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1. 发明申请

WO2016041890A2 COMPOSITIONS, METHODS, AND SYSTEMS FOR TISSUE FIXATION 审中-公开
标题翻译：用于组织固定的组合物，方法和系统
公开(公告)号：WO2016041890A2
公开(公告)日：2016-03-24
申请号：PCT/EP2015/070927
申请日：2015-09-14
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： CHAFIN, David , OTTER, Michael , THEISS, Abbey , BAUER, Daniel
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N1/36 , G01N2001/2873 , G01N2001/305
摘要： The present disclosure relates to use of high-concentration aldehyde-based fixatives to fix tissue samples. Aldehyde concentrations are selected that significantly increase rate of diffusion of the fixative solution into the tissue. When combined in the cold-temperature step of a two-temperature fixation, a substantial improvement in the preservation of post-translationally modified proteins is achieved.
摘要翻译：本公开涉及使用高浓度醛基固定剂来固定组织样品。选择醛浓度显着增加固定剂溶液扩散到组织中的速率。当在双温固定的低温步骤中结合时，实现翻译后修饰蛋白质保存的实质性改进。

2. 发明申请

WO2016097163A1 OBTAINING TRUE DIFFUSIVITY CONSTANT 审中-公开
标题翻译：获得真正的差异性
公开(公告)号：WO2016097163A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080251
申请日：2015-12-17
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/024 , G01N29/07 , G01N29/44
CPC分类号： G01H5/00 , A61B5/066 , A61B8/4483 , A61N2007/0039 , G01N29/024 , G01N29/07 , G01N29/4472 , G01N2291/0245 , G01N2291/02475
摘要： The subject disclosure presents systems and computer-implemented methods for calculating the diffusivity constant of a sample using acoustic time-of-flight (TOF) based information correlated with a diffusion model to reconstruct a sample's diffusivity coefficient. Operations disclosed herein such as acoustically determining the phase differential accumulated through passive fluid exchange (i.e. diffusion) based on the geometry of the tissue sample, modeling the impact of the diffusion on the TOF, and using a post-processing algorithm to correlate the results to determine the diffusivity constant, are enabled by monitoring the changes in the speed of sound caused by penetration of fixative such as formalin into several tissue samples. A tissue preparation system may be adapted to monitor said diffusion of a tissue sample and determine an optimal processing workflow.
摘要翻译：本发明公开提供了使用与扩散模型相关联的基于声学飞行时间（TOF）的信息来计算样本的扩散常数的系统和计算机实现的方法，以重建样本的扩散系数。本文公开的操作，例如基于组织样本的几何形状来声学地确定通过被动流体交换（即扩散）累积的相位差，模拟扩散对TOF的影响，以及使用后处理算法将结果与通过监测由诸如福尔马林等固定剂渗透到几个组织样品中引起的声速变化来确定扩散系数常数。组织制备系统可以适于监测组织样品的所述扩散并确定最佳处理工作流程。

3. 发明申请

WO2012152693A1 METHOD AND SYSTEM FOR SPECTRAL UNMIXING OF TISSUE IMAGES 审中-公开
标题翻译：用于组织图像的光谱分析的方法和系统
公开(公告)号：WO2012152693A1
公开(公告)日：2012-11-15
申请号：PCT/EP2012/058253
申请日：2012-05-04
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG , BAMFORD, Pascal , KURNIK, Ronald , OTTER, Michael
发明人： BAMFORD, Pascal , KURNIK, Ronald , OTTER, Michael
IPC分类号： G06K9/00
CPC分类号： G02B21/361 , G06K9/0014 , G06K2009/4657
摘要： A method and system for spectral demultiplexing of fluorescent species, such as quantum dots, conjugated with a biological tissue. The process of demultiplexing involves a non- liner regression based on curve-fitting of estimated spectra of the quantum dots and confidence intervals describing the parameters of such fitting curve for typical quantum dots.
摘要翻译：用于与生物组织缀合的荧光物质如量子点的光谱解复用的方法和系统。解复用的过程涉及基于量子点的估计光谱的曲线拟合和描述典型量子点的拟合曲线的参数的置信区间的非线性回归。

4. 发明申请

WO2017072320A1 METHODS AND SYSTEMS FOR ANALYZING TISSUE QUALITY USING MID-INFRARED SPECTROSCOPY 审中-公开
标题翻译：使用中红外光谱法分析组织质量的方法和系统
公开(公告)号：WO2017072320A1
公开(公告)日：2017-05-04
申请号：PCT/EP2016/076130
申请日：2016-10-28
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： CHAFIN, David , OTTER, Michael , PETRICH, Wolfgang , BAUER, Daniel , KROEGER-LUI, Niels
IPC分类号： G01N21/35
CPC分类号： G01N21/39 , G01N1/30 , G01N2021/757 , G01N2201/129
摘要： A method of evaluating the quality state (such as a fixation status) of a cellular sample is provided. A MIR spectrum (220) of the sample is obtained, and a classification (211) or quantification (231) algorithm is applied to the MIR spectrum to identify features (221) indicative of the quality state and/or to classify the sample. The quality state may then be used to determine whether the sample is appropriate for an analytical method and/or whether remedial processing (such as further fixation) is appropriate.
摘要翻译：提供评估细胞样品的质量状态（例如固定状态）的方法。获得样品的MIR光谱（220），并将分类（211）或量化（231）算法应用于MIR光谱以识别指示质量状态和/或分类样品的特征（221）。质量状态可以用于确定样品是否适合于分析方法和/或矫正处理（例如进一步固定）是否合适。

5. 发明申请

WO2016128299A1 MATERIALS AND METHODS FOR STANDARDIZING DIFFUSION OF A FLUID INTO TISSUES 审中-公开
标题翻译：用于标准化流体扩散到组织中的材料和方法
公开(公告)号：WO2016128299A1
公开(公告)日：2016-08-18
申请号：PCT/EP2016/052447
申请日：2016-02-05
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： BAUER, Daniel , CHAFIN, David , OTTER, Michael , THEISS, Abbey
IPC分类号： G01N29/024 , G01N29/07 , G01N1/30
CPC分类号： G01N29/024 , G01N1/30 , G01N29/07 , G01N2291/024 , G01N2291/02475
摘要： The subject disclosure presents systems and methods for evaluating a tissue sample that has been removed from a subject. Movement of fluid through the tissue sample is monitored by measuring time of flight of acoustic waves passed through the tissue sample. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. Using the methods and systems, an optimized protocol for ensuring adequate distribution of the fluid throughout a variety of tissues can be developed.
摘要翻译：本公开内容提供了用于评估已经从受试者中移除的组织样品的系统和方法。通过测量通过组织样本的声波的飞行时间来监测通过组织样本的流体的运动。用于执行该方法的系统可以包括输出能量的发射机和被配置为检测发射能量的接收机。使用方法和系统，可以开发用于确保流体遍及各种组织的充分分布的优化协议。

6. 发明申请

WO2016120195A1 METHODS FOR TISSUE SAMPLE FIXATION USING AN EXTENDED SOAK IN ALDEHYDE-BASED FIXATIVE SOLUTIONS 审中-公开
标题翻译：使用基于ALDEHYDE的固定解决方案中扩展的SOAK进行组织样本定位的方法
公开(公告)号：WO2016120195A1
公开(公告)日：2016-08-04
申请号：PCT/EP2016/051431
申请日：2016-01-25
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： CHAFIN, David , OTTER, Michael
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/178 , G01N33/574 , G01N2001/305 , G01N2440/14
摘要： An extended tissue fixation method is provided including at least one soak in a cold aldehyde-based fixative solution followed by a soak in a warm aldehyde-based fixative solution over a period greater than 2 days. Using the processes disclosed herein, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals, e.g. biomarkers, have been accomplished relative to standard room temperature fixation protocols. Moreover, the tissue can be left in the fixative solution up to at least 14 days using these methods, which provides improved flexibility relative to other protocols, enabling fixation to be conducted during transportation, shipping, and over weekends or vacations, while still achieving acceptable staining results.
摘要翻译：提供了一种延伸的组织固定方法，其包括至少一次浸入冷醛基固定液中，然后在大于2天的时间内在温热的基于醛的固定液中浸泡。使用本文公开的方法，改进的组织形态学和IHC染色以及翻译后修饰信号的优异保存，例如。生物标志物相对于标准室温固定方案已经完成。此外，使用这些方法可将组织留在固定溶液中至少14天，这相对于其他方案提供了改进的灵活性，使得在运输，运输和周末或休假期间进行固定，同时仍然可以接受染色结果。

7. 发明申请

WO2016097164A3 ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT 审中-公开
公开(公告)号：WO2016097164A3
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080252
申请日：2015-12-17
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/024 , G01N29/07 , G01N29/44 , G01N1/30
摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of- flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

8. 发明申请

WO2014118326A2 SYSTEMS AND METHODS FOR CALIBRATING, CONFIGURING AND VALIDATING AN IMAGING DEVICE OR SYSTEM FOR MULTIPLEX TISSUE ASSAYS 审中-公开
标题翻译：用于校准，配置和验证用于多组织分析的成像装置或系统的系统和方法
公开(公告)号：WO2014118326A2
公开(公告)日：2014-08-07
申请号：PCT/EP2014/051920
申请日：2014-01-31
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： GARSHA, Karl , OTTER, Michael , PESTANO, Gary Anthony , VENTURA, Frank
IPC分类号： G01J3/28
CPC分类号： G01J3/0297 , G01J3/10 , G01J3/28 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J2003/2826 , G01N21/274 , G02B21/365 , G06K9/0014 , G06T7/80
摘要： A system and method for characterization and/or calibration of performance of a multispectral imaging (MSI) system equipping the MSI system for use with a multitude of different fluorescent specimens while being independent on optical characteristics of a specified specimen and providing an integrated system level test for the MSI system. A system and method are adapted to additionally evaluate and express operational parameters performance of the MSI system in terms of standardized units and/or to determine the acceptable detection range of the MSI system.
摘要翻译：一种用于多光谱成像（MSI）系统的性能表征和/或校准的系统和方法，所述多光谱成像（MSI）系统使MSI系统与多个不同的荧光样本一起使用，同时独立于指定的光学特性标本并为MSI系统提供集成的系统级测试。系统和方法适于根据标准化单元额外地评估和表达MSI系统的操作参数性能和/或确定MSI系统的可接受检测范围。

9. 发明申请

WO2014102183A2 OPPOSABLES AND AUTOMATED SPECIMEN PROCESSING SYSTEMS WITH OPPOSABLES 审中-公开
标题翻译： OPPOSABLES和自动化样品处理系统与OPPOSABLES
公开(公告)号：WO2014102183A2
公开(公告)日：2014-07-03
申请号：PCT/EP2013/077648
申请日：2013-12-20
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： OTTER, Michael , KRAM, Brian H. , JONES, Jessica , MARTIN, Carl , MARSHALL, Kevin David , TSE, Christine , HARRISON, Josh
IPC分类号： G01N1/31
CPC分类号： G01N35/00029 , B01F11/0051 , B01L3/50273 , B01L7/00 , B01L9/52 , B01L2300/0822 , B01L2300/1838 , B01L2400/0406 , B01L2400/0475 , B01L2400/086 , G01N1/312 , G01N35/1002 , G01N2035/00079 , G01N2035/00356 , G01N2035/00465 , G01N2035/00524 , G01N2035/1037
摘要： A specimen processing system is capable of processing specimens carried on slides. The specimen processing system can sequentially deliver slides and opposables to specimen processing stations. The specimen processing stations can use the opposables to apply a series of liquids to the specimens. The applied liquid can be moved along the slide using capillary action while the specimen processing stations control the processing temperatures. The applied liquid can be in a fluid-carrying gap. The opposable can contact the slide to vary a cross section of the fluid-carrying gap.
摘要翻译：样品处理系统能够处理载玻片上的标本。样品处理系统可以将样品处理站的幻灯片和对象顺序传送。样品处理站可以使用对象物将一系列液体施加到样品上。使用毛细管作用的涂抹液体可以沿着载玻片移动，而样品处理站控制加工温度。所施加的液体可以在流体携带间隙中。相对的可以接触滑块以改变流体承载间隙的横截面。

10. 发明申请

WO2012110646A1 METHOD FOR TISSUE SAMPLE FIXATION 审中-公开
标题翻译：组织样本固定方法
公开(公告)号：WO2012110646A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052800
申请日：2012-02-17
申请人： F. HOFFMANN-LA ROCHE AG , VENTANA MEDICAL SYSTEMS, INC.
发明人： OTTER, Michael , PIERSON, Abbey , CHAFIN, David , ROBERTS, Esteban
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N1/31
摘要： An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0°C to at least 15°C. The second temperature typically is from greater than about 22°C to about 55°C, and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.
摘要翻译：导致第一温度的醛固定溶液第一次接触组织样品，此外，在第二温度高于第一温度的第二温度下使醛固定液接触组织样品。第一时间段通常为约15分钟至约4小时，第一温度通常为大于0℃至至少15℃。第二温度通常为大于约22℃至约55℃，第二时间段为约1小时至约4小时。使用这个过程，改进的组织形态和IHC染色以及翻译后修饰信号的优异保存已经在大约4小时内完成，与室温方案相比，24小时，并且观察到更均匀的形态和抗原保存。

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