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1. 发明申请

WO2012031299A2 SYSTEM AND METHOD FOR AUTOMATIC CYCLOTRON PROCEDURES 审中-公开
标题翻译：自动循环程序的系统和方法
公开(公告)号：WO2012031299A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050561
申请日：2011-09-06
申请人： VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH , STEPHANI, Thomas , BEHRENS, Uwe , ROECKEN, Heinrich , BAUMGARTEN, Christian , TIMMER, Jan , HAO, James, P.
发明人： STEPHANI, Thomas , BEHRENS, Uwe , ROECKEN, Heinrich , BAUMGARTEN, Christian , TIMMER, Jan
IPC分类号： A61N5/10 , H05H13/00
CPC分类号： H05H7/02 , A61N5/10 , A61N5/1077 , A61N2005/1087 , H01J3/14 , H05H13/005 , H05H2007/122 , H05H2277/11
摘要： Systems and methods are provided to perform efficient, automatic adjustment of cyclotron beam currents within a wide range for multiple treatment layers within the same patient and treatment session; and to perform efficient, automatic cyclotron initialization, and calibration. In an embodiment, efficient adjustment is achieved by using beam current attenuation by an electrostatic vertical deflector installed in the inner center of the cyclotron. The beam current may, for example, be adjusted by the high voltage applied to the electrostatic vertical deflector, in front of each treatment the attenuation curve of the vertical deflector is recorded. Based on this attenuation curve, the vertical deflector voltage for the needed beam current of each irradiation layer is interpolated. In another embodiment, a process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron.
摘要翻译：提供系统和方法以在相同的患者和治疗期间内的多个治疗层的范围内对回旋加速器束电流进行有效的自动调节; 并执行有效的自动回旋加速器初始化和校准。在一个实施例中，通过使用安装在回旋加速器的内部中心的静电垂直偏转器来使用束流衰减来实现有效的调节。例如，通过施加到静电垂直偏转器的高电压来调节束电流，在每个处理前面记录垂直偏转器的衰减曲线。基于该衰减曲线，对每个照射层所需的束电流的垂直偏转器电压进行插值。在另一个实施例中，提供了一种过程，其允许在过夜或维护强制停机之后对回旋加速器的初始化进行自动化。在一个实施例中，定义了五个独立的回旋加速器系统状态，并且一个状态与另一个状态之间的转换可以例如由回旋加速器的控制系统自动化。

2. 发明申请

WO2015090555A1 IRRADIATION DEVICE AND METHOD 审中-公开
标题翻译：辐射装置和方法
公开(公告)号：WO2015090555A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/003360
申请日：2014-12-15
申请人： VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH
发明人： TIMMER, Jan
IPC分类号： A61N5/10 , H05H7/00
CPC分类号： A61N5/1082 , A61N5/1067 , A61N5/107 , A61N5/1081 , A61N2005/1087 , H01J37/08 , H05H7/001 , H05H2007/002 , H05H2277/11
摘要： Irradiation device for irradiating an irradiation object with heavy charged particles, comprising a support for the irradiation object, and an irradiation nozzle irradiating a charged particle beam towards the irradiation object, wherein the beam is deflected within the irradiation nozzle. The support for the irradiation object is moveable at least horizontally, and the irradiation nozzle is moveable at least vertically and rotatable around a nozzle swivel axis along which the particle beam enters into the irradiation nozzle.
摘要翻译：用于对包含用于照射物体的支撑体的重带电粒子照射被照射物体的照射装置和照射被照射物体的带电粒子束的照射喷嘴，其中，所述光束在所述照射喷嘴内偏转。照射物体的支撑物至少可以水平移动，并且照射喷嘴可以至少垂直移动并且围绕喷嘴旋转轴线旋转，沿着该喷嘴旋转轴线，粒子束沿着该旋转轴线进入照射喷嘴。

3. 发明申请

WO2017053719A1 PARTICLE THERAPY SYSTEM 审中-公开
标题翻译：颗粒治疗系统
公开(公告)号：WO2017053719A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/053331
申请日：2016-09-23
申请人： VARIAN MEDICAL SYSTEMS, INC. , VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH
发明人： BENNER, Anke , CLIFT, Julie , HENSEL, Andreas , KANE, Richard , HARIS, Jan , SINHA, Nilesh , SPATOLA, Brian , TIMMER, Jan
IPC分类号： A61N5/10
CPC分类号： A61N5/1081 , A61N5/1049 , A61N5/1079 , A61N5/1082 , A61N2005/1074 , A61N2005/1087
摘要： A control system is described which provides a user interface that displays a clear graphical representation of relevant data for a particle radiation therapy system (such as a pencil-beam proton therapy system) for treating multiple beam fields as efficiently as possible. The user interface allows a user to visualize a treatment session, select one or multiple beam fields to include in one or more beam applications, and dissociate beam fields previously grouped if necessary. Further embodiments extend the ability to initiate the application of the generated proton therapy beam and the grouping of beam fields to be performed remotely from the treatment room itself, and even automatically, reducing the need for manual interventions to setup between fields.
摘要翻译：描述了一种控制系统，其提供用于显示用于粒子辐射治疗系统（例如，铅笔光束质子治疗系统）的相关数据的清晰图形表示的用户界面，用于尽可能高效地处理多个射束场。用户界面允许用户可视化治疗会话，选择一个或多个光束场以包括在一个或多个光束应用中，并且如果需要，则解离先前分组的光束场。另外的实施例扩展了开始产生的质子治疗束的应用的能力以及要从治疗室本身远程执行的束场的分组，甚至自动地减少对在场之间建立手动干预的需要。

4. 发明授权

EP2611501B1 SYSTEM AND METHOD FOR AUTOMATIC CYCLOTRON PROCEDURES 有权转让
公开(公告)号：EP2611501B1
公开(公告)日：2020-10-28
申请号：EP11822779.2
申请日：2011-09-06
申请人： Varian Medical Systems Particle Therapy GmbH
发明人： STEPHANI, Thomas , BEHRENS, Uwe , ROECKEN, Heinrich , BAUMGARTEN, Christian , TIMMER, Jan
IPC分类号： A61N5/10 , H05H13/00 , H05H7/12 , H05H7/02 , H01J3/14

5. 发明公开

EP3636319A1 MULTI-CRITERIA OPTIMIZATION TOOLS INCLUDING TIME-BASED CRITERIA FOR RADIATION THERAPY 审中-公开
公开(公告)号：EP3636319A1
公开(公告)日：2020-04-15
申请号：EP19199751.9
申请日：2019-09-26
申请人： Varian Medical Systems International AG , Varian Medical Systems, Inc. , Varian Medical Systems Particle Therapy GmbH
发明人： KOPONEN, Timo , NIEMELA, Perttu , BACH, Markus , TIMMER, Jan , SMITH, Christel
IPC分类号： A61N5/10
摘要： Multi-criteria optimization of radiation therapy tools for receiving 210 a plurality of criteria including one or more sets of competing objectives. The competing objective can include delivery time criteria, fractionation criteria or similar time-based criteria. One or more radiation therapy plans can be determined 220 based on a multi-criteria optimization of the plurality of criteria for the radiation therapy treatment. The one or more optimized radiation therapy plans can be output 250 for consideration by one or more members of a radiation oncology team.

6. 发明公开

EP2611501A2 SYSTEM AND METHOD FOR AUTOMATIC CYCLOTRON PROCEDURES 有权转让
标题翻译：系统和方法自动ZYKLOTRONVERFAHREN
公开(公告)号：EP2611501A2
公开(公告)日：2013-07-10
申请号：EP11822779.2
申请日：2011-09-06
申请人： Varian Medical Systems Particle Therapy GmbH
发明人： STEPHANI, Thomas , BEHRENS, Uwe , ROECKEN, Heinrich , BAUMGARTEN, Christian , TIMMER, Jan
IPC分类号： A61N5/10 , H05H13/00
CPC分类号： H05H7/02 , A61N5/10 , A61N5/1077 , A61N2005/1087 , H01J3/14 , H05H13/005 , H05H2007/122 , H05H2277/11
摘要： Systems and methods are provided to perform efficient, automatic adjustment of cyclotron beam currents within a wide range for multiple treatment layers within the same patient and treatment session; and to perform efficient, automatic cyclotron initialization, and calibration. In an embodiment, efficient adjustment is achieved by using beam current attenuation by an electrostatic vertical deflector installed in the inner center of the cyclotron. The beam current may, for example, be adjusted by the high voltage applied to the electrostatic vertical deflector, in front of each treatment the attenuation curve of the vertical deflector is recorded. Based on this attenuation curve, the vertical deflector voltage for the needed beam current of each irradiation layer is interpolated. In another embodiment, a process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron.

7. 发明公开

EP3693062A1 PARTICLE THERAPY SYSTEM 有权转让
公开(公告)号：EP3693062A1
公开(公告)日：2020-08-12
申请号：EP20167016.3
申请日：2016-09-23
申请人： Varian Medical Systems, Inc. , Varian Medical Systems Particle Therapy GmbH
发明人： BENNER, Anke , CLIFT, Julie , HENSEL, Andreas , KANE, Richard , KARIS, Jan , SINHA, Nilesh , SPATOLA, Brian , TIMMER, Jan
IPC分类号： A61N5/10
摘要： A particle therapy device configured to automatically control an emission of a beam of particles to irradiate a plurality of beam fields corresponding to a plurality of iso-centers, wherein a control system is configured to: (i) automatically group beam fields based on beam field or treatment factors and/or provide controls by a beam control interface for a user to add or remove beam fields to and from the beam field grouping; (ii) if adding a beam field to another beam field to create the grouping or adding the beam field to an existing grouping would require the addition, modification, or removal of a beam accessory during a single beam application, disallow the beam field grouping; and (iii) control the emission of the beam of particles to irradiate the beam field grouping in a contiguous beam application.

8. 发明公开

EP4011443A1 SYSTEM AND METHOD FOR RADIOTHERAPY FIELD DELIVERY TIME OPTIMIZATION 审中-公开
公开(公告)号：EP4011443A1
公开(公告)日：2022-06-15
申请号：EP21212010.9
申请日：2021-12-02
申请人： Varian Medical Systems, Inc. , Varian Medical Systems Particle Therapy GmbH & Co. KG , Varian Medical Systems International AG
发明人： MEIJERS, Arturs , NIEMELA, Perttu , HYTONEN, Roni , VAN DER STRAETEN, Reynald , TIMMER, Jan , KOPONEN, Timo , SMITH, Christel , HUTH, Isabel
IPC分类号： A61N5/10
摘要： Treatment fields can be produced as part of a treatment plan that achieves a desired balance between field delivery time and dose based on machine parameters and knowledge, such as machine-specific beam production, transport and scanning logic, and/or a maximum treatment time value. The treatment parameters can be adjusted using a graphical user interface so that treatment time or dosimetry is prioritized. As a result, the overall treatment time is reduced, and hence treatment quality and patient experience are improved.

9. 发明公开

EP3352852A1 PARTICLE THERAPY SYSTEM 有权转让
公开(公告)号：EP3352852A1
公开(公告)日：2018-08-01
申请号：EP16778590.6
申请日：2016-09-23
申请人： Varian Medical Systems, Inc. , Varian Medical Systems Particle Therapy GmbH
发明人： BENNER, Anke , CLIFT, Julie , HENSEL, Andreas , KANE, Richard , HARIS, Jan , SINHA, Nilesh , SPATOLA, Brian , TIMMER, Jan
IPC分类号： A61N5/10
CPC分类号： A61N5/1081 , A61N5/1049 , A61N5/1079 , A61N5/1082 , A61N2005/1074 , A61N2005/1087
摘要： A control system is described which provides a user interface that displays a clear graphical representation of relevant data for a particle radiation therapy system (such as a pencil-beam proton therapy system) for treating multiple beam fields as efficiently as possible. The user interface allows a user to visualize a treatment session, select one or multiple beam fields to include in one or more beam applications, and dissociate beam fields previously grouped if necessary. Further embodiments extend the ability to initiate the application of the generated proton therapy beam and the grouping of beam fields to be performed remotely from the treatment room itself, and even automatically, reducing the need for manual interventions to setup between fields.

10. 发明申请

WO2006095324A1 IMAGE PROCESSING SYSTEM AND METHOD FOR REGISTRATION OF TWO-DIMENSIONAL WITH THREE-DIMENSIONAL VOLUME DATA DURING INTERVENTIONAL PROCEDURES 审中-公开
标题翻译：图像处理系统和在传统程序期间用三维体积数据注册二维图像的方法
公开(公告)号：WO2006095324A1
公开(公告)日：2006-09-14
申请号：PCT/IB2006/050733
申请日：2006-03-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , TIMMER, Jan , HOMAN, Robert, J., F. , MIELEKAMP, Pieter, M.
发明人： TIMMER, Jan , HOMAN, Robert, J., F. , MIELEKAMP, Pieter, M.
IPC分类号： G06T7/00
CPC分类号： A61B6/4441 , G06T7/35 , G06T2207/30004 , Y10S128/922
摘要： Prior to an intervention, a 3D rotational scan is acquired (at block 10) in respect of a body volume and reconstructed. In addition, three-dimensional image data in respect of the body volume is acquired (at block 12) using another modality, such as computerised tomography (CT) or magnetic resonance (MR), reconstructed, and prepared for visualisation. During the actual intervention, live two-dimensional fluoroscopic images are acquired (at block 14), using the imaging system employed to acquire the 3D rotational scan, and processed for visualisation. The 2D image data is registered (at block 16) to the 3D rotational image data acquired and reconstructed in respect of the body volume of interest, and then a 3D-3D registration process is employed (at block 18) to register the 3D image data acquired in respect of the same body volume using, for example, CT or MR imaging systems to the 3D rotational image data, and a display module (20) is used to align the 2D fluoroscopic image and the 3D MR/CT image as a fused or composite image and display the image.
摘要翻译：在干预之前，相对于身体体积获取3D重复扫描（在方框10）并重构。此外，使用诸如计算机断层摄影（CT）或磁共振（MR）之类的另一种模式，获取关于体积的三维图像数据（方框12），并重建并准备用于可视化。在实际干预过程中，使用用于获取3D旋转扫描的成像系统获取活体二维透视图像（在方框14），并进行可视化处理。将2D图像数据（方框16）登记到相对于感兴趣的身体体积获取和重建的3D旋转图像数据，然后采用3D-3D注册处理（在框18处）以登记3D图像数据使用例如CT或MR成像系统相对于3D旋转图像数据获得相同体积的体积，并且显示模块（20）用于将2D透视图像和3D MR / CT图像对准为融合或合成图像并显示图像。

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