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1. 发明申请

WO2016097163A1 OBTAINING TRUE DIFFUSIVITY CONSTANT 审中-公开
标题翻译：获得真正的差异性
公开(公告)号：WO2016097163A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080251
申请日：2015-12-17
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/024 , G01N29/07 , G01N29/44
CPC分类号： G01H5/00 , A61B5/066 , A61B8/4483 , A61N2007/0039 , G01N29/024 , G01N29/07 , G01N29/4472 , G01N2291/0245 , G01N2291/02475
摘要： The subject disclosure presents systems and computer-implemented methods for calculating the diffusivity constant of a sample using acoustic time-of-flight (TOF) based information correlated with a diffusion model to reconstruct a sample's diffusivity coefficient. Operations disclosed herein such as acoustically determining the phase differential accumulated through passive fluid exchange (i.e. diffusion) based on the geometry of the tissue sample, modeling the impact of the diffusion on the TOF, and using a post-processing algorithm to correlate the results to determine the diffusivity constant, are enabled by monitoring the changes in the speed of sound caused by penetration of fixative such as formalin into several tissue samples. A tissue preparation system may be adapted to monitor said diffusion of a tissue sample and determine an optimal processing workflow.
摘要翻译：本发明公开提供了使用与扩散模型相关联的基于声学飞行时间（TOF）的信息来计算样本的扩散常数的系统和计算机实现的方法，以重建样本的扩散系数。本文公开的操作，例如基于组织样本的几何形状来声学地确定通过被动流体交换（即扩散）累积的相位差，模拟扩散对TOF的影响，以及使用后处理算法将结果与通过监测由诸如福尔马林等固定剂渗透到几个组织样品中引起的声速变化来确定扩散系数常数。组织制备系统可以适于监测组织样品的所述扩散并确定最佳处理工作流程。

2. 发明申请

WO2016097164A3 ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT 审中-公开
公开(公告)号：WO2016097164A3
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080252
申请日：2015-12-17
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/024 , G01N29/07 , G01N29/44 , G01N1/30
摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of- flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

3. 发明申请

WO2016087589A1 METHODS, SYSTEMS, AND APPARATUSES FOR QUANTITATIVE ANALYSIS OF HETEROGENEOUS BIOMARKER DISTRIBUTION 审中-公开
标题翻译：异源生物标志物分布定量分析的方法，系统和装置
公开(公告)号：WO2016087589A1
公开(公告)日：2016-06-09
申请号：PCT/EP2015/078532
申请日：2015-12-03
申请人： VENTANA MEDICAL SYSTEMS, INC. , OREGON HEALTH & SCIENCE UNIVERSITY , F. HOFFMANN-LA ROCHE AG
发明人： BARNES, Michael , CHAFIN, David , GARSHA, Karl , GROGAN, Thomas M. , ROBERTS, Esteban , STEVENS, Benjamin , VENTURA, Frank , CHEFD´HOTEL, Christophe , SHANMUGAM, Kandavel , GRAY, Joe , RAMUNNO-JOHNSON, Damien , QUOC VU, Tothu (Tania)
IPC分类号： G06K9/00 , G06K9/62 , G06T7/00 , G01N33/50 , G06T7/40
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/3233 , G06K9/4652 , G06K9/6222 , G06T7/11 , G06T7/90 , G06T2207/10036 , G06T2207/10056 , G06T2207/10064 , G06T2207/20032 , G06T2207/20104 , G06T2207/20152 , G06T2207/30024 , G06T2207/30096
摘要： Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.
摘要翻译：本文公开了用于检测和描述细胞样品中的异质性的方法，系统和装置。生成针对单元样本的图像内的一个或多个感兴趣区域（AOI）的多个视野（FOV）。来自每个FOV的高光谱或多光谱数据被组织成包含一个或多个z层的图像堆叠，每个z层包含FOV中每个像素处的单个标记的强度数据。聚类分析被应用于图像堆叠，其中聚类算法对像素具有在z轴的层之间具有相似比率的可检测标记强度，从而生成具有相似表达模式的多个簇。

4. 发明申请

WO2016189065A1 METHOD AND SYSTEM FOR ASSESSING STAIN QUALITY FOR IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY 审中-公开
标题翻译：评估原位杂交和免疫组织化学染色质量的方法和系统
公开(公告)号：WO2016189065A1
公开(公告)日：2016-12-01
申请号：PCT/EP2016/061859
申请日：2016-05-25
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： GARSHA, Karl , OTTER, Michael , STEVENS, Benjamin , TAFT, Jefferson , VENTURA, Frank
IPC分类号： G06K9/00 , G01N1/30
CPC分类号： G06K9/00127 , G01N1/30
摘要： Immunohistochemistry (IHC) and in situ hybridization (ISH) have the aim of detecting, localizing and quantifying certain analytes for various diagnostic purposes. The quality of the stains which are analyzed may deviate for various reasons. Therefore, the present invention provides a method and system for assessing the stain quality and for establishing objective criteria for assessing the stain quality for application in the fields of in-situ hybridization and immunohistochemistry. In one possible embodiment, the invention comprises the steps of unmixing multi-spectral image data of a tissue specimen to obtain analyte intensity images, each analyte intensity image comprising signals from a single stain, computing metrics based on the analyte intensity images, wherein the metrics are uniformity, distribution and/or dispersion of pixel intensity values in the analyte intensity images and assessing a stain quality of a slide by comparing the computed metrics to pre-determined cutoff values regarding uniformity, distribution and/or dispersion of pixel intensity, wherein the stain quality of the slide is assessed as acceptable if the computed metrics meet or exceed the pre-determined cutoff values, and wherein the stain quality of the slide is assessed as unacceptable if the computed metrics do not meet the pre-determined cutoff values. In order to establish objective criteria for assessing stain quality, in one possible embodiment, the method and system includes the step of deriving cut-off values for uniformity, distribution and/or dispersion of pixel intensity by combining the computed metrics based on the analyte intensity images with pre-established data quantifying the stain quality.
摘要翻译：免疫组化（IHC）和原位杂交（ISH）的目的是检测，定位和量化某些分析物用于各种诊断目的。由于各种原因，分析的污渍的质量可能会偏离。因此，本发明提供了一种用于评估染色质量的方法和系统，并且用于建立用于评估在原位杂交和免疫组织化学领域中应用的染色质量的客观标准。在一个可能的实施例中，本发明包括以下步骤：混合组织样本的多光谱图像数据以获得分析物强度图像，每个分析物强度图像包括来自单个染色层的信号，基于分析物强度图像计算度量，其中度量是分析物强度图像中的像素强度值的均匀性，分布和/或分散，并且通过将所计算的度量与对于像素强度的均匀性，分布和/或色散的预定截止值进行比较来评估载玻片的染色质量，其中如果所计算的度量达到或超过预定的截止值，则幻灯片的染色质量被评估为可接受，并且其中如果所计算的度量不满足预定的截止值，则幻灯片的染色质量被评估为不可接受。为了确定评估染色质量的客观标准，在一个可能的实施例中，该方法和系统包括通过基于分析物强度组合所计算的度量来导出像素强度的均匀性，分布和/或色散的截止值的步骤具有预先确定的数据的图像来量化染色质量。

5. 发明申请

WO2016120224A1 TRANSPORTER SYSTEMS, ASSEMBLIES AND ASSOCIATED METHODS FOR TRANSPORTING TISSUE SAMPLES 审中-公开
标题翻译：运输系统，组装及相关方法运输组织样本
公开(公告)号：WO2016120224A1
公开(公告)日：2016-08-04
申请号：PCT/EP2016/051489
申请日：2016-01-26
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： CRUM, Nathan , KELLER, Timothy , LAING, Alastair , OTTER, Michael , PETRE, Vinnie , PIGMAN, Elizabeth , SHINGLER, Taylor , STACEY, Stanislaw , STEVENS, Benjamin
IPC分类号： B01L3/00 , G01N1/30 , G01N1/31 , B01L7/04
CPC分类号： B01L3/502 , B01L3/50825 , B01L7/04 , B01L9/06 , B01L2200/026 , B01L2200/147 , B01L2200/18 , B01L2300/024 , B01L2300/047 , B01L2300/0609 , B01L2300/1855 , B01L2300/1877 , B01L2300/1883 , B01L2300/1894 , G01N1/31 , G01N35/10 , G01N2001/315
摘要： A tissue sample that has been removed from a subject can be evaluated. A transporter system for carrying a tissue sample includes a transport container, a fixative in the transport container, and a cooling device that reduces and/or maintains the temperature of the fixative to perform a pre-soaking process. A portable transporter system adapted to carry a tissue sample contacting a fixative, can include: a transport container including: a holding chamber; and a fixative; and a container lid including: a cassette holder operable to be coupled to the standard histology cassette and including a first seal; and a cassette receiver operable to be releasably coupled to said transport container and including a second seal, where the cassette holder and cassette receiver are operable to be attachably coupled to one another upon insertion of a standard histology cassette coupled to the cassette holder into the cassette receiver.
摘要翻译：可以评估已经从受试者中除去的组织样品。用于携带组织样本的运输系统包括运输容器，运输容器中的固定剂和降低和/或维持固定剂的温度以进行预浸泡过程的冷却装置。适于携带与定影剂接触的组织样本的便携式运输系统可以包括：运输容器，包括：保持室; 和固定剂以及容器盖，包括：盒支架，其可操作以联接到所述标准组织学盒并且包括第一密封件; 以及盒式接收器，其可操作地可释放地联接到所述运输容器并且包括第二密封件，其中盒式磁带托架和盒式磁带接收器可操作以在插入耦合到盒座的标准组织学盒插入盒式磁带中时可彼此连接接收器。

6. 发明公开

EP3250323A1 TRANSPORTER SYSTEMS, ASSEMBLIES AND ASSOCIATED METHODS FOR TRANSPORTING TISSUE SAMPLES 有权
标题翻译：输送器系统，用于运输组织样品的组件和相关方法
公开(公告)号：EP3250323A1
公开(公告)日：2017-12-06
申请号：EP16703735.7
申请日：2016-01-26
申请人： Ventana Medical Systems, Inc.
发明人： CRUM, Nathan , KELLER, Timothy , LAING, Alastair , OTTER, Michael , PETRE, Vinnie , PIGMAN, Elizabeth , SHINGLER, Taylor , STACEY, Stanislaw , STEVENS, Benjamin
IPC分类号： B01L3/00 , G01N1/30 , G01N1/31 , B01L7/04
CPC分类号： B01L3/502 , B01L3/50825 , B01L7/04 , B01L9/06 , B01L2200/026 , B01L2200/147 , B01L2200/18 , B01L2300/024 , B01L2300/047 , B01L2300/0609 , B01L2300/1855 , B01L2300/1877 , B01L2300/1883 , B01L2300/1894 , G01N1/31 , G01N35/10 , G01N2001/315
摘要： A tissue sample that has been removed from a subject can be properly fixed for evaluation using the disclosed transporter assembly for carrying a tissue sample and method for fixing an unfixed tissue sample. In one embodiment, the disclosed assembly includes a transport container, a fixative in the transport container, and a cooling device that reduces and/or maintains the temperature of the fixative to perform a pre-soaking process at a temperature of less than about 7° C. The pre-soaking process can, for example, be performed during sample transport or during extended periods of storage, such as over a weekend.

7. 发明公开

EP3865870A1 ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT 审中-实审
公开(公告)号：EP3865870A1
公开(公告)日：2021-08-18
申请号：EP21156002.4
申请日：2015-12-17
申请人： Ventana Medical Systems, Inc.
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/44 , G01N29/07 , G01N29/024
摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

8. 发明公开

EP3227830A1 METHODS, SYSTEMS, AND APPARATUSES FOR QUANTITATIVE ANALYSIS OF HETEROGENEOUS BIOMARKER DISTRIBUTION 有权
标题翻译：用于定量分析非均匀生物标记分布的方法，系统和装置
公开(公告)号：EP3227830A1
公开(公告)日：2017-10-11
申请号：EP15813713.3
申请日：2015-12-03
申请人： Ventana Medical Systems, Inc. , Oregon Health & Science University
发明人： BARNES, Michael , CHAFIN, David , GARSHA, Karl , GROGAN, Thomas M. , ROBERTS, Esteban , STEVENS, Benjamin , VENTURA, Frank , CHEFD'HOTEL, Christophe , SHANMUGAM, Kandavel , GRAY, Joe , RAMUNNO-JOHNSON, Damien , VU, Tothu (Tania)
IPC分类号： G06K9/00 , G06K9/62 , G06T7/00 , G01N33/50 , G06T7/40
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/3233 , G06K9/4652 , G06K9/6222 , G06T7/11 , G06T7/90 , G06T2207/10036 , G06T2207/10056 , G06T2207/10064 , G06T2207/20032 , G06T2207/20104 , G06T2207/20152 , G06T2207/30024 , G06T2207/30096
摘要： Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.
摘要翻译：本文公开了用于检测和描述细胞样品中异质性的方法，系统和装置。针对细胞样品的图像内的一个或多个感兴趣区域（AOI）生成多个视场（FOV）。来自每个FOV的高光谱或多光谱数据组织成包含一个或多个z层的图像堆栈，每个z层包含FOV中每个像素处的单个标记的强度数据。将聚类分析应用于图像堆栈，其中聚类算法对具有跨越z轴的层的可检测标记强度的相似比率的像素进行分组，从而生成具有相似表达模式的多个聚类。

9. 发明授权

EP3250323B1 TRANSPORTER SYSTEMS, ASSEMBLIES AND ASSOCIATED METHODS FOR TRANSPORTING TISSUE SAMPLES 有权
公开(公告)号：EP3250323B1
公开(公告)日：2020-12-09
申请号：EP16703735.7
申请日：2016-01-26
申请人： Ventana Medical Systems, Inc.
发明人： CRUM, Nathan , KELLER, Timothy , LAING, Alastair , OTTER, Michael , PETRE, Marvin Arthur , PIGMAN, Elizabeth , SHINGLER, Taylor , STANISLAW, Stacey , STEVENS, Benjamin
IPC分类号： B01L3/00 , G01N1/30 , G01N1/31 , B01L7/04

10. 发明授权

EP3234581B1 OBTAINING A DIFFUSIVITY CONSTANT 有权转让
公开(公告)号：EP3234581B1
公开(公告)日：2020-09-23
申请号：EP15813403.1
申请日：2015-12-17
申请人： Ventana Medical Systems, Inc.
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/024 , G01N29/07 , G01N29/44

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