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1. 发明申请

US20070042451A1 Glycine decarboxylase complex as a herbicidal target 审中-公开
标题翻译：甘氨酸脱羧酶复合物作为除草靶
公开(公告)号：US20070042451A1
公开(公告)日：2007-02-22
申请号：US10578637
申请日：2004-10-27
申请人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke , Kirsten Deist
发明人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke , Kirsten Deist
IPC分类号： C12Q1/48 , A01N63/00
CPC分类号： C12N15/8274 , C12N9/00
摘要： The invention relates to the use of glycine decarboxylase complex, which is used as a target for herbicides in the absence of growth retardations and chlorotic leaves. Novel nucleic acid sequences comprising SEQ ID NO:1 and functional equivalents of SEQ ID NO:1 are thus disclosed. The invention also relates to the use of glycine decarboxylase complex and the functional equivalents thereof in a method for identifying compounds having a herbicidal or growth-regulatory effect, in addition to the use of said compounds identified via said method as herbicides or growth regulators.
摘要翻译：本发明涉及甘氨酸脱羧酶复合物的使用，其在不存在生长迟缓和褪绿叶的情况下用作除草剂的靶标。因此，公开了包含SEQ ID NO：1和SEQ ID NO：1的功能等同物的新型核酸序列。本发明还涉及除用于通过所述方法鉴定的所述化合物作为除草剂或生长调节剂之外，甘氨酸脱羧酶复合物及其功能等同物用于鉴定具有除草或生长调节作用的化合物的方法中。

2. 发明申请

US20070003934A1 2-Methyl-6-solanylbenzoquinone methyltransferase as target for herbicides 审中-公开
标题翻译： 2-甲基-6-苯基苯甲酮甲基转移酶作为除草剂的靶标
公开(公告)号：US20070003934A1
公开(公告)日：2007-01-04
申请号：US10581223
申请日：2004-11-30
申请人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
发明人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
IPC分类号： C12Q1/68 , C12Q1/48 , C12P19/34 , A01N25/00
CPC分类号： A01N61/00 , C12N9/1007 , C12N15/8274 , G01N2333/91011 , G01N2500/00
摘要： The present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase which, when absent, brings about retarded growth and chlorotic leaves, as target for herbicides. In this context, there are provided novel nucleic acid sequences comprising SEQ ID NO:5 and SEQ ID NO:7 and corresponding functional equivalents. Moreover, the present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase and its functional equivalents in a method for identifying herbicidal or growth-regulatory compounds, and to the use of the compounds identifed via the method as herbicides or growth regulators.
摘要翻译：本发明涉及2-甲基-6-苯甲酰基苯并醌甲基转移酶的用途，当不存在时，会导致延迟生长和褪绿叶作为除草剂的靶标。在本文中，提供了包含SEQ ID NO：5和SEQ ID NO：7的新型核酸序列和相应的功能等同物。此外，本发明涉及2-甲基-6-苯基苯醌基甲基转移酶及其功能等同物在鉴定除草或生长调节化合物的方法中的用途，以及通过该方法鉴定的化合物作为除草剂或生长调节剂的用途。

3. 发明申请

US20060058190A1 Malate dehydrogenase as a target for herbicides 审中-公开
标题翻译：苹果酸脱氢酶作为除草剂的靶标
公开(公告)号：US20060058190A1
公开(公告)日：2006-03-16
申请号：US10538544
申请日：2003-12-17
申请人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Kirsten Deist , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
发明人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Kirsten Deist , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
IPC分类号： A01N25/00 , C12Q1/48
CPC分类号： C12N9/0006 , C12N15/8274 , C12Q1/32
摘要： The present invention relates to malate dehydrogenase, which, when absent, brings about reduced growth and chlorotic leaves and is encoded by the nucleic acid sequence SEQ ID NO:2 or by a functional equivalent of this nucleic acid sequence, as target for herbicides. For this purpose, novel nucleic acid sequences encompassing SEQ ID NO:2 and functional equivalents of SEQ ID NO:2 are provided. Moreover, the present invention relates to the use of the abovementioned malate dehydrogenase and its functional equivalents in a method for identifying compounds with herbicidal or growth-regulatory activity, and to the use of the compounds identified by this method as herbicides or growth regulators.
摘要翻译：本发明涉及苹果酸脱氢酶，当不存在时，其产生减少的生长和褪绿叶，并由核酸序列SEQ ID NO：2编码，或通过该核酸序列的功能等同物作为除草剂的靶标。为此，提供了包含SEQ ID NO：2和SEQ ID NO：2的功能等同物的新型核酸序列。此外，本发明涉及上述苹果酸脱氢酶及其功能等同物在鉴定具有除草或生长调节活性的化合物的方法中的用途，以及通过该方法鉴定的化合物作为除草剂或生长调节剂的用途。

4. 发明申请

US20050216967A1 Expression cassettes for transgenic expression of nucleic acids 有权
标题翻译：用于核酸转基因表达的表达盒
公开(公告)号：US20050216967A1
公开(公告)日：2005-09-29
申请号：US10755677
申请日：2004-01-13
申请人： Ute Heim , Helke Hillebrand , Irene Kunze , Karin Herbers , Uwe Sonnewald , Eric Glickmann , Wolfgang Lein , Rudiger Hell , Ricarda Jost
发明人： Ute Heim , Helke Hillebrand , Irene Kunze , Karin Herbers , Uwe Sonnewald , Eric Glickmann , Wolfgang Lein , Rudiger Hell , Ricarda Jost
IPC分类号： A01H1/00 , C12N15/82
CPC分类号： C12N15/8216
摘要： The invention relates to expression cassettes and vectors which contain constitutive promoters of plants and to the use of said expression cassettes or vectors for transgenic expression of nucleic acid sequences, preferably selection markers, in organisms, preferably in plants. The invention further relates to transgenic plants which have been transformed with said expression cassettes or vectors, to cultures, parts or propagation material derived therefrom and also to the use of same for the production of food- and feedstuffs, seed, pharmaceuticals or fine chemicals.
摘要翻译：本发明涉及含有植物组成型启动子的表达盒和载体，以及使用所述表达盒或载体用于在生物体，优选植物中的核酸序列，优选选择标记的转基因表达。本发明还涉及已经用所述表达盒或载体转化的转基因植物，从其衍生的培养物，部分或繁殖材料，以及用于生产食品和饲料，种子，药物或精细化学品的转基因植物。

5. 发明申请

US20050142553A1 Serine hydroxymethyltransferase as a target for herbicides 失效
标题翻译：丝氨酸羟甲基转移酶作为除草剂的靶标
公开(公告)号：US20050142553A1
公开(公告)日：2005-06-30
申请号：US10507989
申请日：2003-03-13
申请人： Uwe Sonnewald , Frederik Bornke , Kirsten Deist , Marc Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
发明人： Uwe Sonnewald , Frederik Bornke , Kirsten Deist , Marc Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
IPC分类号： A01H1/00 , A01H5/00 , A01K67/027 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/82 , C12Q1/02 , C12Q1/48 , C12Q1/68 , A01N25/00 , C12N9/24 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N9/1014 , C12N15/8274
摘要： The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.
摘要翻译：本发明涉及丝氨酸羟甲基转移酶（EC 2.1.2.1）作为除草剂的新靶标，以及编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸序列，当不存在时，其产生生长迟缓症状和褪绿叶包括核酸序列SEQ ID No：3和上述核酸序列或核酸序列SEQ ID NO：7的功能等同物和上述核酸序列的功能等同物。此外，本发明涉及上述核酸序列，SEQ ID NO：3或SEQ ID NO：7的功能类似物或由上述核酸序列之一编码的多肽在除草方法中的用途抑制丝氨酸羟甲基转移酶的活性化合物，以及通过该方法鉴定的这些化合物作为除草剂的用途。

6. 发明授权

US06806085B1 2-deoxyglucose-6-phosphate (2-DOG-6-P) phosphatase DNA sequences as selection marker in plants 失效
标题翻译： 2-脱氧葡萄糖-6-磷酸（2-DOG-6-P）磷酸酶DNA序列作为植物中的选择标记
公开(公告)号：US06806085B1
公开(公告)日：2004-10-19
申请号：US09558284
申请日：2000-04-25
申请人： Uwe Sonnewald , Marcus Ebneth
发明人： Uwe Sonnewald , Marcus Ebneth
IPC分类号： C12N1582
CPC分类号： C12N9/16 , C12N15/8209
摘要： Recombinant DNA molecules are described which contain a DNA sequence encoding a protein with the biological activity of a 2-deoxyglucose-6-phosphate (2-DOG-6-P) phosphatase and being under the control of regulatory sequences of a promoter active in plants and transcription-termination and/or poyladenylation signals. Also, vectors and hosts are described which contain the recombinant DNA molecules according to the invention. Furthermore, processes for producing transformed plant cells and plants using the described recombinant DNA molecules and vectors are provided. The invention also describes transgenic plants, their harvest products and propagation material as well as plant cells and tissues containing the recombinant DNA molecules or vectors according to the invention or having been produced by the process according to the invention.
摘要翻译：描述了重组DNA分子，其含有编码具有2-脱氧葡萄糖-6-磷酸（2-DOG-6-P）磷酸酶的生物活性的蛋白质的DNA序列，并且处于在植物中有活性的启动子的调节序列的控制下和转录终止和/或聚腺苷酸化信号。此外，描述了含有根据本发明的重组DNA分子的载体和宿主。此外，提供了使用所述重组DNA分子和载体产生转化的植物细胞和植物的方法。本发明还描述了转基因植物，其收获产物和繁殖材料以及含有根据本发明的重组DNA分子或载体或已通过本发明方法生产的植物细胞和组织。

7. 发明授权

US5767365A DNA sequences and plasmids for the preparation of plants with changed sucrose concentration 失效
标题翻译：用于制备具有改变的蔗糖浓度的植物的DNA序列和质粒
公开(公告)号：US5767365A
公开(公告)日：1998-06-16
申请号：US356354
申请日：1994-12-20
申请人： Uwe Sonnewald
发明人： Uwe Sonnewald
IPC分类号： A01H5/00 , C12N9/10 , C12N15/09 , C12N15/29 , C12N15/54 , C12N15/82
CPC分类号： C12N9/1066 , C12N15/8245
摘要： DNA sequences are described, that by integration in a plant genome cause the activity of the sucrose-phosphate-synthase (SPS) of the plant to be changed, plasmids, containing these DNA sequences as well as transgenic plants that by introduction of the DNA sequences causes changes in the activity of sucrose-phosphate-synthase.
摘要翻译： PCT No.PCT / EP93 / 01605 371日期1994年12月20日第 102（e）日期1994年12月20日PCT提交1993年6月22日PCT公布。公开号WO94 / 00563 日期1994年1月6日描述了DNA序列，其通过整合植物基因组导致要改变的植物的蔗糖磷酸合酶（SPS）的活性，含有这些DNA序列的质粒以及通过引入DNA序列引起蔗糖磷酸合酶活性的变化。

8. 发明授权

US5723757A Plant promoters specific for sink organ expression of genes 失效
标题翻译：植物启动子特异于宿主器官表达的基因
公开(公告)号：US5723757A
公开(公告)日：1998-03-03
申请号：US448110
申请日：1995-05-23
申请人： Mario Rocha-Sosa , Uwe Sonnewald , Wolf-Bernd Frommer , Lothar Willmitzer , Marina Stratmann
发明人： Mario Rocha-Sosa , Uwe Sonnewald , Wolf-Bernd Frommer , Lothar Willmitzer , Marina Stratmann
IPC分类号： C12N15/29 , C12N15/82 , A01H5/00 , C12N5/04
CPC分类号： C12N15/8235 , C12N15/8227
摘要： There are described 5' transcriptional regulatory regions of plant genes which ensure sink organ specific expression of cis-linked DNA sequences as well as recombinant double stranded DNA molecules comprising these 5' regulatory regions. Furthermore the present invention relates to a method for producing transgenic plants which show a sink tissue specific expression of a desired DNA sequence.
摘要翻译：描述了植物基因的5'转录调节区，其确保顺式连接的DNA序列的宿主器官特异性表达以及包含这5个调节区的重组双链DNA分子。此外，本发明涉及生产转化植物的方法，其显示所需DNA序列的宿组织特异性表达。

9. 发明申请

US20110289622A1 EXPRESSION CASSETTES FOR TRANSGENIC EXPRESSION OF NUCLEIC ACIDS 失效
标题翻译：用于转基因表达核酸的表达载体
公开(公告)号：US20110289622A1
公开(公告)日：2011-11-24
申请号：US13113615
申请日：2011-05-23
申请人： Ute Heim , Helke Hillebrand , Irene Kunze , Karin Herbers , Uwe Sonnewald , Eric Glickmann , Wolfgang Lein , Rüdiger Hell , Ricarda Jost
发明人： Ute Heim , Helke Hillebrand , Irene Kunze , Karin Herbers , Uwe Sonnewald , Eric Glickmann , Wolfgang Lein , Rüdiger Hell , Ricarda Jost
IPC分类号： A01H1/00 , C12N9/00 , C12N5/10 , C12N1/21 , A01H5/00 , C12N1/19 , C12N15/63 , C07K14/00 , C07K16/00 , A01K67/027 , C12Q1/68 , C12N1/15
CPC分类号： C12N15/8216
摘要： The invention relates to expression cassettes and vectors which contain constitutive promoters of plants and to the use of these expression cassettes or vectors for transgenic expression of nucleic acid sequences, preferably selection markers, in organisms, preferably in plants. The invention further relates to transgenic plants which have been transformed with the expression cassettes or vectors, to cultures, parts or propagation material derived from these plants, and to the use of these plants for the production of food and animal feedstuffs, seed, pharmaceuticals, or fine chemicals.
摘要翻译：本发明涉及含有植物的组成型启动子的表达盒和载体，以及这些表达盒或载体用于在生物体，优选植物中的核酸序列，优选选择标记的转基因表达的用途。本发明还涉及已经用表达盒或载体转化的转基因植物，衍生自这些植物的培养物，部分或繁殖材料，以及这些植物用于生产食品和动物饲料，种子，药物，或精细化学品。

10. 发明授权

US07777099B2 Genetic method 有权
标题翻译：遗传方法
公开(公告)号：US07777099B2
公开(公告)日：2010-08-17
申请号：US12329656
申请日：2008-12-08
申请人： Chengcai Chu , Nan Qu , Uwe Sonnewald , Ian Jepson
发明人： Chengcai Chu , Nan Qu , Uwe Sonnewald , Ian Jepson
IPC分类号： C12N15/29 , C12N15/52 , C12N15/82 , A01N5/00
CPC分类号： C12N9/2408 , C12N15/8245
摘要： The present invention describes a method of increasing plan yield. Also described are DNA constructs comprising DNA sequences coding for proteins involved in sucrose transport, metabolism and uptake operably linked to controllable promoter regions and plants transformed with said constructs. More particularly a method for the controlled production of said proteins resulting in an alteration in plant growth characteristics, flowering time and in yield is described.
摘要翻译：本发明描述了提高计划产量的方法。还描述了包含编码参与蔗糖转运，代谢和摄取的蛋白质的DNA序列的DNA构建体，其可操作地连接到可控启动子区域和用所述构建体转化的植物。更具体地，描述了控制生产所述蛋白质的方法，导致植物生长特性，开花时间和产量的变化。

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