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1. 发明授权

US4360521A 7[3,6-Dihydro-1(2H)-p yridyl]-2-oxo-2H-[1,2,4]oxadiazolo[2,3-c]pyrimidine-5-carbamate compounds 失效
标题翻译： 7 [3,6-二氢-1（2H） - 吡啶基] -2-氧代-2H- [1,2,4]恶二唑并[2,3-c]嘧啶-5-氨基甲酸酯化合物
公开(公告)号：US4360521A
公开(公告)日：1982-11-23
申请号：US327384
申请日：1982-12-04
申请人： Urs Hengartner , Jean-Claude Muller , Henri Ramuz
发明人： Urs Hengartner , Jean-Claude Muller , Henri Ramuz
IPC分类号： A61K31/505 , C07D235/06 , C07D498/04 , C07D521/00 , C07D498/22
CPC分类号： C07D235/06 , A61K31/505 , C07D231/12 , C07D233/56 , C07D249/08
摘要： Oxadiazolo[2,3-c]pyrimidine derivatives of the formula ##STR1## wherein R is alkyl, alkenyl, alkynyl or alkoxyalkyl, as well as their salts, are described. The compounds of formula I have valuable, long-lasting vasodilating and/or blood pressure-lowering properties and are useful for the treatment of vascular-conditioned hypertensions or as vasodilators in peripheral blood supply disorders. The compounds are prepared, inter alia, by carbamoylating the corresponding derivative containing a free amino group and optional salt formation.
摘要翻译：描述了其中R是烷基，烯基，炔基或烷氧基烷基的式[IMAGE] I的恶二唑并[2,3-c]嘧啶衍生物及其盐。式I的化合物具有有价值的，持久的血管扩张和/或降血压性质，并且可用于治疗血管性高血压或作为外周血供应障碍中的血管扩张剂。化合物特别是通过氨基甲酰化制备含有游离氨基和任选的盐形成的相应衍生物。

2. 发明授权

US4410698A Oxadiazolopyrimidine derivatives 失效
标题翻译：恶二唑嘧啶衍生物
公开(公告)号：US4410698A
公开(公告)日：1983-10-18
申请号：US407870
申请日：1982-08-13
申请人： Urs Hengartner , Jean-Claude Muller , Henri Ramuz
发明人： Urs Hengartner , Jean-Claude Muller , Henri Ramuz
IPC分类号： A61K31/505 , C07D235/06 , C07D498/04 , C07D521/00 , C07D498/22
CPC分类号： C07D235/06 , A61K31/505 , C07D231/12 , C07D233/56 , C07D249/08
摘要： Oxadiazolo[2,3-c]pyrimidine derivatives of the formula ##STR1## wherein R is alkyl, alkenyl, alkynyl or alkoxyalkyl, as well as their salts, are described. The compounds of formula I have valuable, long-lasting vasodilating and/or blood pressure-lowering properties and are useful for the treatment of vascular-conditioned hypertensions or as vasodilators in peripheral blood supply disorders. The compounds are prepared, inter alia, by carbamoylating the corresponding derivative containing a free amino group and optional salt formation.
摘要翻译：描述了其中R是烷基，烯基，炔基或烷氧基烷基的式[IMAGE] I的恶二唑并[2,3-c]嘧啶衍生物及其盐。式I的化合物具有有价值的，持久的血管扩张和/或降血压性质，并且可用于治疗血管性高血压或作为外周血供应障碍中的血管扩张剂。化合物特别是通过氨基甲酰化制备含有游离氨基和任选的盐形成的相应衍生物。

3. 发明授权

US5120759A Tetrahydronaphthalene derivatives for improving short-term memory 失效
标题翻译：用于改善短期记忆的四氢萘并噻唑衍生物
公开(公告)号：US5120759A
公开(公告)日：1992-06-09
申请号：US690408
申请日：1991-04-23
申请人： Urs Hengartner , Henri Ramuz
发明人： Urs Hengartner , Henri Ramuz
IPC分类号： A61K31/215 , A61K31/357 , A61K31/36 , A61P25/28 , A61P33/02 , A61P35/00 , C07C35/52 , C07C57/58 , C07C57/76 , C07C59/48 , C07C69/732 , C07C215/42 , C07C219/24 , C07C323/52 , C07D317/58 , C07D319/18
CPC分类号： C07C57/76 , C07C219/24 , C07C35/52 , C07C57/58 , C07D317/58 , C07D319/18 , C07C2102/10
摘要： Novel compounds of the formula ##STR1## wherein R.sup.1 is lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkylthio-lower-alkyl or furyl, R.sup.2 is lower-alkyl, phenyl-lower-alkyl or cyclohexyl-lower-alkyl, each of R.sup.3 and R.sup.6 independently is hydrogen or fluorine, each of R.sup.4 and R.sup.5 independently is hydrogen or lower-alkoxy or together are methylenedioxy, ethylenedioxy or ethylenoxy and n is an integer from 1 to 3, have a pronounced activity in counteracting cerebral insufficiency or improving cognitive functions and also reduce the multiple-resistance towards cytostatics in the treatment of tumors or of chloroquine resistance in the treatment of malaria. They can accordingly be used as medicaments, especially for the control or prevention of cerebral insufficiency or for the improvement of cognitive functions. The novel compounds of formula I can be manufactured by O-acylating a likewise novel compound of the formula ##STR2## wherein R.sup.2 is lower-alkyl, phenyl-lower-alkyl or cyclohexyl-lower-alkyl, each of R.sup.3 and R.sup.6 independently is hydrogen or fluorine, each of R.sup.4 and R.sup.5 independently is hydrogen or lower-alkoxy or together are methylenedioxy, ethylendioxy or ethylenoxy and n is an integer from 1 to 3.
摘要翻译：下式的新型化合物其中R 1为低级烷基，低级烷氧基 - 低级 - 烷基，低级 - 烷硫基 - 低级 - 烷基或呋喃基，R 2为低级烷基，苯基 - 低级 - 烷基或环己基 - 低级 - 烷基，R 3和R 6各自独立地为氢或氟，R 4和R 5各自独立地为氢或低级烷氧基或一起为亚甲二氧基，亚乙二氧基或乙烯氧基，n为1至3的整数，在抵抗脑中具有明显的活性功能不全或提高认知功能，并且还可减少治疗疟疾时治疗肿瘤或氯喹抗药性细胞抑制剂的多重阻力。因此，它们可以用作药物，特别是用于控制或预防脑功能不全或改善认知功能。式I的新化合物可以通过O-酰化类似新颖的式II化合物来制备，其中R 2是低级烷基，苯基 - 低级烷基或环己基 - 低级烷基，R 3和R 6各自独立地是氢或氟，R 4和R 5各自独立地为氢或低级烷氧基或一起为亚甲二氧基，乙二氧基或亚乙氧基，n为1至3的整数。

4. 发明授权

US4680310A Tetrahydronaphthalene derivatives 失效
标题翻译：四氢萘衍生物
公开(公告)号：US4680310A
公开(公告)日：1987-07-14
申请号：US786253
申请日：1985-10-10
申请人： Urs Hengartner , Henri Ramuz
发明人： Urs Hengartner , Henri Ramuz
IPC分类号： A61K31/135 , A61K31/215 , A61K31/22 , A61P9/06 , A61P9/10 , A61P9/12 , C07C67/00 , C07C213/00 , C07C217/56 , C07C219/24 , C07C313/00 , C07C323/52 , C07C39/17 , C07C43/18 , C07C69/00 , C07C149/20 , C07D317/44 , C07D319/14
CPC分类号： A61K31/215
摘要： Tetrahydronaphthalene derivatives of the formula ##STR1## wherein Y, m, n, R and R.sup.1 to R.sup.9 are as set forth herein, are described.These compounds have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias and high blood pressure. The compounds of formula I can be prepared by the amination of a compound of the formula ##STR2## with a corresponding N-methyl-phenylalkylamine and optional subsequent O-acylation. Compounds of formula II and IV are also described and are within the scope of the invention.
摘要翻译：描述了其中Y，m，n，R和R 1至R 9的式ⅪⅣ衍生物如本文所述。这些化合物具有显着的钙拮抗作用和抗心律失常活性，因此可用作药物，特别是用于控制或预防心绞痛，局部缺血，心律失常和高血压。式I的化合物可以通过用相应的N-甲基 - 苯基烷基胺胺化化合物式“IMAGE”的化合物和任选的随后的O-酰基化来制备。还描述了式II和IV的化合物，并且在本发明的范围内。

5. 发明授权

US4193850A Alkanoyloxylation of beta-ionone 失效
标题翻译： β-紫罗兰酮的烷酰氧基化
公开(公告)号：US4193850A
公开(公告)日：1980-03-18
申请号：US29170
申请日：1979-04-12
申请人： Urs Hengartner , Gilbert Reymond , Valdemar Toome
发明人： Urs Hengartner , Gilbert Reymond , Valdemar Toome
IPC分类号： C07C69/013 , C07C35/08 , C07C67/00 , C07C401/00 , C07C403/00 , C07C403/16 , C25B3/02 , C25B3/10
CPC分类号： C07C403/16 , C25B3/02 , C07C2101/16
摘要： A method for electrochemically alkanoyloxylation of beta-ionone to alkanoyloxy-beta-ionone, an intermediate for canthaxanthin.
摘要翻译：一种β-紫罗兰酮的电化学烷酰氧基化为烷酰氧基-β-紫罗兰酮的方法，其为角黄素的中间体。

6. 发明授权

US5670548A Pigmentation with carotenoids 失效
公开(公告)号：US5670548A
公开(公告)日：1997-09-23
申请号：US726599
申请日：1996-10-07
申请人： Kurt Bernhard , Jiri Broz , Urs Hengartner , Paul Kreienbuhl , Katharina Schiedt
发明人： Kurt Bernhard , Jiri Broz , Urs Hengartner , Paul Kreienbuhl , Katharina Schiedt
IPC分类号： A23K1/18 , A23K1/00 , A23K1/16 , A23L1/272 , C07C45/74 , C07C49/21 , C07C49/24 , C07C49/255 , C07C403/16 , C07C403/24 , C09B61/00 , F02G1/044 , A01N31/04
CPC分类号： F02G1/0445 , A23K20/179 , C07C403/16 , C07C45/74 , C07C49/24 , C07C49/255 , C07C2101/16 , F02G2250/18 , Y10S426/807
摘要： A method of pigmenting certain parts and products of poultry, fish and crustacea by including in the feed of the pertinent animal one or more of the carotenoids 2'-dehydroplectaniaxanthin, desmethylspheroidenone, spheroidenone, 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione, poultry, fish and crustacea feeds for pigmenting certains parts and products of these animals, beadlets and premixes for adding to poultry, fish and crustacea feeds, and the carotenoids 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione.

7. 发明授权

US5605699A Pigmentation with carotenoids 失效
标题翻译：色素与类胡萝卜素
公开(公告)号：US5605699A
公开(公告)日：1997-02-25
申请号：US263308
申请日：1994-06-21
申请人： Kurt Bernhard , Jiri Broz , Urs Hengartner , Paul Kreienbuhl , Katharina Schiedt
发明人： Kurt Bernhard , Jiri Broz , Urs Hengartner , Paul Kreienbuhl , Katharina Schiedt
IPC分类号： A23K1/18 , A23K1/00 , A23K1/16 , A23L1/272 , C07C45/74 , C07C49/21 , C07C49/24 , C07C49/255 , C07C403/16 , C07C403/24 , C09B61/00 , F02G1/044 , A23K1/165
CPC分类号： F02G1/0445 , A23K20/179 , C07C403/16 , C07C45/74 , C07C49/24 , C07C49/255 , C07C2101/16 , F02G2250/18 , Y10S426/807
摘要： A method of pigmenting certain parts and products of poultry, fish and crustacea by including in the feed of the pertinent animal one or more of the carotenoids 2'-dehydroplectaniaxanthin, desmethylspheroidenone, spheroidenone, 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione, poultry, fish and crustacea feeds for pigmenting certains parts and products of these animals, beadlets and premixes for adding to poultry, fish and crustacea feeds, and the carotenoids 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione.
摘要翻译：一种通过在相关动物的饲料中包含一种或多种类胡萝卜素2'-脱氢黄嘌呤，去甲基海藻素，球形酮，1-羟基-3,4-二脱水-1， 2-二氢-psi，psi-胡萝卜素-2-酮，5'-羟基-5'，6'-二氢-4'-apo-β-胡萝卜素-6'-酮，1'-羟基-3'，4 ' - 二脱氢-1'，2'-二氢-β，psi-胡萝卜素-4,2'-二酮和5'-羟基-5'，6'-二氢-4'-ap-β-胡萝卜素-4,6 '二酮，家禽，鱼类和甲壳类饲料用于着色某些这些动物的部分和产品，用于添加到家禽，鱼和甲壳类饲料中的珠粒和预混物，以及类胡萝卜素1-羟基-3,4-二脱氢-1,2-二二氢-psi，psi-胡萝卜素-2-酮，5'-羟基-5'，6'-二氢-4'-磷酸-β-胡萝卜素-6'-酮，1'-羟基-3'，4'- 二脱氢-1'，2'-二氢-β，psi-胡萝卜素-4,2'-二酮和5'-羟基-5'，6'-二氢-4'-ap-β-胡萝卜素-4,6'- 二酮

8. 发明授权

US4296259A Preparation of a 1,4-pentadien-3-ol 失效
标题翻译： 1,4-戊二烯-3-醇的制备
公开(公告)号：US4296259A
公开(公告)日：1981-10-20
申请号：US157574
申请日：1980-06-09
申请人： Urs Hengartner
发明人： Urs Hengartner
IPC分类号： C07C49/743 , C07C403/00
CPC分类号： C07C403/08 , C07C403/16 , C07C403/24 , C07C2101/16
摘要： A new process for preparing 1-(3-oxo-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-1,4-pentadien-3-ol, a intermediate for canthaxanthin, from hydroxy-.beta.-ionone.
摘要翻译：从羟基制备1-（3-氧代-2,6,6-三甲基-1-环己烯-1-基）-3-甲基-1,4-戊二烯-3-醇的新方法，其为角黄素的中间体 β-戊酮。

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