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1. 发明申请

WO2013033073A1 EXPRESSION OF ETS RELATED GENE (ERG) AND PHOSPHATASE AND TENSIN HOMOLOG (PTEN) CORRELATES WITH PROSTATE CANCER CAPSULAR PENETRATION 审中-公开
标题翻译：表达ETS相关基因（ERG）和磷酸化酶和TENSIN HOMOLOG（PTEN）与前列腺癌囊肿的相关性
公开(公告)号：WO2013033073A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052627
申请日：2012-08-28
申请人： VENTANA MEDICAL SYSTEMS, INC. , PESTANO, Gary , NAGLE, Ray, B. , CORTEZ, Connie , VANPATTEN, Kristie, A. , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , ALGOTAR, Amit, M.
发明人： PESTANO, Gary , NAGLE, Ray, B. , CORTEZ, Connie , VANPATTEN, Kristie, A. , ALGOTAR, Amit, M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N33/5748 , G01N33/6893 , G01N2333/47
摘要： The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be correlated with prostate cancer capsular penetration and more aggressive forms of prostate cancer. Such methods are useful for the prognosis of prostate cancer capsular penetration and for making treatment decisions in patients with prostate cancer that has penetrated the capsule. Also provided are kits that can be used with such methods.
摘要翻译：本公开提供了通过检测ERG，PTEN或两者的表达来表征前列腺癌样品的方法，其中相对于正常对照在本文中显示为与前列腺癌荚膜穿透和更具侵略性形式的前列腺癌相关的变化。这种方法对于前列腺癌囊膜穿透的预后以及用于在已经穿透胶囊的前列腺癌患者中作出治疗决定是有用的。还提供了可以与这些方法一起使用的试剂盒。

2. 发明申请

WO2011046807A2 MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE 审中-公开
标题翻译：多模式对比度和亮度对比度增强，用于增强组织病理学确定和组织中的多分析检测
公开(公告)号：WO2011046807A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/051857
申请日：2010-10-07
申请人： VENTANA MEDICAL SYSTEMS, INC. , GARSHA, Karl , PESTANO, Gary , OTTER, Michael , NAGY, Alexandra, Dea , NAGLE, Ray, B. , MILLER, Phillip , FROEHLICH, Jan , DAY, William
发明人： GARSHA, Karl , PESTANO, Gary , OTTER, Michael , NAGY, Alexandra, Dea , NAGLE, Ray, B. , MILLER, Phillip , FROEHLICH, Jan , DAY, William
IPC分类号： G01N33/483
CPC分类号： G01N21/6456
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.
摘要翻译：可以使用多重形态对比来产生可以组合和渲染的图像，以产生类似于在透射白光照明下观察到的波长吸收染色产生的图像的图像。使用其他补充对比模式获得的图像可以使用基于用于显示相同解剖结构和组织化学的经典对比度方法的工程配色方案来呈现，从而提供与医学培训和经验的相关性。将衍生自折射率和荧光DAPI复染图像的暗视野对比图像组合以产生类似于用于病理解释的常规H＆E染色获得的图像。这种多模态图像数据可以流式传输用于组织学样本的实时导航，并且可以与基因DNA探针（FISH），mRNA表达位点（mRNA-ISH）和局部在该位点上的免疫组织化学（IHC）探针的分子定位相结合相同的组织切片，用于评估和绘制准备用于成像质谱的组织切片。

3. 发明申请

WO2009036427A3 PROSTATE CANCER BIOMARKERS 审中-公开
公开(公告)号：WO2009036427A3
公开(公告)日：2009-03-19
申请号：PCT/US2008/076407
申请日：2008-09-15
申请人： VENTANA MEDICAL SYSTEMS, INC. , PESTANO, Gary , SATHYANARAYANA, Ubaradka, G. , RILEY, Janice , NAGLE, Ray, B.
发明人： PESTANO, Gary , SATHYANARAYANA, Ubaradka, G. , RILEY, Janice , NAGLE, Ray, B.
IPC分类号： C12Q1/68
摘要： Disclosed are biomarkers, at least, useful for the diagnosis and/or prognosis of cancer and for making treatment decisions in cancer, for example prostate cancer.

4. 发明申请

WO2006119265A2 XENOGRAFT TISSUE CONTROL FOR HISTOLOGY 审中-公开
标题翻译： XENOGRAFT组织控制组织学
公开(公告)号：WO2006119265A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016766
申请日：2006-05-01
申请人： VENTANA MEDICAL SYSTEMS, INC. , HARDY, Margaret , GROGAN, Thomas, M. , NAGLE, Ray, B.
发明人： HARDY, Margaret , GROGAN, Thomas, M. , NAGLE, Ray, B.
IPC分类号： G01N33/50 , G01N33/577 , G01N33/567
CPC分类号： G01N33/5005 , G01N1/30 , G01N1/312 , G01N2001/2893 , G01N2015/1018
摘要： An embodiment of the invention is a method of using a xenograft as a control tissue for histology, comprising staining both a patient and a xenograft-derived control sample under substantially similar staining conditions, and assessing the staining outcomes of the two to determine whether the stain was effective for the patient sample. A xenograft has never been used before in histology as a control, as far as the inventors know. The result of using a xenograft as a control is surprisingly advantageous. First, the cell lines grow and differentiate similarly to a human, taking on the general morphology of a real tissue sample. Second, because the same transformed cell line can be grown limitless times in SCID mice, the xenograft control is highly reproducible, leading to a consistent artificial control that is highly manufacturable and subject to genetic manipulation so that antigens or genetic elements may be embedded in the tissue. Another embodiment of the invention is directed generally to a method of making a tissue control substrate, comprising growing a xenograft from a mammalian transformed cell line in a host animal, removing the xenograft from the host animal, processing the xenograft thereby embedding the xenograft tissue in an embedding medium, and finally affixing the embedded xenograft sample onto a substrate. The substrate is generally a microscope slide. The xenograft control slide can then be stained side-by-side with a specimen sample in an automated slide stainer, and act as a control against which the staining quality can be compared. The xenograft control can also be used as a manual staining control. Determining whether the staining was effective for the patient specimen comprises judging the staining intensity of the xenograft control sample to determine if the expected degree and type of staining were realized in the control. If the expected type (nuclear, membranous, or cytoplasmic) and degree (0-4 scale) of staining are realized during the run, then the xenograft control indicates the staining process and reagents are working properly, and so the result in the patient specimen can be trusted. A further embodiment of the invention is a xenograft-derived control slide for histochemical use, comprising at least one xenograft control sample prepared for histological use, and a sample slide upon which the at least one xenograft control sample is affixed.
摘要翻译：本发明的一个实施方案是使用异种移植物作为组织学的对照组织的方法，包括在基本相似的染色条件下染色患者和异种移植物衍生的对照样品，并评估两者的染色结果以确定染色对患者样本有效。就本发明人所知，异种移植物在组织学之前从未被用作对照。使用异种移植物作为对照的结果是惊人的有利的。首先，细胞系与人类相似地生长和分化，承担真实组织样品的一般形态。第二，由于相同的转化细胞系可以在SCID小鼠中无限期地生长，异种移植物控制是高度可重复的，导致一致的人造控制，其是高度可制造的并经受遗传操作，使得抗原或遗传元件可嵌入组织。本发明的另一个实施方案一般涉及一种制备组织对照底物的方法，包括从宿主动物的哺乳动物转化细胞系中生长异种移植物，从宿主动物中除去异种移植物，加工异种移植物，从而将异种移植组织嵌入嵌入介质，最后将嵌入的异种移植样品固定在基底上。基底通常是显微镜载玻片。然后将异种移植物对照载玻片与自动化载玻片染色剂中的标本样品并排染色，并且作为可以比较染色质量的对照。异种移植物控制也可以用作手动染色控制。确定染色对患者标本是否有效包括判断异种移植物对照样品的染色强度，以确定在对照中是否实现预期的染色程度和染色类型。如果在运行期间实现预期的类型（核，膜或细胞质）和染色程度（0-4标度），则异种移植物对照表明染色过程和试剂正常工作，因此导致患者标本可以信任本发明的另一个实施方案是用于组织化学用途的异种移植物衍生的对照载玻片，其包含至少一种用于组织学用途制备的异种移植物对照样品和载有至少一种异种移植物对照样品的样品载玻片。

5. 发明公开

EP2488860A2 MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE 审中-公开
标题翻译： MULTIMODALITÄTSKONTRAST和增强的病理学测定的BREITFELD背景和MEHRANALYTERKENNUNG组织
公开(公告)号：EP2488860A2
公开(公告)日：2012-08-22
申请号：EP10823858.5
申请日：2010-10-07
申请人： Ventana Medical Systems, Inc.
发明人： GARSHA, Karl , PESTANO, Gary , OTTER, Michael , NAGY, Alexandra, Dea , NAGLE, Ray, B. , MILLER, Phillip , FROEHLICH, Jan , DAY, William
IPC分类号： G01N33/483
CPC分类号： G01N21/6456
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.

6. 发明公开

EP2205763A2 PROSTATE CANCER BIOMARKERS 审中-公开
标题翻译：前列腺癌生物标记
公开(公告)号：EP2205763A2
公开(公告)日：2010-07-14
申请号：EP08831230.1
申请日：2008-09-15
申请人： Ventana Medical Systems, Inc.
发明人： PESTANO, Gary , SATHYANARAYANA, Ubaradka, G. , RILEY, Janice , NAGLE, Ray, B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/16 , G01N33/57434 , G01N2800/60
摘要： Disclosed are biomarkers, at least, useful for the diagnosis and/or prognosis of cancer and for making treatment decisions in cancer, for example prostate cancer.

7. 发明公开

EP1877784A2 XENOGRAFT TISSUE CONTROL FOR HISTOLOGY 审中-公开
标题翻译：异种移植ALS REFEERENZPROBE组织学
公开(公告)号：EP1877784A2
公开(公告)日：2008-01-16
申请号：EP06752070.0
申请日：2006-05-01
申请人： Ventana Medical Systems, Inc.
发明人： HARDY, Margaret , GROGAN, Thomas, M. , NAGLE, Ray, B.
IPC分类号： G01N33/50 , G01N33/577 , G01N33/567
CPC分类号： G01N33/5005 , G01N1/30 , G01N1/312 , G01N2001/2893 , G01N2015/1018
摘要： An embodiment of the invention is a method of using a xenograft as a control tissue for histology, comprising staining both a patient and a xenograft-derived control sample under substantially similar staining conditions, and assessing the staining outcomes of the two to determine whether the stain was effective for the patient sample. A xenograft has never been used before in histology as a control, as far as the inventors know. The result of using a xenograft as a control is surprisingly advantageous. First, the cell lines grow and differentiate similarly to a human, taking on the general morphology of a real tissue sample. Second, because the same transformed cell line can be grown limitless times in SCID mice, the xenograft control is highly reproducible, leading to a consistent artificial control that is highly manufacturable and subject to genetic manipulation so that antigens or genetic elements may be embedded in the tissue. Another embodiment of the invention is directed generally to a method of making a tissue control substrate, comprising growing a xenograft from a mammalian transformed cell line in a host animal, removing the xenograft from the host animal, processing the xenograft thereby embedding the xenograft tissue in an embedding medium, and finally affixing the embedded xenograft sample onto a substrate. The substrate is generally a microscope slide. The xenograft control slide can then be stained side-by-side with a specimen sample in an automated slide stainer, and act as a control against which the staining quality can be compared. The xenograft control can also be used as a manual staining control. Determining whether the staining was effective for the patient specimen comprises judging the staining intensity of the xenograft control sample to determine if the expected degree and type of staining were realized in the control. If the expected type (nuclear, membranous, or cytoplasmic) and degree (0-4 scale) of staining are realized during the run, then the xenograft control indicates the staining process and reagents are working properly, and so the result in the patient specimen can be trusted. A further embodiment of the invention is a xenograft-derived control slide for histochemical use, comprising at least one xenograft control sample prepared for histological use, and a sample slide upon which the at least one xenograft control sample is affixed.

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