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1. 发明申请

WO2011046807A3 MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE 审中-公开
标题翻译：多模式对比度和亮度上下文呈现用于增强病理学确定和组织多分析检测
公开(公告)号：WO2011046807A3
公开(公告)日：2011-09-01
申请号：PCT/US2010051857
申请日：2010-10-07
申请人： VENTANA MED SYST INC , GARSHA KARL , PESTANO GARY , OTTER MICHAEL , NAGY ALEXANDRA DEA , NAGLE RAY B , MILLER PHILLIP , FROEHLICH JAN , DAY WILLIAM
发明人： GARSHA KARL , PESTANO GARY , OTTER MICHAEL , NAGY ALEXANDRA DEA , NAGLE RAY B , MILLER PHILLIP , FROEHLICH JAN , DAY WILLIAM
IPC分类号： G01N33/483
CPC分类号： G01N21/6456
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.
摘要翻译：可以使用多种形式的对比度来产生可以组合和渲染的图像，以产生与在透射白光照明下观察到的吸收波长的污渍产生的图像类似的图像。用其他互补对比方式获得的图像可以使用基于经典对比方法的工程颜色方案来呈现，该方法用于揭示相同的解剖结构和组织化学，从而提供与医学训练和经验的相关性。将来自折射率和荧光DAPI复染图像的暗场对比图像组合以产生与用常规H＆E染色获得的用于病理解释的图像相似的图像。这种多模式图像数据可以流式传输组织样本的实时导航，并且可以与基因DNA探针（FISH），mRNA表达位点（mRNA-ISH）和免疫组织化学（IHC）探针位于相同的组织切片，用于评估和映射为成像质谱准备的组织切片。

2. 发明申请

WO2012003478A3 DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY 审中-公开
标题翻译：使用大标签和大量光谱检测目标
公开(公告)号：WO2012003478A3
公开(公告)日：2012-10-18
申请号：PCT/US2011042853
申请日：2011-07-01
申请人： VENTANA MED SYST INC , HONG RUI , WANG HONG , LEFEVER MARK , FROEHLICH JAN , BIENIARZ CHRISTOPHER , KELLY BRIAN , MILLER PHILLIP
发明人： HONG RUI , WANG HONG , LEFEVER MARK , FROEHLICH JAN , BIENIARZ CHRISTOPHER , KELLY BRIAN , MILLER PHILLIP
IPC分类号： A61K49/00 , C12Q1/28 , G01N33/532 , G01N33/543 , G01N33/58 , G01N33/68
CPC分类号： G01N33/6848 , G01N27/62
摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
摘要翻译：本文公开的具体公开的实施方案涉及使用一种或多种各种质量标签，其可以通过直接或间接的酶催化转化特异性沉积在靶上，以提供用于鉴定组织样品中靶标的方法。质量标签可以用稳定同位素标记，以产生具有相同化学结构但质量不同的质量标签。使用质谱检测和/或定量通过电离质量标签产生的质量代码。该方法可用于特定样品中多个目标的多路检测。在一些实施例中，可以制备分成表示组织样本部分的部分的图，其中，图表部分包括对应于量化数据的数据，其中质量峰的大小被确定并与相应组织的靶的量相关联样品部分。

3. 发明公开

EP2488860A4 MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE 审中-公开
标题翻译： MULTIMODALITÄTSKONTRAST和增强的病理学测定的BREITFELD背景和MEHRANALYTERKENNUNG组织
公开(公告)号：EP2488860A4
公开(公告)日：2015-12-16
申请号：EP10823858
申请日：2010-10-07
申请人： VENTANA MED SYST INC
发明人： GARSHA KARL , PESTANO GARY , OTTER MICHAEL , NAGY ALEXANDRA DEA , NAGLE RAY B , MILLER PHILLIP , FROEHLICH JAN , DAY WILLIAM
IPC分类号： G01N33/483 , G01N21/64
CPC分类号： G01N21/6456

4. 发明专利

AU2010307140B2 Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue 未知
公开(公告)号：AU2010307140B2
公开(公告)日：2014-05-15
申请号：AU2010307140
申请日：2010-10-07
申请人： VENTANA MED SYST INC
发明人： GARSHA KARL , PESTANO GARY , OTTER MICHAEL , NAGY ALEXANDRA DEA , NAGLE RAY B , MILLER PHILLIP , FROEHLICH JAN , DAY WILLIAM
IPC分类号： G01N33/483 , G01N21/64 , G02B21/36
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.

5. 发明专利

CA2774422A1 MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE 未知
公开(公告)号：CA2774422A1
公开(公告)日：2011-04-21
申请号：CA2774422
申请日：2010-10-07
申请人： VENTANA MED SYST INC
发明人： GARSHA KARL , PESTANO GARY , OTTER MICHAEL , NAGY ALEXANDRA DEA , NAGLE RAY B , MILLER PHILLIP , FROEHLICH JAN , DAY WILLIAM
IPC分类号： G01N33/483
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.

6. 发明专利

DK2588144T3 Påvisning af mål ved hjælp af massemarkører og massespektrometri 未知
公开(公告)号：DK2588144T3
公开(公告)日：2018-07-23
申请号：DK11731604
申请日：2011-07-01
申请人： VENTANA MED SYST INC
发明人： BIENIARZ CHRISTOPHER , MILLER PHILLIP , HONG RUI , WANG HONG , LEFEVER MARK , KELLY BRIAN DANIEL , FROEHLICH JAN
IPC分类号： A61K49/00 , C12Q1/28 , G01N33/532 , G01N33/543 , G01N33/58 , G01N33/68

7. 发明专利

CA2774422C MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE 未知
公开(公告)号：CA2774422C
公开(公告)日：2017-08-29
申请号：CA2774422
申请日：2010-10-07
申请人： VENTANA MED SYST INC
发明人： GARSHA KARL , PESTANO GARY , OTTER MICHAEL , NAGY ALEXANDRA DEA , NAGLE RAY B , MILLER PHILLIP , FROEHLICH JAN , DAY WILLIAM
IPC分类号： G01N33/483
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.

8. 发明专利

ES2676183T3 Detección de dianas usando marcas de masa y espectrometría de masas 未知
公开(公告)号：ES2676183T3
公开(公告)日：2018-07-17
申请号：ES11731604
申请日：2011-07-01
申请人： VENTANA MED SYST INC
发明人： HONG RUI , WANG HONG , LEFEVER MARK , FROEHLICH JAN , BIENIARZ CHRISTOPHER , KELLY BRIAN DANIEL , MILLER PHILLIP
IPC分类号： A61K49/00 , C12Q1/28 , G01N33/532 , G01N33/543 , G01N33/58 , G01N33/68
摘要： Un procedimiento que comprende: (a) proporcionar una muestra de tejido fijado con formol e incluido en parafina que comprende una pluralidad de dianas; (b) poner en contacto la muestra de tejido con un primer resto de unión específica que puede reconocer y unirse a una primera diana en la muestra de tejido y un segundo resto de unión específica que puede reconocer y unirse a una segunda diana en la muestra de tejido; (c) poner en contacto la muestra de tejido con un primer conjugado que comprende una primera enzima y un primer anticuerpo que puede reconocer y unirse al primer resto de unión específica; (d) poner en contacto la muestra de tejido con un primer resto de sustrato enzimático y un primer precursor de marca de masa, en el que el primer resto de sustrato enzimático reacciona con la primera enzima y el primer precursor de marca de masa para producir y depositar una primera marca de masa en la primera diana; (e) desactivar la primera enzima; (f) poner en contacto la muestra de tejido con un segundo conjugado que comprende una segunda enzima y un segundo anticuerpo que puede reconocer y unirse al segundo resto de unión específica; (g) poner en contacto la muestra de tejido con un segundo resto de sustrato enzimático y un segundo precursor de marca de masa, en el que el segundo resto de sustrato enzimático reacciona con la segunda enzima y el segundo precursor de marca de masa para producir y depositar una segunda marca de masa en la segunda diana, en el que el primer y segundo restos de sustrato enzimático tienen la misma estructura química, el primer y segundo precursores de marcas de masa tienen la misma estructura química y al menos uno del primer precursor de marca de masa o segundo precursor de marca de masa está radiomarcado de modo que la primera marca de masa y la segunda la marca de masa difieren en masa; (h) ionizar la primera marca de masa y la segunda marca de masa para producir un primer código de masa y un segundo código de masa, en el que cada código de masa tiene la misma estructura química pero difiere en masa de cualquier otro código de masa producido a partir de cualquier otra marca de masa; (i) detectar cada código de masa usando un espectrómetro de masas; y (j) cuantificar relativamente cada diana cuantificando una cantidad de cada código de masa midiendo un pico de espectrometría de masas que tiene una proporción m/z correspondiente a una proporción m/z esperada de ese código de masa.

9. 发明专利

AU2010307140A1 Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue 未知
公开(公告)号：AU2010307140A1
公开(公告)日：2012-04-05
申请号：AU2010307140
申请日：2010-10-07
申请人： VENTANA MED SYST INC
发明人： GARSHA KARL , PESTANO GARY , OTTER MICHAEL , NAGY ALEXANDRA DEA , NAGLE RAY B , MILLER PHILLIP , FROEHLICH JAN , DAY WILLIAM
IPC分类号： G01N33/483
摘要： Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.

10. 发明申请

WO2009039853A3 LINEAR ACTUATOR 审中-公开
标题翻译：线性执行器
公开(公告)号：WO2009039853A3
公开(公告)日：2009-07-16
申请号：PCT/DK2008000338
申请日：2008-09-29
申请人： LINAK AS , FROEHLICH JAN
发明人： FROEHLICH JAN
IPC分类号： F16H25/20 , G01B7/02
CPC分类号： F16H25/2015 , F16H2025/2084 , F16H2025/209 , G01B7/003 , G01B7/02
摘要： A linear actuator for instance for use during adjustment of articles of furniture of the type comprising a housing (1) with a reversible electric motor (2), which via a transmission (3) drives a spindle (4). On the spindle there is a spindle nut (5), surrounded by an outer tube (8). The nut (5) is secured against rotation and thus moves in the longitudinal direction when the spindle (4) is rotated. In a guide track (13) is mounted a printed circuit board (12) where a capacitive positioning system is constructed. The capacitive sensors (14) of the positioning system are activated by the activation block (15), mounted on the spindle nut (5). Simultaneously, the spindle nut with the activation block (15) serves to activate the end stop switches (16, 17) also mounted on the printed circuit board (12) when the spindle nut (5) reaches an end position for its migration on the spindle (4).
摘要翻译：线性致动器，例如用于调节类型的家具制品时使用，该家具类型包括具有可逆电动机（2）的壳体（1），该壳体（1）经由变速器（3）驱动主轴（4）。在主轴上有一个由外管（8）包围的主轴螺母（5）。螺母（5）被固定以防止旋转，并且因此当主轴（4）旋转时沿着纵向方向移动。在导轨（13）中安装有构成电容定位系统的印刷电路板（12）。定位系统的电容传感器（14）由安装在主轴螺母（5）上的启动块（15）启动。同时，当主轴螺母（5）到达终端位置时，具有活动块（15）的主轴螺母用于启动也安装在印刷电路板（12）上的端部止动开关（16,17），以在其上移动主轴（4）。

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