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    • 7. 发明授权
    • Process for preparing alpha-hydroxycarboxylic esters
    • 制备α-羟基羧酸酯的方法
    • US08569539B2
    • 2013-10-29
    • US12298034
    • 2007-03-28
    • Alexander MayBernd VogelHermann SiegertJochen AckermannSoenke Broecker
    • Alexander MayBernd VogelHermann SiegertJochen AckermannSoenke Broecker
    • C07C67/20
    • C07C67/20C07C67/54C07C69/675
    • Alpha-hydroxycarboxylic esters are prepared by a continuous process in which alpha-hydroxycarboxamide is reacted with an alcohol in the presence of a catalyst to obtain a product mixture which contains alpha-hydroxycarboxylic ester, ammonia, unconverted alpha-hydroxycarboxamide and alcohol, and catalyst; wherein reactant streams containing an alpha-hydroxycarboxamide, an alcohol and a catalyst are fed into a pressure reactor. The reactant streams are reacted with one another in the pressure reactor at a pressure in the range of 1 bar to 100 bar; and the product mixture is depleted in alcohol and ammonia by distilling off ammonia at a pressure which is constantly kept greater than 1 bar without the aid of additional stripping media. The continuous process can be employed particularly advantageously on the industrial scale.
    • α-羟基羧酸酯通过连续方法制备,其中α-羟基羧酰胺与醇在催化剂存在下反应,得到含有α-羟基羧酸酯,氨,未转化的α-羟基甲酰胺和醇以及催化剂的产物混合物; 其中将含有α-羟基甲酰胺,醇和催化剂的反应物流进料到压力反应器中。 反应物流在压力反应器中在1巴至100巴范围内的压力下彼此反应; 并且通过在不经额外的剥离介质的帮助下,在恒定地保持大于1巴的压力下蒸馏掉氨,产物混合物就会耗尽醇和氨。 该连续方法可以在工业规模上特别有利地使用。