A BIOLOGICAL SAMPLE 有权
标题翻译：方法和设备施加用液体生物样品
公开(公告)号：EP1771730B1
公开(公告)日：2014-08-20
申请号：EP05775429.3
申请日：2005-07-21
申请人： Ventana Medical Systems, Inc.
发明人： LEMME, Charles, D. , REINHARDT, Kurt
IPC分类号： G01N33/53 , G01N33/543 , G01N1/30 , G01N1/31
CPC分类号： B01L3/0293 , B01L2300/0822 , B01L2400/0406 , B01L2400/0475 , G01N1/2813 , G01N1/30 , G01N1/312 , G01N33/543 , G01N33/54366 , Y10T436/112499

9. 发明公开

EP1499872A1 AUTOMATED MOLECULAR PATHOLOGY APPARATUS HAVING FIXED SLIDE PLATFORMS 有权转让
标题翻译：在分子病理学的自动装置具有固定SLIDE PLATFORMS
公开(公告)号：EP1499872A1
公开(公告)日：2005-01-26
申请号：EP03726474.4
申请日：2003-04-28
申请人： VENTANA MEDICAL SYSTEMS, INC.
发明人： LEMME, Charles, D. , BRYANT, David , CAMPBELL, Devon , GHUSSON, Andrew , REINHARDT, Kurt , RICHARDS, William , RIZZO, Vincent , SHOWALTER, Wayne
IPC分类号： G01N21/00 , G01N31/00 , G01N33/00 , G01N15/06 , G01N33/48 , B01L3/02
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed positions, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions are brought to the slides. The apparatus includes a reagent support (1300), nozzle support (1100), and reagent dispensers (1302).

10. 发明授权

EP1073892B1 AUTOMATED MOLECULAR PATHOLOGY APPARATUS HAVING INDEPENDENT SLIDE HEATERS 有权
标题翻译：全部独立SLIDE保温自动化分子病理学DEVICE
公开(公告)号：EP1073892B1
公开(公告)日：2010-11-24
申请号：EP99909630.8
申请日：1999-02-26
申请人： Ventana Medical Systems, Inc.
发明人： RICHARDS, William , LEMME, Charles, D. , CHRISTENSEN, Kimberly , MACREA, Ethel, R.
IPC分类号： G01N1/30
CPC分类号： G01N35/1002 , G01N1/30 , G01N1/31 , G01N1/312 , G01N1/36 , G01N35/1079
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides (37) are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms (64) radially mounted to the carousel (34) for heating the slides (37) and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.

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